Owona, B. A.* , MARY, A.* , Messi, A. N., Ravichandran, K. A., Mbing, J. N., Pegnyemb, E., Moundipa, P. F., & HENEKA, M. (2024). Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Molecular Neurobiology. doi:10.1007/s12035-024-04365-4 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
MARY, A., Mancuso, R., & HENEKA, M. (29 February 2024). Immune Activation in Alzheimer Disease. Annual Review of Immunology, 42 (1). doi:10.1146/annurev-immunol-101921-035222 Peer Reviewed verified by ORBi |
KLEE, M., AHO, V., MAY, P., Heintz-Buschart, A., LANDOULSI, Z., JONSDOTTIR, S., PAULY, C., PAVELKA, L., DELACOUR, L., KAYSEN, A., Krüger, R., WILMES, P., LEIST, A., Acharya, G., Aguayo, G., Alexandre, M., ALI, M., Ammerlann, W., ARENA, G., ... ZELIMKHANOV, G. (2024). Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome. Journal of Prevention of Alzheimer's Disease. doi:10.14283/jpad.2024.19 Peer reviewed |
Kapadia, A., Theil, S., Opitz, S., Villacampa, N., Beckert, H., Schoch, S., HENEKA, M., Kumar, S., & Walter, J. (January 2024). Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system. Autophagy, 20 (1), 166 - 187. doi:10.1080/15548627.2023.2252300 Peer Reviewed verified by ORBi |
TALAVERA ANDUJAR, B., MARY, A., VENEGAS MALDONADO, C. J., Cheng, T., Zaslavsky, L., Bolton, E., HENEKA, M., & SCHYMANSKI, E. (2023). Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients? (2). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/58891. doi:10.26434/chemrxiv-2023-6j2gm-v2 |
Nemali, A., Vockert, N., Berron, D., Maas, A., Bernal, J., Yakupov, R., Peters, O., Gref, D., Cosma, N., Preis, L., Priller, J., Spruth, E., Altenstein, S., Lohse, A., Fliessbach, K., Kimmich, O., Vogt, I., Wiltfang, J., Hansen, N., ... Ziegler, G.*. (December 2023). Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer's disease-A systematic model evaluation. Medical Image Analysis, 90, 102913. doi:10.1016/j.media.2023.102913 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Stark, M., Wolfsgruber, S., Kleineidam, L., Frommann, I., Altenstein, S., Bartels, C., Brosseron, F., Buerger, K., Burow, L., Butryn, M., Ewers, M., Fliessbach, K., Gabelin, T., Glanz, W., Goerss, D., Gref, D., Hansen, N., HENEKA, M., Hinderer, P., ... Wagner, M. (21 November 2023). Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline. Neurology, 101 (21), 2185 - e2196. doi:10.1212/WNL.0000000000207844 Peer Reviewed verified by ORBi |
DADWAL, S., & HENEKA, M. (2023). Microglia heterogeneity in health and disease. FEBS Open Bio. doi:10.1002/2211-5463.13735 Peer Reviewed verified by ORBi |
Bartsch, T., Berg, D., HENEKA, M., & Leypoldt, F. (October 2023). Parkinson- und Alzheimer-Erkrankung als Systemerkrankungen. Nervenarzt, 94 (10), 875 - 884. doi:10.1007/s00115-023-01542-z Peer Reviewed verified by ORBi |
Waschkies, K. F., Soch, J., Darna, M., Richter, A., Altenstein, S., Beyle, A., Brosseron, F., Buchholz, F., Butryn, M., Dobisch, L., Ewers, M., Fliessbach, K., Gabelin, T., Glanz, W., Goerss, D., Gref, D., Janowitz, D., Kilimann, I., Lohse, A., ... Kizilirmak, J. M. (October 2023). Machine learning-based classification of Alzheimer's disease and its at-risk states using personality traits, anxiety, and depression. International Journal of Geriatric Psychiatry, 38 (10), 6007. doi:10.1002/gps.6007 Peer Reviewed verified by ORBi |
TALAVERA ANDUJAR, B., MARY, A., VENEGAS MALDONADO, C. J., Cheng, T., Zaslavsky, L., Bolton, E. E., HENEKA, M., & SCHYMANSKI, E. (21 September 2023). YoungNMC 2023: "Challenges in Developing Non-target Exposomics and Metabolomics Workflows for Cerebrospinal Fluid from Alzheimer's disease and Mild Cognitive Impairment" [Paper presentation]. YoungNMC Symposium, Nijmegen, Netherlands. doi:10.5281/ZENODO.8364324 Peer reviewed |
Karabag, D., Scheiblich, H., Griep, A., Santarelli, F., Schwartz, S., HENEKA, M., & Ising, C. (August 2023). Characterizing microglial senescence: Tau as a key player. Journal of Neurochemistry, 166 (3), 517 - 533. doi:10.1111/jnc.15866 Peer Reviewed verified by ORBi |
TALAVERA ANDUJAR, B., MARY, A., Cheng, T., Zaslavsky, L., Bolton, E., HENEKA, M., & SCHYMANSKI, E. (2023). Non-target LC-HRMS to Study the Exposome of Mild Cognitive Impairment and Alzheimer’s Disease on Cerebrospinal Fluid. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57734. doi:10.26434/chemrxiv-2023-6j2gm |
TALAVERA ANDUJAR, B., MARY, A., Cheng, T., Zaslavsky, L., Bolton, E. E., HENEKA, M., & SCHYMANSKI, E. (07 June 2023). Non-target LC-HRMS to Study the Exposome of Mild Cognitive Impairment and Alzheimer's Disease on Cerebrospinal Fluid [Poster presentation]. 19th Annual International Conference of the Metabolomics Society, Niagara Falls, Canada. doi:10.5281/ZENODO.8017622 Peer reviewed |
Walker, K. A., Le Page, L. M., Terrando, N., Duggan, M. R., HENEKA, M., & Bettcher, B. M. (05 June 2023). The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap. Molecular Neurodegeneration, 18 (1), 37. doi:10.1186/s13024-023-00627-2 Peer Reviewed verified by ORBi |
Kloske, C. M., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Brickman, A. M., Bu, G., Dennison, J., Gearon, M. D., Goate, A. M., Haass, C., HENEKA, M., Hu, W. T., Huggins, L. K. L., Jones, N. S., Koldamova, R., Lemere, C. A., Liddelow, S. A., Marcora, E., Marsh, S. E., ... Carrillo, M. C. (June 2023). APOE and immunity: Research highlights. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 19 (6), 2677 - 2696. doi:10.1002/alz.13020 Peer Reviewed verified by ORBi |
Stratoulias, V., Ruiz, R., Kanatani, S., Osman, A. M., Keane, L., Armengol, J. A., Rodríguez-Moreno, A., Murgoci, A.-N., García-Domínguez, I., Alonso-Bellido, I., González Ibáñez, F., Picard, K., Vázquez-Cabrera, G., Posada-Pérez, M., Vernoux, N., Tejera, D., Grabert, K., Cheray, M., González-Rodríguez, P., ... Joseph, B. (June 2023). ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Nature Neuroscience, 26 (6), 1008 - 1020. doi:10.1038/s41593-023-01326-3 Peer Reviewed verified by ORBi |
Bendella, Z., Widmann, C. N., Layer, J. P., Layer, Y. L., Haase, R., Sauer, M., Bieler, L., Lehnen, N. C., Paech, D., HENEKA, M., Radbruch, A., & Schmeel, F. C. (12 May 2023). Brain Volume Changes after COVID-19 Compared to Healthy Controls by Artificial Intelligence-Based MRI Volumetry. Diagnostics, 13 (10), 1716. doi:10.3390/diagnostics13101716 Peer Reviewed verified by ORBi |
Nemy, M., Dyrba, M., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ewers, M., Fliessbach, K., Glanz, W., Goerss, D., HENEKA, M., Hetzer, S., Incesoy, E. I., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Munk, M. H., Perneczky, R., ... Ferreira, D. (02 May 2023). Cholinergic white matter pathways along the Alzheimer's disease continuum. Brain: a Journal of Neurology, 146 (5), 2075 - 2088. doi:10.1093/brain/awac385 Peer Reviewed verified by ORBi |
Ising, C., & HENEKA, M. (May 2023). Chronic inflammation: a potential target in tauopathies. The Lancet Neurology, 22 (5), 371 - 373. doi:10.1016/S1474-4422(23)00116-3 Peer Reviewed verified by ORBi |
Heinzinger, N., Maass, A., Berron, D., Yakupov, R., Peters, O., Fiebach, J., Villringer, K., Preis, L., Priller, J., Spruth, E. J., Altenstein, S., Schneider, A., Fliessbach, K., Wiltfang, J., Bartels, C., Jessen, F., Maier, F., Glanz, W., Buerger, K., ... Alzheimer’s Disease Neuroimaging Initiative. (13 March 2023). Exploring the ATN classification system using brain morphology. Alzheimer's Research and Therapy, 15 (1), 50. doi:10.1186/s13195-023-01185-x Peer Reviewed verified by ORBi |
Yildirim, Z., Delen, F., Berron, D., Baumeister, H., Ziegler, G., Schütze, H., Glanz, W., Dobisch, L., Peters, O., Freiesleben, S. D., Schneider, L.-S., Priller, J., Spruth, E. J., Schneider, A., Fliessbach, K., Wiltfang, J., Schott, B.-H., Meiberth, D., Buerger, K., ... Duzel, E. (28 February 2023). Brain reserve contributes to distinguishing preclinical Alzheimer's stages 1 and 2. Alzheimer's Research and Therapy, 15 (1), 43. doi:10.1186/s13195-023-01187-9 Peer Reviewed verified by ORBi |
Braatz, C., Komes, M. P., Ravichandran, K. A., de Fragas, M. G., Griep, A., Schwartz, S., McManus, R. M., & HENEKA, M. (2023). NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. Journal of Neurochemistry. doi:10.1111/jnc.15778 Peer Reviewed verified by ORBi |
Jessen, F., Wolfsgruber, S., Kleineindam, L., Spottke, A., Altenstein, S., Bartels, C., Berger, M., Brosseron, F., Daamen, M., Dichgans, M., Dobisch, L., Ewers, M., Fenski, F., Fliessbach, K., Freiesleben, S. D., Glanz, W., Görß, D., Gürsel, S., Janowitz, D., ... Düzel, E. (February 2023). Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 19 (2), 487 - 497. doi:10.1002/alz.12674 Peer Reviewed verified by ORBi |
Ersoezlue, E.* , Rauchmann, B.-S.* , Schneider-Axmann, T., Wagner, M., Ballarini, T., Tato, M., Utecht, J., Kurz, C., Papazov, B., Guersel, S., Burow, L., Koller, G., Stöcklein, S., Keeser, D., Bartels, C., Brosseron, F., Buerger, K., Cetindag, A. C., Dechent, P., ... Perneczky, R. (February 2023). Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease. Neurobiology of Aging, 122, 33 - 44. doi:10.1016/j.neurobiolaging.2022.05.015 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Brosseron, F., Maass, A., Kleineidam, L., Ravichandran, K. A., Kolbe, C.-C., Wolfsgruber, S., Santarelli, F., Häsler, L. M., McManus, R., Ising, C., Röske, S., Peters, O., Cosma, N.-C., Schneider, L.-S., Wang, X., Priller, J., Spruth, E. J., Altenstein, S., Schneider, A., ... DELCODE study group. (12 January 2023). Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study. Alzheimer's Research and Therapy, 15 (1), 13. doi:10.1186/s13195-022-01118-0 Peer Reviewed verified by ORBi |
Henning, L., Antony, H., Breuer, A., Müller, J., Seifert, G., Audinat, E., Singh, P., Brosseron, F., HENEKA, M., Steinhäuser, C., & Bedner, P. (2023). Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy. Glia, 71 (2), 168-186. doi:10.1002/glia.24265 Peer Reviewed verified by ORBi |
HENEKA, M. (2023). ApoE4 makes microglia trem(2)bling. Neuron, 111 (2), 142-144. doi:10.1016/j.neuron.2022 Peer Reviewed verified by ORBi |
Ersoezlue, E.* , Perneczky, R.* , Tato, M., Utecht, J., Kurz, C., Häckert, J., Guersel, S., Burow, L., Koller, G., Stoecklein, S., Keeser, D., Papazov, B., Totzke, M., Ballarini, T., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ewers, M., ... DELCODE study group. (2023). A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum. Journal of Alzheimer's Disease, 92 (3), 925 - 940. doi:10.3233/JAD-220464 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Teipel, S. J., Dyrba, M., Levin, F., Altenstein, S., Berger, M., Beyle, A., Brosseron, F., Buerger, K., Burow, L., Dobisch, L., Ewers, M., Fliessbach, K., Frommann, I., Glanz, W., Goerss, D., Gref, D., Hansen, N., HENEKA, M., Incesoy, E. I., ... DELCODE study group and the Alzheimer’s Disease Neuroimaging Initiative. (2023). Cognitive Trajectories in Preclinical and Prodromal Alzheimer's Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach. Journal of Alzheimer's disease reports, 7 (1), 1055 - 1076. doi:10.3233/ADR-230027 Peer reviewed |
Jansen, I. E., van der Lee, S. J., Gomez-Fonseca, D., de Rojas, I., Dalmasso, M. C., Grenier-Boley, B., Zettergren, A., Mishra, A., Ali, M., Andrade, V., Bellenguez, C., Kleineidam, L., Küçükali, F., Sung, Y. J., Tesí, N., Vromen, E. M., Wightman, D. P., Alcolea, D., Alegret, M., ... van der Flier, W. (November 2022). Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. Acta Neuropathologica, 144 (5), 821 - 842. doi:10.1007/s00401-022-02454-z Peer Reviewed verified by ORBi |
