Profil

SCHWAMBORN Jens Christian

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Developmental and Cellular Biology

Main Referenced Co-authors
BOLOGNIN, Silvia  (28)
JARAZO, Javier  (23)
ANTONY, Paul  (21)
KRÜGER, Rejko  (17)
SMITS, Lisa  (16)
Main Referenced Keywords
Animals (21); Mice (14); Cells, Cultured (9); Humans (8); Cell Proliferation (5);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Developmental and Cellular Biology (Schwamborn Group) (18)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group) (3)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (49)
Genetics & genetic processes (29)
Biotechnology (25)
Life sciences: Multidisciplinary, general & others (17)
Neurology (7)

Publications (total 128)

The most downloaded
774 downloads
Le Grand, J. N., Gonzalez Cano, L., Pavlou, M. A., & Schwamborn, J. C. (2015). Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression. Cellular and Molecular Life Sciences. doi:10.1007/s00018-014-1774-1 https://hdl.handle.net/10993/18827

The most cited

448 citations (Scopus®)

Han, D. W., Tapia, N., Hermann, A., Hemmer, K., Hoing, S., Arauzo-Bravo, M. J., Zaehres, H., Wu, G., Frank, S., Moritz, S., Greber, B., Yang, J. H., Lee, H. T., Schwamborn, J. C., Storch, A., & Scholer, H. R. (2012). Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell, 10 (4), 465-72. doi:10.1016/j.stem.2012.02.021 https://hdl.handle.net/10993/2730

HEINS MARROQUIN, U., SINGH, R., PERATHONER, S., GAVOTTO, F., Merino Ruiz, C., PATRASKAKI, M., Gomez-Giro, G., Kleine Borgmann, F., Meyer, M., Carpentier, A., WARMOES, M. O., Jäger, C., MITTELBRONN, M., SCHWAMBORN, J. C., Cordero-Maldonado, M. L., CRAWFORD, A., SCHYMANSKI, E., & LINSTER, C. (March 2024). CLN3 deficiency leads to neurological and metabolic perturbations during early development. Life Science Alliance, 7 (3). doi:10.26508/lsa.202302057
Peer Reviewed verified by ORBi

Sabate-Soler, S., Kurniawan, H., & Schwamborn, J. C. (2024). Advanced brain organoids for neuroinflammation disease modeling. Neural Regeneration Research.
Peer Reviewed verified by ORBi

KLEE, M., AHO, V., MAY, P., Heintz-Buschart, A., LANDOULSI, Z., JONSDOTTIR, S., PAULY, C., PAVELKA, L., DELACOUR, L., KAYSEN, A., Krüger, R., WILMES, P., LEIST, A., Acharya, G., Aguayo, G., Alexandre, M., ALI, M., Ammerlann, W., ARENA, G., ... ZELIMKHANOV, G. (2024). Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome. Journal of Prevention of Alzheimer's Disease. doi:10.14283/jpad.2024.19
Peer reviewed

ZAGARE, A., Preciat, G., NICKELS, S. L., Luo, X., MONZEL, A. S., Gomez-Giro, G., ROBERTSON, G., Jaeger, C., Sharif, J., Koseki, H., DIEDERICH, N., GLAAB, E., FLEMING, R. M., & SCHWAMBORN, J. C. (20 November 2023). Omics data integration suggests a potential idiopathic Parkinson's disease signature. Communications Biology, 6 (1), 1179. doi:10.1038/s42003-023-05548-w
Peer Reviewed verified by ORBi

Mavrommatis, L., Jeong, H.-W., Kindler, U., Gomez-Giro, G., Kienitz, M.-C., Stehling, M., Psathaki, O. E., Zeuschner, D., Bixel, M. G., Han, D., Morosan-Puopolo, G., Gerovska, D., Yang, J. H., Kim, J. B., Arauzo-Bravo, M. J., SCHWAMBORN, J. C., Hahn, S. A., Adams, R. H., Schöler, H. R., ... Zaehres, H. (14 November 2023). Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors. eLife, 12. doi:10.7554/elife.87081.3
Peer Reviewed verified by ORBi

Mendes-Pinheiro, B., Campos, J., Marote, A., Soares-Cunha, C., NICKELS, S. L., MONZEL, A. S., Cibrão, J. R., Loureiro-Campos, E., Serra, S. C., Barata-Antunes, S., Duarte-Silva, S., Pinto, L., SCHWAMBORN, J. C., & Salgado, A. J. (02 November 2023). Treating Parkinson's Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration. Cells, 12 (21), 2565. doi:10.3390/cells12212565
Peer Reviewed verified by ORBi

MULICA, P., Venegas, C., LANDOULSI, Z., BADANJAK, K., DELCAMBRE, S., TZIORTZIOU, M., HEZZAZ, S., Ghelfi, J., SMAJIC, S., SCHWAMBORN, J. C., Krüger, R., ANTONY, P., MAY, P., GLAAB, E., GRÜNEWALD, A.* , & Pereira, S. L.*. (20 September 2023). Comparison of two protocols for the generation of iPSC-derived human astrocytes. Biological Procedures Online, 25 (1), 26. doi:10.1186/s12575-023-00218-x
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Sabaté Soler, S., Schwamborn, J. C., & Cowley, S. (27 April 2023). Means and methods for generating immunocompetent midbrain assembloid.

