![]() ![]() | Owona, B. A.* , MARY, A.* , Messi, A. N., Ravichandran, K. A., Mbing, J. N., Pegnyemb, E., Moundipa, P. F., & HENEKA, M. (2024). Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Molecular Neurobiology. doi:10.1007/s12035-024-04365-4 ![]() * These authors have contributed equally to this work. |
![]() ![]() | MARY, A., Mancuso, R., & HENEKA, M. (29 February 2024). Immune Activation in Alzheimer Disease. Annual Review of Immunology, 42 (1). doi:10.1146/annurev-immunol-101921-035222 ![]() |
![]() ![]() | KLEE, M., AHO, V., MAY, P., Heintz-Buschart, A., LANDOULSI, Z., JONSDOTTIR, S., PAULY, C., PAVELKA, L., DELACOUR, L., KAYSEN, A., Krüger, R., WILMES, P., LEIST, A., Acharya, G., Aguayo, G., Alexandre, M., ALI, M., Ammerlann, W., ARENA, G., ... ZELIMKHANOV, G. (2024). Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome. Journal of Prevention of Alzheimer's Disease. doi:10.14283/jpad.2024.19 ![]() |
![]() ![]() | Kapadia, A., Theil, S., Opitz, S., Villacampa, N., Beckert, H., Schoch, S., HENEKA, M., Kumar, S., & Walter, J. (January 2024). Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system. Autophagy, 20 (1), 166 - 187. doi:10.1080/15548627.2023.2252300 ![]() |
![]() ![]() | TALAVERA ANDUJAR, B., MARY, A., VENEGAS MALDONADO, C. J., Cheng, T., Zaslavsky, L., Bolton, E., HENEKA, M., & SCHYMANSKI, E. (2023). Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients? (2). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/58891. doi:10.26434/chemrxiv-2023-6j2gm-v2 |
![]() ![]() | Nemali, A., Vockert, N., Berron, D., Maas, A., Bernal, J., Yakupov, R., Peters, O., Gref, D., Cosma, N., Preis, L., Priller, J., Spruth, E., Altenstein, S., Lohse, A., Fliessbach, K., Kimmich, O., Vogt, I., Wiltfang, J., Hansen, N., ... Ziegler, G.*. (December 2023). Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer's disease-A systematic model evaluation. Medical Image Analysis, 90, 102913. doi:10.1016/j.media.2023.102913 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Stark, M., Wolfsgruber, S., Kleineidam, L., Frommann, I., Altenstein, S., Bartels, C., Brosseron, F., Buerger, K., Burow, L., Butryn, M., Ewers, M., Fliessbach, K., Gabelin, T., Glanz, W., Goerss, D., Gref, D., Hansen, N., HENEKA, M., Hinderer, P., ... Wagner, M. (21 November 2023). Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline. Neurology, 101 (21), 2185 - e2196. doi:10.1212/WNL.0000000000207844 ![]() |
![]() ![]() | DADWAL, S., & HENEKA, M. (2023). Microglia heterogeneity in health and disease. FEBS Open Bio. doi:10.1002/2211-5463.13735 ![]() |
![]() ![]() | Waschkies, K. F., Soch, J., Darna, M., Richter, A., Altenstein, S., Beyle, A., Brosseron, F., Buchholz, F., Butryn, M., Dobisch, L., Ewers, M., Fliessbach, K., Gabelin, T., Glanz, W., Goerss, D., Gref, D., Janowitz, D., Kilimann, I., Lohse, A., ... Kizilirmak, J. M. (October 2023). Machine learning-based classification of Alzheimer's disease and its at-risk states using personality traits, anxiety, and depression. International Journal of Geriatric Psychiatry, 38 (10), 6007. doi:10.1002/gps.6007 ![]() |
![]() ![]() | Bartsch, T., Berg, D., HENEKA, M., & Leypoldt, F. (October 2023). Parkinson- und Alzheimer-Erkrankung als Systemerkrankungen. Nervenarzt, 94 (10), 875 - 884. doi:10.1007/s00115-023-01542-z ![]() |
![]() ![]() | TALAVERA ANDUJAR, B., MARY, A., VENEGAS MALDONADO, C. J., Cheng, T., Zaslavsky, L., Bolton, E. E., HENEKA, M., & SCHYMANSKI, E. (21 September 2023). YoungNMC 2023: "Challenges in Developing Non-target Exposomics and Metabolomics Workflows for Cerebrospinal Fluid from Alzheimer's disease and Mild Cognitive Impairment" [Paper presentation]. YoungNMC Symposium, Nijmegen, Netherlands. doi:10.5281/ZENODO.8364324 ![]() |
![]() ![]() | Karabag, D., Scheiblich, H., Griep, A., Santarelli, F., Schwartz, S., HENEKA, M., & Ising, C. (August 2023). Characterizing microglial senescence: Tau as a key player. Journal of Neurochemistry, 166 (3), 517 - 533. doi:10.1111/jnc.15866 ![]() |
![]() ![]() | TALAVERA ANDUJAR, B., MARY, A., Cheng, T., Zaslavsky, L., Bolton, E., HENEKA, M., & SCHYMANSKI, E. (2023). Non-target LC-HRMS to Study the Exposome of Mild Cognitive Impairment and Alzheimer’s Disease on Cerebrospinal Fluid. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57734. doi:10.26434/chemrxiv-2023-6j2gm |
![]() ![]() | TALAVERA ANDUJAR, B., MARY, A., Cheng, T., Zaslavsky, L., Bolton, E. E., HENEKA, M., & SCHYMANSKI, E. (07 June 2023). Non-target LC-HRMS to Study the Exposome of Mild Cognitive Impairment and Alzheimer's Disease on Cerebrospinal Fluid [Poster presentation]. 19th Annual International Conference of the Metabolomics Society, Niagara Falls, Canada. doi:10.5281/ZENODO.8017622 ![]() |
![]() ![]() | Walker, K. A., Le Page, L. M., Terrando, N., Duggan, M. R., HENEKA, M., & Bettcher, B. M. (05 June 2023). The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap. Molecular Neurodegeneration, 18 (1), 37. doi:10.1186/s13024-023-00627-2 ![]() |
![]() ![]() | Stratoulias, V., Ruiz, R., Kanatani, S., Osman, A. M., Keane, L., Armengol, J. A., Rodríguez-Moreno, A., Murgoci, A.-N., García-Domínguez, I., Alonso-Bellido, I., González Ibáñez, F., Picard, K., Vázquez-Cabrera, G., Posada-Pérez, M., Vernoux, N., Tejera, D., Grabert, K., Cheray, M., González-Rodríguez, P., ... Joseph, B. (June 2023). ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Nature Neuroscience, 26 (6), 1008 - 1020. doi:10.1038/s41593-023-01326-3 ![]() |
![]() ![]() | Kloske, C. M., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Brickman, A. M., Bu, G., Dennison, J., Gearon, M. D., Goate, A. M., Haass, C., HENEKA, M., Hu, W. T., Huggins, L. K. L., Jones, N. S., Koldamova, R., Lemere, C. A., Liddelow, S. A., Marcora, E., Marsh, S. E., ... Carrillo, M. C. (June 2023). APOE and immunity: Research highlights. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 19 (6), 2677 - 2696. doi:10.1002/alz.13020 ![]() |
![]() ![]() | Bendella, Z., Widmann, C. N., Layer, J. P., Layer, Y. L., Haase, R., Sauer, M., Bieler, L., Lehnen, N. C., Paech, D., HENEKA, M., Radbruch, A., & Schmeel, F. C. (12 May 2023). Brain Volume Changes after COVID-19 Compared to Healthy Controls by Artificial Intelligence-Based MRI Volumetry. Diagnostics, 13 (10), 1716. doi:10.3390/diagnostics13101716 ![]() |
![]() ![]() | Nemy, M., Dyrba, M., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ewers, M., Fliessbach, K., Glanz, W., Goerss, D., HENEKA, M., Hetzer, S., Incesoy, E. I., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Munk, M. H., Perneczky, R., ... Ferreira, D. (02 May 2023). Cholinergic white matter pathways along the Alzheimer's disease continuum. Brain: a Journal of Neurology, 146 (5), 2075 - 2088. doi:10.1093/brain/awac385 ![]() |
![]() ![]() | Ising, C., & HENEKA, M. (May 2023). Chronic inflammation: a potential target in tauopathies. The Lancet Neurology, 22 (5), 371 - 373. doi:10.1016/S1474-4422(23)00116-3 ![]() |
![]() ![]() | Heinzinger, N., Maass, A., Berron, D., Yakupov, R., Peters, O., Fiebach, J., Villringer, K., Preis, L., Priller, J., Spruth, E. J., Altenstein, S., Schneider, A., Fliessbach, K., Wiltfang, J., Bartels, C., Jessen, F., Maier, F., Glanz, W., Buerger, K., ... Alzheimer’s Disease Neuroimaging Initiative. (13 March 2023). Exploring the ATN classification system using brain morphology. Alzheimer's Research and Therapy, 15 (1), 50. doi:10.1186/s13195-023-01185-x ![]() |
![]() ![]() | Yildirim, Z., Delen, F., Berron, D., Baumeister, H., Ziegler, G., Schütze, H., Glanz, W., Dobisch, L., Peters, O., Freiesleben, S. D., Schneider, L.-S., Priller, J., Spruth, E. J., Schneider, A., Fliessbach, K., Wiltfang, J., Schott, B.-H., Meiberth, D., Buerger, K., ... Duzel, E. (28 February 2023). Brain reserve contributes to distinguishing preclinical Alzheimer's stages 1 and 2. Alzheimer's Research and Therapy, 15 (1), 43. doi:10.1186/s13195-023-01187-9 ![]() |
![]() ![]() | Braatz, C., Komes, M. P., Ravichandran, K. A., de Fragas, M. G., Griep, A., Schwartz, S., McManus, R. M., & HENEKA, M. (2023). NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. Journal of Neurochemistry. doi:10.1111/jnc.15778 ![]() |
![]() ![]() | Jessen, F., Wolfsgruber, S., Kleineindam, L., Spottke, A., Altenstein, S., Bartels, C., Berger, M., Brosseron, F., Daamen, M., Dichgans, M., Dobisch, L., Ewers, M., Fenski, F., Fliessbach, K., Freiesleben, S. D., Glanz, W., Görß, D., Gürsel, S., Janowitz, D., ... Düzel, E. (February 2023). Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 19 (2), 487 - 497. doi:10.1002/alz.12674 ![]() |
![]() ![]() | Ersoezlue, E.* , Rauchmann, B.-S.* , Schneider-Axmann, T., Wagner, M., Ballarini, T., Tato, M., Utecht, J., Kurz, C., Papazov, B., Guersel, S., Burow, L., Koller, G., Stöcklein, S., Keeser, D., Bartels, C., Brosseron, F., Buerger, K., Cetindag, A. C., Dechent, P., ... Perneczky, R. (February 2023). Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease. Neurobiology of Aging, 122, 33 - 44. doi:10.1016/j.neurobiolaging.2022.05.015 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Brosseron, F., Maass, A., Kleineidam, L., Ravichandran, K. A., Kolbe, C.-C., Wolfsgruber, S., Santarelli, F., Häsler, L. M., McManus, R., Ising, C., Röske, S., Peters, O., Cosma, N.-C., Schneider, L.-S., Wang, X., Priller, J., Spruth, E. J., Altenstein, S., Schneider, A., ... DELCODE study group. (12 January 2023). Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study. Alzheimer's Research and Therapy, 15 (1), 13. doi:10.1186/s13195-022-01118-0 ![]() |
![]() ![]() | Henning, L., Antony, H., Breuer, A., Müller, J., Seifert, G., Audinat, E., Singh, P., Brosseron, F., HENEKA, M., Steinhäuser, C., & Bedner, P. (2023). Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy. Glia, 71 (2), 168-186. doi:10.1002/glia.24265 ![]() |
![]() ![]() | HENEKA, M. (2023). ApoE4 makes microglia trem(2)bling. Neuron, 111 (2), 142-144. doi:10.1016/j.neuron.2022 ![]() |
![]() ![]() | Teipel, S. J., Dyrba, M., Levin, F., Altenstein, S., Berger, M., Beyle, A., Brosseron, F., Buerger, K., Burow, L., Dobisch, L., Ewers, M., Fliessbach, K., Frommann, I., Glanz, W., Goerss, D., Gref, D., Hansen, N., HENEKA, M., Incesoy, E. I., ... DELCODE study group and the Alzheimer’s Disease Neuroimaging Initiative. (2023). Cognitive Trajectories in Preclinical and Prodromal Alzheimer's Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach. Journal of Alzheimer's disease reports, 7 (1), 1055 - 1076. doi:10.3233/ADR-230027 ![]() |
Ersoezlue, E.* , Perneczky, R.* , Tato, M., Utecht, J., Kurz, C., Häckert, J., Guersel, S., Burow, L., Koller, G., Stoecklein, S., Keeser, D., Papazov, B., Totzke, M., Ballarini, T., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ewers, M., ... DELCODE study group. (2023). A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum. Journal of Alzheimer's Disease, 92 (3), 925 - 940. doi:10.3233/JAD-220464 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Jansen, I. E., van der Lee, S. J., Gomez-Fonseca, D., de Rojas, I., Dalmasso, M. C., Grenier-Boley, B., Zettergren, A., Mishra, A., Ali, M., Andrade, V., Bellenguez, C., Kleineidam, L., Küçükali, F., Sung, Y. J., Tesí, N., Vromen, E. M., Wightman, D. P., Alcolea, D., Alegret, M., ... van der Flier, W. (November 2022). Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. Acta Neuropathologica, 144 (5), 821 - 842. doi:10.1007/s00401-022-02454-z ![]() |
![]() ![]() | Janssen, O., Jansen, W. J., Vos, S. J. B., Boada, M., Parnetti, L., Gabryelewicz, T., Fladby, T., Molinuevo, J. L., Villeneuve, S., Hort, J., Epelbaum, S., Lleó, A., Engelborghs, S., van der Flier, W. M., Landau, S., Popp, J., Wallin, A., Scheltens, P., Rikkert, M. O., ... Visser, P. J. (October 2022). Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 18 (10), 1832 - 1845. doi:10.1002/alz.12512 ![]() |