Janssen, O., Jansen, W. J., Vos, S. J. B., Boada, M., Parnetti, L., Gabryelewicz, T., Fladby, T., Molinuevo, J. L., Villeneuve, S., Hort, J., Epelbaum, S., Lleó, A., Engelborghs, S., van der Flier, W. M., Landau, S., Popp, J., Wallin, A., Scheltens, P., Rikkert, M. O., ... Visser, P. J. (October 2022). Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 18 (10), 1832 - 1845. doi:10.1002/alz.12512 Peer Reviewed verified by ORBi |
Billette, O. V., Ziegler, G., Aruci, M., Schütze, H., Kizilirmak, J. M., Richter, A., Altenstein, S., Bartels, C., Brosseron, F., Cardenas-Blanco, A., Dahmen, P., Dechent, P., Dobisch, L., Fliessbach, K., Freiesleben, S. D., Glanz, W., Göerß, D., Haynes, J. D., HENEKA, M., ... DELCODE Study Group. (23 August 2022). Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease. Neurology, 99 (8), 775 - e788. doi:10.1212/WNL.0000000000200667 Peer Reviewed verified by ORBi |
Krieger, J., Frackowiak, M., Berger, M., HENEKA, M., & Jacobs, A. H. (August 2022). Falls at advanced age - The importance to search for benign paroxysmal positional vertigo (BPPV). Experimental Gerontology, 165, 111868. doi:10.1016/j.exger.2022.111868 Peer Reviewed verified by ORBi |
Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., HENEKA, M., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. (July 2022). Infection and inflammation: New perspectives on Alzheimer's disease. Brain, behavior, & immunity. Health, 22, 100462. doi:10.1016/j.bbih.2022.100462 Peer reviewed |
Manabe, T., & HENEKA, M. (July 2022). Cerebral dysfunctions caused by sepsis during ageing. Nature Reviews. Immunology, 22 (7), 444 - 458. doi:10.1038/s41577-021-00643-7 Peer Reviewed verified by ORBi |
Düzel, E., Ziegler, G., Berron, D., Maass, A., Schütze, H., Cardenas-Blanco, A., Glanz, W., Metzger, C., Dobisch, L., Reuter, M., Spottke, A., Brosseron, F., Fliessbach, K., HENEKA, M., Laske, C., Peters, O., Priller, J., Spruth, E. J., Ramirez, A., ... Jessen, F. (24 May 2022). Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain: a Journal of Neurology, 145 (4), 1473 - 1485. doi:10.1093/brain/awab405 Peer Reviewed verified by ORBi |
Gordon, M. N., HENEKA, M., Le Page, L. M., Limberger, C., Morgan, D., Tenner, A. J., Terrando, N., Willette, A. A., & Willette, S. A. (May 2022). Impact of COVID-19 on the Onset and Progression of Alzheimer's Disease and Related Dementias: A Roadmap for Future Research. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 18 (5), 1038 - 1046. doi:10.1002/alz.12488 Peer Reviewed verified by ORBi |
Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., ... Lambert, J.-C. (April 2022). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics, 54 (4), 412 - 436. doi:10.1038/s41588-022-01024-z Peer Reviewed verified by ORBi |
Jansen, W. J., Janssen, O., Tijms, B. M., Vos, S. J. B., Ossenkoppele, R., Visser, P. J., Amyloid Biomarker Study Group, Aarsland, D., Alcolea, D., Altomare, D., von Arnim, C., Baiardi, S., Baldeiras, I., Barthel, H., Bateman, R. J., Van Berckel, B., Binette, A. P., Blennow, K., Boada, M., ... Zetterberg, H. (01 March 2022). Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurology, 79 (3), 228 - 243. doi:10.1001/jamaneurol.2021.5216 Peer Reviewed verified by ORBi |
Perea, J. R., Bolós, M., Cuadros, R., García, E., García-Escudero, V., Hernández, F., McManus, R. M., HENEKA, M., & Avila, J. (March 2022). p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular Neurobiology, 59 (3), 1632 - 1648. doi:10.1007/s12035-021-02715-0 Peer Reviewed verified by ORBi |
Castro-Gomez, S., Binder, J., Schievelkamp, A.-H., & HENEKA, M. (2022). CNS Superficial Siderosis Mimicking a Motor Neuron Disease. Brain Sciences, 12 (11). doi:10.3390/brainsci12111558 Peer Reviewed verified by ORBi |
Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G. C., ... Wyss-Coray, T. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110 (21), 3458-3483. doi:10.1016/j.neuron.2022.10.020 Peer Reviewed verified by ORBi |
Mercan, D., & HENEKA, M. (2022). The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease. Biology, 11 (12). doi:10.3390/biology11121822 Peer Reviewed verified by ORBi |
Brosseron, F., Maass, A., Kleineidam, L., Ravichandran, K. A., González, P. G., McManus, R. M., Ising, C., Santarelli, F., Kolbe, C.-C., Häsler, L. M., Wolfsgruber, S., Marquié, M., Boada, M., Orellana, A., de Rojas, I., Röske, S., Peters, O., Cosma, N.-C., Cetindag, A., ... HENEKA, M. (2022). Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease. Neuron, 110 (6), 1009-1022.e4. doi:10.1016/j.neuron.2021.12.016 Peer Reviewed verified by ORBi |
Wolfsgruber, S., Kleineidam, L., Weyrauch, A.-S., Barkhoff, M., Röske, S., Peters, O., Preis, L., Gref, D., Spruth, E. J., Altenstein, S., Priller, J., Fließbach, K., Schneider, A., Wiltfang, J., Bartels, C., Jessen, F., Maier, F., Düzel, E., Metzger, C., ... DELCODE study group. (2022). Relevance of Subjective Cognitive Decline in Older Adults with a First-Degree Family History of Alzheimer's Disease. Journal of Alzheimer's Disease, 87 (2), 545 - 555. doi:10.3233/JAD-215416 Peer Reviewed verified by ORBi |
Berron, D., Ziegler, G., Vieweg, P., Billette, O., Güsten, J., Grande, X., HENEKA, M., Schneider, A., Teipel, S., Jessen, F., Wagner, M., & Düzel, E. (2022). Feasibility of Digital Memory Assessments in an Unsupervised and Remote Study Setting. Frontiers in Digital Health, 4, 892997. doi:10.3389/fdgth.2022.892997 Peer Reviewed verified by ORBi |
Teipel, S. J., Dyrba, M., Ballarini, T., Brosseron, F., Bruno, D., Buerger, K., Cosma, N.-C., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Haynes, J. D., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C. D., Munk, M. H., ... HENEKA, M. (2022). Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum. Journal of Alzheimer's Disease, 85 (3), 1267 - 1282. doi:10.3233/JAD-215196 Peer Reviewed verified by ORBi |
Kleineidam, L., Wolfsgruber, S., Weyrauch, A.-S., Zulka, L. E., Forstmeier, S., Roeske, S., van den Bussche, H., Kaduszkiewicz, H., Wiese, B., Weyerer, S., Werle, J., Fuchs, A., Pentzek, M., Brettschneider, C., König, H.-H., Weeg, D., Bickel, H., Luppa, M., Rodriguez, F. S., ... Wagner, M. (2022). Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve. Frontiers in Psychology, 13, 957308. doi:10.3389/fpsyg.2022.957308 Peer Reviewed verified by ORBi |
Ravichandran, K. A., & HENEKA, M. (22 December 2021). Inflammasome activation in neurodegenerative diseases. Essays in Biochemistry, 65 (7), 885 - 904. doi:10.1042/EBC20210021 Peer Reviewed verified by ORBi |
Kummer, M. P., Ising, C., Kummer, C., Sarlus, H., Griep, A., Vieira-Saecker, A., Schwartz, S., Halle, A., Brückner, M., Händler, K., Schultze, J. L., Beyer, M., Latz, E., & HENEKA, M. (15 December 2021). Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO Journal, 40 (24), 108662. doi:10.15252/embj.2021108662 Peer Reviewed verified by ORBi |
Joshi, P., Riffel, F., Satoh, K., Enomoto, M., Qamar, S., Scheiblich, H., Villacampa, N., Kumar, S., Theil, S., Parhizkar, S., Haass, C., HENEKA, M., Fraser, P. E., St George-Hyslop, P., & Walter, J. (December 2021). Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia, 69 (12), 2917 - 2932. doi:10.1002/glia.24077 Peer Reviewed verified by ORBi |
Dyrba, M., Hanzig, M., Altenstein, S., Bader, S., Ballarini, T., Brosseron, F., Buerger, K., Cantré, D., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Glanz, W., Haynes, J.-D., HENEKA, M., Janowitz, D., Keles, D. B., Kilimann, I., ... ADNI, A. D. S. G. (23 November 2021). Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer's disease. Alzheimer's Research and Therapy, 13 (1), 191. doi:10.1186/s13195-021-00924-2 Peer Reviewed verified by ORBi |
Widmann, C. N., Wieberneit, M., Bieler, L., Bernsen, S., Gräfenkämper, R., Brosseron, F., Schmeel, C., Tacik, P., Skowasch, D., Radbruch, A., & HENEKA, M. (11 November 2021). Longitudinal Neurocognitive and Pulmonological Profile of Long COVID-19: Protocol for the COVIMMUNE-Clin Study. JMIR Research Protocols, 10 (11), 30259. doi:10.2196/30259 Peer Reviewed verified by ORBi |
Islam, M. R., Kaurani, L., Berulava, T., Heilbronner, U., Budde, M., Centeno, T. P., Elerdashvili, V., Zafieriou, M.-P., Benito, E., Sertel, S. M., Goldberg, M., Senner, F., Kalman, J. L., Burkhardt, S., Oepen, A. S., Sakib, M. S., Kerimoglu, C., Wirths, O., Bickeböller, H., ... Fischer, A. (08 November 2021). A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Molecular Medicine, 13 (11), 13659. doi:10.15252/emmm.202013659 Peer Reviewed verified by ORBi |
Rueda-Carrasco, J., Martin-Bermejo, M. J., Pereyra, G., Mateo, M. I., Borroto, A., Brosseron, F., Kummer, M. P., Schwartz, S., López-Atalaya, J. P., Alarcon, B., Esteve, P., HENEKA, M., & Bovolenta, P. (04 November 2021). SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation. EMBO Reports, 22 (11), 51696. doi:10.15252/embr.202051696 Peer Reviewed verified by ORBi |
Bettcher, B. M., Tansey, M. G., Dorothée, G., & HENEKA, M. (November 2021). Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nature Reviews. Neurology, 17 (11), 689 - 701. doi:10.1038/s41582-021-00549-x Peer Reviewed verified by ORBi |
Manabe, T., Rácz, I., Schwartz, S., Oberle, L., Santarelli, F., Emmrich, J. V., Neher, J. J., & HENEKA, M. (November 2021). Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing. Journal of Neurochemistry, 159 (3), 525 - 542. doi:10.1111/jnc.15491 Peer Reviewed verified by ORBi |
Bettcher, B. M., Tansey, M. G., Dorothée, G., & HENEKA, M. (November 2021). Publisher Correction: Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nature Reviews. Neurology, 17 (11), 724. doi:10.1038/s41582-021-00579-5 Peer Reviewed verified by ORBi |
Joshi, P., Riffel, F., Kumar, S., Villacampa, N., Theil, S., Parhizkar, S., Haass, C., Colonna, M., HENEKA, M., Arzberger, T., Herms, J., & Walter, J. (18 October 2021). TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits. Acta Neuropathologica Communications, 9 (1), 168. doi:10.1186/s40478-021-01263-x Peer Reviewed verified by ORBi |
Keane, L., Antignano, I., RIECHERS, S.-P. H., Zollinger, R., Dumas, A. A., Offermann, N., Bernis, M. E., Russ, J., Graelmann, F., McCormick, P. N., Esser, J., Tejera, D., Nagano, A., Wang, J., Chelala, C., Biederbick, Y., Halle, A., Salomoni, P., HENEKA, M., & Capasso, M. (15 October 2021). mTOR-dependent translation amplifies microglia priming in aging mice. Journal of Clinical Investigation, 131 (20). doi:10.1172/JCI155208 Peer Reviewed verified by ORBi |
Scheiblich, H., Bousset, L., Schwartz, S., Griep, A., Latz, E., Melki, R., & HENEKA, M. (15 October 2021). Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies. Journal of Immunology, 207 (8), 2143 - 2154. doi:10.4049/jimmunol.2100035 Peer Reviewed verified by ORBi |
Aretz, B., Janssen, F., Vonk, J. M., HENEKA, M., Boezen, H. M., & Doblhammer, G. (October 2021). Long-term exposure to fine particulate matter, lung function and cognitive performance: A prospective Dutch cohort study on the underlying routes. Environmental Research, 201, 111533. doi:10.1016/j.envres.2021.111533 Peer Reviewed verified by ORBi |