HEINS MARROQUIN, U., SINGH, R., PERATHONER, S., GAVOTTO, F., Ruiz, C. M., PATRASKAKI, M., Gomez-Giro, G., Borgmann, F. K., Meyer, M., Carpentier, A., WARMOES, M. O., JÄGER, C., MITTELBRONN, M., SCHWAMBORN, J. C., CORDERO MALDONADO, M. L., CRAWFORD, A., SCHYMANSKI, E., & LINSTER, C. (2023). CLN3 deficiency leads to neurological and metabolic perturbations during early development. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57737. doi:10.1101/2023.03.17.533107

Smirnova, L., Caffo, B., Garcias, D., Huang, Q., Morales Pantoja, I., Tang, B., Zack, D., Berlinicke, C., Boyd, J., Harris, T., Johnson, E., Kagan, B., Kahn, J., Muotri, A., Paulhamus, B., Schwamborn, J. C., Plotkin, J., Szalay, A., Vogelstein, J., ... Hartung, T. (2023). Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish. Frontiers in Science.
Peer reviewed

Chemla, A., Arena, G., Onal, G., Walter, J., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G>A (p.R272Q) or c.1348C>T (p.R450C) in the RHOT1 gene encoding Miro1. Stem Cell Research, 103145. doi:10.1016/j.scr.2023.103145
Peer reviewed

Hartung, T., Smirnova, L., Morales Pantoja, I., Akwaboah, A., Alam El Din, D., Berlinicke, C., Boyd, J., Caffo, B., Cappiello, B., Cohen-Karni, T., Curley, J., Etienne-Cummings, R., Dastgheyb, R., Gracias, D., Gilbert, F., Habela, C., Han, F., Harris, T., Herrmann, K., ... Zack, D. (2023). The Baltimore declaration toward the exploration of organoid intelligence. Frontiers in Science.
Peer reviewed

Mészáros, M., Phan, T., Vigh, J., Porkoláb, G., Kocsis, A., Páli, E., Polgár, T., Walter, F., Bolognin, S., Schwamborn, J. C., Janáky, T., Deli, M., & Veszelka, S. (2023). Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood-Brain Barrier Model and Entry to Human Brain Organoids. Cells. doi:10.3390/cells12030503
Peer Reviewed verified by ORBi

Minoia, A., Dalle Carbonare, L., Schwamborn, J. C., Bolognin, S., & Valenti, M. (2023). Bone Tissue and the Nervous System: What Do They Have in Common? Cells. doi:10.3390/cells12010051
Peer Reviewed verified by ORBi

Chemla, A., Arena, G., Saraiva, C., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Klein, C., Seibler, P., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1. Stem Cell Research, 69, 103085. doi:10.1016/j.scr.2023.103085
Peer Reviewed verified by ORBi

Garcia Santa Cruz, B., Sölter, J., Gomez Giro, G., Saraiva, C., Sabaté Soler, S., Modamio Chamarro, J., Barmpa, K., Schwamborn, J. C., Hertel, F., Jarazo, J., & Husch, A. (2022). Generalising from conventional pipelines using deep learning in high‑throughput screening workfows. Scientific Reports. doi:10.1038/s41598-022-15623-7
Peer Reviewed verified by ORBi

Danileviciute, E., Zeng, N., Capelle, C. M., Paczia, N., Gillespie, M. A., Kurniawan, H., Benzarti, M., Merz, M. P., Coowar, D., Fritah, S., Vogt Weisenhorn, D. M., Gomez Giro, G., Grusdat, M., Baron, A., Guerin, C., Franchina, D. G., Léonard, C., Domingues, O., Delhalle, S., ... He, F. (26 May 2022). PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing. Nature Metabolism, 4 (5), 589-607. doi:10.1038/s42255-022-00576-y
Peer Reviewed verified by ORBi

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446
Peer Reviewed verified by ORBi

Zagare, A., Barmpa, K., Smajic, S., Smits, L., Grzyb, K., Grünewald, A., Skupin, A., Nickels, S. L., & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.12.009
Peer Reviewed verified by ORBi

Cassotta, M., Geerts, H., Harbom, L., Outeiro, T. F., Pediaditakis, I., Reiner, O., Schildknecht, S., Schwamborn, J. C., Bailey, J., Herrmann, K., & Hogberg, H. T. (2022). The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible. ALTEX: Alternatives to Animal Experimentation. doi:10.14573/altex.2203161
Peer Reviewed verified by ORBi

Sabaté Soler, S., Nickels, S. L., Saraiva, C., Berger, E., Dubonyte, U., Barmpa, K., Lan, Y. J., Kouno, T., Jarazo, J., Robertson, G., Sharif, J., Koseki, H., Thome, C., Shin, J., Cowley, S., & Schwamborn, J. C. (2022). Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. doi:10.1002/glia.24167
Peer Reviewed verified by ORBi

Trezzi, J.-P., Aho, V., Jäger, C., Schade, S., Janzen, A., Hickl, O., Kunath, B., Thomas, M., Schmit, K., Garcia, P., Sciortino, A., Martin-Gallausiaux, C., Halder, R., Huarte, O. U., Heurtaux, T., Heins-Marroquin, U., Gomez-Giro, G., Weidenbach, K., Delacour, L., ... Wilmes, P. (2022). An archaeal compound as a driver of Parkinson’s disease pathogenesis. (1). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51987. doi:10.21203/rs.3.rs-1827631/v1

Sabate-Soler, S., Bernini, M., & Schwamborn, J. C. (2022). Immunocompetent brain organoids – Microglia enter the stage. Progress in Biomedical Engineering. doi:10.1088/2516-1091/ac8dcf
Peer reviewed

Bolognin, S., Smits, L., Nickels, S. L., Magni, S., Antony, P., Grzyb, K., Krüger, R., Skupin, A., & Schwamborn, J. C. (2021). A new brain organoid model to study Parkinson’s Disease. Biomedical Science and Engineering.

