Dementia; education; gut microbiome; mediation; mild cognitive impairment; Neurology (clinical); Psychiatry and Mental Health; General Medicine
Abstract :
[en] Background: With differences apparent in the gut microbiome in mild cognitive impairment (MCI) and dementia, and risk factors of dementia linked to alterations of the gut microbiome, the question remains if gut microbiome characteristics may mediate associations of education with MCI. Objectives: We sought to examine potential mediation of the association of education and MCI by gut microbiome diversity or composition. Design: Cross-sectional study. Setting: Luxembourg, the Greater Region (surrounding areas in Belgium, France, Germany). Participants: Control participants of the Luxembourg Parkinson’s Study. Measurements: Gut microbiome composition, ascertained with 16S rRNA gene amplicon sequencing. Differential abundance, assessed across education groups (0–10, 11–16, 16+ years of education). Alpha diversity (Chao1, Shannon and inverse Simpson indices). Mediation analysis with effect decomposition was conducted with education as exposure, MCI as outcome and gut microbiome metrics as mediators. Results: After exclusion of participants below 50, or with missing data, n=258 participants (n=58 MCI) were included (M [SD] Age=64.6 [8.3] years). Higher education (16+ years) was associated with MCI (Odds ratio natural direct effect=0.35 [95% CI 0.15–0.81]. Streptococcus and Lachnospiraceae-UCG-001 genera were more abundant in higher education. Conclusions: Education is associated with gut microbiome composition and MCI risk without clear evidence for mediation. However, our results suggest signatures of the gut microbiome that have been identified previously in AD and MCI to be reflected in lower education and suggest education as important covariate in microbiome studies.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group) Luxembourg Centre for Systems Biomedicine (LCSB): Developmental and Cellular Biology (Schwamborn Group) LIH - Luxembourg Institute of Health Integrative Research Unit: Social and Individual Development (INSIDE) > PEARL Institute for Research on Socio-Economic Inequality (IRSEI)
KLEE, Matthias ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
AHO, Velma ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Systems Ecology > Team Paul WILMES
MAY, Patrick ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Heintz-Buschart, A.; Swammerdam Institute of Life Sciences at University of Amsterdam, Amsterdam, Netherlands
LANDOULSI, Zied ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
JONSDOTTIR, Sonja ; University of Luxembourg ; Parkinson’s Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg (Belair), Luxembourg ; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg
PAULY, Claire ; University of Luxembourg ; Parkinson’s Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg (Belair), Luxembourg ; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg
PAVELKA, Lukas ; University of Luxembourg ; Parkinson’s Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg (Belair), Luxembourg ; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology, Centre Hospitalier de Luxembourg, Luxembourg (Belair), Luxembourg
DELACOUR, Lea ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations > Innovation and Partnering
KAYSEN, Anne ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Krüger, R.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Parkinson’s Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg (Belair), Luxembourg ; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology, Centre Hospitalier de Luxembourg, Luxembourg (Belair), Luxembourg ; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
WILMES, Paul ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology
LEIST, Anja ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
Acharya, Geeta; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Aguayo, Gloria; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Alexandre, Myriam; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
ALI, Muhammad ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Ammerlann, Wim; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
ARENA, Giuseppe ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Balling, Rudi; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
BASSIS, Michele ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Developmental and Cellular Biology ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Beaumont, Katy; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
BECKER, Regina ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Research BioCore ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Bellora, Camille; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
BERCHEM, Guy Joseph Maximilien Jean ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Berg, Daniela; Center of Neurology and Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University Hospital Tübingen, Tübingen, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Bisdorff, Alexandre; Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
BOUSSAAD, Ibrahim ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Brockmann, Kathrin; Center of Neurology and Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University Hospital Tübingen, Tübingen, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Calmes, Jessica; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Castillo, Lorieza; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Contesotto, Gessica; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Diederich, Nico; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Dondelinger, Rene; Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Esteves, Daniela; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
FAGHERAZZI, Guy ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Ferrand, Jean-Yves; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Gantenbein, Manon; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Gasser, Thomas; Center of Neurology and Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University Hospital Tübingen, Tübingen, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