Rauchmann, B.-S., Ersoezlue, E., Stoecklein, S., Keeser, D., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ertl-Wagner, B., Fliessbach, K., Haynes, J. D., HENEKA, M., Incesoy, E. I., Janowitz, D., Kilimann, I., Laske, C., Metzger, C. D., Munk, M. H., Peters, O., ... DELCODE study group and the Alzheimer's Disease Neuroimaging Initiative (ADNI). (01 October 2021). Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes. Cerebral Cortex, 31 (11), 4901 - 4915. doi:10.1093/cercor/bhab130 Peer Reviewed verified by ORBi |
Scheiblich, H., Dansokho, C., Mercan, D., Schmidt, S. V., Bousset, L., Wischhof, L., Eikens, F., Odainic, A., Spitzer, J., Griep, A., Schwartz, S., Bano, D., Latz, E., Melki, R., & HENEKA, M. (30 September 2021). Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell, 184 (20), 5089 - 5106.e21. doi:10.1016/j.cell.2021.09.007 Peer Reviewed verified by ORBi |
Jiang, S., Maphis, N. M., Binder, J., Chisholm, D., Weston, L., Duran, W., Peterson, C., Zimmerman, A., Mandell, M. A., Jett, S. D., Bigio, E., Geula, C., Mellios, N., Weick, J. P., Rosenberg, G. A., Latz, E., HENEKA, M., & Bhaskar, K. (21 September 2021). Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Reports, 36 (12), 109720. doi:10.1016/j.celrep.2021.109720 Peer Reviewed verified by ORBi |
Odoj, K., Brawek, B., Asavapanumas, N., Mojtahedi, N., HENEKA, M., & Garaschuk, O. (August 2021). In vivo mechanisms of cortical network dysfunction induced by systemic inflammation. Brain, Behavior and Immunity, 96, 113 - 126. doi:10.1016/j.bbi.2021.05.021 Peer Reviewed verified by ORBi |
Bergström, S., Remnestål, J., Yousef, J., Olofsson, J., Markaki, I., Carvalho, S., Corvol, J.-C., Kultima, K., Kilander, L., Löwenmark, M., Ingelsson, M., Blennow, K., Zetterberg, H., Nellgård, B., Brosseron, F., HENEKA, M., Bosch, B., Sanchez-Valle, R., Månberg, A., ... Nilsson, P. (July 2021). Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease. Annals of Clinical and Translational Neurology, 8 (7), 1456 - 1470. doi:10.1002/acn3.51402 Peer Reviewed verified by ORBi |
de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., ... Ruiz, A. (07 June 2021). Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications, 12 (1), 3417. doi:10.1038/s41467-021-22491-8 Peer Reviewed verified by ORBi |
Brosseron, F., Kleemann, K., Kolbe, C.-C., Santarelli, F., Castro-Gomez, S., Tacik, P., Latz, E., Jessen, F., & HENEKA, M. (June 2021). Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation. Journal of Neurochemistry, 157 (6), 2210 - 2224. doi:10.1111/jnc.15175 Peer Reviewed verified by ORBi |
Ballarini, T., Melo van Lent, D., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Duzel, E., Ertl-Wagner, B., Fliessbach, K., Freiesleben, S. D., Frommann, I., Glanz, W., Hauser, D., Haynes, J. D., HENEKA, M., ... DELCODE study group. (05 May 2021). Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology, 96 (24), 2920 - e2932. doi:10.1212/WNL.0000000000012067 Peer Reviewed verified by ORBi |
Mantile, F., Capasso, A., Villacampa, N., Donnini, M., Liguori, G. L., Constantin, G., De Berardinis, P.* , HENEKA, M.* , & Prisco, A.*. (May 2021). Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice. Aging Clinical and Experimental Research, 33 (5), 1383 - 1387. doi:10.1007/s40520-019-01414-0 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Ribon, M., Leone, C., Chiot, A., Berriat, F., Rampanana, M., Cottin, J., Bohl, D., Millecamps, S., Lobsiger, C. S., HENEKA, M., & Boillée, S. (May 2021). Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice. Neurobiology of Aging, 101, 181 - 186. doi:10.1016/j.neurobiolaging.2021.01.015 Peer Reviewed verified by ORBi |
Nitsch, L.* , Petzinna, S.* , Zimmermann, J., Schneider, L., Krauthausen, M., HENEKA, M., Getts, D. R., Becker, A., & Müller, M. (27 April 2021). Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model. Journal of Neuroinflammation, 18 (1), 101. doi:10.1186/s12974-021-02140-z Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., HENEKA, M., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., ... Dinarello, C. A. (February 2021). Author Correction: A guiding map for inflammation. Nature Immunology, 22 (2), 254. doi:10.1038/s41590-020-00846-5 Peer Reviewed verified by ORBi |
Franzmeier, N., Ren, J., Damm, A., Monté-Rubio, G., Boada, M., Ruiz, A., Ramirez, A., Jessen, F., Düzel, E., Rodríguez Gómez, O., Benzinger, T., Goate, A., Karch, C. M., Fagan, A. M., McDade, E., Buerger, K., Levin, J., Duering, M., Dichgans, M., ... Ewers, M. (February 2021). The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry, 26 (2), 614 - 628. doi:10.1038/s41380-019-0404-6 Peer Reviewed verified by ORBi |
Castro-Gomez, S., Radermacher, B., Tacik, P., Mirandola, S. R., HENEKA, M., & Weydt, P. (2021). Teaching an old dog new tricks: serum troponin T as a biomarker in amyotrophic lateral sclerosis. Brain Communications, 3 (4), 274. doi:10.1093/braincomms/fcab274 Peer Reviewed verified by ORBi |
Keane, L., Antignano, I., RIECHERS, S.-P. H., Zollinger, R., Dumas, A. A., Offermann, N., Bernis, M. E., Russ, J., Graelmann, F., McCormick, P. N., Esser, J., Tejera, D., Nagano, A., Wang, J., Chelala, C., Biederbick, Y., Halle, A., Salomoni, P., HENEKA, M., & Capasso, M. (2021). mTOR-dependent translation amplifies microglia priming in aging mice. Journal of Clinical Investigation, 131 (1). Peer Reviewed verified by ORBi |
Lage, C., González-Suárez, A., Alcalde-Hierro, M. P., Sampedro-González, M. I., Villanueva-Eguaras, M. Á., Sánchez-Crespo, M. R., Widmann, C., Brosseron, F., Pozueta, A., López-García, S., García-Martínez, M., Kazimierczak, M., Bravo-González, M., Fernández-Rodríguez, A., Drake-Pérez, M., Irure-Ventura, J., López-Hoyos, M., Rodríguez-Rodríguez, E., HENEKA, M., & Sánchez-Juan, P. (2021). Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology. Journal of Alzheimer's Disease, 79 (2), 863 - 874. doi:10.3233/JAD-191229 Peer Reviewed verified by ORBi |
Fritze, T., Doblhammer, G., Widmann, C. N., & HENEKA, M. (January 2021). Time course of dementia following sepsis in German health claims data. Neurology: Neuroimmunology and Neuroinflammation, 8 (1). doi:10.1212/NXI.0000000000000911 Peer Reviewed verified by ORBi |
Hansen, N., Singh, A., Bartels, C., Brosseron, F., Buerger, K., Cetindag, A. C., Dobisch, L., Dechent, P., Ertl-Wagner, B. B., Fliessbach, K., Haynes, J. D., HENEKA, M., Janowitz, D., Kilimann, I., Laske, C., Metzger, C. D., Munk, M. H., Peters, O., Priller, J., ... Goya-Maldonado, R. (2021). Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline. Frontiers in Aging Neuroscience, 13, 626974. doi:10.3389/fnagi.2021.626974 Peer Reviewed verified by ORBi |
Lučiūnaitė, A., McManus, R. M., Jankunec, M., Rácz, I., Dansokho, C., Dalgėdienė, I., Schwartz, S., Brosseron, F., & HENEKA, M. (December 2020). Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. Journal of Neurochemistry, 155 (6), 650 - 661. doi:10.1111/jnc.14945 Peer Reviewed verified by ORBi |
Finsterwalder, S.* , Vlegels, N.* , Gesierich, B., Araque Caballero, M. Á., Weaver, N. A., Franzmeier, N., Georgakis, M. K., Konieczny, M. J., Koek, H. L., Dominantly Inherited Alzheimer Network (DIAN), Karch, C. M., Graff-Radford, N. R., Salloway, S., Oh, H., Allegri, R. F., Chhatwal, J. P., DELCODE study group, Jessen, F., Düzel, E., ... Duering, M. (November 2020). Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 16 (11), 1504 - 1514. doi:10.1002/alz.12150 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Sannemann, L., Schild, A.-K., Altenstein, S., Bartels, C., Brosseron, F., Buerger, K., Cosma, N. C., Fliessbach, K., Freiesleben, S. D., Glanz, W., HENEKA, M., Janowitz, D., Kilimann, I., Kobeleva, X., Laske, C., Metzger, C. D., Munk, M. H. J., Perneczky, R., Peters, O., ... DELCODE Study Group. (16 October 2020). Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study. Alzheimer's Research and Therapy, 12 (1), 131. doi:10.1186/s13195-020-00701-7 Peer Reviewed verified by ORBi |
Unger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., HENEKA, M., Attems, J., & Aigner, L. (October 2020). CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice. Brain, Behavior and Immunity, 89, 67 - 86. doi:10.1016/j.bbi.2020.05.070 Peer Reviewed verified by ORBi |
Wolfsgruber, S., Kleineidam, L., Guski, J., Polcher, A., Frommann, I., Roeske, S., Spruth, E. J., Franke, C., Priller, J., Kilimann, I., Teipel, S., Buerger, K., Janowitz, D., Laske, C., Buchmann, M., Peters, O., Menne, F., Fuentes Casan, M., Wiltfang, J., ... DELCODE Study Group. (01 September 2020). Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology, 95 (9), 1134 - e1143. doi:10.1212/WNL.0000000000010142 Peer Reviewed verified by ORBi |
Beyer, M. M. S., Lonnemann, N., Remus, A., Latz, E., HENEKA, M., & Korte, M. (08 July 2020). Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent. Journal of Neuroscience, 40 (28), 5480 - 5494. doi:10.1523/JNEUROSCI.0200-20.2020 Peer Reviewed verified by ORBi |
Riester, K., Brawek, B., Savitska, D., Fröhlich, N., Zirdum, E., Mojtahedi, N., HENEKA, M., & Garaschuk, O. (July 2020). In vivo characterization of functional states of cortical microglia during peripheral inflammation. Brain, Behavior and Immunity, 87, 243 - 255. doi:10.1016/j.bbi.2019.12.007 Peer Reviewed verified by ORBi |
HENEKA, M., Golenbock, D., Latz, E., Morgan, D., & Brown, R. (04 June 2020). Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimer's Research and Therapy, 12 (1), 69. doi:10.1186/s13195-020-00640-3 Peer Reviewed verified by ORBi |
Kleineidam, L., Chouraki, V., Próchnicki, T., van der Lee, S. J., Madrid-Márquez, L., Wagner-Thelen, H., Karaca, I., Weinhold, L., Wolfsgruber, S., Boland, A., Martino Adami, P. V., Lewczuk, P., Popp, J., Brosseron, F., Jansen, I. E., Hulsman, M., Kornhuber, J., Peters, O., Berr, C., ... Ramirez, A.*. (June 2020). PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta Neuropathologica, 139 (6), 1025 - 1044. doi:10.1007/s00401-020-02138-6 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Schröder, N., Schaffrath, A., Welter, J. A., Putzka, T., Griep, A., Ziegler, P., Brandt, E., Samer, S., HENEKA, M., Kaddatz, H., Zhan, J., Kipp, E., Pufe, T., Tauber, S. C., Kipp, M., & Brandenburg, L.-O. (24 April 2020). Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease. Journal of Neuroinflammation, 17 (1), 131. doi:10.1186/s12974-020-01816-2 Peer Reviewed verified by ORBi |
Villacampa, N., & HENEKA, M. (06 April 2020). Microglia in Alzheimer's disease: Local heroes! Journal of Experimental Medicine, 217 (4). doi:10.1084/jem.20192311 Peer Reviewed verified by ORBi |
McManus, R. M., & HENEKA, M. (April 2020). T cells in Alzheimer's disease: space invaders. The Lancet Neurology, 19 (4), 285 - 287. doi:10.1016/S1474-4422(20)30076-4 Peer Reviewed verified by ORBi |
Scheiblich, H., Trombly, M., Ramirez, A., & HENEKA, M. (April 2020). Neuroimmune Connections in Aging and Neurodegenerative Diseases. Trends in Immunology, 41 (4), 300 - 312. doi:10.1016/j.it.2020.02.002 Peer Reviewed verified by ORBi |
Itzhaki, R. F., Golde, T. E., HENEKA, M., & Readhead, B. (April 2020). Do infections have a role in the pathogenesis of Alzheimer disease? Nature Reviews. Neurology, 16 (4), 193 - 197. doi:10.1038/s41582-020-0323-9 Peer Reviewed verified by ORBi |