Nickels, S. L., & Schwamborn, J. C. (2021). Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease? Neural Regeneration Research. doi:10.4103/1673-5374.293140
Peer Reviewed verified by ORBi

Klima, S., Brüll, M., Spreng, A.-S., Suciu, I., Falt, T., Schwamborn, J. C., Waldmann, T., & Leist, M. (2021). A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling. Archives of Toxicology. doi:10.1007/s00204-021-03024-0
Peer Reviewed verified by ORBi

Boussaad, I., Cruciani, G., Bolognin, S., Antony, P., Dording, C., Kwon, Y.-J., Heuting, P., Fava, E., Schwamborn, J. C., & Krüger, R. (2021). Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening. Scientific Reports. doi:10.1038/s41598-021-81129-3
Peer Reviewed verified by ORBi

Zanetti, C., Spitz, S., Berger, E., Bolognin, S., Smits, L., Crepaz, P., Rothbauer, M., Rosser, J. M., Marchetti'Deschmann, M., Schwamborn, J. C., & Ertl, P. (2021). Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson’s disease modeling and drug screening. Analyst. doi:10.1039/d0an02206c
Peer Reviewed verified by ORBi

Brown, S. J., Boussaad, I., Jarazo, J., Fitzgerald, J. C., Antony, P., Keatinge, M., Blechman, J., Schwamborn, J. C., Krüger, R., Placzek, M., & Bandmann, O. (2021). PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons. Scientific Reports. doi:10.1038/s41598-021-84278-7
Peer Reviewed verified by ORBi

Zagare, A., Gobin, M., Monzel, A., & Schwamborn, J. C. (2021). A robust protocol for the generation of human midbrain organoids. STAR Protocols. doi:10.1016/j.xpro.2021.100524
Peer Reviewed verified by ORBi

Walter, J., Bolognin, S., Poovathingal, S., Magni, S., Gerard, D., Antony, P., Nickels, S. L., Salamanca, L., Berger, E., Smits, L., Grzyb, K., Perfeito, R., Hoel, F., Qing, X., Ohnmacht, J., Bertacchi, M., Jarazo, J., Ignac, T., Monzel, A., ... Schwamborn, J. C. (2021). The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Reports. doi:10.1016/j.celrep.2021.109864
Peer Reviewed verified by ORBi

Badanjak, K., Mulica, P., Smajic, S., Delcambre, S., Tranchevent, L.-C., Diederich, N., Rauen, T., Schwamborn, J. C., Glaab, E., Cowley, S. A., Antony, P., Pereira, S. L., Venegas, C., & Grünewald, A. (2021). iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease. Frontiers in Cell and Developmental Biology, 9, 740758. doi:10.3389/fcell.2021.740758
Peer Reviewed verified by ORBi

Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L., Su, J., Arias-Fuenzalida, Walter, J., Gomez Giro, G., Monzel, A., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., ... Schwamborn, J. C. (2021). Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment. Movement Disorders. doi:10.1002/mds.28810
Peer Reviewed verified by ORBi

Mommaerts, K., Bellora, C., Lambert, P., Tuerkmen, S., Schwamborn, J. C., & Betsou, F. (2021). Method Optimization of Skin Biopsy-Derived Fibroblast Culture for Reprogramming Into Induced Pluripotent Stem Cells. Biopreservation and Biobanking. doi:10.1089/bio.2020.0159
Peer Reviewed verified by ORBi

Mutti, V., Bono, F., Tomasoni, Z., Bontempi, L., Guglielmi, A., Bolognin, S., Schwamborn, J. C., Missale, C., & Fiorentini, C. (2021). Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway. Molecular Neurobiology. doi:10.1007/s12035-022-02748-z
Peer Reviewed verified by ORBi

Veszelka, S., Mészáros, M., Porkoláb, G., Szecskó, A., Kondor, N., Ferenc, G., Polgár, T. F., Katona, G., Kóta, Z., Kelemen, L., Páli, T., Vigh, J. P., Walter, F. R., Bolognin, S., Schwamborn, J. C., Jan, J.-S., & Deli, M. A. (2021). A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model. Pharmaceutics. doi:10.3390/pharmaceutics14010086
Peer Reviewed verified by ORBi

Hanss, Z., Larsen, S., Antony, P., Mencke, P., Massart, F., Jarazo, J., Schwamborn, J. C., Barbuti, P., Mellick, G., & Krüger, R. (2020). Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons. Movement Disorders. doi:10.1002/mds.28365
Peer Reviewed verified by ORBi

Rajan, R., Divya, K. P., Kandadai, R. M., Yadav, R., Satagopam, V., Madhusoodanan, U. K., Agarwal, P., Kumar, N., Ferreira, T., Kumar, H., Sreeram Prasad, A. V., Shetty, K., Mehta, S., Desai, S., Kumar, S., Prashanth, L. K., Bhatt, M., Wadia, P., Ramalingam, S., ... Sharma, M. (18 June 2020). Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research. Frontiers in Neurology, 11, 524. doi:10.3389/fneur.2020.00524
Peer Reviewed verified by ORBi

Lee, M.-H., Liu, K.-T., Thomas, J. L., Su, Z.-L., O'Hare, D., van Wüllen, T. M., Modamio Chamarro, J., Bolognin, S., Luo, S.-C., Schwamborn, J. C., & Lin, H.-Y. (2020). Peptide-Imprinted Poly(hydroxymethyl 3,4-ethylenedioxythiophene) Nanotubes for Detection of Alpha Synuclein in Human Brain Organoids. ACS Applied Nano Materials. doi:10.1021/acsanm.0c01476
Peer Reviewed verified by ORBi

Kane, K., Jarazo, J., Lucumi Moreno, E., Fleming, R., & Schwamborn, J. C. (2020). Passive controlled flow for Parkinson’s disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip.
Peer reviewed

Smits, L., Magni, S., Kinugawa, K., Grzyb, K., Luginbühl, J., Sabaté Soler, S., Bolognin, S., Shin, J., Mori, E., Skupin, A., & Schwamborn, J. C. (2020). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and Tissue Research. doi:10.1007/s00441-020-03249-y
Peer Reviewed verified by ORBi