![]() ![]() | Billette, O. V., Ziegler, G., Aruci, M., Schütze, H., Kizilirmak, J. M., Richter, A., Altenstein, S., Bartels, C., Brosseron, F., Cardenas-Blanco, A., Dahmen, P., Dechent, P., Dobisch, L., Fliessbach, K., Freiesleben, S. D., Glanz, W., Göerß, D., Haynes, J. D., HENEKA, M., ... DELCODE Study Group. (23 August 2022). Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease. Neurology, 99 (8), 775 - e788. doi:10.1212/WNL.0000000000200667 ![]() |
![]() ![]() | Krieger, J., Frackowiak, M., Berger, M., HENEKA, M., & Jacobs, A. H. (August 2022). Falls at advanced age - The importance to search for benign paroxysmal positional vertigo (BPPV). Experimental Gerontology, 165, 111868. doi:10.1016/j.exger.2022.111868 ![]() |
![]() ![]() | Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., HENEKA, M., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. (July 2022). Infection and inflammation: New perspectives on Alzheimer's disease. Brain, behavior, & immunity. Health, 22, 100462. doi:10.1016/j.bbih.2022.100462 ![]() |
![]() ![]() | Manabe, T., & HENEKA, M. (July 2022). Cerebral dysfunctions caused by sepsis during ageing. Nature Reviews. Immunology, 22 (7), 444 - 458. doi:10.1038/s41577-021-00643-7 ![]() |
![]() ![]() | Düzel, E., Ziegler, G., Berron, D., Maass, A., Schütze, H., Cardenas-Blanco, A., Glanz, W., Metzger, C., Dobisch, L., Reuter, M., Spottke, A., Brosseron, F., Fliessbach, K., HENEKA, M., Laske, C., Peters, O., Priller, J., Spruth, E. J., Ramirez, A., ... Jessen, F. (24 May 2022). Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain: a Journal of Neurology, 145 (4), 1473 - 1485. doi:10.1093/brain/awab405 ![]() |
![]() ![]() | Gordon, M. N., HENEKA, M., Le Page, L. M., Limberger, C., Morgan, D., Tenner, A. J., Terrando, N., Willette, A. A., & Willette, S. A. (May 2022). Impact of COVID-19 on the Onset and Progression of Alzheimer's Disease and Related Dementias: A Roadmap for Future Research. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 18 (5), 1038 - 1046. doi:10.1002/alz.12488 ![]() |
![]() ![]() | Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., ... Lambert, J.-C. (April 2022). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics, 54 (4), 412 - 436. doi:10.1038/s41588-022-01024-z ![]() |
![]() ![]() | Perea, J. R., Bolós, M., Cuadros, R., García, E., García-Escudero, V., Hernández, F., McManus, R. M., HENEKA, M., & Avila, J. (March 2022). p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular Neurobiology, 59 (3), 1632 - 1648. doi:10.1007/s12035-021-02715-0 ![]() |
Jansen, W. J., Janssen, O., Tijms, B. M., Vos, S. J. B., Ossenkoppele, R., Visser, P. J., Amyloid Biomarker Study Group, Aarsland, D., Alcolea, D., Altomare, D., von Arnim, C., Baiardi, S., Baldeiras, I., Barthel, H., Bateman, R. J., Van Berckel, B., Binette, A. P., Blennow, K., Boada, M., ... Zetterberg, H. (01 March 2022). Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurology, 79 (3), 228 - 243. doi:10.1001/jamaneurol.2021.5216 ![]() |
![]() ![]() | Castro-Gomez, S., Binder, J., Schievelkamp, A.-H., & HENEKA, M. (2022). CNS Superficial Siderosis Mimicking a Motor Neuron Disease. Brain Sciences, 12 (11). doi:10.3390/brainsci12111558 ![]() |
![]() ![]() | Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G. C., ... Wyss-Coray, T. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110 (21), 3458-3483. doi:10.1016/j.neuron.2022.10.020 ![]() |
![]() ![]() | Brosseron, F., Maass, A., Kleineidam, L., Ravichandran, K. A., González, P. G., McManus, R. M., Ising, C., Santarelli, F., Kolbe, C.-C., Häsler, L. M., Wolfsgruber, S., Marquié, M., Boada, M., Orellana, A., de Rojas, I., Röske, S., Peters, O., Cosma, N.-C., Cetindag, A., ... HENEKA, M. (2022). Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease. Neuron, 110 (6), 1009-1022.e4. doi:10.1016/j.neuron.2021.12.016 ![]() |
![]() ![]() | Kleineidam, L., Wolfsgruber, S., Weyrauch, A.-S., Zulka, L. E., Forstmeier, S., Roeske, S., van den Bussche, H., Kaduszkiewicz, H., Wiese, B., Weyerer, S., Werle, J., Fuchs, A., Pentzek, M., Brettschneider, C., König, H.-H., Weeg, D., Bickel, H., Luppa, M., Rodriguez, F. S., ... Wagner, M. (2022). Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve. Frontiers in Psychology, 13, 957308. doi:10.3389/fpsyg.2022.957308 ![]() |
![]() ![]() | Mercan, D., & HENEKA, M. (2022). The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease. Biology, 11 (12). doi:10.3390/biology11121822 ![]() |
![]() ![]() | Berron, D., Ziegler, G., Vieweg, P., Billette, O., Güsten, J., Grande, X., HENEKA, M., Schneider, A., Teipel, S., Jessen, F., Wagner, M., & Düzel, E. (2022). Feasibility of Digital Memory Assessments in an Unsupervised and Remote Study Setting. Frontiers in Digital Health, 4, 892997. doi:10.3389/fdgth.2022.892997 ![]() |
Teipel, S. J., Dyrba, M., Ballarini, T., Brosseron, F., Bruno, D., Buerger, K., Cosma, N.-C., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Haynes, J. D., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C. D., Munk, M. H., ... HENEKA, M. (2022). Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum. Journal of Alzheimer's Disease, 85 (3), 1267 - 1282. doi:10.3233/JAD-215196 ![]() |
Wolfsgruber, S., Kleineidam, L., Weyrauch, A.-S., Barkhoff, M., Röske, S., Peters, O., Preis, L., Gref, D., Spruth, E. J., Altenstein, S., Priller, J., Fließbach, K., Schneider, A., Wiltfang, J., Bartels, C., Jessen, F., Maier, F., Düzel, E., Metzger, C., ... DELCODE study group. (2022). Relevance of Subjective Cognitive Decline in Older Adults with a First-Degree Family History of Alzheimer's Disease. Journal of Alzheimer's Disease, 87 (2), 545 - 555. doi:10.3233/JAD-215416 ![]() |
Ravichandran, K. A., & HENEKA, M. (22 December 2021). Inflammasome activation in neurodegenerative diseases. Essays in Biochemistry, 65 (7), 885 - 904. doi:10.1042/EBC20210021 ![]() |
![]() ![]() | Kummer, M. P., Ising, C., Kummer, C., Sarlus, H., Griep, A., Vieira-Saecker, A., Schwartz, S., Halle, A., Brückner, M., Händler, K., Schultze, J. L., Beyer, M., Latz, E., & HENEKA, M. (15 December 2021). Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO Journal, 40 (24), 108662. doi:10.15252/embj.2021108662 ![]() |
![]() ![]() | Joshi, P., Riffel, F., Satoh, K., Enomoto, M., Qamar, S., Scheiblich, H., Villacampa, N., Kumar, S., Theil, S., Parhizkar, S., Haass, C., HENEKA, M., Fraser, P. E., St George-Hyslop, P., & Walter, J. (December 2021). Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia, 69 (12), 2917 - 2932. doi:10.1002/glia.24077 ![]() |
![]() ![]() | Dyrba, M., Hanzig, M., Altenstein, S., Bader, S., Ballarini, T., Brosseron, F., Buerger, K., Cantré, D., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Glanz, W., Haynes, J.-D., HENEKA, M., Janowitz, D., Keles, D. B., Kilimann, I., ... ADNI, A. D. S. G. (23 November 2021). Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer's disease. Alzheimer's Research and Therapy, 13 (1), 191. doi:10.1186/s13195-021-00924-2 ![]() |
![]() ![]() | Widmann, C. N., Wieberneit, M., Bieler, L., Bernsen, S., Gräfenkämper, R., Brosseron, F., Schmeel, C., Tacik, P., Skowasch, D., Radbruch, A., & HENEKA, M. (11 November 2021). Longitudinal Neurocognitive and Pulmonological Profile of Long COVID-19: Protocol for the COVIMMUNE-Clin Study. JMIR Research Protocols, 10 (11), 30259. doi:10.2196/30259 ![]() |
![]() ![]() | Islam, M. R., Kaurani, L., Berulava, T., Heilbronner, U., Budde, M., Centeno, T. P., Elerdashvili, V., Zafieriou, M.-P., Benito, E., Sertel, S. M., Goldberg, M., Senner, F., Kalman, J. L., Burkhardt, S., Oepen, A. S., Sakib, M. S., Kerimoglu, C., Wirths, O., Bickeböller, H., ... Fischer, A. (08 November 2021). A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Molecular Medicine, 13 (11), 13659. doi:10.15252/emmm.202013659 ![]() |
![]() ![]() | Rueda-Carrasco, J., Martin-Bermejo, M. J., Pereyra, G., Mateo, M. I., Borroto, A., Brosseron, F., Kummer, M. P., Schwartz, S., López-Atalaya, J. P., Alarcon, B., Esteve, P., HENEKA, M., & Bovolenta, P. (04 November 2021). SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation. EMBO Reports, 22 (11), 51696. doi:10.15252/embr.202051696 ![]() |
![]() ![]() | Manabe, T., Rácz, I., Schwartz, S., Oberle, L., Santarelli, F., Emmrich, J. V., Neher, J. J., & HENEKA, M. (November 2021). Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing. Journal of Neurochemistry, 159 (3), 525 - 542. doi:10.1111/jnc.15491 ![]() |
![]() ![]() | Bettcher, B. M., Tansey, M. G., Dorothée, G., & HENEKA, M. (November 2021). Publisher Correction: Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nature Reviews. Neurology, 17 (11), 724. doi:10.1038/s41582-021-00579-5 ![]() |
![]() ![]() | Bettcher, B. M., Tansey, M. G., Dorothée, G., & HENEKA, M. (November 2021). Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nature Reviews. Neurology, 17 (11), 689 - 701. doi:10.1038/s41582-021-00549-x ![]() |
![]() ![]() | Joshi, P., Riffel, F., Kumar, S., Villacampa, N., Theil, S., Parhizkar, S., Haass, C., Colonna, M., HENEKA, M., Arzberger, T., Herms, J., & Walter, J. (18 October 2021). TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits. Acta Neuropathologica Communications, 9 (1), 168. doi:10.1186/s40478-021-01263-x ![]() |
![]() ![]() | Keane, L., Antignano, I., RIECHERS, S.-P. H., Zollinger, R., Dumas, A. A., Offermann, N., Bernis, M. E., Russ, J., Graelmann, F., McCormick, P. N., Esser, J., Tejera, D., Nagano, A., Wang, J., Chelala, C., Biederbick, Y., Halle, A., Salomoni, P., HENEKA, M., & Capasso, M. (15 October 2021). mTOR-dependent translation amplifies microglia priming in aging mice. Journal of Clinical Investigation, 131 (20). doi:10.1172/JCI155208 ![]() |
![]() ![]() | Scheiblich, H., Bousset, L., Schwartz, S., Griep, A., Latz, E., Melki, R., & HENEKA, M. (15 October 2021). Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies. Journal of Immunology, 207 (8), 2143 - 2154. doi:10.4049/jimmunol.2100035 ![]() |
![]() ![]() | Aretz, B., Janssen, F., Vonk, J. M., HENEKA, M., Boezen, H. M., & Doblhammer, G. (October 2021). Long-term exposure to fine particulate matter, lung function and cognitive performance: A prospective Dutch cohort study on the underlying routes. Environmental Research, 201, 111533. doi:10.1016/j.envres.2021.111533 ![]() |
![]() ![]() | Rauchmann, B.-S., Ersoezlue, E., Stoecklein, S., Keeser, D., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ertl-Wagner, B., Fliessbach, K., Haynes, J. D., HENEKA, M., Incesoy, E. I., Janowitz, D., Kilimann, I., Laske, C., Metzger, C. D., Munk, M. H., Peters, O., ... DELCODE study group and the Alzheimer's Disease Neuroimaging Initiative (ADNI). (01 October 2021). Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes. Cerebral Cortex, 31 (11), 4901 - 4915. doi:10.1093/cercor/bhab130 ![]() |
![]() ![]() | Scheiblich, H., Dansokho, C., Mercan, D., Schmidt, S. V., Bousset, L., Wischhof, L., Eikens, F., Odainic, A., Spitzer, J., Griep, A., Schwartz, S., Bano, D., Latz, E., Melki, R., & HENEKA, M. (30 September 2021). Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell, 184 (20), 5089 - 5106.e21. doi:10.1016/j.cell.2021.09.007 ![]() |
![]() ![]() | Jiang, S., Maphis, N. M., Binder, J., Chisholm, D., Weston, L., Duran, W., Peterson, C., Zimmerman, A., Mandell, M. A., Jett, S. D., Bigio, E., Geula, C., Mellios, N., Weick, J. P., Rosenberg, G. A., Latz, E., HENEKA, M., & Bhaskar, K. (21 September 2021). Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Reports, 36 (12), 109720. doi:10.1016/j.celrep.2021.109720 ![]() |
![]() ![]() | Odoj, K., Brawek, B., Asavapanumas, N., Mojtahedi, N., HENEKA, M., & Garaschuk, O. (August 2021). In vivo mechanisms of cortical network dysfunction induced by systemic inflammation. Brain, Behavior and Immunity, 96, 113 - 126. doi:10.1016/j.bbi.2021.05.021 ![]() |