GAWRON, Piotr ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Visualisation ; Department of Neurology Philipps, University Marburg, Marburg, Germany
GHOSH, Soumyabrata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
GIRAITIS, Marijus ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
GLAAB, Enrico ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Gómez De Lope, Elisa; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Graas, Jérôme; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Graziano, Mariella; Department of Neurology Philipps, University Marburg, Marburg, Germany ; Association of Physiotherapists in Parkinson’s Disease Europe, Esch-sur-Alzette, Luxembourg
GROUES, Valentin ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Grünewald, Anne; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
GU, Wei ; University of Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Hammot, Gaël; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Hanff, Anne-Marie; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
HANSEN, Linda ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
HENEKA, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Henry, Estelle; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Herbrink, Sylvia; Centre Hospitalier du Nord, Ettelbrück, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
HERZINGER, Sascha ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Heymann, Michael; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Hu, Michele; Oxford Parkinson’s Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Hundt, Alexander; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Jacoby, Nadine; Department of Neurology Philipps, University Marburg, Marburg, Germany ; Private practice, Ettelbruck, Luxembourg
Jaroslaw Lebioda, Jacek; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
JAROSZ, Yohan ; University of Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
JONSDOTTIR, Sonja ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
KLOPFENSTEIN, Quentin ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Biomedical Data Science > Team Enrico GLAAB ; Department of Neurology Philipps, University Marburg, Marburg, Germany
KLUCKEN, Jochen ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine ; Luxembourg Institute of Health, Strassen, Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Krüger, Rejko; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Lambert, Pauline; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
LANDOULSI, Zied ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Lentz, Roseline; Parkinson Luxembourg Association, Leudelange, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Liepelt, Inga; Center of Neurology and Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University Hospital Tübingen, Tübingen, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Liszka, Robert; Westpfalz-Klinikum GmbH, Kaiserslautern, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Longhino, Laura; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Lorentz, Victoria; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Lupu, Paula Cristina; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Mackay, Clare; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, United Kingdom ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Maetzler, Walter; Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Marcus, Katrin; Ruhr-University of Bochum, Bochum, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Marques, Guilherme; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Marques, Tainá M.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Martins Conde, Patricia; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
MAY, Patrick ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Mcintyre, Deborah; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Mediouni, Chouaib; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Meisch, Francoise; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Menster, Myriam; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Minelli, Maura; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
MITTELBRONN, Michel ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Neuropathology ; Laboratoire National de Santé, Dudelange, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Mollenhauer, Brit; Paracelsus-Elena-Klinik, Kassel, Germany ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Mühlschlegel, Friedrich; Laboratoire National de Santé, Dudelange, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Nati, Romain; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
NEHRBASS, Ulf ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) ; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
NICKELS, Sarah Louise ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Developmental and Cellular Biology ; Department of Neurology Philipps, University Marburg, Marburg, Germany
NICOLAI, Beatrice ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Nicolay, Jean-Paul; Department of Neurology Philipps, University Marburg, Marburg, Germany ; Private practice, Luxembourg, Luxembourg
NOOR, Fozia ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
OSTASZEWSKI, Marek ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
GOMES, Clarissa ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Department of Neurology Philipps, University Marburg, Marburg, Germany
PACHCHEK, Sinthuja ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Translational Neuroscience > Team Rejko KRÜGER ; Department of Neurology Philipps, University Marburg, Marburg, Germany
PAULY, Claire ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
PAULY, Laure ; University of Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
PAVELKA, Lukas ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
PERQUIN, Magali ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Ramos Lima, Rosalina; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