Barbuti, P., Antony, P., Rodrigues Santos, B., Massart, F., Cruciani, G., Dording, C., Arias, J., Schwamborn, J. C., & Krüger, R. (2020). Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson's Disease Point Mutation A30P. Cells, 9 (9). doi:10.3390/cells9092065
Peer Reviewed verified by ORBi

Lee, M.-H., Thomas, J., Su, Z.-L., Yeh, W.-K., Monzel, A. S., Bolognin, S., Schwamborn, J. C., Yang, C.-H., & Lin, H.-Y. (2020). Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium. Biosensors and Bioelectronics. doi:10.1016/j.bios.2020.112852
Peer Reviewed verified by ORBi

Bono, F., Mutti, V., Devoto, P., Bolognin, S., Schwamborn, J. C., Missale, C., & Fiorentini, C. (2020). Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson’s disease patients carrying the LRRK2 G2019S mutation. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2020.12.001
Peer Reviewed verified by ORBi

Smits, L., & Schwamborn, J. C. (2020). Midbrain organoids: A new tool to investigate Parkinson's disease. Frontiers in Cell and Developmental Biology. doi:10.3389/fcell.2020.00359
Peer Reviewed verified by ORBi

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Dietrich, C., Jarazo, J., Henck, J., Balachan, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (2020). Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/49376.

Gomez Giro, G., Arias-Fuenzalida, J., Jarazo, J., Zeuschner, D., Ali, M., Possemis, N., Bolognin, S., Halder, R., Jäger, C., Kuper, W., van Hasselt, P., Zaehres, H., del Sol Mesa, A., van der Putten, H., Schoeler, H., & Schwamborn, J. C. (2020). Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta Neuropathologica Communications. doi:10.1186/s40478-019-0871-7
Peer Reviewed verified by ORBi

Kano, M., Takanashi, M., Oyama, G., Yoritaka, A., Hatano, T., Shiba-Fukushima, K., Nagai, M., Nishiyama, K., Hasegawa, K., Inoshita, T., Ishikawa, K.-I., Akamatsu, W., Imai, Y., Bolognin, S., Schwamborn, J. C., & Hattori, N. (2020). Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. NPJ Parkinson's Disease. doi:10.1038/s41531-020-00137-8
Peer Reviewed verified by ORBi

Monzel, A. S., Hemmer, K., Smits, L., Bolognin, S., Lucarelli, P., Rosety, I., Zagare, A., Antony, P., Nickels, S., Krüger, R., & Schwamborn, J. C. (2020). Machine learning-assisted neurotoxicity prediction in human midbrain organoids. Parkinsonism and Related Disorders. doi:10.1016/j.parkreldis.2020.05.011
Peer Reviewed verified by ORBi

Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease. Human Molecular Genetics. doi:10.1093/hmg/ddaa066
Peer Reviewed verified by ORBi

Nickels, S. L., Modamio Chamarro, J., Mendes-Pinheiro, B., Monzel, A. S., Betsou, F., & Schwamborn, J. C. (2020). Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease. Stem Cell Research. doi:10.1016/j.scr.2020.101870
Peer Reviewed verified by ORBi

Boussaad, I., Obermaier, C. D., Hanss, Z., Bobbili, D. R., Bolognin, S., Glaab, E., Wołyńska, K., Weisschuh, N., De Conti, L., May, C., Giesert, F., Grossmann, D., Lambert, A., Kirchen, S., Biryukov, M., Burbulla, L. F., Massart, F., Bohler, J., Cruciani, G., ... Krüger, R. (2020). A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Science Translational Medicine, 12 (560). doi:10.1126/scitranslmed.aau3960
Peer Reviewed verified by ORBi

Spitz, S., Zanetti, C., Bolognin, S., Muwanigwa, M. N., Smits, L., Berger, E., Jordan, C., Harasek, M., Schwamborn, J. C., & Ertl, P. (2019). Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/43479. doi:10.1101/869701

Garcia Santa Cruz, B., Jarazo, J., Saraiva, C., Gomez Giro, G., Modamio Chamarro, J., Sabaté Soler, S., Kyriaki, B., Antony, P., Schwamborn, J. C., Hertel, F., & Husch, A. (29 November 2019). From tech to bench: Deep Learning pipeline for image segmentation of high-throughput high-content microscopy data [Poster presentation]. Advances in Computational Biology, Barcelona, Spain.

Garcia Santa Cruz, B., Jarazo, J., Schwamborn, J. C., Hertel, F., & Husch, A. (10 October 2019). Deep Learning Quality Control for High-Throughput High-Content Screening Microscopy Images [Poster presentation]. EMBO|EMBL Symposia - Seeing is Believing - Imaging the Molecular Processes of Life, Heidelberg, Germany.

Arias, J., Jarazo, J., Walter, J., Gomez Giro, G., Forster, J., Antony, P., Krüger, R., & Schwamborn, J. C. (2019). Automated high-throughput high-content autophagy and mitophagy analysis platform. Scientific Reports. doi:10.1038/s41598-019-45917-2
Peer Reviewed verified by ORBi

Smits, L., Magni, S., Grzyb, K., Antony, P., Krüger, R., Skupin, A., Bolognin, S., & Schwamborn, J. C. (2019). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/39342. doi:10.1101/589598

Kane, K., Lucumi Moreno, E., Hachi, S., Walter, M., Jarazo, J., Oliveira, M., Hankemeier, T., Vulto, P., Schwamborn, J. C., Thoma, M., & Fleming, R. (2019). Automated microfluidic cell culture of stem cell derived dopaminergic neurons. Scientific Reports. doi:10.1038/s41598-018-34828-3
Peer Reviewed verified by ORBi

Jarazo, J., Qing, X., & Schwamborn, J. C. (2019). Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing. Frontiers in Genetics. doi:10.3389/fgene.2019.00190
Peer Reviewed verified by ORBi

