Profil

ARENA Giuseppe

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience

ORCID
0000-0003-2398-5503
Main Referenced Co-authors
KRÜGER, Rejko  (11)
GRÜNEWALD, Anne  (7)
Valente, Enza Maria (6)
ANTONY, Paul  (5)
BOUSSAAD, Ibrahim  (5)
Main Referenced Keywords
Humans (18); Cell Line, Tumor (7); Animals (5); PINK1 (5); Mitochondria/metabolism (4);
Main Referenced Unit & Research Centers
LIH - Luxembourg Institute of Health (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) (2)
Integrative Research Unit: Social and Individual Development (INSIDE) > PEARL Institute for Research on Socio-Economic Inequality (IRSEI) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (22)
Microbiology (6)
Genetics & genetic processes (5)
Neurology (2)
Oncology (1)

Publications (total 36)

The most downloaded
434 downloads
Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025 https://hdl.handle.net/10993/51271

The most cited

219 citations (Scopus®)

Al Amir Dache, Z., Otandault, A., Tanos, R., Pastor, B., Meddeb, R., Sanchez, C., Arena, G., Lasorsa, L., Bennett, A., Grange, T., El Messaoudi, S., Mazard, T., Prevostel, C., & Thierry, A. R. (2020). Blood contains circulating cell-free respiratory competent mitochondria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34 (3), 3616-3630. doi:10.1096/fj.201901917RR https://hdl.handle.net/10993/54783

KLEE, M., AHO, V., MAY, P., Heintz-Buschart, A., LANDOULSI, Z., JONSDOTTIR, S., PAULY, C., PAVELKA, L., DELACOUR, L., KAYSEN, A., Krüger, R., WILMES, P., LEIST, A., Acharya, G., Aguayo, G., Alexandre, M., ALI, M., Ammerlann, W., ARENA, G., ... ZELIMKHANOV, G. (2024). Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome. Journal of Prevention of Alzheimer's Disease. doi:10.14283/jpad.2024.19
Peer reviewed

Gomez Ramos, B., Ohnmacht, J., de Lange, N., VALCESCHINI, E., GINOLHAC, A., CATILLON, M., FERRANTE, D., Rakovic, A., HALDER, R., Massart, F., ARENA, G., ANTONY, P., BOLOGNIN, S., Klein, C., KRAUSE, R., Schulz, M. H., SAUTER, T., Krüger, R., & SINKKONEN, L. (2023). Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation. EMBO Reports. doi:10.1038/s44319-023-00024-2
Peer Reviewed verified by ORBi

OLEKSY, C., Massart, F., Goldwurm, S., Arado, A., ARENA, G., BOUSSAAD, I., & Krüger, R. (October 2023). Generation and characterization of induced pluripotent stem cells from a Parkinson's disease patient carrying the digenic LRRK2 p.G2019S and GBA1 p.N409S mutations. Stem Cell Research, 72, 103212. doi:10.1016/j.scr.2023.103212
Peer Reviewed verified by ORBi

Bitar, S., Baumann, T., Weber, C., Abusaada, M., Rojas-Charry, L., Ziegler, P., Schettgen, T., Randerath, I. E., Venkataramani, V., Michalke, B., ARENA, G., KRÜGER, R., Zhang, L., & Methner, A. (2023). Mitochondrial CISD1 is a downstream target that mediates PINK1 and Parkin loss-of-function phenotypes. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/60005. doi:10.1101/2023.09.28.559909

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., Antony, P., Boussaad, I., Bobbili, D. R., Sreelatha, A. A. K., Pavelka, L., Klein, C., Seibler, P., Glaab, E., Sharma, M., Krüger, R., May, P., & Grünewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05.12.23289877. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55367. doi:10.1101/2023.05.12.23289877

Chemla, A., Arena, G., Saraiva, C., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Klein, C., Seibler, P., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1. Stem Cell Research, 69, 103085. doi:10.1016/j.scr.2023.103085
Peer Reviewed verified by ORBi

Chemla, A., Arena, G., Onal, G., Walter, J., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G>A (p.R272Q) or c.1348C>T (p.R450C) in the RHOT1 gene encoding Miro1. Stem Cell Research, 103145. doi:10.1016/j.scr.2023.103145
Peer reviewed

Nedara, K., Reinhardt, C., Lebraud, E., Arena, G., Gracia, C., Buard, V., Pioche-Durieu, C., Castelli, F., Colsch, B., Bénit, P., Rustin, P., Albaud, B., Gestraud, P., Baulande, S., Servant, N., Deutsch, E., Verbavatz, J.-M., Brenner, C., Milliat, F., & Modjtahedi, N. (31 October 2022). Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation. Frontiers in Oncology, 12 (958155). doi:10.3389/fonc.2022.958155
Peer Reviewed verified by ORBi