![]() ![]() | Bergström, S., Remnestål, J., Yousef, J., Olofsson, J., Markaki, I., Carvalho, S., Corvol, J.-C., Kultima, K., Kilander, L., Löwenmark, M., Ingelsson, M., Blennow, K., Zetterberg, H., Nellgård, B., Brosseron, F., HENEKA, M., Bosch, B., Sanchez-Valle, R., Månberg, A., ... Nilsson, P. (July 2021). Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease. Annals of Clinical and Translational Neurology, 8 (7), 1456 - 1470. doi:10.1002/acn3.51402 ![]() |
![]() ![]() | de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., ... Ruiz, A. (07 June 2021). Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications, 12 (1), 3417. doi:10.1038/s41467-021-22491-8 ![]() |
![]() ![]() | Brosseron, F., Kleemann, K., Kolbe, C.-C., Santarelli, F., Castro-Gomez, S., Tacik, P., Latz, E., Jessen, F., & HENEKA, M. (June 2021). Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation. Journal of Neurochemistry, 157 (6), 2210 - 2224. doi:10.1111/jnc.15175 ![]() |
![]() ![]() | Ballarini, T., Melo van Lent, D., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Duzel, E., Ertl-Wagner, B., Fliessbach, K., Freiesleben, S. D., Frommann, I., Glanz, W., Hauser, D., Haynes, J. D., HENEKA, M., ... DELCODE study group. (05 May 2021). Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology, 96 (24), 2920 - e2932. doi:10.1212/WNL.0000000000012067 ![]() |
![]() ![]() | Mantile, F., Capasso, A., Villacampa, N., Donnini, M., Liguori, G. L., Constantin, G., De Berardinis, P.* , HENEKA, M.* , & Prisco, A.*. (May 2021). Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice. Aging Clinical and Experimental Research, 33 (5), 1383 - 1387. doi:10.1007/s40520-019-01414-0 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Ribon, M., Leone, C., Chiot, A., Berriat, F., Rampanana, M., Cottin, J., Bohl, D., Millecamps, S., Lobsiger, C. S., HENEKA, M., & Boillée, S. (May 2021). Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice. Neurobiology of Aging, 101, 181 - 186. doi:10.1016/j.neurobiolaging.2021.01.015 ![]() |
![]() ![]() | Nitsch, L.* , Petzinna, S.* , Zimmermann, J., Schneider, L., Krauthausen, M., HENEKA, M., Getts, D. R., Becker, A., & Müller, M. (27 April 2021). Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model. Journal of Neuroinflammation, 18 (1), 101. doi:10.1186/s12974-021-02140-z ![]() * These authors have contributed equally to this work. |
![]() ![]() | Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., HENEKA, M., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., ... Dinarello, C. A. (February 2021). Author Correction: A guiding map for inflammation. Nature Immunology, 22 (2), 254. doi:10.1038/s41590-020-00846-5 ![]() |
![]() ![]() | Franzmeier, N., Ren, J., Damm, A., Monté-Rubio, G., Boada, M., Ruiz, A., Ramirez, A., Jessen, F., Düzel, E., Rodríguez Gómez, O., Benzinger, T., Goate, A., Karch, C. M., Fagan, A. M., McDade, E., Buerger, K., Levin, J., Duering, M., Dichgans, M., ... Ewers, M. (February 2021). The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry, 26 (2), 614 - 628. doi:10.1038/s41380-019-0404-6 ![]() |
![]() ![]() | Keane, L., Antignano, I., RIECHERS, S.-P. H., Zollinger, R., Dumas, A. A., Offermann, N., Bernis, M. E., Russ, J., Graelmann, F., McCormick, P. N., Esser, J., Tejera, D., Nagano, A., Wang, J., Chelala, C., Biederbick, Y., Halle, A., Salomoni, P., HENEKA, M., & Capasso, M. (2021). mTOR-dependent translation amplifies microglia priming in aging mice. Journal of Clinical Investigation, 131 (1). ![]() |
![]() ![]() | Fritze, T., Doblhammer, G., Widmann, C. N., & HENEKA, M. (January 2021). Time course of dementia following sepsis in German health claims data. Neurology: Neuroimmunology and Neuroinflammation, 8 (1). doi:10.1212/NXI.0000000000000911 ![]() |
![]() ![]() | Castro-Gomez, S., Radermacher, B., Tacik, P., Mirandola, S. R., HENEKA, M., & Weydt, P. (2021). Teaching an old dog new tricks: serum troponin T as a biomarker in amyotrophic lateral sclerosis. Brain Communications, 3 (4), 274. doi:10.1093/braincomms/fcab274 ![]() |
![]() ![]() | Hansen, N., Singh, A., Bartels, C., Brosseron, F., Buerger, K., Cetindag, A. C., Dobisch, L., Dechent, P., Ertl-Wagner, B. B., Fliessbach, K., Haynes, J. D., HENEKA, M., Janowitz, D., Kilimann, I., Laske, C., Metzger, C. D., Munk, M. H., Peters, O., Priller, J., ... Goya-Maldonado, R. (2021). Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline. Frontiers in Aging Neuroscience, 13, 626974. doi:10.3389/fnagi.2021.626974 ![]() |
Lage, C., González-Suárez, A., Alcalde-Hierro, M. P., Sampedro-González, M. I., Villanueva-Eguaras, M. Á., Sánchez-Crespo, M. R., Widmann, C., Brosseron, F., Pozueta, A., López-García, S., García-Martínez, M., Kazimierczak, M., Bravo-González, M., Fernández-Rodríguez, A., Drake-Pérez, M., Irure-Ventura, J., López-Hoyos, M., Rodríguez-Rodríguez, E., HENEKA, M., & Sánchez-Juan, P. (2021). Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology. Journal of Alzheimer's Disease, 79 (2), 863 - 874. doi:10.3233/JAD-191229 ![]() |
![]() ![]() | Lučiūnaitė, A., McManus, R. M., Jankunec, M., Rácz, I., Dansokho, C., Dalgėdienė, I., Schwartz, S., Brosseron, F., & HENEKA, M. (December 2020). Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. Journal of Neurochemistry, 155 (6), 650 - 661. doi:10.1111/jnc.14945 ![]() |
![]() ![]() | Finsterwalder, S.* , Vlegels, N.* , Gesierich, B., Araque Caballero, M. Á., Weaver, N. A., Franzmeier, N., Georgakis, M. K., Konieczny, M. J., Koek, H. L., Dominantly Inherited Alzheimer Network (DIAN), Karch, C. M., Graff-Radford, N. R., Salloway, S., Oh, H., Allegri, R. F., Chhatwal, J. P., DELCODE study group, Jessen, F., Düzel, E., ... Duering, M. (November 2020). Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 16 (11), 1504 - 1514. doi:10.1002/alz.12150 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Sannemann, L., Schild, A.-K., Altenstein, S., Bartels, C., Brosseron, F., Buerger, K., Cosma, N. C., Fliessbach, K., Freiesleben, S. D., Glanz, W., HENEKA, M., Janowitz, D., Kilimann, I., Kobeleva, X., Laske, C., Metzger, C. D., Munk, M. H. J., Perneczky, R., Peters, O., ... DELCODE Study Group. (16 October 2020). Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study. Alzheimer's Research and Therapy, 12 (1), 131. doi:10.1186/s13195-020-00701-7 ![]() |
![]() ![]() | Unger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., HENEKA, M., Attems, J., & Aigner, L. (October 2020). CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice. Brain, Behavior and Immunity, 89, 67 - 86. doi:10.1016/j.bbi.2020.05.070 ![]() |
Wolfsgruber, S., Kleineidam, L., Guski, J., Polcher, A., Frommann, I., Roeske, S., Spruth, E. J., Franke, C., Priller, J., Kilimann, I., Teipel, S., Buerger, K., Janowitz, D., Laske, C., Buchmann, M., Peters, O., Menne, F., Fuentes Casan, M., Wiltfang, J., ... DELCODE Study Group. (01 September 2020). Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology, 95 (9), 1134 - e1143. doi:10.1212/WNL.0000000000010142 ![]() |
![]() ![]() | Beyer, M. M. S., Lonnemann, N., Remus, A., Latz, E., HENEKA, M., & Korte, M. (08 July 2020). Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent. Journal of Neuroscience, 40 (28), 5480 - 5494. doi:10.1523/JNEUROSCI.0200-20.2020 ![]() |
![]() ![]() | Riester, K., Brawek, B., Savitska, D., Fröhlich, N., Zirdum, E., Mojtahedi, N., HENEKA, M., & Garaschuk, O. (July 2020). In vivo characterization of functional states of cortical microglia during peripheral inflammation. Brain, Behavior and Immunity, 87, 243 - 255. doi:10.1016/j.bbi.2019.12.007 ![]() |
![]() ![]() | HENEKA, M., Golenbock, D., Latz, E., Morgan, D., & Brown, R. (04 June 2020). Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimer's Research and Therapy, 12 (1), 69. doi:10.1186/s13195-020-00640-3 ![]() |
![]() ![]() | Kleineidam, L., Chouraki, V., Próchnicki, T., van der Lee, S. J., Madrid-Márquez, L., Wagner-Thelen, H., Karaca, I., Weinhold, L., Wolfsgruber, S., Boland, A., Martino Adami, P. V., Lewczuk, P., Popp, J., Brosseron, F., Jansen, I. E., Hulsman, M., Kornhuber, J., Peters, O., Berr, C., ... Ramirez, A.*. (June 2020). PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta Neuropathologica, 139 (6), 1025 - 1044. doi:10.1007/s00401-020-02138-6 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Schröder, N., Schaffrath, A., Welter, J. A., Putzka, T., Griep, A., Ziegler, P., Brandt, E., Samer, S., HENEKA, M., Kaddatz, H., Zhan, J., Kipp, E., Pufe, T., Tauber, S. C., Kipp, M., & Brandenburg, L.-O. (24 April 2020). Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease. Journal of Neuroinflammation, 17 (1), 131. doi:10.1186/s12974-020-01816-2 ![]() |
![]() ![]() | Villacampa, N., & HENEKA, M. (06 April 2020). Microglia in Alzheimer's disease: Local heroes! Journal of Experimental Medicine, 217 (4). doi:10.1084/jem.20192311 ![]() |
![]() ![]() | McManus, R. M., & HENEKA, M. (April 2020). T cells in Alzheimer's disease: space invaders. The Lancet Neurology, 19 (4), 285 - 287. doi:10.1016/S1474-4422(20)30076-4 ![]() |
![]() ![]() | Scheiblich, H., Trombly, M., Ramirez, A., & HENEKA, M. (April 2020). Neuroimmune Connections in Aging and Neurodegenerative Diseases. Trends in Immunology, 41 (4), 300 - 312. doi:10.1016/j.it.2020.02.002 ![]() |
![]() ![]() | Itzhaki, R. F., Golde, T. E., HENEKA, M., & Readhead, B. (April 2020). Do infections have a role in the pathogenesis of Alzheimer disease? Nature Reviews. Neurology, 16 (4), 193 - 197. doi:10.1038/s41582-020-0323-9 ![]() |
![]() ![]() | Friker, L. L., Scheiblich, H., Hochheiser, I. V., Brinkschulte, R., Riedel, D., Latz, E., Geyer, M., & HENEKA, M. (17 March 2020). β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell Reports, 30 (11), 3743 - 3754.e6. doi:10.1016/j.celrep.2020.02.025 ![]() |
![]() ![]() | Wijasa, T. S., Sylvester, M., Brocke-Ahmadinejad, N., Schwartz, S., Santarelli, F., Gieselmann, V., Klockgether, T., Brosseron, F., & HENEKA, M. (March 2020). Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease. Journal of Neurochemistry, 152 (6), 710 - 726. doi:10.1111/jnc.14870 ![]() |
![]() ![]() | Kumar, S., Kapadia, A., Theil, S., Joshi, P., Riffel, F., HENEKA, M., & Walter, J. (2020). Novel Phosphorylation-State Specific Antibodies Reveal Differential Deposition of Ser26 Phosphorylated Aβ Species in a Mouse Model of Alzheimer's Disease. Frontiers in Molecular Neuroscience, 13, 619639. doi:10.3389/fnmol.2020.619639 ![]() |
![]() ![]() | Karsak, M.* , Glebov, K.* , Scheffold, M., Bajaj, T., Kawalia, A., Karaca, I., Rading, S., Kornhuber, J., Peters, O., Diez-Fairen, M., Frölich, L., Hüll, M., Wiltfang, J., Scherer, M., Riedel-Heller, S., Schneider, A., HENEKA, M., Fliessbach, K., Sharaf, A., ... Ramirez, A. (January 2020). A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Human Mutation, 41 (1), 169 - 181. doi:10.1002/humu.23904 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Webers, A., HENEKA, M., & Gleeson, P. A. (January 2020). The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. Immunology and Cell Biology, 98 (1), 28 - 41. doi:10.1111/imcb.12301 ![]() |
![]() ![]() | HENEKA, M. (January 2020). An immune-cell signature marks the brain in Alzheimer's disease. Nature, 577 (7790), 322 - 323. doi:10.1038/d41586-019-03892-8 ![]() |
Traschütz, A., Enkirch, S. J., Polomac, N., Widmann, C. N., Schild, H. H., HENEKA, M., & Hattingen, E. (2020). The Entorhinal Cortex Atrophy Score Is Diagnostic and Prognostic in Mild Cognitive Impairment. Journal of Alzheimer's Disease, 75 (1), 99 - 108. doi:10.3233/JAD-181150 ![]() |
![]() ![]() | Herdick, M., Dyrba, M., Fritz, H.-C. J., Altenstein, S., Ballarini, T., Brosseron, F., Buerger, K., Can Cetindag, A., Dechent, P., Dobisch, L., Duezel, E., Ertl-Wagner, B., Fliessbach, K., Dawn Freiesleben, S., Frommann, I., Glanz, W., Dylan Haynes, J., HENEKA, M., Janowitz, D., ... Grothe, M. J. (2020). Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer's disease spectrum. NeuroImage: Clinical, 28, 102495. doi:10.1016/j.nicl.2020.102495 ![]() |