RAUSCHENBERGER, Armin ; University of Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
RAWAL, Rajesh ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Reddy Bobbili, Dheeraj; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Roomp, Kirsten; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Rosales, Eduardo; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
ROSETY, Isabel ; University of Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Sandt, Estelle; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
SAPIENZA, Stefano ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine ; Department of Neurology Philipps, University Marburg, Marburg, Germany
SATAGOPAM, Venkata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Schmitt, Margaux; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
SCHMITZ, Sabine Katharina ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations > Communication Office ; Department of Neurology Philipps, University Marburg, Marburg, Germany
SCHNEIDER, Reinhard ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
SCHWAMBORN, Jens Christian ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Developmental and Cellular Biology ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Sharify, Amir; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
SOBOLEVA, Ekaterina ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Sokolowska, Kate; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Thien, Hermann; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
THIRY, Elodie ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Ting Jiin Loo, Rebecca; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
TREFOIS, Christophe ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > R3 and IT infrastructure ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Trouet, Johanna; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
TSURKALENKO, Olena ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Vaillant, Michel; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Valenti, Mesele; Luxembourg Institute of Health, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Vega, Carlos; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Vilas Boas, Liliana; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
VYAS, Maharshi ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Department of Neurology Philipps, University Marburg, Marburg, Germany
Wade-Martins, Richard; Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom ; Department of Neurology Philipps, University Marburg, Marburg, Germany
WILMES, Paul ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology ; Department of Neurology Philipps, University Marburg, Marburg, Germany
WOLLSCHEID-LENGELING, Evi ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine ; Department of Neurology Philipps, University Marburg, Marburg, Germany
ZELIMKHANOV, Gelani ; University of Luxembourg ; Centre Hospitalier de Luxembourg, Strassen, Luxembourg ; Department of Neurology Philipps, University Marburg, Marburg, Germany
H2020 - 803239 - CRISP - Cognitive Aging: From Educational Opportunities to Individual Risk Profiles H2020 - 863664 - ExpoBiome - Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease
FnR Project :
FNR11264123 - Ncer-pd, 2015 (01/01/2015-30/11/2020) - Rejko Krüger FNR6682797 - Comprehensive Assessment Of Endophenotypes In Neurodegenerative Diseases - Translating Impaired Molecular Signalling Pathways Into Novel Therapeutic Strategies For Parkinson’S Disease, 2013 (01/06/2014-31/05/2019) - Rejko Krüger FNR11676395 - Mitochondrial Risk Factors In Parkinson's Disease, 2017 (01/03/2018-31/08/2021) - Rejko Krüger FNR11250962 - Reduced Penetrance In Hereditary Movement Disorders: Elucidating Mechanisms Of Endogenous Disease Protection P1: Markers And Mechanisms Of Reduced Penetrance In Lrrk2 Mutation Carriers, 2016 (01/01/2017-30/06/2020) - Anne Grünewald
Name of the research project :
MCI-BIOME_2019
Funders :
Unilu - University of Luxembourg [LU] Union Européenne [BE]
Funding text :
Funding: This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme [grant number 803239, to AKL and grant agreement No. 863664 to PW]. This research was funded in part, by the Luxembourg National Research Fund (FNR), grant reference ([FNR/NCER13/BM/11264123], PEARL program [FNR/ P13/6682797 to RK], MotaSYN [12719684 to RK], MAMaSyn [to RK], MiRisk-PD [C17/BM/11676395 to RK, PM], and the FNR/German Research Foundation [DFG] Core INTER [ProtectMove, FNR11250962 to PM]). For the purpose of open access, and in fulfilment of the obligations arising from the grant agreement, the author has applied a Creative Commons Attribution 4.0 International (CC BY 4.0) license to any Author Accepted Manuscript version arising from this submission. AKL, RK and PW acknowledge financial support of the Institute for Advanced Studies of the University of Luxembourg through an AUDACITY grant (ref. no. MCI-BIOME_2019). Mr Klee and Dr Leist are funded by the European Research Council. No other financial disclosures were reported by the authors of this paper. The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; in the preparation of the manuscript; or in the review or approval of the manuscript.Data used in the preparation of this manuscript were obtained from the National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD). The National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD) is funded by the Luxembourg National Research Fund (FNR/NCER13/BM/11264123). We would like to thank all participants of the Luxembourg Parkinson’s Study for their important support of our research. Furthermore, we acknowledge the joint effort of the NCER-PD Consortium members from the partner institutions Luxembourg Centre for Systems Biomedicine, Luxembourg Institute of Health, Centre Hospitalier de Luxembourg, and Laboratoire National de Santé generally contributing to the Luxembourg Parkinson’s Study as listed below.
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