![]() ![]() | KLEE, M., AHO, V., MAY, P., Heintz-Buschart, A., LANDOULSI, Z., JONSDOTTIR, S., PAULY, C., PAVELKA, L., DELACOUR, L., KAYSEN, A., Krüger, R., WILMES, P., LEIST, A., Acharya, G., Aguayo, G., Alexandre, M., ALI, M., Ammerlann, W., ARENA, G., ... ZELIMKHANOV, G. (2024). Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome. Journal of Prevention of Alzheimer's Disease. doi:10.14283/jpad.2024.19 ![]() |
![]() ![]() | ZAGARE, A., Preciat, G., NICKELS, S. L., Luo, X., MONZEL, A. S., Gomez-Giro, G., ROBERTSON, G., Jaeger, C., Sharif, J., Koseki, H., DIEDERICH, N., GLAAB, E., FLEMING, R. M., & SCHWAMBORN, J. C. (20 November 2023). Omics data integration suggests a potential idiopathic Parkinson's disease signature. Communications Biology, 6 (1), 1179. doi:10.1038/s42003-023-05548-w ![]() |
![]() ![]() | Mendes-Pinheiro, B., Campos, J., Marote, A., Soares-Cunha, C., NICKELS, S. L., MONZEL, A. S., Cibrão, J. R., Loureiro-Campos, E., Serra, S. C., Barata-Antunes, S., Duarte-Silva, S., Pinto, L., SCHWAMBORN, J. C., & Salgado, A. J. (02 November 2023). Treating Parkinson's Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration. Cells, 12 (21), 2565. doi:10.3390/cells12212565 ![]() |
![]() ![]() | SABATÉ SOLER, S., NICKELS, S. L., SARAIVA, C., Berger, E., Dubonyte, U., BARMPA, K., Lan, Y. J., Kouno, T., JARAZO, J., ROBERTSON, G., Sharif, J., Koseki, H., Thome, C., Shin, J., Cowley, S., & SCHWAMBORN, J. C. (2022). Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. doi:10.1002/glia.24167 ![]() |
![]() ![]() | ZAGARE, A., BARMPA, K., SMAJIC, S., SMITS, L., GRZYB, K., GRÜNEWALD, A., SKUPIN, A., NICKELS, S. L., & SCHWAMBORN, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.12.009 ![]() |
BOLOGNIN, S., SMITS, L., NICKELS, S. L., MAGNI, S., ANTONY, P., GRZYB, K., KRÜGER, R., SKUPIN, A., & SCHWAMBORN, J. C. (2021). A new brain organoid model to study Parkinson’s Disease. Biomedical Science and Engineering. |
![]() ![]() | NICKELS, S. L., & SCHWAMBORN, J. C. (2021). Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease? Neural Regeneration Research. doi:10.4103/1673-5374.293140 ![]() |
![]() ![]() | Walter, J., BOLOGNIN, S., Poovathingal, S., MAGNI, S., GERARD, D., ANTONY, P., NICKELS, S. L., Salamanca, L., Berger, E., SMITS, L., GRZYB, K., Perfeito, R., Hoel, F., Qing, X., OHNMACHT, J., Bertacchi, M., Jarazo, J., Ignac, T., Monzel, A., ... SCHWAMBORN, J. C. (2021). The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Reports. doi:10.1016/j.celrep.2021.109864 ![]() |
![]() ![]() | NICKELS, S. L., MODAMIO CHAMARRO, J., Mendes-Pinheiro, B., MONZEL, A. S., BETSOU, F., & SCHWAMBORN, J. C. (2020). Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease. Stem Cell Research. doi:10.1016/j.scr.2020.101870 ![]() |
![]() ![]() | Walter, J., BOLOGNIN, S., ANTONY, P., NICKELS, S., Poovathhingal, S., Salamanca, L., MAGNI, S., Perfeito, R., Hoel, F., Qing, X., JARAZO, J., Arias-Fuenzalida, J., Ignac, T., MONZEL, A. S., Gonzalez-Cano, L., Pereira de Almeida, L., SKUPIN, A., Tronstad, K., & SCHWAMBORN, J. C. (2019). Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality. Stem Cell Reports. doi:10.1016/j.stemcr.2019.03.004 ![]() |
![]() ![]() | NICKELS, S., Walter, J., BOLOGNIN, S., GERARD, D., Jäger, C., Qing, X., Tisserand, J., JARAZO, J., Hemmer, K., Harms, A., HALDER, R., Lucarelli, P., Berger, E., ANTONY, P., GLAAB, E., Hankemeier, T., Klein, C., SAUTER, T., SINKKONEN, L., & SCHWAMBORN, J. C. (2019). Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism and Related Disorders. doi:10.1016/j.parkreldis.2019.09.018 ![]() |
![]() ![]() | BOLOGNIN, S., Fossépré, M., Qing, X., JARAZO, J., Ščančar, J., LUCUMI MORENO, E., NICKELS, S., WASNER, K., OUZREN, N., WALTER, J., GRÜNEWALD, A., GLAAB, E., Salamanca, L., Fleming, R. M. T., ANTONY, P., & SCHWAMBORN, J. C. (2018). 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science. doi:10.1002/advs.201800927 ![]() |
![]() ![]() | NICKELS, S. (2017). Stem cells for modeling Parkinson's disease [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/32753 |
![]() ![]() | WALTER, J., NICKELS, S., & SCHWAMBORN, J. C. (2017). Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders. Stem Cell Investigation. doi:10.21037/sci.2017.11.08 ![]() |
![]() ![]() | ARIAS, J., JARAZO, J., QING, X., WALTER, J., GOMEZ GIRO, G., NICKELS, S., Zaehres, H., Schoeler, H. R., & SCHWAMBORN, J. C. (2017). FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling. Stem Cell Reports. doi:10.1016/j.stemcr.2017.08.026 ![]() |
![]() ![]() | Palm, T., BOLOGNIN, S., MEISER, J., NICKELS, S., Traeger, C., Meilenbrock, R.-L., Brockhaus, J., Streitmueller, M., Missler, M., & SCHWAMBORN, J. C. (2015). Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia. Scientific Reports, 5. doi:10.1038/srep16321 ![]() |