![]() ![]() | Nitsch, L., Zimmermann, J., Krauthausen, M., Hofer, M. J., Saggu, R., Petzold, G. C., HENEKA, M., Getts, D. R., Becker, A., Campbell, I. L., & Müller, M. (December 2019). CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. Molecular Neurobiology, 56 (12), 7977 - 7993. doi:10.1007/s12035-019-1640-0 ![]() |
![]() ![]() | Bainbridge, W. A., Berron, D., Schütze, H., Cardenas-Blanco, A., Metzger, C., Dobisch, L., Bittner, D., Glanz, W., Spottke, A., Rudolph, J., Brosseron, F., Buerger, K., Janowitz, D., Fliessbach, K., HENEKA, M., Laske, C., Buchmann, M., Peters, O., Diesing, D., ... Düzel, E. (December 2019). Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11 (1), 610 - 618. doi:10.1016/j.dadm.2019.07.005 ![]() |
Venegas, C., & HENEKA, M. (December 2019). Inflammasome-mediated innate immunity in Alzheimer's disease. FASEB Journal, 33 (12), 13075 - 13084. doi:10.1096/fj.201900439 ![]() |
![]() ![]() | Mercan, D., & HENEKA, M. (November 2019). Norepinephrine as a modulator of microglial dynamics. Nature Neuroscience, 22 (11), 1745 - 1746. doi:10.1038/s41593-019-0526-9 ![]() |
![]() ![]() | Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., ... HENEKA, M. (November 2019). NLRP3 inflammasome activation drives tau pathology. Nature, 575 (7784), 669 - 673. doi:10.1038/s41586-019-1769-z ![]() |
![]() ![]() | Berron, D., Cardenas-Blanco, A., Bittner, D., Metzger, C. D., Spottke, A., HENEKA, M., Fliessbach, K., Schneider, A., Teipel, S. J., Wagner, M., Speck, O., Jessen, F., & Düzel, E. (30 October 2019). Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. Journal of Neuroscience, 39 (44), 8788 - 8797. doi:10.1523/JNEUROSCI.1279-19.2019 ![]() |
![]() ![]() | Tejera, D., Mercan, D., Sanchez-Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & HENEKA, M. (02 September 2019). Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. EMBO Journal, 38 (17), 101064. doi:10.15252/embj.2018101064 ![]() |
![]() ![]() | Castro-Gomez, S., Binder, J., & HENEKA, M. (September 2019). Neuroinflammation als Motor der Alzheimer-Erkrankung. Nervenarzt, 90 (9), 898 - 906. doi:10.1007/s00115-019-0778-3 ![]() |
![]() ![]() | Herrera-Rivero, M., Santarelli, F., Brosseron, F., Kummer, M. P., & HENEKA, M. (September 2019). Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression. Molecular Neurobiology, 56 (9), 6539 - 6550. doi:10.1007/s12035-019-1540-3 ![]() |
![]() ![]() | Bertens, D., Vos, S., Kehoe, P., Wolf, H., Nobili, F., Mendonça, A., van Rossum, I., Hort, J., Molinuevo, J. L., HENEKA, M., Petersen, R., Scheltens, P., & Visser, P. J. (22 August 2019). Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey. Alzheimer's Research and Therapy, 11 (1), 74. doi:10.1186/s13195-019-0525-9 ![]() |
![]() ![]() | Esteve, P., Rueda-Carrasco, J., Inés Mateo, M., Martin-Bermejo, M. J., Draffin, J., Pereyra, G., Sandonís, Á., Crespo, I., Moreno, I., Aso, E., Garcia-Esparcia, P., Gomez-Tortosa, E., Rábano, A., Fortea, J., Alcolea, D., Lleo, A., HENEKA, M., Valpuesta, J. M., Esteban, J. A., ... Bovolenta, P. (August 2019). Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis. Nature Neuroscience, 22 (8), 1258 - 1268. doi:10.1038/s41593-019-0432-1 ![]() |
![]() ![]() | Miebach, L., Wolfsgruber, S., Polcher, A., Peters, O., Menne, F., Luther, K., Incesoy, E., Priller, J., Spruth, E., Altenstein, S., Buerger, K., Catak, C., Janowitz, D., Perneczky, R., Utecht, J., Laske, C., Buchmann, M., Schneider, A., Fliessbach, K., ... Wagner, M. (31 July 2019). Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study. Alzheimer's Research and Therapy, 11 (1), 66. doi:10.1186/s13195-019-0515-y ![]() |
![]() ![]() | HENEKA, M., McManus, R. M., & Latz, E. (March 2019). Author Correction: Inflammasome signalling in brain function and neurodegenerative disease. Nature Reviews. Neuroscience, 20 (3), 187. doi:10.1038/s41583-019-0137-1 ![]() |
![]() ![]() | HENEKA, M. (February 2019). Microglia take centre stage in neurodegenerative disease. Nature Reviews. Immunology, 19 (2), 79 - 80. doi:10.1038/s41577-018-0112-5 ![]() |
Hu, X., Teunissen, C. E., Spottke, A., HENEKA, M., Düzel, E., Peters, O., Li, S., Priller, J., Buerger, K., Teipel, S., Laske, C., Verfaillie, S. C. J., Barkhof, F., Coll-Padrós, N., Rami, L., Molinuevo, J. L., van der Flier, W. M., & Jessen, F. (February 2019). Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 15 (2), 185 - 193. doi:10.1016/j.jalz.2018.09.002 ![]() |
![]() ![]() | Wolfsgruber, S., Molinuevo, J. L., Wagner, M., Teunissen, C. E., Rami, L., Coll-Padrós, N., Bouwman, F. H., Slot, R. E. R., Wesselman, L. M. P., Peters, O., Luther, K., Buerger, K., Priller, J., Laske, C., Teipel, S., Spottke, A., HENEKA, M., Düzel, E., Drzezga, A., ... Euro-SCD working group. (17 January 2019). Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimer's Research and Therapy, 11 (1), 8. doi:10.1186/s13195-018-0463-y ![]() |
![]() ![]() | Teipel, S. J., Kuper-Smith, J. O., Bartels, C., Brosseron, F., Buchmann, M., Buerger, K., Catak, C., Janowitz, D., Dechent, P., Dobisch, L., Ertl-Wagner, B., Fließbach, K., Haynes, J.-D., HENEKA, M., Kilimann, I., Laske, C., Li, S., Menne, F., Metzger, C. D., ... DELCODE study group. (2019). Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer's Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness. Journal of Alzheimer's Disease, 72 (2), 455 - 465. doi:10.3233/JAD-190446 ![]() |
![]() ![]() | Traschütz, A., & HENEKA, M. (2019). Screening for Niemann-Pick Type C Disease in a Memory Clinic Cohort. JIMD Reports, 44, 109 - 114. doi:10.1007/8904_2018_133 ![]() |
Tejera, D., & HENEKA, M. (2019). Microglia in Neurodegenerative Disorders. Methods in Molecular Biology, 2034, 57 - 67. doi:10.1007/978-1-4939-9658-2_5 ![]() |
Tejera, D., & HENEKA, M. (2019). In Vivo Phagocytosis Analysis of Amyloid Beta. Methods in Molecular Biology, 2034, 287 - 292. doi:10.1007/978-1-4939-9658-2_21 ![]() |
![]() ![]() | Traschütz, A., Kummer, M. P., Schwartz, S., & HENEKA, M. (December 2018). Variability and temporal dynamics of novel object recognition in aging male C57BL/6 mice. Behavioural Processes, 157, 711 - 716. doi:10.1016/j.beproc.2017.11.009 ![]() |
![]() ![]() | HENEKA, M., McManus, R. M., & Latz, E. (October 2018). Inflammasome signalling in brain function and neurodegenerative disease. Nature Reviews. Neuroscience, 19 (10), 610 - 621. doi:10.1038/s41583-018-0055-7 ![]() |
![]() ![]() | Rammes, G., Seeser, F., Mattusch, K., Zhu, K., Haas, L., Kummer, M., HENEKA, M., Herms, J., & Parsons, C. G. (15 September 2018). The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP). Neuropharmacology, 140, 184 - 192. doi:10.1016/j.neuropharm.2018.07.021 ![]() |
![]() ![]() | Tzeng, T.-C., Hasegawa, Y., Iguchi, R., Cheung, A., Caffrey, D. R., Thatcher, E. J., Mao, W., Germain, G., Tamburro, N. D., Okabe, S., HENEKA, M., Latz, E., Futai, K., & Golenbock, D. T. (04 September 2018). Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proceedings of the National Academy of Sciences of the United States of America, 115 (36), 9002 - 9007. doi:10.1073/pnas.1801802115 ![]() |
![]() ![]() | Unger, M. S., Marschallinger, J., Kaindl, J., Klein, B., Johnson, M., Khundakar, A. A., Roßner, S., HENEKA, M., Couillard-Despres, S., Rockenstein, E., Masliah, E., Attems, J., & Aigner, L. (August 2018). Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology? Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 14 (8), 1022 - 1037. doi:10.1016/j.jalz.2018.02.017 ![]() |
![]() ![]() | Ludolph, A. C.* , Schuster, J.* , Dorst, J., Dupuis, L., Dreyhaupt, J., Weishaupt, J. H., Kassubek, J., Weiland, U., Petri, S., Meyer, T., Grosskreutz, J., Schrank, B., Boentert, M., Emmer, A., Hermann, A., Zeller, D., Prudlo, J., Winkler, A. S., Grehl, T., ... RAS-ALS Study Group. (August 2018). Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial. The Lancet Neurology, 17 (8), 681 - 688. doi:10.1016/S1474-4422(18)30176-5 ![]() * These authors have contributed equally to this work. |
Enkirch, S. J., Traschütz, A., Müller, A., Widmann, C. N., Gielen, G. H., HENEKA, M., Jurcoane, A., Schild, H. H., & Hattingen, E. (July 2018). The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease. Radiology, 288 (1), 226 - 333. doi:10.1148/radiol.2018171888 ![]() |
![]() ![]() | Lehmer, C., Schludi, M. H., Ransom, L., Greiling, J., Junghänel, M., Exner, N., Riemenschneider, H., van der Zee, J., Van Broeckhoven, C., Weydt, P., HENEKA, M., & Edbauer, D. (June 2018). A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS. EMBO Molecular Medicine, 10 (6). doi:10.15252/emmm.201708558 ![]() |
![]() ![]() | Kalinin, S., González-Prieto, M., Scheiblich, H., Lisi, L., Kusumo, H., HENEKA, M., Madrigal, J. L. M., Pandey, S. C., & Feinstein, D. L. (14 May 2018). Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. Journal of Neuroinflammation, 15 (1), 141. doi:10.1186/s12974-018-1184-7 ![]() |
![]() ![]() | Dansokho, C., & HENEKA, M. (May 2018). Neuroinflammatory responses in Alzheimer's disease. Journal of Neural Transmission, 125 (5), 771 - 779. doi:10.1007/s00702-017-1831-7 ![]() |
![]() ![]() | Franzmeier, N., Düzel, E., Jessen, F., Buerger, K., Levin, J., Duering, M., Dichgans, M., Haass, C., Suárez-Calvet, M., Fagan, A. M., Paumier, K., Benzinger, T., Masters, C. L., Morris, J. C., Perneczky, R., Janowitz, D., Catak, C., Wolfsgruber, S., Wagner, M., ... Ewers, M. (01 April 2018). Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain: a Journal of Neurology, 141 (4), 1186 - 1200. doi:10.1093/brain/awy008 ![]() |
![]() ![]() | Brosseron, F., Traschütz, A., Widmann, C. N., Kummer, M. P., Tacik, P., Santarelli, F., Jessen, F., & HENEKA, M. (26 February 2018). Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimer's Research and Therapy, 10 (1), 25. doi:10.1186/s13195-018-0353-3 ![]() |
![]() ![]() | Villacampa, N., & HENEKA, M. (20 February 2018). Microglia: You'll Never Walk Alone! Immunity, 48 (2), 195 - 197. doi:10.1016/j.immuni.2018.02.009 ![]() |
![]() ![]() | Jessen, F., Spottke, A., Boecker, H., Brosseron, F., Buerger, K., Catak, C., Fliessbach, K., Franke, C., Fuentes, M., HENEKA, M., Janowitz, D., Kilimann, I., Laske, C., Menne, F., Nestor, P., Peters, O., Priller, J., Pross, V., Ramirez, A., ... Düzel, E. (07 February 2018). Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimer's Research and Therapy, 10 (1), 15. doi:10.1186/s13195-017-0314-2 ![]() |
![]() ![]() | Zimmermann, J., Emrich, M., Krauthausen, M., Saxe, S., Nitsch, L., HENEKA, M., Campbell, I. L., & Müller, M. (February 2018). IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination. Molecular Neurobiology, 55 (2), 946 - 957. doi:10.1007/s12035-016-0368-3 ![]() |
![]() ![]() | Labzin, L. I., HENEKA, M., & Latz, E. (29 January 2018). Innate Immunity and Neurodegeneration. Annual Review of Medicine, 69 (1), 437 - 449. doi:10.1146/annurev-med-050715-104343 ![]() |
![]() ![]() | Ising, C., & HENEKA, M. (25 January 2018). Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration. Cell Death and Disease, 9 (2), 120. doi:10.1038/s41419-017-0153-x ![]() |
![]() ![]() | Teipel, S. J., Metzger, C. D., Brosseron, F., Buerger, K., Brueggen, K., Catak, C., Diesing, D., Dobisch, L., Fliebach, K., Franke, C., HENEKA, M., Kilimann, I., Kofler, B., Menne, F., Peters, O., Polcher, A., Priller, J., Schneider, A., Spottke, A., ... DELCODE study group. (2018). Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease. Journal of Alzheimer's Disease, 64 (3), 801 - 813. doi:10.3233/JAD-180106 ![]() |
![]() ![]() | Faivre, E., Coelho, J. E., Zornbach, K., Malik, E., Baqi, Y., Schneider, M., Cellai, L., Carvalho, K., Sebda, S., Figeac, M., Eddarkaoui, S., Caillierez, R., Chern, Y., HENEKA, M., Sergeant, N., Müller, C. E., Halle, A., Buée, L., Lopes, L. V., & Blum, D. (2018). Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Frontiers in Molecular Neuroscience, 11, 235. doi:10.3389/fnmol.2018.00235 ![]() |