Smits, L., Reinhardt, L., Reinhardt, P., Glatza, M., Monzel, A. S., Stanslowsky, N., Rosato-Siri, M., Zanon, A., Antony, P., Bellmann, J., Nicklas, S., Hemmer, K., Qing, X., Berger, E., Kalmbach, N., Ehrlich, M., Bolognin, S., Hicks, A., Wegner, F., ... Schwamborn, J. C. (2019). Modeling Parkinson’s disease in midbrain-like organoids. NPJ Parkinson's Disease. doi:10.1038/s41531-019-0078-4
Peer Reviewed verified by ORBi

Zhao, M., Song, K., Hao, W., Wang, L., Patil, G., Li, Q., Xu, L., Hua, F., Fu, B., Schwamborn, J. C., Dorf, M., & Li, S. (2019). Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway. Journal of Molecular Cell Biology. doi:10.1093/jmcb/mjz081
Peer Reviewed verified by ORBi

Walter, J., Bolognin, S., Antony, P., Nickels, S., Poovathhingal, S., Salamanca, L., Magni, S., Perfeito, R., Hoel, F., Qing, X., Jarazo, J., Arias-Fuenzalida, J., Ignac, T., Monzel, A. S., Gonzalez-Cano, L., Pereira de Almeida, L., Skupin, A., Tronstad, K., & Schwamborn, J. C. (2019). Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality. Stem Cell Reports. doi:10.1016/j.stemcr.2019.03.004
Peer Reviewed verified by ORBi

Nickels, S., Walter, J., Bolognin, S., GERARD, D., Jäger, C., Qing, X., Tisserand, J., Jarazo, J., Hemmer, K., Harms, A., Halder, R., Lucarelli, P., Berger, E., Antony, P., Glaab, E., Hankemeier, T., Klein, C., Sauter, T., Sinkkonen, L., & Schwamborn, J. C. (2019). Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism and Related Disorders. doi:10.1016/j.parkreldis.2019.09.018
Peer Reviewed verified by ORBi

Henriques, D., Moreira, R., Schwamborn, J. C., Pereira de Almeida, L., & Simoes Mendonca, L. (2019). Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation. Frontiers in Neuroscience. doi:10.3389/fnins.2019.01194
Peer Reviewed verified by ORBi

Zhu, J.-W., Zou, M.-M., Li, Y.-F., Chen, W.-J., Liu, J.-C., Chen, H., Fang, L.-P., Zhang, Y., Wang, Z.-T., Chen, J.-B., Huang, W., Li, S., Jia, W.-Q., Wang, Q.-Q., Zhen, X.-C., Liu, C.-F., Li, S., Xiao, Z.-C., Xu, G.-Q., ... Xu, R.-X. (2019). Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. Cerebral Cortex. doi:10.1093/cercor/bhz306
Peer Reviewed verified by ORBi

Hanss, Z., Boussaad, I., Jarazo, J., Schwamborn, J. C., & Krüger, R. (2019). Quality Control Strategy for CRISPRCas9- based Gene Editing Complicated by a Pseudogene. Frontiers in Genetics. doi:10.3389/fgene.2019.01297
Peer Reviewed verified by ORBi

Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Lucumi Moreno, E., Nickels, S., Wasner, K., Ouzren, N., Walter, J., Grünewald, A., Glaab, E., Salamanca, L., Fleming, R. M. T., Antony, P., & Schwamborn, J. C. (2018). 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science. doi:10.1002/advs.201800927
Peer Reviewed verified by ORBi

Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G., Ellinger-Ziegelbauer, H., & Daneshian, M. (2018). Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems. ALTEX: Alternativen zu Tierexperimenten.
Peer Reviewed verified by ORBi

Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L., Negri, G. L., Schwamborn, J. C., Jensen, P., Mackenzie, I., Taubert, S., & Sorensen, P. (2018). Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. Acta Neuropathologica Communications. doi:10.1186/s40478-018-0554-9
Peer Reviewed verified by ORBi

Hemmer, K., Smits, L., Bolognin, S., & Schwamborn, J. C. (2018). In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading. Opera Medica et Physiologica.
Peer reviewed

Berger, E., Magliaro, C., Paczia, N., Monzel, A. S., Antony, P., Linster, C., Bolognin, S., Ahluwalia, A., & Schwamborn, J. C. (2018). Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a Chip - Miniaturisation for Chemistry and Biology. doi:10.1039/c8lc00206a
Peer reviewed

Nicklas, S., Hillje, A.-L., Okawa, S., Rudolph, I.-M., Collmann, F. M., Van Wüllen, T. M., del Sol Mesa, A., & Schwamborn, J. C. (2018). A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification. Cell Death and Differentiation. doi:10.1038/s41418-018-0144-1
Peer reviewed

Pinho, R., Paiva, I., Jerčić, K. G., Fonseca-Ornelas, L., Gerhardt, E., Fahlbusch, C., Garcia-Esparcia, P., Kerimoglu, C., Pavlou, M. A., Villar-Piqué, A., Szegő, É., Fonseca, T. L., Odoardi, F., Soeroes, S., Rego, A. C., Fischle, W., Schwamborn, J. C., Meyer, T., Kügler, S., ... Outeiro, T. F. (2018). Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein. Human Molecular Genetics. doi:10.1093/hmg/ddy326
Peer Reviewed verified by ORBi

Schwamborn, J. C. (2018). Is Parkinson’s disease a neurodevelopmental disorder and will brain organoids help us to understand it? Stem Cells and Development. doi:10.1089/scd.2017.0289
Peer Reviewed verified by ORBi

Gonzalez-Cano, L., Menzl, I., Tisserand, J., Nicklas, S., & Schwamborn, J. C. (2017). Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32. Molecular Neurobiology. doi:10.1007/s12035-017-0570-y
Peer Reviewed verified by ORBi