Di Rienzo, M., Romagnoli, A., Ciccosanti, F., Refolo, G., Consalvi, V., Arena, G., Valente, E. M., Piacentini, M., & Fimia, G. M. (August 2022). AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability. Autophagy, 18 (8), 1752-1762. doi:10.1080/15548627.2021.1997052
Peer Reviewed verified by ORBi

Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025
Peer reviewed

Brunelli, F., Torosantucci, L., Gelmetti, V., Franzone, D., Grünewald, A., Krüger, R., Arena, G., & Valente, E. M. (2022). PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage. Cells, 11 (4). doi:10.3390/cells11040678
Peer Reviewed verified by ORBi

Arena, G., Sharma, K., Agyeah, G., Krüger, R., Grünewald, A., & Fitzgerald, J. C. (2022). Neurodegeneration and Neuroinflammation in Parkinson’s Disease: a Self-Sustained Loop. Current Neurology and Neuroscience Reports, 22 (8), 427 – 440. doi:10.1007/s11910-022-01207-5
Peer reviewed

Ragimbeau, R., El Kebriti, L., Sebti, S., Fourgous, E. F., Boulahtouf, A., Arena, G., Espert, L., Turtoi, A., Gongora, C., Houédé, N., & Pattingre, S. (February 2021). BAG6 promotes PINK1 signaling pathway and is essential for mitophagy. FASEB Journal, 35 (2), 21361. doi:10.1096/fj.202000930R
Peer Reviewed verified by ORBi

Arena, G., & Krüger, R. (2021). Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay. Neural Regeneration Research. doi:10.4103/1673-5374.310679
Peer Reviewed verified by ORBi

Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L., Su, J., Arias-Fuenzalida, Walter, J., Gomez Giro, G., Monzel, A., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., ... Schwamborn, J. C. (2021). Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment. Movement Disorders. doi:10.1002/mds.28810
Peer Reviewed verified by ORBi

Bus, C., Zizmare, L., Feldkaemper, M., Geisler, S., Zarani, M., Schaedler, A., Klose, F., Admard, J., Mageean, C. J., Arena, G., Fallier-Becker, P., Ugun-Klusek, A., Maruszczak, K. K., Kapolou, K., Schmid, B., Rapaport, D., Ueffing, M., Casadei, N., Krüger, R., ... Fitzgerald, J. C. (2020). Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors. iScience, 23 (12), 101797. doi:10.1016/j.isci.2020.101797
Peer Reviewed verified by ORBi

Grossmann, D., Berenguer-Escuder, C., Chemla, A., Arena, G., & Krüger, R. (2020). The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease. Frontiers in Neurology, 11, 587. doi:10.3389/fneur.2020.00587
Peer Reviewed verified by ORBi

Brunelli, F., Valente, E. M., & Arena, G. (2020). Mechanisms of neurodegeneration in Parkinson’s disease: keep neurons in the PINK1. Mechanisms of Ageing and Development. doi:10.1016/j.mad.2020.111277
Peer Reviewed verified by ORBi

Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease. Human Molecular Genetics. doi:10.1093/hmg/ddaa066
Peer Reviewed verified by ORBi

Lacroix, M., Riscal, R., Arena, G., Linares, L. K., & Le Cam, L. (2020). Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer. Molecular Metabolism, 33, 2-22. doi:10.1016/j.molmet.2019.10.002
Peer Reviewed verified by ORBi

Reinhardt, C., Arena, G., Nedara, K., Edwards, R., Brenner, C., Tokatlidis, K., & Modjtahedi, N. (2020). AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866 (6), 165746. doi:10.1016/j.bbadis.2020.165746
Peer Reviewed verified by ORBi

Cissé, M. Y., Pyrdziak, S., Firmin, N., Gayte, L., Heuillet, M., Bellvert, F., Fuentes, M., Delpech, H., Riscal, R., Arena, G., Chibon, F., Le Gellec, S., Maran-Gonzalez, A., Chateau, M.-C., Theillet, C., Carrere, S., Portais, J.-C., Le Cam, L., & Linares, L. K. (2020). Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma. Science Translational Medicine, 12 (547). doi:10.1126/scitranslmed.aay2163
Peer Reviewed verified by ORBi

Al Amir Dache, Z., Otandault, A., Tanos, R., Pastor, B., Meddeb, R., Sanchez, C., Arena, G., Lasorsa, L., Bennett, A., Grange, T., El Messaoudi, S., Mazard, T., Prevostel, C., & Thierry, A. R. (2020). Blood contains circulating cell-free respiratory competent mitochondria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34 (3), 3616-3630. doi:10.1096/fj.201901917RR
Peer reviewed