![]() ![]() | Ativie, F.* , Komorowska, J. A.* , Beins, E., Albayram, Ö., Zimmer, T., Zimmer, A., Tejera, D., HENEKA, M., & Bilkei-Gorzo, A. (2018). Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity. Frontiers in Molecular Neuroscience, 11, 295. doi:10.3389/fnmol.2018.00295 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Düzel, E., Berron, D., Schütze, H., Cardenas-Blanco, A., Metzger, C., Betts, M., Ziegler, G., Chen, Y., Dobisch, L., Bittner, D., Glanz, W., Reuter, M., Spottke, A., Rudolph, J., Brosseron, F., Buerger, K., Janowitz, D., Fliessbach, K., HENEKA, M., ... Jessen, F. (2018). CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 10 (1), 782 - 790. doi:10.1016/j.dadm.2018.10.003 ![]() |
![]() ![]() | Kaczmarczyk, R., Tejera, D., Simon, B. J., & HENEKA, M. (21 December 2017). Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease. Journal of Neurochemistry, 146 (1), 76 - 85. doi:10.1111/jnc.14284 ![]() |
![]() ![]() | Tejera, D., & HENEKA, M. (20 December 2017). United Again: STING and the Police. Neuron, 96 (6), 1207 - 1208. doi:10.1016/j.neuron.2017.12.015 ![]() |
Venegas, C., Kumar, S., Franklin, B. S., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M. P., Griep, A., Gelpi, E., Beilharz, M., Riedel, D., Golenbock, D. T., Geyer, M., Walter, J., Latz, E., & HENEKA, M. (20 December 2017). Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease. Nature, 552 (7685), 355 - 361. doi:10.1038/nature25158 ![]() |
![]() ![]() | Ardura-Fabregat, A., Boddeke, E. W. G. M., Boza-Serrano, A., Brioschi, S., Castro-Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., HENEKA, M., Hoeijmakers, L., Hoffmann, A., Iaccarino, L., Jahnert, S., Kuhbandner, K., Landreth, G., Lonnemann, N., Löschmann, P. A., McManus, R. M., ... Yang, Y. (December 2017). Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS Drugs, 31 (12), 1057 - 1082. doi:10.1007/s40263-017-0483-3 ![]() |
Scheiblich, H., Schlütter, A., Golenbock, D. T., Latz, E., Martinez-Martinez, P., & HENEKA, M. (December 2017). Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of Neurochemistry, 143 (5), 534 - 550. doi:10.1111/jnc.14225 ![]() |
![]() ![]() | Wijasa, T. S., Sylvester, M., Brocke-Ahmadinejad, N., Kummer, M. P., Brosseron, F., Gieselmann, V., & HENEKA, M. (01 November 2017). Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags. Journal of Neuroscience Methods, 291, 95 - 100. doi:10.1016/j.jneumeth.2017.08.005 ![]() |
Sarlus, H., & HENEKA, M. (01 September 2017). Microglia in Alzheimer's disease. Journal of Clinical Investigation, 127 (9), 3240 - 3249. doi:10.1172/JCI90606 ![]() |
![]() ![]() | Müller, S., Preische, O., Göpfert, J. C., Yañez, V. A. C., Joos, T. O., Boecker, H., Düzel, E., Falkai, P., Priller, J., Buerger, K., Catak, C., Janowitz, D., HENEKA, M., Brosseron, F., Nestor, P., Peters, O., Menne, F., Schipke, C. G., Schneider, A., ... Laske, C. (25 August 2017). Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Scientific Reports, 7 (1), 9529. doi:10.1038/s41598-017-08779-0 ![]() |
![]() ![]() | Simchovitz, A., HENEKA, M., & Soreq, H. (August 2017). Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of Neurochemistry, 142 Suppl 2 (Suppl Suppl 2), 178 - 187. doi:10.1111/jnc.13928 ![]() |
![]() ![]() | Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., HENEKA, M., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., ... Dinarello, C. A. (19 July 2017). A guiding map for inflammation. Nature Immunology, 18 (8), 826 - 831. doi:10.1038/ni.3790 ![]() |
![]() ![]() | Kemmerling, N., Wunderlich, P., Theil, S., Linnartz-Gerlach, B., Hersch, N., Hoffmann, B., HENEKA, M., de Strooper, B., Neumann, H., & Walter, J. (July 2017). Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia. Glia, 65 (7), 1103 - 1118. doi:10.1002/glia.23147 ![]() |
![]() ![]() | McManus, R. M., & HENEKA, M. (04 March 2017). Role of neuroinflammation in neurodegeneration: new insights. Alzheimer's Research and Therapy, 9 (1), 14. doi:10.1186/s13195-017-0241-2 ![]() |
![]() ![]() | van der Zee, J., Gijselinck, I., Van Mossevelde, S., Perrone, F., Dillen, L., Heeman, B., Bäumer, V., Engelborghs, S., De Bleecker, J., Baets, J., Gelpi, E., Rojas-García, R., Clarimón, J., Lleó, A., Diehl-Schmid, J., Alexopoulos, P., Perneczky, R., Synofzik, M., Just, J., ... Testi, S. (March 2017). TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Human Mutation, 38 (3), 297 - 309. doi:10.1002/humu.23161 ![]() |
![]() ![]() | HENEKA, M. (March 2017). Inflammasome activation and innate immunity in Alzheimer's disease. Brain Pathology, 27 (2), 220 - 222. doi:10.1111/bpa.12483 ![]() |
![]() ![]() | Venegas, C., & HENEKA, M. (January 2017). Danger-associated molecular patterns in Alzheimer's disease. Journal of Leukocyte Biology, 101 (1), 87 - 98. doi:10.1189/jlb.3MR0416-204R ![]() |
![]() ![]() | Unger, M. S., Marschallinger, J., Kaindl, J., Höfling, C., Rossner, S., HENEKA, M., Van der Linden, A., & Aigner, L. (October 2016). Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease. Molecular Neurobiology, 53 (8), 5796 - 5806. doi:10.1007/s12035-016-0018-9 ![]() |
![]() ![]() | HENEKA, M., & Nicotera, P. (05 May 2016). Thoughts on Obesity and Brain Glucose. Cell, 165 (4), 773 - 775. doi:10.1016/j.cell.2016.04.057 ![]() |
![]() ![]() | Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., HENEKA, M., Struyfs, H., Engelborghs, S., ... Haass, C. (May 2016). sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO Molecular Medicine, 8 (5), 466 - 476. doi:10.15252/emmm.201506123 ![]() |
![]() ![]() | Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., De Nardo, D., Labzin, L. I., Kerksiek, A., Hempel, C., HENEKA, M., Hawxhurst, V., Fitzgerald, M. L., Trebicka, J., Björkhem, I., Gustafsson, J.-Å., Westerterp, M., Tall, A. R., ... Latz, E. (06 April 2016). Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 (333), 333ra50. doi:10.1126/scitranslmed.aad6100 ![]() |
![]() ![]() | Vercruysse, P., Sinniger, J., El Oussini, H., Scekic-Zahirovic, J., Dieterlé, S., Dengler, R., Meyer, T., Zierz, S., Kassubek, J., Fischer, W., Dreyhaupt, J., Grehl, T., Hermann, A., Grosskreutz, J., Witting, A., Van Den Bosch, L., Spreux-Varoquaux, O., GERP ALS Study, G., Ludolph, A. C., ... Wessig, C. (Other coll.). (April 2016). Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis. Brain: a Journal of Neurology, 139 (Pt 4), 1106-22. doi:10.1093/brain/aww004 ![]() |
Tejera, D., & HENEKA, M. (2016). Microglia in Alzheimer's disease: the good, the bad and the ugly. Current Alzheimer Research, 13 (4), 370 - 380. doi:10.2174/1567205013666151116125012 ![]() |
![]() ![]() | Traschütz, A., Tzaridis, T., Penner, A.-H., Kuchelmeister, K., Urbach, H., Hattingen, E., & HENEKA, M. (December 2015). Reduction of microbleeds by immunosuppression in a patient with Aβ-related vascular inflammation. Neurology: Neuroimmunology and Neuroinflammation, 2 (6), 165. doi:10.1212/NXI.0000000000000165 ![]() |
![]() ![]() | Hong, G.-S., Schwandt, T., Stein, K., Schneiker, B., Kummer, M. P., HENEKA, M., Kitamura, K., Kalff, J. C., & Wehner, S. (November 2015). Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model. British Journal of Surgery, 102 (12), 1506 - 1516. doi:10.1002/bjs.9907 ![]() |
![]() ![]() | Willem, M., Tahirovic, S., Busche, M. A., Ovsepian, S. V., Chafai, M., Kootar, S., Hornburg, D., Evans, L. D. B., Moore, S., Daria, A., Hampel, H., Müller, V., Giudici, C., Nuscher, B., Wenninger-Weinzierl, A., Kremmer, E., HENEKA, M., Thal, D. R., Giedraitis, V., ... Haass, C. (15 October 2015). η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature, 526 (7573), 443 - 447. doi:10.1038/nature14864 ![]() |
![]() ![]() | Kurzwelly, D., Krüger, S., Biskup, S., & HENEKA, M. (September 2015). A distinct clinical phenotype in a German kindred with motor neuron disease carrying a CHCHD10 mutation. Brain: a Journal of Neurology, 138 (Pt 9), 376. doi:10.1093/brain/awv014 ![]() |
HENEKA, M., Fink, A., & Doblhammer, G. (August 2015). Effect of pioglitazone medication on the incidence of dementia. Annals of Neurology, 78 (2), 284 - 294. doi:10.1002/ana.24439 ![]() |
![]() ![]() | Schmidt, R., Hofer, E., Bouwman, F. H., Buerger, K., Cordonnier, C., Fladby, T., Galimberti, D., Georges, J., HENEKA, M., Hort, J., Laczó, J., Molinuevo, J. L., O'Brien, J. T., Religa, D., Scheltens, P., Schott, J. M., & Sorbi, S. (June 2015). EFNS-ENS/EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer's disease. European Journal of Neurology, 22 (6), 889 - 898. doi:10.1111/ene.12707 ![]() |
![]() ![]() | Heilmann, S., Drichel, D., Clarimon, J., Fernández, V., Lacour, A., Wagner, H., Thelen, M., Hernández, I., Fortea, J., Alegret, M., Blesa, R., Mauleón, A., Roca, M. R., Kornhuber, J., Peters, O., Heun, R., Frölich, L., Hüll, M., HENEKA, M., ... Ramirez, A. (02 April 2015). PLD3 in non-familial Alzheimer's disease. Nature, 520 (7545), 3 - E5. doi:10.1038/nature14039 ![]() |
![]() ![]() | HENEKA, M., Carson, M. J., El Khoury, J., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., Herrup, K., Frautschy, S. A., Finsen, B., Brown, G. C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., ... Kummer, M. P. (April 2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14 (4), 388 - 405. doi:10.1016/S1474-4422(15)70016-5 ![]() |
![]() ![]() | Kummer, M. P., Schwarzenberger, R., Sayah-Jeanne, S., Dubernet, M., Walczak, R., Hum, D. W., Schwartz, S., Axt, D., & HENEKA, M. (April 2015). Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits. Molecular Neurobiology, 51 (2), 661 - 671. doi:10.1007/s12035-014-8743-4 ![]() |
![]() ![]() | HENEKA, M., Golenbock, D. T., & Latz, E. (March 2015). Innate immunity in Alzheimer's disease. Nature Immunology, 16 (3), 229 - 236. doi:10.1038/ni.3102 ![]() |
![]() ![]() | Lindlau, A., Widmann, C. N., Putensen, C., Jessen, F., Semmler, A., & HENEKA, M. (February 2015). Predictors of hippocampal atrophy in critically ill patients. European Journal of Neurology, 22 (2), 410 - 415. doi:10.1111/ene.12443 ![]() |
Lovestone, S., Boada, M., Dubois, B., Hüll, M., Rinne, J. O., Huppertz, H.-J., Calero, M., Andrés, M. V., Gómez-Carrillo, B., León, T., del Ser, T., ARGO, I., Fernández, M. (Other coll.), Pérez de las Heras, S. (Other coll.), Alom, J. (Other coll.), Sola, D. (Other coll.), Sánchez-Valle, R. (Other coll.), Molinuevo, J. L. (Other coll.), LLadó, A. (Other coll.), ... Keskinarkaus, I. (Other coll.). (2015). A phase II trial of tideglusib in Alzheimer's disease. Journal of Alzheimer's Disease, 45 (1), 75-88. doi:10.3233/JAD-141959 ![]() |
![]() ![]() | Bach, J.-P., Gold, M., Mengel, D., Hattesohl, A., Lubbe, D., Schmid, S., Tackenberg, B., Rieke, J., Maddula, S., Baumbach, J. I., Nell, C., Boeselt, T., Michelis, J., Alferink, J., HENEKA, M., Oertel, W., Jessen, F., Janciauskiene, S., Vogelmeier, C., ... Koczulla, A. R. (2015). Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson's Disease. PLoS ONE, 10 (7), 0132227. doi:10.1371/journal.pone.0132227 ![]() |
![]() ![]() | Krauthausen, M., Kummer, M. P., Zimmermann, J., Reyes-Irisarri, E., Terwel, D., Bulic, B., HENEKA, M., & Müller, M. (January 2015). CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. Journal of Clinical Investigation, 125 (1), 365 - 378. doi:10.1172/JCI66771 ![]() |
Meiberth, D., Scheef, L., Wolfsgruber, S., Boecker, H., Block, W., Träber, F., Erk, S., HENEKA, M., Jacobi, H., Spottke, A., Walter, H., Wagner, M., Hu, X., & Jessen, F. (2015). Cortical thinning in individuals with subjective memory impairment. Journal of Alzheimer's Disease, 45 (1), 139 - 146. doi:10.3233/JAD-142322 ![]() |
![]() ![]() | Ramirez, A., van der Flier, W. M., Herold, C., Ramonet, D., Heilmann, S., Lewczuk, P., Popp, J., Lacour, A., Drichel, D., Louwersheimer, E., Kummer, M. P., Cruchaga, C., Hoffmann, P., Teunissen, C., Holstege, H., Kornhuber, J., Peters, O., Naj, A. C., Chouraki, V., ... Nöthen, M. M. (15 December 2014). SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human Molecular Genetics, 23 (24), 6644 - 6658. doi:10.1093/hmg/ddu372 ![]() |