Spathis, A., Asvos, X., Ziavra, D., Karampelas, T., Topouzis, S., Cournia, Z., Qing, X., Alexakos, P., Smits, L., Dalla, C., Rideout, H., Schwamborn, J. C., Tamvakopoulos, C., Fokas, D., & Vassilatis, D. (2017). Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1616874114
Peer Reviewed verified by ORBi

Monzel, A. S., Smits, L., Hemmer, K., Hachi, S., Lucumi Moreno, E., Van Wüllen, T. M., Jarazo, J., Walter, J., Werthschulte, I., Boussaad, I., Berger, E., Fleming, R. M., Bolognin, S., & Schwamborn, J. C. (2017). Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. doi:10.1016/j.stemcr.2017.03.010
Peer Reviewed verified by ORBi

Hemmer, K., Smits, L., Bolognin, S., & Schwamborn, J. C. (2017). In Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading. bioRxiv.

Kane, K., Lucumi Moreno, E., Hachi, S., Walter, M., Jarazo, J., Hankemeier, T., Vulto, P., Schwamborn, J. C., Thoma, M., & Fleming, R. M. (2017). Automated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease. bioRxiv. doi:10.1038/s41598-018-34828-3

Walter, J., Nickels, S., & Schwamborn, J. C. (2017). Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders. Stem Cell Investigation. doi:10.21037/sci.2017.11.08
Peer reviewed

Arias, J., Jarazo, J., Qing, X., Walter, J., Gomez Giro, G., Nickels, S., Zaehres, H., Schoeler, H. R., & Schwamborn, J. C. (2017). FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling. Stem Cell Reports. doi:10.1016/j.stemcr.2017.08.026
Peer Reviewed verified by ORBi

Qing, X., Walter, J., Jarazo, J., Arias, J., Hillje, A.-L., & Schwamborn, J. C. (2017). CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons. Stem Cell Research. doi:10.1016/j.scr.2017.08.013
Peer reviewed

Hillje, A.-L., & Schwamborn, J. C. (2016). Utilization of stem cells to model Parkinson's disease – current state and future challenges. Future Neurology. doi:10.2217/fnl.16.7
Peer Reviewed verified by ORBi

Fricke, I., Viel, T., Worlitzer, M., Collmann, F., Vrachimis, A., Faust, A., Wachsmuth, L., Faber, C., Dolle, F., Kuhlmann, M., Schaefers, K., Hermann, S., Schwamborn, J. C., & Jacobs, A. (2016). 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute micro- and astrogliosis in the nigrostriatal system but no Bioluminescence Imaging detectable alteration in adult neurogenesis. European Journal of Neuroscience. doi:10.1111/ejn.13232
Peer Reviewed verified by ORBi

Okawa, S., Nicklas, S., Zickenrott, S., Schwamborn, J. C., & del Sol Mesa, A. (2016). A generalized gene regulatory network model of stem cell differentiation for predicting lineage specifiers. Stem Cell Reports. doi:10.1016/j.stemcr.2016.07.014
Peer Reviewed verified by ORBi

Sakalem, M. E., Seidenbecher, T., Zhang, M., Saffari, R., Kravchenko, M., Wördemann, S., Diederich, K., Schwamborn, J. C., Zhang, W., & Ambrée, O. (2016). Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis. Hippocampus. doi:10.1002/hipo.22669
Peer Reviewed verified by ORBi

Pavlou, M. A., Colombo, N., Fuertes-Alvarez, S., Nicklas, S., Gonzalez Cano, L., Marin, M., Goncalves, J., & Schwamborn, J. C. (2016). Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32. Molecular Neurobiology. doi:10.1007/s12035-016-9989-9
Peer Reviewed verified by ORBi

Bunk, E., Ertaylan, G., Ortega, F., Pavlou, M. A., Gonzalez Cano, L., Stergiopoulos, A., Safaiyan, S., Voels, S., van Cann, M., Politis, P., Berninger, B., del Sol Mesa, A., & Schwamborn, J. C. (2016). Prox1 is required for oligodendrocyte cell identity in adult neural stem cells of the subventricular zone. Stem Cells. doi:10.1002/stem.2374
Peer Reviewed verified by ORBi

Fatima, M., Kumari, R., Schwamborn, J. C., Mahadevan, A., Shankar, S., Raja, R., & Seth, P. (2016). Tripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 Neurodegeneration. Cell Death and Differentiation. doi:10.1038/cdd.2015.138
Peer reviewed

Nicklas, S., Okawa, S., Hillje, A.-L., Gonzalez Cano, L., del Sol Mesa, A., & Schwamborn, J. C. (2015). The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs. Nucleic Acids Research. doi:10.1093/nar/gkv138
Peer Reviewed verified by ORBi

Bahnassawy, L. A., Perumal, T., Gonzalez Cano, L., Hillje, A.-L., Taher, L., Makalowski, W., Suzuki, Y., Fuellen, G., del Sol Mesa, A., & Schwamborn, J. C. (2015). TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability. Scientific Reports. doi:10.1038/srep13456
Peer Reviewed verified by ORBi

Bishi, Wang, L., Ding, H., Schwamborn, J. C., Li, S., & Dorf, M. (2015). TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase. PLoS Pathogens.
Peer Reviewed verified by ORBi

Palm, T., Bolognin, S., Meiser, J., Nickels, S., Traeger, C., Meilenbrock, R.-L., Brockhaus, J., Streitmueller, M., Missler, M., & Schwamborn, J. C. (2015). Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia. Scientific Reports, 5. doi:10.1038/srep16321
Peer Reviewed verified by ORBi