Friker, L. L., Scheiblich, H., Hochheiser, I. V., Brinkschulte, R., Riedel, D., Latz, E., Geyer, M., & HENEKA, M. (17 March 2020). β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell Reports, 30 (11), 3743 - 3754.e6. doi:10.1016/j.celrep.2020.02.025 Peer Reviewed verified by ORBi |
Wijasa, T. S., Sylvester, M., Brocke-Ahmadinejad, N., Schwartz, S., Santarelli, F., Gieselmann, V., Klockgether, T., Brosseron, F., & HENEKA, M. (March 2020). Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease. Journal of Neurochemistry, 152 (6), 710 - 726. doi:10.1111/jnc.14870 Peer Reviewed verified by ORBi |
Kumar, S., Kapadia, A., Theil, S., Joshi, P., Riffel, F., HENEKA, M., & Walter, J. (2020). Novel Phosphorylation-State Specific Antibodies Reveal Differential Deposition of Ser26 Phosphorylated Aβ Species in a Mouse Model of Alzheimer's Disease. Frontiers in Molecular Neuroscience, 13, 619639. doi:10.3389/fnmol.2020.619639 Peer Reviewed verified by ORBi |
Karsak, M.* , Glebov, K.* , Scheffold, M., Bajaj, T., Kawalia, A., Karaca, I., Rading, S., Kornhuber, J., Peters, O., Diez-Fairen, M., Frölich, L., Hüll, M., Wiltfang, J., Scherer, M., Riedel-Heller, S., Schneider, A., HENEKA, M., Fliessbach, K., Sharaf, A., ... Ramirez, A. (January 2020). A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Human Mutation, 41 (1), 169 - 181. doi:10.1002/humu.23904 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Traschütz, A., Enkirch, S. J., Polomac, N., Widmann, C. N., Schild, H. H., HENEKA, M., & Hattingen, E. (2020). The Entorhinal Cortex Atrophy Score Is Diagnostic and Prognostic in Mild Cognitive Impairment. Journal of Alzheimer's Disease, 75 (1), 99 - 108. doi:10.3233/JAD-181150 Peer Reviewed verified by ORBi |
Webers, A., HENEKA, M., & Gleeson, P. A. (January 2020). The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. Immunology and Cell Biology, 98 (1), 28 - 41. doi:10.1111/imcb.12301 Peer Reviewed verified by ORBi |
HENEKA, M. (January 2020). An immune-cell signature marks the brain in Alzheimer's disease. Nature, 577 (7790), 322 - 323. doi:10.1038/d41586-019-03892-8 Peer Reviewed verified by ORBi |
Herdick, M., Dyrba, M., Fritz, H.-C. J., Altenstein, S., Ballarini, T., Brosseron, F., Buerger, K., Can Cetindag, A., Dechent, P., Dobisch, L., Duezel, E., Ertl-Wagner, B., Fliessbach, K., Dawn Freiesleben, S., Frommann, I., Glanz, W., Dylan Haynes, J., HENEKA, M., Janowitz, D., ... Grothe, M. J. (2020). Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer's disease spectrum. NeuroImage: Clinical, 28, 102495. doi:10.1016/j.nicl.2020.102495 Peer Reviewed verified by ORBi |
Bainbridge, W. A., Berron, D., Schütze, H., Cardenas-Blanco, A., Metzger, C., Dobisch, L., Bittner, D., Glanz, W., Spottke, A., Rudolph, J., Brosseron, F., Buerger, K., Janowitz, D., Fliessbach, K., HENEKA, M., Laske, C., Buchmann, M., Peters, O., Diesing, D., ... Düzel, E. (December 2019). Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11 (1), 610 - 618. doi:10.1016/j.dadm.2019.07.005 Peer Reviewed verified by ORBi |
Nitsch, L., Zimmermann, J., Krauthausen, M., Hofer, M. J., Saggu, R., Petzold, G. C., HENEKA, M., Getts, D. R., Becker, A., Campbell, I. L., & Müller, M. (December 2019). CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. Molecular Neurobiology, 56 (12), 7977 - 7993. doi:10.1007/s12035-019-1640-0 Peer Reviewed verified by ORBi |
Venegas, C., & HENEKA, M. (December 2019). Inflammasome-mediated innate immunity in Alzheimer's disease. FASEB Journal, 33 (12), 13075 - 13084. doi:10.1096/fj.201900439 Peer Reviewed verified by ORBi |
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., ... HENEKA, M. (November 2019). NLRP3 inflammasome activation drives tau pathology. Nature, 575 (7784), 669 - 673. doi:10.1038/s41586-019-1769-z Peer Reviewed verified by ORBi |
Mercan, D., & HENEKA, M. (November 2019). Norepinephrine as a modulator of microglial dynamics. Nature Neuroscience, 22 (11), 1745 - 1746. doi:10.1038/s41593-019-0526-9 Peer Reviewed verified by ORBi |
Berron, D., Cardenas-Blanco, A., Bittner, D., Metzger, C. D., Spottke, A., HENEKA, M., Fliessbach, K., Schneider, A., Teipel, S. J., Wagner, M., Speck, O., Jessen, F., & Düzel, E. (30 October 2019). Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. Journal of Neuroscience, 39 (44), 8788 - 8797. doi:10.1523/JNEUROSCI.1279-19.2019 Peer Reviewed verified by ORBi |
Tejera, D., Mercan, D., Sanchez-Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & HENEKA, M. (02 September 2019). Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. EMBO Journal, 38 (17), 101064. doi:10.15252/embj.2018101064 Peer Reviewed verified by ORBi |
Herrera-Rivero, M., Santarelli, F., Brosseron, F., Kummer, M. P., & HENEKA, M. (September 2019). Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression. Molecular Neurobiology, 56 (9), 6539 - 6550. doi:10.1007/s12035-019-1540-3 Peer Reviewed verified by ORBi |
Castro-Gomez, S., Binder, J., & HENEKA, M. (September 2019). Neuroinflammation als Motor der Alzheimer-Erkrankung. Nervenarzt, 90 (9), 898 - 906. doi:10.1007/s00115-019-0778-3 Peer Reviewed verified by ORBi |
Bertens, D., Vos, S., Kehoe, P., Wolf, H., Nobili, F., Mendonça, A., van Rossum, I., Hort, J., Molinuevo, J. L., HENEKA, M., Petersen, R., Scheltens, P., & Visser, P. J. (22 August 2019). Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey. Alzheimer's Research and Therapy, 11 (1), 74. doi:10.1186/s13195-019-0525-9 Peer Reviewed verified by ORBi |
Esteve, P., Rueda-Carrasco, J., Inés Mateo, M., Martin-Bermejo, M. J., Draffin, J., Pereyra, G., Sandonís, Á., Crespo, I., Moreno, I., Aso, E., Garcia-Esparcia, P., Gomez-Tortosa, E., Rábano, A., Fortea, J., Alcolea, D., Lleo, A., HENEKA, M., Valpuesta, J. M., Esteban, J. A., ... Bovolenta, P. (August 2019). Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis. Nature Neuroscience, 22 (8), 1258 - 1268. doi:10.1038/s41593-019-0432-1 Peer Reviewed verified by ORBi |
Miebach, L., Wolfsgruber, S., Polcher, A., Peters, O., Menne, F., Luther, K., Incesoy, E., Priller, J., Spruth, E., Altenstein, S., Buerger, K., Catak, C., Janowitz, D., Perneczky, R., Utecht, J., Laske, C., Buchmann, M., Schneider, A., Fliessbach, K., ... Wagner, M. (31 July 2019). Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study. Alzheimer's Research and Therapy, 11 (1), 66. doi:10.1186/s13195-019-0515-y Peer Reviewed verified by ORBi |
HENEKA, M., McManus, R. M., & Latz, E. (March 2019). Author Correction: Inflammasome signalling in brain function and neurodegenerative disease. Nature Reviews. Neuroscience, 20 (3), 187. doi:10.1038/s41583-019-0137-1 Peer Reviewed verified by ORBi |
Hu, X., Teunissen, C. E., Spottke, A., HENEKA, M., Düzel, E., Peters, O., Li, S., Priller, J., Buerger, K., Teipel, S., Laske, C., Verfaillie, S. C. J., Barkhof, F., Coll-Padrós, N., Rami, L., Molinuevo, J. L., van der Flier, W. M., & Jessen, F. (February 2019). Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 15 (2), 185 - 193. doi:10.1016/j.jalz.2018.09.002 Peer Reviewed verified by ORBi |
HENEKA, M. (February 2019). Microglia take centre stage in neurodegenerative disease. Nature Reviews. Immunology, 19 (2), 79 - 80. doi:10.1038/s41577-018-0112-5 Peer Reviewed verified by ORBi |
Wolfsgruber, S., Molinuevo, J. L., Wagner, M., Teunissen, C. E., Rami, L., Coll-Padrós, N., Bouwman, F. H., Slot, R. E. R., Wesselman, L. M. P., Peters, O., Luther, K., Buerger, K., Priller, J., Laske, C., Teipel, S., Spottke, A., HENEKA, M., Düzel, E., Drzezga, A., ... Euro-SCD working group. (17 January 2019). Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimer's Research and Therapy, 11 (1), 8. doi:10.1186/s13195-018-0463-y Peer Reviewed verified by ORBi |
Teipel, S. J., Kuper-Smith, J. O., Bartels, C., Brosseron, F., Buchmann, M., Buerger, K., Catak, C., Janowitz, D., Dechent, P., Dobisch, L., Ertl-Wagner, B., Fließbach, K., Haynes, J.-D., HENEKA, M., Kilimann, I., Laske, C., Li, S., Menne, F., Metzger, C. D., ... DELCODE study group. (2019). Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer's Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness. Journal of Alzheimer's Disease, 72 (2), 455 - 465. doi:10.3233/JAD-190446 Peer Reviewed verified by ORBi |
Tejera, D., & HENEKA, M. (2019). Microglia in Neurodegenerative Disorders. Methods in Molecular Biology, 2034, 57 - 67. doi:10.1007/978-1-4939-9658-2_5 Peer Reviewed verified by ORBi |
Tejera, D., & HENEKA, M. (2019). In Vivo Phagocytosis Analysis of Amyloid Beta. Methods in Molecular Biology, 2034, 287 - 292. doi:10.1007/978-1-4939-9658-2_21 Peer Reviewed verified by ORBi |
Traschütz, A., & HENEKA, M. (2019). Screening for Niemann-Pick Type C Disease in a Memory Clinic Cohort. JIMD Reports, 44, 109 - 114. doi:10.1007/8904_2018_133 Peer Reviewed verified by ORBi |
Traschütz, A., Kummer, M. P., Schwartz, S., & HENEKA, M. (December 2018). Variability and temporal dynamics of novel object recognition in aging male C57BL/6 mice. Behavioural Processes, 157, 711 - 716. doi:10.1016/j.beproc.2017.11.009 Peer Reviewed verified by ORBi |
HENEKA, M., McManus, R. M., & Latz, E. (October 2018). Inflammasome signalling in brain function and neurodegenerative disease. Nature Reviews. Neuroscience, 19 (10), 610 - 621. doi:10.1038/s41583-018-0055-7 Peer Reviewed verified by ORBi |
Rammes, G., Seeser, F., Mattusch, K., Zhu, K., Haas, L., Kummer, M., HENEKA, M., Herms, J., & Parsons, C. G. (15 September 2018). The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP). Neuropharmacology, 140, 184 - 192. doi:10.1016/j.neuropharm.2018.07.021 Peer Reviewed verified by ORBi |
Tzeng, T.-C., Hasegawa, Y., Iguchi, R., Cheung, A., Caffrey, D. R., Thatcher, E. J., Mao, W., Germain, G., Tamburro, N. D., Okabe, S., HENEKA, M., Latz, E., Futai, K., & Golenbock, D. T. (04 September 2018). Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proceedings of the National Academy of Sciences of the United States of America, 115 (36), 9002 - 9007. doi:10.1073/pnas.1801802115 Peer Reviewed verified by ORBi |
Unger, M. S., Marschallinger, J., Kaindl, J., Klein, B., Johnson, M., Khundakar, A. A., Roßner, S., HENEKA, M., Couillard-Despres, S., Rockenstein, E., Masliah, E., Attems, J., & Aigner, L. (August 2018). Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology? Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 14 (8), 1022 - 1037. doi:10.1016/j.jalz.2018.02.017 Peer Reviewed verified by ORBi |
Ludolph, A. C.* , Schuster, J.* , Dorst, J., Dupuis, L., Dreyhaupt, J., Weishaupt, J. H., Kassubek, J., Weiland, U., Petri, S., Meyer, T., Grosskreutz, J., Schrank, B., Boentert, M., Emmer, A., Hermann, A., Zeller, D., Prudlo, J., Winkler, A. S., Grehl, T., ... RAS-ALS Study Group. (August 2018). Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial. The Lancet Neurology, 17 (8), 681 - 688. doi:10.1016/S1474-4422(18)30176-5 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Enkirch, S. J., Traschütz, A., Müller, A., Widmann, C. N., Gielen, G. H., HENEKA, M., Jurcoane, A., Schild, H. H., & Hattingen, E. (July 2018). The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease. Radiology, 288 (1), 226 - 333. doi:10.1148/radiol.2018171888 Peer Reviewed verified by ORBi |
Lehmer, C., Schludi, M. H., Ransom, L., Greiling, J., Junghänel, M., Exner, N., Riemenschneider, H., van der Zee, J., Van Broeckhoven, C., Weydt, P., HENEKA, M., & Edbauer, D. (June 2018). A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS. EMBO Molecular Medicine, 10 (6). doi:10.15252/emmm.201708558 Peer Reviewed verified by ORBi |