![]() ![]() | Thelen, M., Razquin, C., Hernández, I., Gorostidi, A., Sánchez-Valle, R., Ortega-Cubero, S., Wolfsgruber, S., Drichel, D., Fliessbach, K., Duenkel, T., Damian, M., Heilmann, S., Slotosch, A., Lennarz, M., Seijo-Martínez, M., Rene, R., Kornhuber, J., Peters, O., Luckhaus, C., ... Ramirez, A. (November 2014). Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. Neurobiology of Aging, 35 (11), 2657.e13 - 2657.e19. doi:10.1016/j.neurobiolaging.2014.06.018 ![]() |
![]() ![]() | Widmann, C. N., Schewe, J.-C., & HENEKA, M. (October 2014). Sepsis-associated encephalopathy versus sepsis-induced encephalopathy--authors' reply. The Lancet Neurology, 13 (10), 968 - 969. doi:10.1016/S1474-4422(14)70204-2 ![]() |
![]() ![]() | Brosseron, F., Krauthausen, M., Kummer, M., & HENEKA, M. (October 2014). Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview. Molecular Neurobiology, 50 (2), 534 - 544. doi:10.1007/s12035-014-8657-1 ![]() |
![]() ![]() | van der Zee, J., Van Langenhove, T., Kovacs, G. G., Dillen, L., Deschamps, W., Engelborghs, S., Matěj, R., Vandenbulcke, M., Sieben, A., Dermaut, B., Smets, K., Van Damme, P., Merlin, C., Laureys, A., Van Den Broeck, M., Mattheijssens, M., Peeters, K., Benussi, L., Binetti, G., ... Van Broeckhoven, C. (September 2014). Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration. Acta Neuropathologica, 128 (3), 397 - 410. doi:10.1007/s00401-014-1298-7 ![]() |
![]() ![]() | Gockel, I.* , Becker, J.* , Wouters, M. M., Niebisch, S., Gockel, H. R., Hess, T., Ramonet, D., Zimmermann, J., Vigo, A. G., Trynka, G., de León, A. R., de la Serna, J. P., Urcelay, E., Kumar, V., Franke, L., Westra, H.-J., Drescher, D., Kneist, W., Marquardt, J. U., ... Schumacher, J.*. (August 2014). Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nature Genetics, 46 (8), 901 - 904. doi:10.1038/ng.3029 ![]() * These authors have contributed equally to this work. |
![]() ![]() | HENEKA, M. (28 July 2014). Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction. Journal of Experimental Medicine, 211 (8), 1500. doi:10.1084/jem.2118insight1 ![]() |
Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., Tahirovic, S., Lleó, A., Alcolea, D., Fortea, J., Willem, M., Lammich, S., Molinuevo, J. L., Sánchez-Valle, R., Antonell, A., ... Haass, C. (02 July 2014). TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine, 6 (243), 243ra86. doi:10.1126/scitranslmed.3009093 ![]() |
![]() ![]() | HENEKA, M., Kummer, M. P., & Latz, E. (July 2014). Innate immune activation in neurodegenerative disease. Nature Reviews. Immunology, 14 (7), 463 - 477. doi:10.1038/nri3705 ![]() |
![]() ![]() | Kummer, M. P.* , Hammerschmidt, T.* , Martinez, A., Terwel, D., Eichele, G., Witten, A., Figura, S., Stoll, M., Schwartz, S., Pape, H.-C., Schultze, J. L., Weinshenker, D., HENEKA, M., & Urban, I. (25 June 2014). Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. Journal of Neuroscience, 34 (26), 8845 - 8854. doi:10.1523/JNEUROSCI.4027-13.2014 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Krauthausen, M.* , Saxe, S.* , Zimmermann, J., Emrich, M., HENEKA, M., & Müller, M. (16 June 2014). CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system. Journal of Neuroinflammation, 11 (1), 109. doi:10.1186/1742-2094-11-109 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Widmann, C. N., & HENEKA, M. (June 2014). Long-term cerebral consequences of sepsis. The Lancet Neurology, 13 (6), 630 - 636. doi:10.1016/S1474-4422(14)70017-1 ![]() |
![]() ![]() | HENEKA, M., & Widmann Catherine. (June 2014). Michael Thomas Heneka. The Lancet Neurology, 13 (6), 542. doi:10.1016/s1474-4422(14)70107-3 ![]() |
![]() ![]() | Malhotra, A., Younesi, E., Gündel, M., Müller, B., HENEKA, M., & Hofmann-Apitius, M. (March 2014). ADO: a disease ontology representing the domain knowledge specific to Alzheimer's disease. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 10 (2), 238 - 246. doi:10.1016/j.jalz.2013.02.009 ![]() |
![]() ![]() | Peter, J., Scheef, L., Abdulkadir, A., Boecker, H., HENEKA, M., Wagner, M., Koppara, A., Klöppel, S., Jessen, F., & Alzheimer's Disease Neuroimaging Initiative. (January 2014). Gray matter atrophy pattern in elderly with subjective memory impairment. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 10 (1), 99 - 108. doi:10.1016/j.jalz.2013.05.1764 ![]() |
![]() ![]() | Kummer, M. P., & HENEKA, M. (2014). Truncated and modified amyloid-beta species. Alzheimer's Research and Therapy, 6 (3), 28. doi:10.1186/alzrt258 ![]() |
![]() ![]() | Mattsson, N., Andreasson, U., Persson, S., Carrillo, M. C., Collins, S., Chalbot, S., Cutler, N., Dufour-Rainfray, D., Fagan, A. M., Heegaard, N. H. H., Robin Hsiung, G.-Y., Hyman, B., Iqbal, K., Kaeser, S. A., Lachno, D. R., Lleó, A., Lewczuk, P., Molinuevo, J. L., Parchi, P., ... Blennow, K. (Other coll.). (May 2013). CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 9 (3), 251-61. doi:10.1016/j.jalz.2013.01.010 ![]() |
![]() ![]() | Hammerschmidt, T., Kummer, M. P., Terwel, D., Martinez, A., Gorji, A., Pape, H.-C., Rommelfanger, K. S., Schroeder, J. P., Stoll, M., Schultze, J., Weinshenker, D., & HENEKA, M. (01 March 2013). Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice. Biological Psychiatry, 73 (5), 454 - 463. doi:10.1016/j.biopsych.2012.06.013 ![]() |
![]() ![]() | van der Zee, J.* , Gijselinck, I.* , Dillen, L., Van Langenhove, T., Theuns, J., Engelborghs, S., Philtjens, S., Vandenbulcke, M., Sleegers, K., Sieben, A., Bäumer, V., Maes, G., Corsmit, E., Borroni, B., Padovani, A., Archetti, S., Perneczky, R., Diehl-Schmid, J., de Mendonça, A., ... European Early-Onset Dementia Consortium. (February 2013). A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats. Human Mutation, 34 (2), 363 - 373. doi:10.1002/humu.22244 ![]() * These authors have contributed equally to this work. |
![]() ![]() | HENEKA, M., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., Gelpi, E., Halle, A., Korte, M., Latz, E., & Golenbock, D. T. (31 January 2013). NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature, 493 (7434), 674 - 678. doi:10.1038/nature11729 ![]() |
![]() ![]() | Zimmermann, J., Krauthausen, M., Hofer, M. J., HENEKA, M., Campbell, I. L., & Müller, M. (2013). CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia. PLoS ONE, 8 (2), 57307. doi:10.1371/journal.pone.0057307 ![]() |
Molinuevo, J. L., Gispert, J. D., Dubois, B., HENEKA, M., Lleo, A., Engelborghs, S., Pujol, J., de Souza, L. C., Alcolea, D., Jessen, F., Sarazin, M., Lamari, F., Balasa, M., Antonell, A., & Rami, L. (2013). The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study. Journal of Alzheimer's Disease, 36 (1), 67 - 77. doi:10.3233/JAD-130203 ![]() |
![]() ![]() | Chalermpalanupap, T., Kinkead, B., Hu, W. T., Kummer, M. P., Hammerschmidt, T., HENEKA, M., Weinshenker, D., & Levey, A. I. (2013). Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease. Alzheimer's Research and Therapy, 5 (2), 21. doi:10.1186/alzrt175 ![]() |
![]() ![]() | Semmler, A., Okulla, T., Kaiser, M., Seifert, B., & HENEKA, M. (January 2013). Long-term neuromuscular sequelae of critical illness. Journal of Neurology, 260 (1), 151 - 157. doi:10.1007/s00415-012-6605-4 ![]() |
![]() ![]() | Okroglic, S., Widmann, C. N., Urbach, H., Scheltens, P., & HENEKA, M. (2013). Clinical symptoms and risk factors in cerebral microangiopathy patients. PLoS ONE, 8 (2), 53455. doi:10.1371/journal.pone.0053455 ![]() |
![]() ![]() | Semmler, A.* , Widmann, C. N.* , Okulla, T., Urbach, H., Kaiser, M., Widman, G., Mormann, F., Weide, J., Fliessbach, K., Hoeft, A., Jessen, F., Putensen, C., & HENEKA, M. (January 2013). Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors. Journal of Neurology, Neurosurgery and Psychiatry, 84 (1), 62 - 69. doi:10.1136/jnnp-2012-302883 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Rapic, S., Backes, H., Viel, T., Kummer, M. P., Monfared, P., Neumaier, B., Vollmar, S., Hoehn, M., Van der Linden, A., HENEKA, M., & Jacobs, A. H. (January 2013). Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. Neurobiology of Aging, 34 (1), 351 - 354. doi:10.1016/j.neurobiolaging.2012.04.016 ![]() |
Gaikwad, S. M., & HENEKA, M. (2013). Studying M1 and M2 states in adult microglia. Methods in Molecular Biology, 1041, 185 - 197. doi:10.1007/978-1-62703-520-0_18 ![]() |
![]() ![]() | Kummer, M. P., Vogl, T., Axt, D., Griep, A., Vieira-Saecker, A., Jessen, F., Gelpi, E., Roth, J., & HENEKA, M. (05 December 2012). Mrp14 deficiency ameliorates amyloid β burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing. Journal of Neuroscience, 32 (49), 17824 - 17829. doi:10.1523/JNEUROSCI.1504-12.2012 ![]() |
![]() ![]() | Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & HENEKA, M. (28 November 2012). PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. Journal of Neuroscience, 32 (48), 17321 - 17331. doi:10.1523/JNEUROSCI.1569-12.2012 ![]() |
Scheef, L., Spottke, A., Daerr, M., Joe, A., Striepens, N., Kölsch, H., Popp, J., Daamen, M., Gorris, D., HENEKA, M., Boecker, H., Biersack, H. J., Maier, W., Schild, H. H., Wagner, M., & Jessen, F. (25 September 2012). Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology, 79 (13), 1332 - 1339. doi:10.1212/WNL.0b013e31826c1a8d ![]() |
![]() ![]() | Jacobs, A. H., Tavitian, B., INMiND consortium, & HENEKA, M. (July 2012). Noninvasive molecular imaging of neuroinflammation. Journal of Cerebral Blood Flow and Metabolism, 32 (7), 1393 - 1415. doi:10.1038/jcbfm.2012.53 ![]() |
![]() ![]() | Parpura, V., HENEKA, M., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., Pekny, M., Pekna, M., Zorec, R., & Verkhratsky, A. (April 2012). Glial cells in (patho)physiology. Journal of Neurochemistry, 121 (1), 4 - 27. doi:10.1111/j.1471-4159.2012.07664.x ![]() |
![]() ![]() | Kummer, M. P., Hülsmann, C., Hermes, M., Axt, D., & HENEKA, M. (March 2012). Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice. Journal of Neuroimmune Pharmacology, 7 (1), 165 - 172. doi:10.1007/s11481-011-9339-7 ![]() |
![]() ![]() | Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., Rübe, C. E., Walter, J., HENEKA, M., Hartmann, T., Menger, M. D., & Fassbender, K. (01 February 2012). TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. Journal of Immunology, 188 (3), 1098 - 1107. doi:10.4049/jimmunol.1101121 ![]() |
![]() ![]() | Rey, N. L., Jardanhazi-Kurutz, D., Terwel, D., Kummer, M. P., Jourdan, F., Didier, A., & HENEKA, M. (February 2012). Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice. Neurobiology of Aging, 33 (2), 426.e1. doi:10.1016/j.neurobiolaging.2010.10.009 ![]() |
![]() ![]() | Dupuis, L., Dengler, R., HENEKA, M., Meyer, T., Zierz, S., Kassubek, J., Fischer, W., Steiner, F., Lindauer, E., Otto, M., Dreyhaupt, J., Grehl, T., Hermann, A., Winkler, A. S., Bogdahn, U., Benecke, R., Schrank, B., Wessig, C., Grosskreutz, J., ... GERP ALS Study Group. (2012). A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis. PLoS ONE, 7 (6), 37885. doi:10.1371/journal.pone.0037885 ![]() |
![]() ![]() | HENEKA, M., Reyes-Irisarri, E., Hüll, M., & Kummer, M. P. (December 2011). Impact and Therapeutic Potential of PPARs in Alzheimer's Disease. Current Neuropharmacology, 9 (4), 643 - 650. doi:10.2174/157015911798376325 ![]() |
![]() ![]() | Krauthausen, M., Ellis, S. L., Zimmermann, J., Sarris, M., Wakefield, D., HENEKA, M., Campbell, I. L., & Müller, M. (November 2011). Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12. American Journal of Pathology, 179 (5), 2346 - 2359. doi:10.1016/j.ajpath.2011.07.041 ![]() |
![]() ![]() | Kummer, M. P., Hermes, M., Delekarte, A., Hammerschmidt, T., Kumar, S., Terwel, D., Walter, J., Pape, H.-C., König, S., Roeber, S., Jessen, F., Klockgether, T., Korte, M., & HENEKA, M. (08 September 2011). Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron, 71 (5), 833 - 844. doi:10.1016/j.neuron.2011.07.001 ![]() |