Hillje, A.-L., Beckmann, E., Pavlou, M. A., Jäger, C., Pacheco, M., Sauter, T., Schwamborn, J. C., & Lewejohann, L. (2015). The neural stem cell fate determinant TRIM32 regulates complex behavioral traits. Frontiers in Cellular Neuroscience. doi:10.3389/fncel.2015.00075
Peer Reviewed verified by ORBi

Le Grand, J. N., Gonzalez Cano, L., Pavlou, M. A., & Schwamborn, J. C. (2015). Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression. Cellular and Molecular Life Sciences. doi:10.1007/s00018-014-1774-1
Peer Reviewed verified by ORBi

Lucumi Moreno, E., Hachi, S., Hemmer, K., Trietsch, S., Baumuratov, A., Hankemeier, T., Vulto, P., Schwamborn, J. C., & Fleming, R. M. (2015). Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture. Lab on a Chip - Miniaturisation for Chemistry and Biology, 15, 2419-2428. doi:10.1039/C5LC00180C
Peer reviewed

Ertaylan, G., Okawa, S., Schwamborn, J. C., & del Sol Mesa, A. (2014). Gene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain. Frontiers in Cellular Neuroscience. doi:10.3389/fncel.2014.00437
Peer Reviewed verified by ORBi

Hemmer, K., Zhang, M., van Wuellen, T., Sakalem, M., Tapia, N., Baumuratov, A., Kaltschmidt, C., Kaltschmidt, B., Schoeler, H. R., Zhang, W., & Schwamborn, J. C. (2014). Induced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain. Stem Cell Reports. doi:10.1016/j.stemcr.2014.06.017
Peer Reviewed verified by ORBi

Hargus, G., Ehrlicher, M., Arauzo-Bravo, M., Hemmer, K., Hallmann, A.-L., Reinhardt, P., Kee-Pyo, K., Adachi, K., Santourlidis, Ghanjati, F., Fauser, M., Ossig, C., Storch, Kim, J. B., Schwamborn, J. C., Sterneckert, J., Schoeler, H., Kuhlmann, T., & Zaehres, H. (2014). Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain. Cell Reports. doi:10.1016/j.celrep.2014.08.014
Peer Reviewed verified by ORBi

Worlitzer, M., & Schwamborn, J. C. (2014). The Notch co-repressor protein NKAP is highly expressed in adult mouse subventricular zone neural progenitor cells. Neuroscience. doi:10.1016/j.neuroscience.2014.02.019
Peer Reviewed verified by ORBi

Palm, T., Hemmer, K., Winter, J., Fricke, I. B., Tarbashevich, K., Sadeghi Shakib, F., Rudolph, I.-M., Hillje, A.-L., De Luca, P., Bahnassawy, L. A., Madel, R., Viel, T., De Siervi, A., Jacobs, A. H., Diederichs, S., & Schwamborn, J. C. (2013). A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop. Nucleic Acids Research, 41 (6), 3699-712. doi:10.1093/nar/gkt070
Peer Reviewed verified by ORBi

Reinhardt, P., Glatza, M., Hemmer, K., Tsytsyura, Y., Thiel, C. S., Hoing, S., Moritz, S., Parga, J. A., Wagner, L., Bruder, J. M., Wu, G., Schmid, B., Ropke, A., Klingauf, J., Schwamborn, J. C., Gasser, T., Scholer, H. R., & Sterneckert, J. (2013). Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE, 8 (3), 59252. doi:10.1371/journal.pone.0059252
Peer Reviewed verified by ORBi

Worlitzer, M. M. A., Viel, T., Jacobs, A. H., & Schwamborn, J. C. (2013). The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation. European Journal of Neuroscience. doi:10.1111/ejn.12269
Peer Reviewed verified by ORBi

Gonzalez-Cano, L., Hillje, A.-L., Fuertes-Alvarez, S., Marques, M. M., Blanch, A., Ian, R. W., Irwin, M. S., Schwamborn, J. C., & Marin, M. C. (2013). Regulatory feedback loop between TP73 and TRIM32. Cell Death and Disease, 4, 704. doi:10.1038/cddis.2013.224
Peer Reviewed verified by ORBi

Hillje, A.-L., Pavlou, M. A., Beckmann, E., Worlitzer, M., Bahnassawy, L., Lewejohann, L., Palm, T., & Schwamborn, J. C. (2013). TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation. Cell Death and Disease. doi:10.1038/cddis.2013.487
Peer Reviewed verified by ORBi

Bahnassawy, L. A., Nicklas, S., Palm, T., Menzl, I., Birzele, F., Gillardon, F., & Schwamborn, J. C. (2013). The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells. Stem Cells and Development. doi:10.1089/scd.2013.0163
Peer Reviewed verified by ORBi

Palm, T., Bahnassawy, L. A., & Schwamborn, J. C. (2012). MiRNAs and neural stem cells: a team to treat Parkinson's disease? RNA Biology, 9 (6), 720-30. doi:10.4161/rna.19984
Peer Reviewed verified by ORBi

Wiedemann, A., Hemmer, K., Bernemann, I., Gohring, G., Pogozhykh, O., Figueiredo, C., Glage, S., Schambach, A., Schwamborn, J. C., Blasczyk, R., & Muller, T. (2012). Induced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector. Cellular Reprogramming, 14 (6), 485-96. doi:10.1089/cell.2012.0036
Peer Reviewed verified by ORBi

Nicklas, S., Otto, A., Wu, X., Miller, P., Stelzer, S., Wen, Y., Kuang, S., Wrogemann, K., Patel, K., Ding, H., & Schwamborn, J. C. (2012). TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration. PLoS ONE, 7 (1), 30445. doi:10.1371/journal.pone.0030445
Peer Reviewed verified by ORBi

Imielski, Y., Schwamborn, J. C., Luningschror, P., Heimann, P., Holzberg, M., Werner, H., Leske, O., Puschel, A. W., Memet, S., Heumann, R., Israel, A., Kaltschmidt, C., & Kaltschmidt, B. (2012). Regrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus. PLoS ONE, 7 (2), 30838. doi:10.1371/journal.pone.0030838
Peer Reviewed verified by ORBi