Kalinin, S., González-Prieto, M., Scheiblich, H., Lisi, L., Kusumo, H., HENEKA, M., Madrigal, J. L. M., Pandey, S. C., & Feinstein, D. L. (14 May 2018). Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. Journal of Neuroinflammation, 15 (1), 141. doi:10.1186/s12974-018-1184-7 Peer Reviewed verified by ORBi |
Dansokho, C., & HENEKA, M. (May 2018). Neuroinflammatory responses in Alzheimer's disease. Journal of Neural Transmission, 125 (5), 771 - 779. doi:10.1007/s00702-017-1831-7 Peer Reviewed verified by ORBi |
Franzmeier, N., Düzel, E., Jessen, F., Buerger, K., Levin, J., Duering, M., Dichgans, M., Haass, C., Suárez-Calvet, M., Fagan, A. M., Paumier, K., Benzinger, T., Masters, C. L., Morris, J. C., Perneczky, R., Janowitz, D., Catak, C., Wolfsgruber, S., Wagner, M., ... Ewers, M. (01 April 2018). Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain: a Journal of Neurology, 141 (4), 1186 - 1200. doi:10.1093/brain/awy008 Peer Reviewed verified by ORBi |
Brosseron, F., Traschütz, A., Widmann, C. N., Kummer, M. P., Tacik, P., Santarelli, F., Jessen, F., & HENEKA, M. (26 February 2018). Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimer's Research and Therapy, 10 (1), 25. doi:10.1186/s13195-018-0353-3 Peer Reviewed verified by ORBi |
Villacampa, N., & HENEKA, M. (20 February 2018). Microglia: You'll Never Walk Alone! Immunity, 48 (2), 195 - 197. doi:10.1016/j.immuni.2018.02.009 Peer Reviewed verified by ORBi |
Jessen, F., Spottke, A., Boecker, H., Brosseron, F., Buerger, K., Catak, C., Fliessbach, K., Franke, C., Fuentes, M., HENEKA, M., Janowitz, D., Kilimann, I., Laske, C., Menne, F., Nestor, P., Peters, O., Priller, J., Pross, V., Ramirez, A., ... Düzel, E. (07 February 2018). Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimer's Research and Therapy, 10 (1), 15. doi:10.1186/s13195-017-0314-2 Peer Reviewed verified by ORBi |
Zimmermann, J., Emrich, M., Krauthausen, M., Saxe, S., Nitsch, L., HENEKA, M., Campbell, I. L., & Müller, M. (February 2018). IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination. Molecular Neurobiology, 55 (2), 946 - 957. doi:10.1007/s12035-016-0368-3 Peer Reviewed verified by ORBi |
Labzin, L. I., HENEKA, M., & Latz, E. (29 January 2018). Innate Immunity and Neurodegeneration. Annual Review of Medicine, 69 (1), 437 - 449. doi:10.1146/annurev-med-050715-104343 Peer Reviewed verified by ORBi |
Ising, C., & HENEKA, M. (25 January 2018). Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration. Cell Death and Disease, 9 (2), 120. doi:10.1038/s41419-017-0153-x Peer Reviewed verified by ORBi |
Faivre, E., Coelho, J. E., Zornbach, K., Malik, E., Baqi, Y., Schneider, M., Cellai, L., Carvalho, K., Sebda, S., Figeac, M., Eddarkaoui, S., Caillierez, R., Chern, Y., HENEKA, M., Sergeant, N., Müller, C. E., Halle, A., Buée, L., Lopes, L. V., & Blum, D. (2018). Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Frontiers in Molecular Neuroscience, 11, 235. doi:10.3389/fnmol.2018.00235 Peer Reviewed verified by ORBi |
Teipel, S. J., Metzger, C. D., Brosseron, F., Buerger, K., Brueggen, K., Catak, C., Diesing, D., Dobisch, L., Fliebach, K., Franke, C., HENEKA, M., Kilimann, I., Kofler, B., Menne, F., Peters, O., Polcher, A., Priller, J., Schneider, A., Spottke, A., ... DELCODE study group. (2018). Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease. Journal of Alzheimer's Disease, 64 (3), 801 - 813. doi:10.3233/JAD-180106 Peer Reviewed verified by ORBi |
Düzel, E., Berron, D., Schütze, H., Cardenas-Blanco, A., Metzger, C., Betts, M., Ziegler, G., Chen, Y., Dobisch, L., Bittner, D., Glanz, W., Reuter, M., Spottke, A., Rudolph, J., Brosseron, F., Buerger, K., Janowitz, D., Fliessbach, K., HENEKA, M., ... Jessen, F. (2018). CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 10 (1), 782 - 790. doi:10.1016/j.dadm.2018.10.003 Peer Reviewed verified by ORBi |
Ativie, F.* , Komorowska, J. A.* , Beins, E., Albayram, Ö., Zimmer, T., Zimmer, A., Tejera, D., HENEKA, M., & Bilkei-Gorzo, A. (2018). Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity. Frontiers in Molecular Neuroscience, 11, 295. doi:10.3389/fnmol.2018.00295 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Kaczmarczyk, R., Tejera, D., Simon, B. J., & HENEKA, M. (21 December 2017). Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease. Journal of Neurochemistry, 146 (1), 76 - 85. doi:10.1111/jnc.14284 Peer Reviewed verified by ORBi |
Venegas, C., Kumar, S., Franklin, B. S., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M. P., Griep, A., Gelpi, E., Beilharz, M., Riedel, D., Golenbock, D. T., Geyer, M., Walter, J., Latz, E., & HENEKA, M. (20 December 2017). Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease. Nature, 552 (7685), 355 - 361. doi:10.1038/nature25158 Peer Reviewed verified by ORBi |
Tejera, D., & HENEKA, M. (20 December 2017). United Again: STING and the Police. Neuron, 96 (6), 1207 - 1208. doi:10.1016/j.neuron.2017.12.015 Peer Reviewed verified by ORBi |
Ardura-Fabregat, A., Boddeke, E. W. G. M., Boza-Serrano, A., Brioschi, S., Castro-Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., HENEKA, M., Hoeijmakers, L., Hoffmann, A., Iaccarino, L., Jahnert, S., Kuhbandner, K., Landreth, G., Lonnemann, N., Löschmann, P. A., McManus, R. M., ... Yang, Y. (December 2017). Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS Drugs, 31 (12), 1057 - 1082. doi:10.1007/s40263-017-0483-3 Peer Reviewed verified by ORBi |
Scheiblich, H., Schlütter, A., Golenbock, D. T., Latz, E., Martinez-Martinez, P., & HENEKA, M. (December 2017). Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of Neurochemistry, 143 (5), 534 - 550. doi:10.1111/jnc.14225 Peer Reviewed verified by ORBi |
Wijasa, T. S., Sylvester, M., Brocke-Ahmadinejad, N., Kummer, M. P., Brosseron, F., Gieselmann, V., & HENEKA, M. (01 November 2017). Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags. Journal of Neuroscience Methods, 291, 95 - 100. doi:10.1016/j.jneumeth.2017.08.005 Peer Reviewed verified by ORBi |
Sarlus, H., & HENEKA, M. (01 September 2017). Microglia in Alzheimer's disease. Journal of Clinical Investigation, 127 (9), 3240 - 3249. doi:10.1172/JCI90606 Peer Reviewed verified by ORBi |
Müller, S., Preische, O., Göpfert, J. C., Yañez, V. A. C., Joos, T. O., Boecker, H., Düzel, E., Falkai, P., Priller, J., Buerger, K., Catak, C., Janowitz, D., HENEKA, M., Brosseron, F., Nestor, P., Peters, O., Menne, F., Schipke, C. G., Schneider, A., ... Laske, C. (25 August 2017). Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Scientific Reports, 7 (1), 9529. doi:10.1038/s41598-017-08779-0 Peer Reviewed verified by ORBi |
Simchovitz, A., HENEKA, M., & Soreq, H. (August 2017). Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of Neurochemistry, 142 Suppl 2 (Suppl Suppl 2), 178 - 187. doi:10.1111/jnc.13928 Peer Reviewed verified by ORBi |
Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., HENEKA, M., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., ... Dinarello, C. A. (19 July 2017). A guiding map for inflammation. Nature Immunology, 18 (8), 826 - 831. doi:10.1038/ni.3790 Peer Reviewed verified by ORBi |
Kemmerling, N., Wunderlich, P., Theil, S., Linnartz-Gerlach, B., Hersch, N., Hoffmann, B., HENEKA, M., de Strooper, B., Neumann, H., & Walter, J. (July 2017). Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia. Glia, 65 (7), 1103 - 1118. doi:10.1002/glia.23147 Peer Reviewed verified by ORBi |
McManus, R. M., & HENEKA, M. (04 March 2017). Role of neuroinflammation in neurodegeneration: new insights. Alzheimer's Research and Therapy, 9 (1), 14. doi:10.1186/s13195-017-0241-2 Peer Reviewed verified by ORBi |
van der Zee, J., Gijselinck, I., Van Mossevelde, S., Perrone, F., Dillen, L., Heeman, B., Bäumer, V., Engelborghs, S., De Bleecker, J., Baets, J., Gelpi, E., Rojas-García, R., Clarimón, J., Lleó, A., Diehl-Schmid, J., Alexopoulos, P., Perneczky, R., Synofzik, M., Just, J., ... Testi, S. (March 2017). TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Human Mutation, 38 (3), 297 - 309. doi:10.1002/humu.23161 Peer Reviewed verified by ORBi |
HENEKA, M. (March 2017). Inflammasome activation and innate immunity in Alzheimer's disease. Brain Pathology, 27 (2), 220 - 222. doi:10.1111/bpa.12483 Peer Reviewed verified by ORBi |
Venegas, C., & HENEKA, M. (January 2017). Danger-associated molecular patterns in Alzheimer's disease. Journal of Leukocyte Biology, 101 (1), 87 - 98. doi:10.1189/jlb.3MR0416-204R Peer Reviewed verified by ORBi |
Unger, M. S., Marschallinger, J., Kaindl, J., Höfling, C., Rossner, S., HENEKA, M., Van der Linden, A., & Aigner, L. (October 2016). Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease. Molecular Neurobiology, 53 (8), 5796 - 5806. doi:10.1007/s12035-016-0018-9 Peer Reviewed verified by ORBi |
HENEKA, M., & Nicotera, P. (05 May 2016). Thoughts on Obesity and Brain Glucose. Cell, 165 (4), 773 - 775. doi:10.1016/j.cell.2016.04.057 Peer Reviewed verified by ORBi |
Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., HENEKA, M., Struyfs, H., Engelborghs, S., ... Haass, C. (May 2016). sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO Molecular Medicine, 8 (5), 466 - 476. doi:10.15252/emmm.201506123 Peer Reviewed verified by ORBi |
Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., De Nardo, D., Labzin, L. I., Kerksiek, A., Hempel, C., HENEKA, M., Hawxhurst, V., Fitzgerald, M. L., Trebicka, J., Björkhem, I., Gustafsson, J.-Å., Westerterp, M., Tall, A. R., ... Latz, E. (06 April 2016). Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 (333), 333ra50. doi:10.1126/scitranslmed.aad6100 Peer Reviewed verified by ORBi |
Vercruysse, P., Sinniger, J., El Oussini, H., Scekic-Zahirovic, J., Dieterlé, S., Dengler, R., Meyer, T., Zierz, S., Kassubek, J., Fischer, W., Dreyhaupt, J., Grehl, T., Hermann, A., Grosskreutz, J., Witting, A., Van Den Bosch, L., Spreux-Varoquaux, O., GERP ALS Study, G., Ludolph, A. C., ... Wessig, C. (Other coll.). (April 2016). Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis. Brain: a Journal of Neurology, 139 (Pt 4), 1106-22. doi:10.1093/brain/aww004 Peer Reviewed verified by ORBi |
Tejera, D., & HENEKA, M. (2016). Microglia in Alzheimer's disease: the good, the bad and the ugly. Current Alzheimer Research, 13 (4), 370 - 380. doi:10.2174/1567205013666151116125012 Peer Reviewed verified by ORBi |
Traschütz, A., Tzaridis, T., Penner, A.-H., Kuchelmeister, K., Urbach, H., Hattingen, E., & HENEKA, M. (December 2015). Reduction of microbleeds by immunosuppression in a patient with Aβ-related vascular inflammation. Neurology: Neuroimmunology and Neuroinflammation, 2 (6), 165. doi:10.1212/NXI.0000000000000165 Peer Reviewed verified by ORBi |
Hong, G.-S., Schwandt, T., Stein, K., Schneiker, B., Kummer, M. P., HENEKA, M., Kitamura, K., Kalff, J. C., & Wehner, S. (November 2015). Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model. British Journal of Surgery, 102 (12), 1506 - 1516. doi:10.1002/bjs.9907 Peer Reviewed verified by ORBi |
Willem, M., Tahirovic, S., Busche, M. A., Ovsepian, S. V., Chafai, M., Kootar, S., Hornburg, D., Evans, L. D. B., Moore, S., Daria, A., Hampel, H., Müller, V., Giudici, C., Nuscher, B., Wenninger-Weinzierl, A., Kremmer, E., HENEKA, M., Thal, D. R., Giedraitis, V., ... Haass, C. (15 October 2015). η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature, 526 (7573), 443 - 447. doi:10.1038/nature14864 Peer Reviewed verified by ORBi |