![]() ![]() | Juckel, G., Manitz, M. P., Brüne, M., Friebe, A., HENEKA, M., & Wolf, R. J. (September 2011). Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study. Schizophrenia Research, 131 (1-3), 96 - 100. doi:10.1016/j.schres.2011.06.018 ![]() |
![]() ![]() | Mildner, A., Schlevogt, B., Kierdorf, K., Böttcher, C., Erny, D., Kummer, M. P., Quinn, M., Brück, W., Bechmann, I., HENEKA, M., Priller, J., & Prinz, M. (03 August 2011). Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. Journal of Neuroscience, 31 (31), 11159 - 11171. doi:10.1523/JNEUROSCI.6209-10.2011 ![]() |
![]() ![]() | Terwel, D., Löschmann, Y.-N., Schmidt, H. H.-J., Schöler, H. R., Cantz, T., & HENEKA, M. (July 2011). Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. Journal of Neurochemistry, 118 (1), 105 - 112. doi:10.1111/j.1471-4159.2011.07278.x ![]() |
![]() ![]() | Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S. D., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, M. A., Carrillo, M. C., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, A. M., Forlenza, O., Frisoni, G. B., Galasko, D., ... Blennow, K. (July 2011). The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 7 (4), 386 - 395.e6. doi:10.1016/j.jalz.2011.05.2243 ![]() |
![]() ![]() | Kumar, S., Rezaei-Ghaleh, N., Terwel, D., Thal, D. R., Richard, M., Hoch, M., Mc Donald, J. M., Wüllner, U., Glebov, K., HENEKA, M., Walsh, D. M., Zweckstetter, M., & Walter, J. (01 June 2011). Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO Journal, 30 (11), 2255 - 2265. doi:10.1038/emboj.2011.138 ![]() |
![]() ![]() | Terwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & HENEKA, M. (11 May 2011). Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. Journal of Neuroscience, 31 (19), 7049 - 7059. doi:10.1523/JNEUROSCI.6546-10.2011 ![]() |
![]() ![]() | Jardanhazi-Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Thiele, A., & HENEKA, M. (10 March 2011). Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience, 176, 396 - 407. doi:10.1016/j.neuroscience.2010.11.052 ![]() |
HENEKA, M., Kummer, M. P., Weggen, S., Bulic, B., Multhaup, G., Münter, L., Hüll, M., Pflanzner, T., & Pietrzik, C. U. (March 2011). Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Current Alzheimer Research, 8 (2), 115 - 131. doi:10.2174/156720511795256099 ![]() |
![]() ![]() | Perez Nievas, B. G., Hammerschmidt, T., Kummer, M. P., Terwel, D., Leza, J. C., & HENEKA, M. (January 2011). Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice. Journal of Neurochemistry, 116 (1), 43 - 52. doi:10.1111/j.1471-4159.2010.07083.x ![]() |
![]() ![]() | Tamboli, I. Y., Barth, E., Christian, L., Siepmann, M., Kumar, S., Singh, S., Tolksdorf, K., HENEKA, M., Lütjohann, D., Wunderlich, P., & Walter, J. (26 November 2010). Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. Journal of Biological Chemistry, 285 (48), 37405 - 37414. doi:10.1074/jbc.M110.149468 ![]() |
![]() ![]() | Jardanhazi-Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Dyrks, T., Thiele, A., & HENEKA, M. (November 2010). Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochemistry International, 57 (4), 375 - 382. doi:10.1016/j.neuint.2010.02.001 ![]() |
![]() ![]() | Fleisher-Berkovich, S., Filipovich-Rimon, T., Ben-Shmuel, S., Hülsmann, C., Kummer, M. P., & HENEKA, M. (11 October 2010). Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides (i). Journal of Neuroinflammation, 7 (1), 61. doi:10.1186/1742-2094-7-61 ![]() |
![]() ![]() | HENEKA, M., O'Banion, M. K., Terwel, D., & Kummer, M. P. (August 2010). Neuroinflammatory processes in Alzheimer's disease. Journal of Neural Transmission, 117 (8), 919 - 947. doi:10.1007/s00702-010-0438-z ![]() |
![]() ![]() | HENEKA, M. (July 2010). Verlaufsmodifizierende Therapien der Alzheimer-Demenz. Nervenarzt, 81 (7), 807 - 814. doi:10.1007/s00115-010-3000-1 ![]() |
![]() ![]() | HENEKA, M., Rodríguez, J. J., & Verkhratsky, A. (May 2010). Neuroglia in neurodegeneration. Brain Research Reviews, 63 (1-2), 189 - 211. doi:10.1016/j.brainresrev.2009.11.004 ![]() |
![]() ![]() | HENEKA, M., Nadrigny, F., Regen, T., Martinez-Hernandez, A., Dumitrescu-Ozimek, L., Terwel, D., Jardanhazi-Kurutz, D., Walter, J., Kirchhoff, F., Hanisch, U.-K., & Kummer, M. P. (30 March 2010). Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proceedings of the National Academy of Sciences of the United States of America, 107 (13), 6058 - 6063. doi:10.1073/pnas.0909586107 ![]() |
![]() ![]() | Schlachetzki, J. C. M., Fiebich, B. L., Haake, E., de Oliveira, A. C. P., Candelario-Jalil, E., HENEKA, M., & Hüll, M. (11 January 2010). Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. Journal of Neuroinflammation, 7 (1), 2. doi:10.1186/1742-2094-7-2 ![]() |
Jäger, S., Leuchtenberger, S., Martin, A., Czirr, E., Wesselowski, J., Dieckmann, M., Waldron, E., Korth, C., Koo, E. H., HENEKA, M., Weggen, S., & Pietrzik, C. U. (December 2009). alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. Journal of Neurochemistry, 111 (6), 1369 - 1382. doi:10.1111/j.1471-4159.2009.06420.x ![]() |
![]() ![]() | Weberpals, M., Hermes, M., Hermann, S., Kummer, M. P., Terwel, D., Semmler, A., Berger, M., Schäfers, M., & HENEKA, M. (11 November 2009). NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. Journal of Neuroscience, 29 (45), 14177 - 14184. doi:10.1523/JNEUROSCI.3238-09.2009 ![]() |
Papi, A., Tatenhorst, L., Terwel, D., Hermes, M., Kummer, M. P., Orlandi, M., & HENEKA, M. (June 2009). PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. Journal of Neurochemistry, 109 (6), 1779 - 1790. doi:10.1111/j.1471-4159.2009.06111.x ![]() |
![]() ![]() | HENEKA, M. (June 2009). Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients. Experimental Neurology, 217 (2), 237 - 239. doi:10.1016/j.expneurol.2009.03.013 ![]() |
![]() ![]() | Tamboli, I. Y., Prager, K., Thal, D. R., Thelen, K. M., Dewachter, I., Pietrzik, C. U., St George-Hyslop, P., Sisodia, S. S., De Strooper, B., HENEKA, M., Filippov, M. A., Müller, U., van Leuven, F., Lütjohann, D., & Walter, J. (12 November 2008). Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. Journal of Neuroscience, 28 (46), 12097 - 12106. doi:10.1523/JNEUROSCI.2635-08.2008 ![]() |
![]() ![]() | Semmler, A., Hermann, S., Mormann, F., Weberpals, M., Paxian, S. A., Okulla, T., Schäfers, M., Kummer, M. P., Klockgether, T., & HENEKA, M. (15 September 2008). Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. Journal of Neuroinflammation, 5 (1), 38. doi:10.1186/1742-2094-5-38 ![]() |
![]() ![]() | Landreth, G., Jiang, Q., Mandrekar, S., & HENEKA, M. (July 2008). PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics, 5 (3), 481 - 489. doi:10.1016/j.nurt.2008.05.003 ![]() |
![]() ![]() | Winkeler, A., Waerzeggers, Y., Klose, A., Monfared, P., Thomas, A. V., Schubert, M., HENEKA, M., & Jacobs, A. H. (March 2008). Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 35 Suppl 1 (Suppl 1), 107 - S113. doi:10.1007/s00259-007-0710-0 ![]() |
![]() ![]() | Seufert, S., Coras, R., Tränkle, C., Zlotos, D. P., Blümcke, I., Tatenhorst, L., HENEKA, M., & Hahnen, E. (2008). PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Research, 2008, 513943. doi:10.1155/2008/513943 ![]() |
![]() ![]() | Tatenhorst, L., Hahnen, E., & HENEKA, M. (2008). Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Research, 2008, 204514. doi:10.1155/2008/204514 ![]() |
![]() ![]() | Kummer, M. P., & HENEKA, M. (2008). PPARs in Alzheimer's Disease. PPAR Research, 2008, 403896. doi:10.1155/2008/403896 ![]() |
Jiang, Q., HENEKA, M., & Landreth, G. E. (2008). The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. CNS Drugs, 22 (1), 1 - 14. doi:10.2165/00023210-200822010-00001 ![]() |
![]() ![]() | HENEKA, M., Landreth, G. E., & Hüll, M. (September 2007). Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nature Clinical Practice Neurology, 3 (9), 496 - 504. doi:10.1038/ncpneuro0586 ![]() |
![]() ![]() | Kalinin, S., Gavrilyuk, V., Polak, P. E., Vasser, R., Zhao, J., HENEKA, M., & Feinstein, D. L. (August 2007). Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiology of Aging, 28 (8), 1206 - 1214. doi:10.1016/j.neurobiolaging.2006.06.003 ![]() |
![]() ![]() | HENEKA, M., & Landreth, G. E. (August 2007). PPARs in the brain. Biochimica et Biophysica Acta, 1771 (8), 1031 - 1045. doi:10.1016/j.bbalip.2007.04.016 ![]() |
![]() ![]() | Winkeler, A., Sena-Esteves, M., Paulis, L. E. M., Li, H., Waerzeggers, Y., Rückriem, B., Himmelreich, U., Klein, M., Monfared, P., Rueger, M. A., HENEKA, M., Vollmar, S., Hoehn, M., Fraefel, C., Graf, R., Wienhard, K., Heiss, W. D., & Jacobs, A. H. (13 June 2007). Switching on the lights for gene therapy. PLoS ONE, 2 (6), 528. doi:10.1371/journal.pone.0000528 ![]() |
![]() ![]() | Semmler, A., Frisch, C., Debeir, T., Ramanathan, M., Okulla, T., Klockgether, T., & HENEKA, M. (April 2007). Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Experimental Neurology, 204 (2), 733 - 740. doi:10.1016/j.expneurol.2007.01.003 ![]() |
![]() ![]() | HENEKA, M., & O'Banion, M. K. (March 2007). Inflammatory processes in Alzheimer's disease. Journal of Neuroimmunology, 184 (1-2), 69 - 91. doi:10.1016/j.jneuroim.2006.11.017 ![]() |
![]() ![]() | Jacobs, A. H., Rueger, M. A., Winkeler, A., Li, H., Vollmar, S., Waerzeggers, Y., Rueckriem, B., Kummer, C., Dittmar, C., Klein, M., HENEKA, M., Herrlinger, U., Fraefel, C., Graf, R., Wienhard, K., & Heiss, W.-D. (15 February 2007). Imaging-guided gene therapy of experimental gliomas. Cancer Research, 67 (4), 1706 - 1715. doi:10.1158/0008-5472.CAN-06-2418 ![]() |
![]() ![]() | Thees, C., Kaiser, M., Scholz, M., Semmler, A., HENEKA, M., Baumgarten, G., Hoeft, A., & Putensen, C. (2007). Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome. Critical Care, 11 (6), 123. doi:10.1186/cc6185 ![]() |
![]() ![]() | Kummer, C., Winkeler, A., Dittmar, C., Bauer, B., Rueger, M. A., Rueckriem, B., HENEKA, M., Vollmar, S., Wienhard, K., Fraefel, C., Heiss, W.-D., & Jacobs, A. H. (2007). Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. Molecular Imaging, 6 (3), 181 - 192. doi:10.2310/7290.2007.00015 ![]() |
![]() ![]() | Wahle, T., Thal, D. R., Sastre, M., Rentmeister, A., Bogdanovic, N., Famulok, M., HENEKA, M., & Walter, J. (06 December 2006). GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. Journal of Neuroscience, 26 (49), 12838 - 12846. doi:10.1523/JNEUROSCI.1982-06.2006 ![]() |
Grommes, C., Landreth, G. E., Sastre, M., Beck, M., Feinstein, D. L., Jacobs, A. H., Schlegel, U., & HENEKA, M. (November 2006). Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment. Molecular Pharmacology, 70 (5), 1524 - 1533. doi:10.1124/mol.106.022194 ![]() |
![]() ![]() | Ambrée, O., Leimer, U., Herring, A., Görtz, N., Sachser, N., HENEKA, M., Paulus, W., & Keyvani, K. (August 2006). Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. American Journal of Pathology, 169 (2), 544 - 552. doi:10.2353/ajpath.2006.051107 ![]() |
Sundararajan, S., Jiang, Q., HENEKA, M., & Landreth, G. (July 2006). PPARgamma as a therapeutic target in central nervous system diseases. Neurochemistry International, 49 (2), 136 - 144. doi:10.1016/j.neuint.2006.03.020 ![]() |
![]() ![]() | HENEKA, M., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Galldiks, N., Zimmer, A., Hoehn, M., Heiss, W.-D., Klockgether, T., & Staufenbiel, M. (01 February 2006). Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. Journal of Neuroscience, 26 (5), 1343 - 1354. doi:10.1523/JNEUROSCI.4236-05.2006 ![]() |
![]() ![]() | Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., Walter, J., Klockgether, T., van Leuven, F., & HENEKA, M. (10 January 2006). Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proceedings of the National Academy of Sciences of the United States of America, 103 (2), 443 - 448. doi:10.1073/pnas.0503839103 ![]() |
Sastre, M., Klockgether, T., & HENEKA, M. (2006). Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. International Journal of Developmental Neuroscience, 24 (2-3), 167 - 176. doi:10.1016/j.ijdevneu.2005.11.014 ![]() |