Arena, G., Cissé, M. Y., Pyrdziak, S., Chatre, L., Riscal, R., Fuentes, M., Arnold, J. J., Kastner, M., Gayte, L., Bertrand-Gaday, C., Nay, K., Angebault-Prouteau, C., Murray, K., Chabi, B., Koechlin-Ramonatxo, C., Orsetti, B., Vincent, C., Casas, F., Marine, J.-C., ... Le Cam, L. (2018). Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53. Molecular Cell, 69 (4), 594-609.e8. doi:10.1016/j.molcel.2018.01.023
Peer Reviewed verified by ORBi

Arena, G., Riscal, R., Linares, L. K., & Le Cam, L. (2018). MDM2 controls gene expression independently of p53 in both normal and cancer cells. Cell Death and Differentiation, 25 (9), 1533-1535. doi:10.1038/s41418-018-0156-x
Peer Reviewed verified by ORBi

Chatre, L., Fernandes, J., Michel, V., Fiette, L., Avé, P., Arena, G., Jain, U., Haas, R., Wang, T. C., Ricchetti, M., & Touati, E. (2017). Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms. Scientific Reports, 7 (1), 15901. doi:10.1038/s41598-017-15567-3
Peer Reviewed verified by ORBi

Gelmetti, V., De Rosa, P., Torosantucci, L., Marini, E. S., Romagnoli, A., Di Rienzo, M., Arena, G., Vignone, D., Fimia, G. M., & Valente, E. M. (2017). PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy, 13 (4), 654-669. doi:10.1080/15548627.2016.1277309
Peer Reviewed verified by ORBi

Arena, G., & Valente, E. M. (2017). PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease. The Journal of pathology, 241 (2), 251-263. doi:10.1002/path.4815
Peer reviewed

Riscal, R., Schrepfer, E., Arena, G., Cissé, M. Y., Bellvert, F., Heuillet, M., Rambow, F., Bonneil, E., Sabourdy, F., Vincent, C., Ait-Arsa, I., Levade, T., Thibaut, P., Marine, J.-C., Portais, J.-C., Sarry, J.-E., Le Cam, L., & Linares, L. K. (2016). Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Molecular Cell, 62 (6), 890-902. doi:10.1016/j.molcel.2016.04.033
Peer Reviewed verified by ORBi

Arena, G., Gelmetti, V., Torosantucci, L., Vignone, D., Lamorte, G., De Rosa, P., Cilia, E., Jonas, E. A., & Valente, E. M. (2013). PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage. Cell Death and Differentiation, 20 (7), 920-30. doi:10.1038/cdd.2013.19
Peer Reviewed verified by ORBi

De Leo, A., Arena, G., Lacanna, E., Oliviero, G., Colavita, F., & Mattia, E. (2012). Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets. Antiviral Research, 96 (2), 196-202. doi:10.1016/j.antiviral.2012.09.003
Peer Reviewed verified by ORBi

Valente, E. M., Arena, G., Torosantucci, L., & Gelmetti, V. (2012). Molecular pathways in sporadic PD. Parkinsonism & related disorders, 18 Suppl 1, 71-3.
Peer reviewed

De Leo, A., Arena, G., Stecca, C., Raciti, M., & Mattia, E. (2011). Resveratrol inhibits proliferation and survival of Epstein Barr virus-infected Burkitt's lymphoma cells depending on viral latency program. Molecular cancer research : MCR, 9 (10), 1346-55. doi:10.1158/1541-7786.MCR-11-0145
Peer reviewed

De Leo, A., Matusali, G., Arena, G., Di Renzo, L., & Mattia, E. (2010). Epstein-Barr virus lytic cycle activation alters proteasome subunit expression in Burkitt's lymphoma cells. Biological Chemistry, 391 (9), 1041-6. doi:10.1515/BC.2010.107
Peer Reviewed verified by ORBi

Michiorri, S., Gelmetti, V., Giarda, E., Lombardi, F., Romano, F., Marongiu, R., Nerini-Molteni, S., Sale, P., Vago, R., Arena, G., Torosantucci, L., Cassina, L., Russo, M. A., Dallapiccola, B., Valente, E. M., & Casari, G. (2010). The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death and Differentiation, 17 (6), 962-74. doi:10.1038/cdd.2009.200
Peer Reviewed verified by ORBi

Matusali, G., Arena, G., De Leo, A., Di Renzo, L., & Mattia, E. (2009). Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds. Molecular Cancer, 8, 18. doi:10.1186/1476-4598-8-18
Peer Reviewed verified by ORBi

Contact ORBilu