Kurzwelly, D., Krüger, S., Biskup, S., & HENEKA, M. (September 2015). A distinct clinical phenotype in a German kindred with motor neuron disease carrying a CHCHD10 mutation. Brain: a Journal of Neurology, 138 (Pt 9), 376. doi:10.1093/brain/awv014 Peer Reviewed verified by ORBi |
HENEKA, M., Fink, A., & Doblhammer, G. (August 2015). Effect of pioglitazone medication on the incidence of dementia. Annals of Neurology, 78 (2), 284 - 294. doi:10.1002/ana.24439 Peer Reviewed verified by ORBi |
Schmidt, R., Hofer, E., Bouwman, F. H., Buerger, K., Cordonnier, C., Fladby, T., Galimberti, D., Georges, J., HENEKA, M., Hort, J., Laczó, J., Molinuevo, J. L., O'Brien, J. T., Religa, D., Scheltens, P., Schott, J. M., & Sorbi, S. (June 2015). EFNS-ENS/EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer's disease. European Journal of Neurology, 22 (6), 889 - 898. doi:10.1111/ene.12707 Peer Reviewed verified by ORBi |
Heilmann, S., Drichel, D., Clarimon, J., Fernández, V., Lacour, A., Wagner, H., Thelen, M., Hernández, I., Fortea, J., Alegret, M., Blesa, R., Mauleón, A., Roca, M. R., Kornhuber, J., Peters, O., Heun, R., Frölich, L., Hüll, M., HENEKA, M., ... Ramirez, A. (02 April 2015). PLD3 in non-familial Alzheimer's disease. Nature, 520 (7545), 3 - E5. doi:10.1038/nature14039 Peer Reviewed verified by ORBi |
Kummer, M. P., Schwarzenberger, R., Sayah-Jeanne, S., Dubernet, M., Walczak, R., Hum, D. W., Schwartz, S., Axt, D., & HENEKA, M. (April 2015). Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits. Molecular Neurobiology, 51 (2), 661 - 671. doi:10.1007/s12035-014-8743-4 Peer Reviewed verified by ORBi |
HENEKA, M., Carson, M. J., El Khoury, J., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., Herrup, K., Frautschy, S. A., Finsen, B., Brown, G. C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., ... Kummer, M. P. (April 2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14 (4), 388 - 405. doi:10.1016/S1474-4422(15)70016-5 Peer Reviewed verified by ORBi |
HENEKA, M., Golenbock, D. T., & Latz, E. (March 2015). Innate immunity in Alzheimer's disease. Nature Immunology, 16 (3), 229 - 236. doi:10.1038/ni.3102 Peer Reviewed verified by ORBi |
Lindlau, A., Widmann, C. N., Putensen, C., Jessen, F., Semmler, A., & HENEKA, M. (February 2015). Predictors of hippocampal atrophy in critically ill patients. European Journal of Neurology, 22 (2), 410 - 415. doi:10.1111/ene.12443 Peer Reviewed verified by ORBi |
Krauthausen, M., Kummer, M. P., Zimmermann, J., Reyes-Irisarri, E., Terwel, D., Bulic, B., HENEKA, M., & Müller, M. (January 2015). CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. Journal of Clinical Investigation, 125 (1), 365 - 378. doi:10.1172/JCI66771 Peer Reviewed verified by ORBi |
Lovestone, S., Boada, M., Dubois, B., Hüll, M., Rinne, J. O., Huppertz, H.-J., Calero, M., Andrés, M. V., Gómez-Carrillo, B., León, T., del Ser, T., ARGO, I., Fernández, M. (Other coll.), Pérez de las Heras, S. (Other coll.), Alom, J. (Other coll.), Sola, D. (Other coll.), Sánchez-Valle, R. (Other coll.), Molinuevo, J. L. (Other coll.), LLadó, A. (Other coll.), ... Keskinarkaus, I. (Other coll.). (2015). A phase II trial of tideglusib in Alzheimer's disease. Journal of Alzheimer's Disease, 45 (1), 75-88. doi:10.3233/JAD-141959 Peer Reviewed verified by ORBi |
Bach, J.-P., Gold, M., Mengel, D., Hattesohl, A., Lubbe, D., Schmid, S., Tackenberg, B., Rieke, J., Maddula, S., Baumbach, J. I., Nell, C., Boeselt, T., Michelis, J., Alferink, J., HENEKA, M., Oertel, W., Jessen, F., Janciauskiene, S., Vogelmeier, C., ... Koczulla, A. R. (2015). Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson's Disease. PLoS ONE, 10 (7), 0132227. doi:10.1371/journal.pone.0132227 Peer Reviewed verified by ORBi |
Meiberth, D., Scheef, L., Wolfsgruber, S., Boecker, H., Block, W., Träber, F., Erk, S., HENEKA, M., Jacobi, H., Spottke, A., Walter, H., Wagner, M., Hu, X., & Jessen, F. (2015). Cortical thinning in individuals with subjective memory impairment. Journal of Alzheimer's Disease, 45 (1), 139 - 146. doi:10.3233/JAD-142322 Peer Reviewed verified by ORBi |
Ramirez, A., van der Flier, W. M., Herold, C., Ramonet, D., Heilmann, S., Lewczuk, P., Popp, J., Lacour, A., Drichel, D., Louwersheimer, E., Kummer, M. P., Cruchaga, C., Hoffmann, P., Teunissen, C., Holstege, H., Kornhuber, J., Peters, O., Naj, A. C., Chouraki, V., ... Nöthen, M. M. (15 December 2014). SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human Molecular Genetics, 23 (24), 6644 - 6658. doi:10.1093/hmg/ddu372 Peer Reviewed verified by ORBi |
Thelen, M., Razquin, C., Hernández, I., Gorostidi, A., Sánchez-Valle, R., Ortega-Cubero, S., Wolfsgruber, S., Drichel, D., Fliessbach, K., Duenkel, T., Damian, M., Heilmann, S., Slotosch, A., Lennarz, M., Seijo-Martínez, M., Rene, R., Kornhuber, J., Peters, O., Luckhaus, C., ... Ramirez, A. (November 2014). Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. Neurobiology of Aging, 35 (11), 2657.e13 - 2657.e19. doi:10.1016/j.neurobiolaging.2014.06.018 Peer Reviewed verified by ORBi |
Brosseron, F., Krauthausen, M., Kummer, M., & HENEKA, M. (October 2014). Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview. Molecular Neurobiology, 50 (2), 534 - 544. doi:10.1007/s12035-014-8657-1 Peer Reviewed verified by ORBi |
Widmann, C. N., Schewe, J.-C., & HENEKA, M. (October 2014). Sepsis-associated encephalopathy versus sepsis-induced encephalopathy--authors' reply. The Lancet Neurology, 13 (10), 968 - 969. doi:10.1016/S1474-4422(14)70204-2 Peer Reviewed verified by ORBi |
van der Zee, J., Van Langenhove, T., Kovacs, G. G., Dillen, L., Deschamps, W., Engelborghs, S., Matěj, R., Vandenbulcke, M., Sieben, A., Dermaut, B., Smets, K., Van Damme, P., Merlin, C., Laureys, A., Van Den Broeck, M., Mattheijssens, M., Peeters, K., Benussi, L., Binetti, G., ... Van Broeckhoven, C. (September 2014). Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration. Acta Neuropathologica, 128 (3), 397 - 410. doi:10.1007/s00401-014-1298-7 Peer Reviewed verified by ORBi |
Gockel, I.* , Becker, J.* , Wouters, M. M., Niebisch, S., Gockel, H. R., Hess, T., Ramonet, D., Zimmermann, J., Vigo, A. G., Trynka, G., de León, A. R., de la Serna, J. P., Urcelay, E., Kumar, V., Franke, L., Westra, H.-J., Drescher, D., Kneist, W., Marquardt, J. U., ... Schumacher, J.*. (August 2014). Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nature Genetics, 46 (8), 901 - 904. doi:10.1038/ng.3029 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
HENEKA, M. (28 July 2014). Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction. Journal of Experimental Medicine, 211 (8), 1500. doi:10.1084/jem.2118insight1 Peer Reviewed verified by ORBi |
Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., Tahirovic, S., Lleó, A., Alcolea, D., Fortea, J., Willem, M., Lammich, S., Molinuevo, J. L., Sánchez-Valle, R., Antonell, A., ... Haass, C. (02 July 2014). TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine, 6 (243), 243ra86. doi:10.1126/scitranslmed.3009093 Peer Reviewed verified by ORBi |
HENEKA, M., Kummer, M. P., & Latz, E. (July 2014). Innate immune activation in neurodegenerative disease. Nature Reviews. Immunology, 14 (7), 463 - 477. doi:10.1038/nri3705 Peer Reviewed verified by ORBi |
Kummer, M. P.* , Hammerschmidt, T.* , Martinez, A., Terwel, D., Eichele, G., Witten, A., Figura, S., Stoll, M., Schwartz, S., Pape, H.-C., Schultze, J. L., Weinshenker, D., HENEKA, M., & Urban, I. (25 June 2014). Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. Journal of Neuroscience, 34 (26), 8845 - 8854. doi:10.1523/JNEUROSCI.4027-13.2014 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Krauthausen, M.* , Saxe, S.* , Zimmermann, J., Emrich, M., HENEKA, M., & Müller, M. (16 June 2014). CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system. Journal of Neuroinflammation, 11 (1), 109. doi:10.1186/1742-2094-11-109 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
HENEKA, M., & Widmann Catherine. (June 2014). Michael Thomas Heneka. The Lancet Neurology, 13 (6), 542. doi:10.1016/s1474-4422(14)70107-3 Peer Reviewed verified by ORBi |
Widmann, C. N., & HENEKA, M. (June 2014). Long-term cerebral consequences of sepsis. The Lancet Neurology, 13 (6), 630 - 636. doi:10.1016/S1474-4422(14)70017-1 Peer Reviewed verified by ORBi |
Malhotra, A., Younesi, E., Gündel, M., Müller, B., HENEKA, M., & Hofmann-Apitius, M. (March 2014). ADO: a disease ontology representing the domain knowledge specific to Alzheimer's disease. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 10 (2), 238 - 246. doi:10.1016/j.jalz.2013.02.009 Peer Reviewed verified by ORBi |
Peter, J., Scheef, L., Abdulkadir, A., Boecker, H., HENEKA, M., Wagner, M., Koppara, A., Klöppel, S., Jessen, F., & Alzheimer's Disease Neuroimaging Initiative. (January 2014). Gray matter atrophy pattern in elderly with subjective memory impairment. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 10 (1), 99 - 108. doi:10.1016/j.jalz.2013.05.1764 Peer Reviewed verified by ORBi |
Kummer, M. P., & HENEKA, M. (2014). Truncated and modified amyloid-beta species. Alzheimer's Research and Therapy, 6 (3), 28. doi:10.1186/alzrt258 Peer Reviewed verified by ORBi |
Mattsson, N., Andreasson, U., Persson, S., Carrillo, M. C., Collins, S., Chalbot, S., Cutler, N., Dufour-Rainfray, D., Fagan, A. M., Heegaard, N. H. H., Robin Hsiung, G.-Y., Hyman, B., Iqbal, K., Kaeser, S. A., Lachno, D. R., Lleó, A., Lewczuk, P., Molinuevo, J. L., Parchi, P., ... Blennow, K. (Other coll.). (May 2013). CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 9 (3), 251-61. doi:10.1016/j.jalz.2013.01.010 Peer Reviewed verified by ORBi |
Hammerschmidt, T., Kummer, M. P., Terwel, D., Martinez, A., Gorji, A., Pape, H.-C., Rommelfanger, K. S., Schroeder, J. P., Stoll, M., Schultze, J., Weinshenker, D., & HENEKA, M. (01 March 2013). Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice. Biological Psychiatry, 73 (5), 454 - 463. doi:10.1016/j.biopsych.2012.06.013 Peer Reviewed verified by ORBi |
van der Zee, J.* , Gijselinck, I.* , Dillen, L., Van Langenhove, T., Theuns, J., Engelborghs, S., Philtjens, S., Vandenbulcke, M., Sleegers, K., Sieben, A., Bäumer, V., Maes, G., Corsmit, E., Borroni, B., Padovani, A., Archetti, S., Perneczky, R., Diehl-Schmid, J., de Mendonça, A., ... European Early-Onset Dementia Consortium. (February 2013). A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats. Human Mutation, 34 (2), 363 - 373. doi:10.1002/humu.22244 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
HENEKA, M., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., Gelpi, E., Halle, A., Korte, M., Latz, E., & Golenbock, D. T. (31 January 2013). NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature, 493 (7434), 674 - 678. doi:10.1038/nature11729 Peer Reviewed verified by ORBi |
Semmler, A.* , Widmann, C. N.* , Okulla, T., Urbach, H., Kaiser, M., Widman, G., Mormann, F., Weide, J., Fliessbach, K., Hoeft, A., Jessen, F., Putensen, C., & HENEKA, M. (January 2013). Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors. Journal of Neurology, Neurosurgery and Psychiatry, 84 (1), 62 - 69. doi:10.1136/jnnp-2012-302883 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Molinuevo, J. L., Gispert, J. D., Dubois, B., HENEKA, M., Lleo, A., Engelborghs, S., Pujol, J., de Souza, L. C., Alcolea, D., Jessen, F., Sarazin, M., Lamari, F., Balasa, M., Antonell, A., & Rami, L. (2013). The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study. Journal of Alzheimer's Disease, 36 (1), 67 - 77. doi:10.3233/JAD-130203 Peer Reviewed verified by ORBi |