Hüll, M., Berger, M., & HENEKA, M. (2006). Disease-modifying therapies in Alzheimer's disease: how far have we come? Drugs, 66 (16), 2075 - 2093. doi:10.2165/00003495-200666160-00004 ![]() |
![]() ![]() | Klotz, L., Schmidt, M., Giese, T., Sastre, M., Knolle, P., Klockgether, T., & HENEKA, M. (15 October 2005). Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients. Journal of Immunology, 175 (8), 4948 - 4955. doi:10.4049/jimmunol.175.8.4948 ![]() |
![]() ![]() | HENEKA, M., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (07 October 2005). Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. Journal of Neuroinflammation, 2 (1), 22. doi:10.1186/1742-2094-2-22 ![]() |
![]() ![]() | Semmler, A., Okulla, T., Sastre, M., Dumitrescu-Ozimek, L., & HENEKA, M. (October 2005). Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. Journal of Chemical Neuroanatomy, 30 (2-3), 144 - 157. doi:10.1016/j.jchemneu.2005.07.003 ![]() |
![]() ![]() | Schütz, B., Reimann, J., Dumitrescu-Ozimek, L., Kappes-Horn, K., Landreth, G. E., Schürmann, B., Zimmer, A., & HENEKA, M. (24 August 2005). The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. Journal of Neuroscience, 25 (34), 7805 - 7812. doi:10.1523/JNEUROSCI.2038-05.2005 ![]() |
![]() ![]() | Tamboli, I. Y., Prager, K., Barth, E., HENEKA, M., Sandhoff, K., & Walter, J. (29 July 2005). Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. Journal of Biological Chemistry, 280 (30), 28110 - 28117. doi:10.1074/jbc.M414525200 ![]() |
![]() ![]() | HENEKA, M., Sastre, M., Dumitrescu-Ozimek, L., Hanke, A., Dewachter, I., Kuiperi, C., O'Banion, K., Klockgether, T., Van Leuven, F., & Landreth, G. E. (June 2005). Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain: a Journal of Neurology, 128 (Pt 6), 1442 - 1453. doi:10.1093/brain/awh452 ![]() |
Grommes, C., Landreth, G. E., Schlegel, U., & HENEKA, M. (May 2005). The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells. Journal of Pharmacology and Experimental Therapeutics, 313 (2), 806 - 813. doi:10.1124/jpet.104.078972 ![]() |
![]() ![]() | Rueger, M. A., Winkeler, A., Miletic, H., Kaestle, C., Richter, R., Schneider, G., Hilker, R., HENEKA, M., Ernestus, R. I., Hampl, J. A., Fraefel, C., & Jacobs, A. H. (April 2005). Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors. Gene Therapy, 12 (7), 588 - 596. doi:10.1038/sj.gt.3302462 ![]() |
![]() ![]() | Lacombe, P., Mathews, P. M., Schmidt, S. D., Breidert, T., HENEKA, M., Landreth, G. E., Feinstein, D. L., & Galea, E. (02 July 2004). Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. Journal of Neuroinflammation, 1 (1), 11. doi:10.1186/1742-2094-1-11 ![]() |
![]() ![]() | Grommes, C., Landreth, G. E., & HENEKA, M. (July 2004). Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. The Lancet Oncology, 5 (7), 419 - 429. doi:10.1016/S1470-2045(04)01509-8 ![]() |
![]() ![]() | Pershadsingh, H. A., HENEKA, M., Saini, R., Amin, N. M., Broeske, D. J., & Feinstein, D. L. (20 April 2004). Effect of pioglitazone treatment in a patient with secondary multiple sclerosis. Journal of Neuroinflammation, 1 (1), 3. doi:10.1186/1742-2094-1-3 ![]() |
![]() ![]() | Schmidt, S., Moric, E., Schmidt, M., Sastre, M., Feinstein, D. L., & HENEKA, M. (March 2004). Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. Journal of Leukocyte Biology, 75 (3), 478 - 485. doi:10.1189/jlb.0803402 ![]() |
Dehmer, T., HENEKA, M., Sastre, M., Dichgans, J., & Schulz, J. B. (January 2004). Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. Journal of Neurochemistry, 88 (2), 494 - 501. doi:10.1046/j.1471-4159.2003.02210.x ![]() |
![]() ![]() | Pedraza, C. E., Baltrons, M. A., HENEKA, M., & García, A. (November 2003). Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in brain cells: NO-independent destabilization of protein and NO-dependent decrease of mRNA. Journal of Neuroimmunology, 144 (1-2), 80 - 90. doi:10.1016/j.jneuroim.2003.08.034 ![]() |
![]() ![]() | Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., van Leuven, F., & HENEKA, M. (29 October 2003). Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. Journal of Neuroscience, 23 (30), 9796 - 9804. doi:10.1523/JNEUROSCI.23-30-09796.2003 ![]() |
![]() ![]() | Galea, E., HENEKA, M., Dello Russo, C., & Feinstein, D. L. (October 2003). Intrinsic regulation of brain inflammatory responses. Cellular and Molecular Neurobiology, 23 (4-5), 625 - 635. doi:10.1023/a:1025084415833 ![]() |
Klotz, L., Sastre, M., Kreutz, A., Gavrilyuk, V., Klockgether, T., Feinstein, D. L., & HENEKA, M. (August 2003). Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons. Journal of Neurochemistry, 86 (4), 907 - 916. doi:10.1046/j.1471-4159.2003.01909.x ![]() |
HENEKA, M., Gavrilyuk, V., Landreth, G. E., O'Banion, M. K., Weinberg, G., & Feinstein, D. L. (April 2003). Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression. Journal of Neurochemistry, 85 (2), 387 - 398. doi:10.1046/j.1471-4159.2003.01694.x ![]() |
Harzheim, M., Altenschmidt, M., HENEKA, M., Schröder, R., Klockgether, T., & Schmidt, S. (February 2003). IFN-beta1a (Rebif) modifies the expression of microfilament-associated cell-cell contacts in C6 glioma cells. Journal of Interferon and Cytokine Research, 23 (2), 83 - 89. doi:10.1089/107999003321455471 ![]() |
![]() ![]() | Feinstein, D. L., HENEKA, M., Gavrilyuk, V., Dello Russo, C., Weinberg, G., & Galea, E. (November 2002). Noradrenergic regulation of inflammatory gene expression in brain. Neurochemistry International, 41 (5), 357 - 365. doi:10.1016/s0197-0186(02)00049-9 ![]() |
![]() ![]() | Gavrilyuk, V., Dello Russo, C., HENEKA, M., Pelligrino, D., Weinberg, G., & Feinstein, D. L. (16 August 2002). Norepinephrine increases I kappa B alpha expression in astrocytes. Journal of Biological Chemistry, 277 (33), 29662 - 29668. doi:10.1074/jbc.M203256200 ![]() |
Breidert, T., Callebert, J., HENEKA, M., Landreth, G., Launay, J. M., & Hirsch, E. C. (August 2002). Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. Journal of Neurochemistry, 82 (3), 615 - 624. doi:10.1046/j.1471-4159.2002.00990.x ![]() |
![]() ![]() | Baltrons, M. A., Pedraza, C. E., HENEKA, M., & García, A. (July 2002). Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells. Neurobiology of Disease, 10 (2), 139 - 149. doi:10.1006/nbdi.2002.0492 ![]() |
![]() ![]() | Feinstein, D. L., Galea, E., Gavrilyuk, V., Brosnan, C. F., Whitacre, C. C., Dumitrescu-Ozimek, L., Landreth, G. E., Pershadsingh, H. A., Weinberg, G., & HENEKA, M. (June 2002). Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Annals of Neurology, 51 (6), 694 - 702. doi:10.1002/ana.10206 ![]() |
Zander, T., Kraus, J. A., Grommes, C., Schlegel, U., Feinstein, D., Klockgether, T., Landreth, G., Koenigsknecht, J., & HENEKA, M. (June 2002). Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. Journal of Neurochemistry, 81 (5), 1052 - 1060. doi:10.1046/j.1471-4159.2002.00899.x ![]() |
![]() ![]() | HENEKA, M., Galea, E., Gavriluyk, V., Dumitrescu-Ozimek, L., Daeschner, J., O'Banion, M. K., Weinberg, G., Klockgether, T., & Feinstein, D. L. (01 April 2002). Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. Journal of Neuroscience, 22 (7), 2434 - 2442. doi:10.1523/JNEUROSCI.22-07-02434.2002 ![]() |
Murphy, P., Sharp, A., Shin, J., Gavrilyuk, V., Dello Russo, C., Weinberg, G., Sharp, F. R., Lu, A., HENEKA, M., & Feinstein, D. L. (15 February 2002). Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis. Journal of Neuroscience Research, 67 (4), 461 - 470. doi:10.1002/jnr.10139 ![]() |
![]() ![]() | HENEKA, M., Wiesinger, H., Dumitrescu-Ozimek, L., Riederer, P., Feinstein, D. L., & Klockgether, T. (September 2001). Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease. Journal of Neuropathology and Experimental Neurology, 60 (9), 906 - 916. doi:10.1093/jnen/60.9.906 ![]() |
HENEKA, M., Sharp, A., Murphy, P., Lyons, J.-A., Dumitrescu, L., & Feinstein, D. L. (April 2001). The heat shock response reduces myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in mice. Journal of Neurochemistry, 77 (2), 568 - 579. doi:10.1046/j.1471-4159.2001.00260.x ![]() |
![]() ![]() | HENEKA, M., & Feinstein, D. L. (01 March 2001). Expression and function of inducible nitric oxide synthase in neurons. Journal of Neuroimmunology, 114 (1-2), 8 - 18. doi:10.1016/s0165-5728(01)00246-6 ![]() |
![]() ![]() | HENEKA, M., Landreth, G. E., & Feinstein, D. L. (February 2001). Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease. Annals of Neurology, 49 (2), 276. doi:10.1002/1531-8249(20010201)49:2 ![]() |
![]() ![]() | Landreth, G. E., & HENEKA, M. (2001). Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiology of Aging, 22 (6), 937 - 944. doi:10.1016/s0197-4580(01)00296-2 ![]() |
![]() ![]() | HENEKA, M., Klockgether, T., & Feinstein, D. L. (15 September 2000). Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. Journal of Neuroscience, 20 (18), 6862 - 6867. doi:10.1523/JNEUROSCI.20-18-06862.2000 ![]() |
![]() ![]() | HENEKA, M., Sharp, A., Klockgether, T., Gavrilyuk, V., & Feinstein, D. L. (May 2000). The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain. Journal of Cerebral Blood Flow and Metabolism, 20 (5), 800 - 811. doi:10.1097/00004647-200005000-00006 ![]() |
![]() ![]() | HENEKA, M., Dumitrescu, L., Löschmann, P.-A., Wüllner, U., & Klockgether, T. (April 2000). Temporal, regional, and cell-specific changes of iNOS expression after intrastriatal microinjection of interferon gamma and bacterial lipopolysaccharide. Journal of Chemical Neuroanatomy, 18 (4), 167 - 179. doi:10.1016/s0891-0618(00)00041-7 ![]() |
![]() ![]() | HENEKA, M., Feinstein, D. L., Galea, E., Gleichmann, M., Wüllner, U., & Klockgether, T. (December 1999). Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. Journal of Neuroimmunology, 100 (1-2), 156 - 168. doi:10.1016/s0165-5728(99)00192-7 ![]() |
![]() ![]() | HENEKA, M., Schmidlin, A., & Wiesinger, H. (August 1999). Induction of argininosuccinate synthetase in rat brain glial cells after striatal microinjection of immunostimulants. Journal of Cerebral Blood Flow and Metabolism, 19 (8), 898 - 907. doi:10.1097/00004647-199908000-00009 ![]() |
![]() ![]() | Roller, A., Bähr, O. R., Streffer, J., Winter, S., HENEKA, M., Deininger, M., Meyermann, R., Naumann, U., Gulbins, E., & Weller, M. (16 June 1999). Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP. Biochemical and Biophysical Research Communications, 259 (3), 600 - 605. doi:10.1006/bbrc.1999.0825 ![]() |
![]() ![]() | Wüllner, U., Seyfried, J., Groscurth, P., Beinroth, S., Winter, S., Gleichmann, M., HENEKA, M., Löschmann, P.-A., Schulz, J. B., Weller, M., & Klockgether, T. (24 April 1999). Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function. Brain Research, 826 (1), 53 - 62. doi:10.1016/s0006-8993(99)01228-7 ![]() |
![]() ![]() | Rieger, J., Ständer, M., Löschmann, P. A., HENEKA, M., Dichgans, J., Klockgether, T., & Weller, M. (05 November 1998). Synthesis and biological effects of NO in malignant glioma cells: modulation by cytokines including CD95L and TGF-beta, dexamethasone, and p53 gene transfer. Oncogene, 17 (18), 2323 - 2332. doi:10.1038/sj.onc.1202154 ![]() |
![]() ![]() | Schulz, J. B., Weller, M., Matthews, R. T., HENEKA, M., Groscurth, P., Martinou, J.-C., Lommatzsch, J., von Coelln, R., Wüllner, U., Löschmann, P.-A., Beal, M. F., Dichgans, J., & Klockgether, T. (October 1998). Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death and Differentiation, 5 (10), 847 - 857. doi:10.1038/sj.cdd.4400420 ![]() |
![]() ![]() | Ständer, M., Naumann, U., Dumitrescu, L., HENEKA, M., Löschmann, P., Gulbins, E., Dichgans, J., & Weller, M. (September 1998). Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo. Gene Therapy, 5 (9), 1187 - 1194. doi:10.1038/sj.gt.3300709 ![]() |
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