Kelava, I., Reillo, I., Murayama, A. Y., Kalinka, A. T., Stenzel, D., Tomancak, P., Matsuzaki, F., Lebrand, C., Sasaki, E., Schwamborn, J. C., Okano, H., Huttner, W. B., & Borrell, V. (2012). Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus. Cerebral Cortex, 22 (2), 469-81. doi:10.1093/cercor/bhr301
Peer Reviewed verified by ORBi

Hoing, S., Rudhard, Y., Reinhardt, P., Glatza, M., Stehling, M., Wu, G., Peiker, C., Bocker, A., Parga, J. A., Bunk, E., Schwamborn, J. C., Slack, M., Sterneckert, J., & Scholer, H. R. (2012). Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay. Cell Stem Cell, 11 (5), 620-32. doi:10.1016/j.stem.2012.07.005
Peer Reviewed verified by ORBi

Han, D. W., Tapia, N., Hermann, A., Hemmer, K., Hoing, S., Arauzo-Bravo, M. J., Zaehres, H., Wu, G., Frank, S., Moritz, S., Greber, B., Yang, J. H., Lee, H. T., Schwamborn, J. C., Storch, A., & Scholer, H. R. (2012). Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell, 10 (4), 465-72. doi:10.1016/j.stem.2012.02.021
Peer Reviewed verified by ORBi

Worlitzer, M. M., Bunk, E. C., Hemmer, K., & Schwamborn, J. C. (2012). Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice. Stem Cell Research and Therapy, 3 (4), 33. doi:10.1186/scrt124
Peer Reviewed verified by ORBi

Stelzer, S., Worlitzer, M. M. A., Bahnassawy, L. A., Hemmer, K., Rugani, K., Werthschulte, I., Schon, A.-L., Brinkmann, B. F., Bunk, E. C., Palm, T., Ebnet, K., & Schwamborn, J. C. (2012). JAM-C is an apical surface marker for neural stem cells. Stem Cells and Development, 21 (5), 757-66. doi:10.1089/scd.2011.0274
Peer Reviewed verified by ORBi

Bunk, E. C., Stelzer, S., Hermann, S., Schafers, M., Schlatt, S., & Schwamborn, J. C. (2011). Cellular organization of adult neurogenesis in the Common Marmoset. Aging Cell, 10 (1), 28-38. doi:10.1111/j.1474-9726.2010.00639.x
Peer Reviewed verified by ORBi

Khazaei, M. R., Bunk, E. C., Hillje, A.-L., Jahn, H. M., Riegler, E. M., Knoblich, J. A., Young, P., & Schwamborn, J. C. (2011). The E3-ubiquitin ligase TRIM2 regulates neuronal polarization. Journal of Neurochemistry, 117 (1), 29-37. doi:10.1111/j.1471-4159.2010.06971.x
Peer Reviewed verified by ORBi

Hillje, A.-L., Worlitzer, M. M. A., Palm, T., & Schwamborn, J. C. (2011). Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32. Stem Cells, 29 (9), 1437-47. doi:10.1002/stem.687
Peer Reviewed verified by ORBi

Stelzer, S., Ebnet, K., & Schwamborn, J. C. (2010). JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain. BMC Neuroscience, 11, 27. doi:10.1186/1471-2202-11-27
Peer Reviewed verified by ORBi

Palm, T., & Schwamborn, J. C. (2010). Brain tumor stem cells. Biological Chemistry, 391 (6), 607-17. doi:10.1515/BC.2010.059
Peer reviewed

Schwamborn, J. C., Berezikov, E., & Knoblich, J. A. (2009). The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell, 136 (5), 913-25. doi:10.1016/j.cell.2008.12.024
Peer Reviewed verified by ORBi

Schlomann, U., Schwamborn, J. C., Muller, M., Fassler, R., & Puschel, A. W. (2009). The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase. Journal of Cell Science, 122 (Pt 12), 2034-42. doi:10.1242/jcs.038232
Peer Reviewed verified by ORBi

Schwamborn, J. C., & Knoblich, J. A. (2008). LIS1 and spindle orientation in neuroepithelial cells. Cell Stem Cell, 2 (3), 193-4. doi:10.1016/j.stem.2008.02.010
Peer Reviewed verified by ORBi

Liedtke, T., Schwamborn, J. C., Schroer, U., & Thanos, S. (2007). Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2). Molecular and Cellular Proteomics, 6 (5), 895-907. doi:10.1074/mcp.M600245-MCP200
Peer reviewed

Schwamborn, J. C., Li, Y., & Puschel, A. W. (2006). GTPases and the control of neuronal polarity. Methods in Enzymology, 406, 715-27. doi:10.1016/S0076-6879(06)06056-3
Peer Reviewed verified by ORBi

Schwamborn, J. C., & Puschel, A. W. (2004). The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nature Neuroscience, 7 (9), 923-9. doi:10.1038/nn1295
Peer Reviewed verified by ORBi

Schwamborn, J. C., Fiore, R., Bagnard, D., Kappler, J., Kaltschmidt, C., & Puschel, A. W. (2004). Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells. Journal of Biological Chemistry, 279 (30), 30923-6. doi:10.1074/jbc.C400082200
Peer Reviewed verified by ORBi

Schwamborn, J. C., Lindecke, A., Elvers, M., Horejschi, V., Kerick, M., Rafigh, M., Pfeiffer, J., Prullage, M., Kaltschmidt, B., & Kaltschmidt, C. (2003). Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells. BMC Genomics, 4 (1), 46. doi:10.1186/1471-2164-4-46
Peer Reviewed verified by ORBi

Contact ORBilu