Zimmermann, J., Krauthausen, M., Hofer, M. J., HENEKA, M., Campbell, I. L., & Müller, M. (2013). CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia. PLoS ONE, 8 (2), 57307. doi:10.1371/journal.pone.0057307 Peer Reviewed verified by ORBi |
Okroglic, S., Widmann, C. N., Urbach, H., Scheltens, P., & HENEKA, M. (2013). Clinical symptoms and risk factors in cerebral microangiopathy patients. PLoS ONE, 8 (2), 53455. doi:10.1371/journal.pone.0053455 Peer Reviewed verified by ORBi |
Chalermpalanupap, T., Kinkead, B., Hu, W. T., Kummer, M. P., Hammerschmidt, T., HENEKA, M., Weinshenker, D., & Levey, A. I. (2013). Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease. Alzheimer's Research and Therapy, 5 (2), 21. doi:10.1186/alzrt175 Peer Reviewed verified by ORBi |
Gaikwad, S. M., & HENEKA, M. (2013). Studying M1 and M2 states in adult microglia. Methods in Molecular Biology, 1041, 185 - 197. doi:10.1007/978-1-62703-520-0_18 Peer Reviewed verified by ORBi |
Semmler, A., Okulla, T., Kaiser, M., Seifert, B., & HENEKA, M. (January 2013). Long-term neuromuscular sequelae of critical illness. Journal of Neurology, 260 (1), 151 - 157. doi:10.1007/s00415-012-6605-4 Peer Reviewed verified by ORBi |
Rapic, S., Backes, H., Viel, T., Kummer, M. P., Monfared, P., Neumaier, B., Vollmar, S., Hoehn, M., Van der Linden, A., HENEKA, M., & Jacobs, A. H. (January 2013). Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. Neurobiology of Aging, 34 (1), 351 - 354. doi:10.1016/j.neurobiolaging.2012.04.016 Peer Reviewed verified by ORBi |
Kummer, M. P., Vogl, T., Axt, D., Griep, A., Vieira-Saecker, A., Jessen, F., Gelpi, E., Roth, J., & HENEKA, M. (05 December 2012). Mrp14 deficiency ameliorates amyloid β burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing. Journal of Neuroscience, 32 (49), 17824 - 17829. doi:10.1523/JNEUROSCI.1504-12.2012 Peer Reviewed verified by ORBi |
Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & HENEKA, M. (28 November 2012). PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. Journal of Neuroscience, 32 (48), 17321 - 17331. doi:10.1523/JNEUROSCI.1569-12.2012 Peer Reviewed verified by ORBi |
Scheef, L., Spottke, A., Daerr, M., Joe, A., Striepens, N., Kölsch, H., Popp, J., Daamen, M., Gorris, D., HENEKA, M., Boecker, H., Biersack, H. J., Maier, W., Schild, H. H., Wagner, M., & Jessen, F. (25 September 2012). Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology, 79 (13), 1332 - 1339. doi:10.1212/WNL.0b013e31826c1a8d Peer Reviewed verified by ORBi |
Jacobs, A. H., Tavitian, B., INMiND consortium, & HENEKA, M. (July 2012). Noninvasive molecular imaging of neuroinflammation. Journal of Cerebral Blood Flow and Metabolism, 32 (7), 1393 - 1415. doi:10.1038/jcbfm.2012.53 Peer Reviewed verified by ORBi |
Parpura, V., HENEKA, M., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., Pekny, M., Pekna, M., Zorec, R., & Verkhratsky, A. (April 2012). Glial cells in (patho)physiology. Journal of Neurochemistry, 121 (1), 4 - 27. doi:10.1111/j.1471-4159.2012.07664.x Peer Reviewed verified by ORBi |
Kummer, M. P., Hülsmann, C., Hermes, M., Axt, D., & HENEKA, M. (March 2012). Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice. Journal of Neuroimmune Pharmacology, 7 (1), 165 - 172. doi:10.1007/s11481-011-9339-7 Peer reviewed |
Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., Rübe, C. E., Walter, J., HENEKA, M., Hartmann, T., Menger, M. D., & Fassbender, K. (01 February 2012). TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. Journal of Immunology, 188 (3), 1098 - 1107. doi:10.4049/jimmunol.1101121 Peer Reviewed verified by ORBi |
Rey, N. L., Jardanhazi-Kurutz, D., Terwel, D., Kummer, M. P., Jourdan, F., Didier, A., & HENEKA, M. (February 2012). Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice. Neurobiology of Aging, 33 (2), 426.e1. doi:10.1016/j.neurobiolaging.2010.10.009 Peer Reviewed verified by ORBi |
Dupuis, L., Dengler, R., HENEKA, M., Meyer, T., Zierz, S., Kassubek, J., Fischer, W., Steiner, F., Lindauer, E., Otto, M., Dreyhaupt, J., Grehl, T., Hermann, A., Winkler, A. S., Bogdahn, U., Benecke, R., Schrank, B., Wessig, C., Grosskreutz, J., ... GERP ALS Study Group. (2012). A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis. PLoS ONE, 7 (6), 37885. doi:10.1371/journal.pone.0037885 Peer Reviewed verified by ORBi |
HENEKA, M., Reyes-Irisarri, E., Hüll, M., & Kummer, M. P. (December 2011). Impact and Therapeutic Potential of PPARs in Alzheimer's Disease. Current Neuropharmacology, 9 (4), 643 - 650. doi:10.2174/157015911798376325 Peer Reviewed verified by ORBi |
Krauthausen, M., Ellis, S. L., Zimmermann, J., Sarris, M., Wakefield, D., HENEKA, M., Campbell, I. L., & Müller, M. (November 2011). Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12. American Journal of Pathology, 179 (5), 2346 - 2359. doi:10.1016/j.ajpath.2011.07.041 Peer Reviewed verified by ORBi |
Kummer, M. P., Hermes, M., Delekarte, A., Hammerschmidt, T., Kumar, S., Terwel, D., Walter, J., Pape, H.-C., König, S., Roeber, S., Jessen, F., Klockgether, T., Korte, M., & HENEKA, M. (08 September 2011). Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron, 71 (5), 833 - 844. doi:10.1016/j.neuron.2011.07.001 Peer Reviewed verified by ORBi |
Juckel, G., Manitz, M. P., Brüne, M., Friebe, A., HENEKA, M., & Wolf, R. J. (September 2011). Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study. Schizophrenia Research, 131 (1-3), 96 - 100. doi:10.1016/j.schres.2011.06.018 Peer Reviewed verified by ORBi |
Mildner, A., Schlevogt, B., Kierdorf, K., Böttcher, C., Erny, D., Kummer, M. P., Quinn, M., Brück, W., Bechmann, I., HENEKA, M., Priller, J., & Prinz, M. (03 August 2011). Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. Journal of Neuroscience, 31 (31), 11159 - 11171. doi:10.1523/JNEUROSCI.6209-10.2011 Peer Reviewed verified by ORBi |
Terwel, D., Löschmann, Y.-N., Schmidt, H. H.-J., Schöler, H. R., Cantz, T., & HENEKA, M. (July 2011). Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. Journal of Neurochemistry, 118 (1), 105 - 112. doi:10.1111/j.1471-4159.2011.07278.x Peer Reviewed verified by ORBi |
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S. D., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, M. A., Carrillo, M. C., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, A. M., Forlenza, O., Frisoni, G. B., Galasko, D., ... Blennow, K. (July 2011). The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 7 (4), 386 - 395.e6. doi:10.1016/j.jalz.2011.05.2243 Peer Reviewed verified by ORBi |
Kumar, S., Rezaei-Ghaleh, N., Terwel, D., Thal, D. R., Richard, M., Hoch, M., Mc Donald, J. M., Wüllner, U., Glebov, K., HENEKA, M., Walsh, D. M., Zweckstetter, M., & Walter, J. (01 June 2011). Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO Journal, 30 (11), 2255 - 2265. doi:10.1038/emboj.2011.138 Peer Reviewed verified by ORBi |
Terwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & HENEKA, M. (11 May 2011). Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. Journal of Neuroscience, 31 (19), 7049 - 7059. doi:10.1523/JNEUROSCI.6546-10.2011 Peer Reviewed verified by ORBi |
Jardanhazi-Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Thiele, A., & HENEKA, M. (10 March 2011). Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience, 176, 396 - 407. doi:10.1016/j.neuroscience.2010.11.052 Peer Reviewed verified by ORBi |
HENEKA, M., Kummer, M. P., Weggen, S., Bulic, B., Multhaup, G., Münter, L., Hüll, M., Pflanzner, T., & Pietrzik, C. U. (March 2011). Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Current Alzheimer Research, 8 (2), 115 - 131. doi:10.2174/156720511795256099 Peer Reviewed verified by ORBi |
Perez Nievas, B. G., Hammerschmidt, T., Kummer, M. P., Terwel, D., Leza, J. C., & HENEKA, M. (January 2011). Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice. Journal of Neurochemistry, 116 (1), 43 - 52. doi:10.1111/j.1471-4159.2010.07083.x Peer Reviewed verified by ORBi |
Tamboli, I. Y., Barth, E., Christian, L., Siepmann, M., Kumar, S., Singh, S., Tolksdorf, K., HENEKA, M., Lütjohann, D., Wunderlich, P., & Walter, J. (26 November 2010). Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. Journal of Biological Chemistry, 285 (48), 37405 - 37414. doi:10.1074/jbc.M110.149468 Peer Reviewed verified by ORBi |
Jardanhazi-Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Dyrks, T., Thiele, A., & HENEKA, M. (November 2010). Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochemistry International, 57 (4), 375 - 382. doi:10.1016/j.neuint.2010.02.001 Peer Reviewed verified by ORBi |
Fleisher-Berkovich, S., Filipovich-Rimon, T., Ben-Shmuel, S., Hülsmann, C., Kummer, M. P., & HENEKA, M. (11 October 2010). Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides (i). Journal of Neuroinflammation, 7 (1), 61. doi:10.1186/1742-2094-7-61 Peer Reviewed verified by ORBi |
HENEKA, M., O'Banion, M. K., Terwel, D., & Kummer, M. P. (August 2010). Neuroinflammatory processes in Alzheimer's disease. Journal of Neural Transmission, 117 (8), 919 - 947. doi:10.1007/s00702-010-0438-z Peer Reviewed verified by ORBi |
HENEKA, M. (July 2010). Verlaufsmodifizierende Therapien der Alzheimer-Demenz. Nervenarzt, 81 (7), 807 - 814. doi:10.1007/s00115-010-3000-1 Peer Reviewed verified by ORBi |
HENEKA, M., Rodríguez, J. J., & Verkhratsky, A. (May 2010). Neuroglia in neurodegeneration. Brain Research Reviews, 63 (1-2), 189 - 211. doi:10.1016/j.brainresrev.2009.11.004 Peer Reviewed verified by ORBi |
HENEKA, M., Nadrigny, F., Regen, T., Martinez-Hernandez, A., Dumitrescu-Ozimek, L., Terwel, D., Jardanhazi-Kurutz, D., Walter, J., Kirchhoff, F., Hanisch, U.-K., & Kummer, M. P. (30 March 2010). Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proceedings of the National Academy of Sciences of the United States of America, 107 (13), 6058 - 6063. doi:10.1073/pnas.0909586107 Peer Reviewed verified by ORBi |
Schlachetzki, J. C. M., Fiebich, B. L., Haake, E., de Oliveira, A. C. P., Candelario-Jalil, E., HENEKA, M., & Hüll, M. (11 January 2010). Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. Journal of Neuroinflammation, 7 (1), 2. doi:10.1186/1742-2094-7-2 Peer Reviewed verified by ORBi |
Jäger, S., Leuchtenberger, S., Martin, A., Czirr, E., Wesselowski, J., Dieckmann, M., Waldron, E., Korth, C., Koo, E. H., HENEKA, M., Weggen, S., & Pietrzik, C. U. (December 2009). alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. Journal of Neurochemistry, 111 (6), 1369 - 1382. doi:10.1111/j.1471-4159.2009.06420.x Peer Reviewed verified by ORBi |
Weberpals, M., Hermes, M., Hermann, S., Kummer, M. P., Terwel, D., Semmler, A., Berger, M., Schäfers, M., & HENEKA, M. (11 November 2009). NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. Journal of Neuroscience, 29 (45), 14177 - 14184. doi:10.1523/JNEUROSCI.3238-09.2009 Peer Reviewed verified by ORBi |
Papi, A., Tatenhorst, L., Terwel, D., Hermes, M., Kummer, M. P., Orlandi, M., & HENEKA, M. (June 2009). PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. Journal of Neurochemistry, 109 (6), 1779 - 1790. doi:10.1111/j.1471-4159.2009.06111.x Peer Reviewed verified by ORBi |
HENEKA, M. (June 2009). Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients. Experimental Neurology, 217 (2), 237 - 239. doi:10.1016/j.expneurol.2009.03.013 Peer Reviewed verified by ORBi |
Tamboli, I. Y., Prager, K., Thal, D. R., Thelen, K. M., Dewachter, I., Pietrzik, C. U., St George-Hyslop, P., Sisodia, S. S., De Strooper, B., HENEKA, M., Filippov, M. A., Müller, U., van Leuven, F., Lütjohann, D., & Walter, J. (12 November 2008). Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. Journal of Neuroscience, 28 (46), 12097 - 12106. doi:10.1523/JNEUROSCI.2635-08.2008 Peer Reviewed verified by ORBi |
Semmler, A., Hermann, S., Mormann, F., Weberpals, M., Paxian, S. A., Okulla, T., Schäfers, M., Kummer, M. P., Klockgether, T., & HENEKA, M. (15 September 2008). Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. Journal of Neuroinflammation, 5 (1), 38. doi:10.1186/1742-2094-5-38 Peer Reviewed verified by ORBi |
Landreth, G., Jiang, Q., Mandrekar, S., & HENEKA, M. (July 2008). PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics, 5 (3), 481 - 489. doi:10.1016/j.nurt.2008.05.003 Peer Reviewed verified by ORBi |
Winkeler, A., Waerzeggers, Y., Klose, A., Monfared, P., Thomas, A. V., Schubert, M., HENEKA, M., & Jacobs, A. H. (March 2008). Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 35 Suppl 1 (Suppl 1), 107 - S113. doi:10.1007/s00259-007-0710-0 Peer Reviewed verified by ORBi |
Tatenhorst, L., Hahnen, E., & HENEKA, M. (2008). Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Research, 2008, 204514. doi:10.1155/2008/204514 Peer Reviewed verified by ORBi |
Seufert, S., Coras, R., Tränkle, C., Zlotos, D. P., Blümcke, I., Tatenhorst, L., HENEKA, M., & Hahnen, E. (2008). PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Research, 2008, 513943. doi:10.1155/2008/513943 Peer Reviewed verified by ORBi |
Jiang, Q., HENEKA, M., & Landreth, G. E. (2008). The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. CNS Drugs, 22 (1), 1 - 14. doi:10.2165/00023210-200822010-00001 Peer Reviewed verified by ORBi |
Kummer, M. P., & HENEKA, M. (2008). PPARs in Alzheimer's Disease. PPAR Research, 2008, 403896. doi:10.1155/2008/403896 Peer Reviewed verified by ORBi |
HENEKA, M., Landreth, G. E., & Hüll, M. (September 2007). Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nature Clinical Practice Neurology, 3 (9), 496 - 504. doi:10.1038/ncpneuro0586 Peer Reviewed verified by ORBi |
Kalinin, S., Gavrilyuk, V., Polak, P. E., Vasser, R., Zhao, J., HENEKA, M., & Feinstein, D. L. (August 2007). Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiology of Aging, 28 (8), 1206 - 1214. doi:10.1016/j.neurobiolaging.2006.06.003 Peer Reviewed verified by ORBi |
HENEKA, M., & Landreth, G. E. (August 2007). PPARs in the brain. Biochimica et Biophysica Acta, 1771 (8), 1031 - 1045. doi:10.1016/j.bbalip.2007.04.016 Peer Reviewed verified by ORBi |
Winkeler, A., Sena-Esteves, M., Paulis, L. E. M., Li, H., Waerzeggers, Y., Rückriem, B., Himmelreich, U., Klein, M., Monfared, P., Rueger, M. A., HENEKA, M., Vollmar, S., Hoehn, M., Fraefel, C., Graf, R., Wienhard, K., Heiss, W. D., & Jacobs, A. H. (13 June 2007). Switching on the lights for gene therapy. PLoS ONE, 2 (6), 528. doi:10.1371/journal.pone.0000528 Peer Reviewed verified by ORBi |
Semmler, A., Frisch, C., Debeir, T., Ramanathan, M., Okulla, T., Klockgether, T., & HENEKA, M. (April 2007). Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Experimental Neurology, 204 (2), 733 - 740. doi:10.1016/j.expneurol.2007.01.003 Peer Reviewed verified by ORBi |
HENEKA, M., & O'Banion, M. K. (March 2007). Inflammatory processes in Alzheimer's disease. Journal of Neuroimmunology, 184 (1-2), 69 - 91. doi:10.1016/j.jneuroim.2006.11.017 Peer Reviewed verified by ORBi |
Jacobs, A. H., Rueger, M. A., Winkeler, A., Li, H., Vollmar, S., Waerzeggers, Y., Rueckriem, B., Kummer, C., Dittmar, C., Klein, M., HENEKA, M., Herrlinger, U., Fraefel, C., Graf, R., Wienhard, K., & Heiss, W.-D. (15 February 2007). Imaging-guided gene therapy of experimental gliomas. Cancer Research, 67 (4), 1706 - 1715. doi:10.1158/0008-5472.CAN-06-2418 Peer Reviewed verified by ORBi |
Thees, C., Kaiser, M., Scholz, M., Semmler, A., HENEKA, M., Baumgarten, G., Hoeft, A., & Putensen, C. (2007). Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome. Critical Care, 11 (6), 123. doi:10.1186/cc6185 Peer Reviewed verified by ORBi |
Kummer, C., Winkeler, A., Dittmar, C., Bauer, B., Rueger, M. A., Rueckriem, B., HENEKA, M., Vollmar, S., Wienhard, K., Fraefel, C., Heiss, W.-D., & Jacobs, A. H. (2007). Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. Molecular Imaging, 6 (3), 181 - 192. doi:10.2310/7290.2007.00015 Peer Reviewed verified by ORBi |
Wahle, T., Thal, D. R., Sastre, M., Rentmeister, A., Bogdanovic, N., Famulok, M., HENEKA, M., & Walter, J. (06 December 2006). GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. Journal of Neuroscience, 26 (49), 12838 - 12846. doi:10.1523/JNEUROSCI.1982-06.2006 Peer Reviewed verified by ORBi |
Grommes, C., Landreth, G. E., Sastre, M., Beck, M., Feinstein, D. L., Jacobs, A. H., Schlegel, U., & HENEKA, M. (November 2006). Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment. Molecular Pharmacology, 70 (5), 1524 - 1533. doi:10.1124/mol.106.022194 Peer Reviewed verified by ORBi |
Ambrée, O., Leimer, U., Herring, A., Görtz, N., Sachser, N., HENEKA, M., Paulus, W., & Keyvani, K. (August 2006). Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. American Journal of Pathology, 169 (2), 544 - 552. doi:10.2353/ajpath.2006.051107 Peer Reviewed verified by ORBi |
Sundararajan, S., Jiang, Q., HENEKA, M., & Landreth, G. (July 2006). PPARgamma as a therapeutic target in central nervous system diseases. Neurochemistry International, 49 (2), 136 - 144. doi:10.1016/j.neuint.2006.03.020 Peer Reviewed verified by ORBi |
HENEKA, M., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Galldiks, N., Zimmer, A., Hoehn, M., Heiss, W.-D., Klockgether, T., & Staufenbiel, M. (01 February 2006). Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. Journal of Neuroscience, 26 (5), 1343 - 1354. doi:10.1523/JNEUROSCI.4236-05.2006 Peer Reviewed verified by ORBi |
Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., Walter, J., Klockgether, T., van Leuven, F., & HENEKA, M. (10 January 2006). Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proceedings of the National Academy of Sciences of the United States of America, 103 (2), 443 - 448. doi:10.1073/pnas.0503839103 Peer Reviewed verified by ORBi |
Sastre, M., Klockgether, T., & HENEKA, M. (2006). Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. International Journal of Developmental Neuroscience, 24 (2-3), 167 - 176. doi:10.1016/j.ijdevneu.2005.11.014 Peer Reviewed verified by ORBi |
Hüll, M., Berger, M., & HENEKA, M. (2006). Disease-modifying therapies in Alzheimer's disease: how far have we come? Drugs, 66 (16), 2075 - 2093. doi:10.2165/00003495-200666160-00004 Peer Reviewed verified by ORBi |
Klotz, L., Schmidt, M., Giese, T., Sastre, M., Knolle, P., Klockgether, T., & HENEKA, M. (15 October 2005). Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients. Journal of Immunology, 175 (8), 4948 - 4955. doi:10.4049/jimmunol.175.8.4948 Peer Reviewed verified by ORBi |
HENEKA, M., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (07 October 2005). Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. Journal of Neuroinflammation, 2 (1), 22. doi:10.1186/1742-2094-2-22 Peer Reviewed verified by ORBi |
Semmler, A., Okulla, T., Sastre, M., Dumitrescu-Ozimek, L., & HENEKA, M. (October 2005). Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. Journal of Chemical Neuroanatomy, 30 (2-3), 144 - 157. doi:10.1016/j.jchemneu.2005.07.003 Peer Reviewed verified by ORBi |
Schütz, B., Reimann, J., Dumitrescu-Ozimek, L., Kappes-Horn, K., Landreth, G. E., Schürmann, B., Zimmer, A., & HENEKA, M. (24 August 2005). The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. Journal of Neuroscience, 25 (34), 7805 - 7812. doi:10.1523/JNEUROSCI.2038-05.2005 Peer Reviewed verified by ORBi |
Tamboli, I. Y., Prager, K., Barth, E., HENEKA, M., Sandhoff, K., & Walter, J. (29 July 2005). Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. Journal of Biological Chemistry, 280 (30), 28110 - 28117. doi:10.1074/jbc.M414525200 Peer Reviewed verified by ORBi |
HENEKA, M., Sastre, M., Dumitrescu-Ozimek, L., Hanke, A., Dewachter, I., Kuiperi, C., O'Banion, K., Klockgether, T., Van Leuven, F., & Landreth, G. E. (June 2005). Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain: a Journal of Neurology, 128 (Pt 6), 1442 - 1453. doi:10.1093/brain/awh452 Peer Reviewed verified by ORBi |
Grommes, C., Landreth, G. E., Schlegel, U., & HENEKA, M. (May 2005). The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells. Journal of Pharmacology and Experimental Therapeutics, 313 (2), 806 - 813. doi:10.1124/jpet.104.078972 Peer Reviewed verified by ORBi |
Rueger, M. A., Winkeler, A., Miletic, H., Kaestle, C., Richter, R., Schneider, G., Hilker, R., HENEKA, M., Ernestus, R. I., Hampl, J. A., Fraefel, C., & Jacobs, A. H. (April 2005). Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors. Gene Therapy, 12 (7), 588 - 596. doi:10.1038/sj.gt.3302462 Peer Reviewed verified by ORBi |
Lacombe, P., Mathews, P. M., Schmidt, S. D., Breidert, T., HENEKA, M., Landreth, G. E., Feinstein, D. L., & Galea, E. (02 July 2004). Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. Journal of Neuroinflammation, 1 (1), 11. doi:10.1186/1742-2094-1-11 Peer Reviewed verified by ORBi |
Grommes, C., Landreth, G. E., & HENEKA, M. (July 2004). Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. The Lancet Oncology, 5 (7), 419 - 429. doi:10.1016/S1470-2045(04)01509-8 Peer Reviewed verified by ORBi |
Pershadsingh, H. A., HENEKA, M., Saini, R., Amin, N. M., Broeske, D. J., & Feinstein, D. L. (20 April 2004). Effect of pioglitazone treatment in a patient with secondary multiple sclerosis. Journal of Neuroinflammation, 1 (1), 3. doi:10.1186/1742-2094-1-3 Peer Reviewed verified by ORBi |
Schmidt, S., Moric, E., Schmidt, M., Sastre, M., Feinstein, D. L., & HENEKA, M. (March 2004). Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. Journal of Leukocyte Biology, 75 (3), 478 - 485. doi:10.1189/jlb.0803402 Peer Reviewed verified by ORBi |
Dehmer, T., HENEKA, M., Sastre, M., Dichgans, J., & Schulz, J. B. (January 2004). Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. Journal of Neurochemistry, 88 (2), 494 - 501. doi:10.1046/j.1471-4159.2003.02210.x Peer Reviewed verified by ORBi |
Pedraza, C. E., Baltrons, M. A., HENEKA, M., & García, A. (November 2003). Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in brain cells: NO-independent destabilization of protein and NO-dependent decrease of mRNA. Journal of Neuroimmunology, 144 (1-2), 80 - 90. doi:10.1016/j.jneuroim.2003.08.034 Peer Reviewed verified by ORBi |
Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., van Leuven, F., & HENEKA, M. (29 October 2003). Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. Journal of Neuroscience, 23 (30), 9796 - 9804. doi:10.1523/JNEUROSCI.23-30-09796.2003 Peer Reviewed verified by ORBi |
Galea, E., HENEKA, M., Dello Russo, C., & Feinstein, D. L. (October 2003). Intrinsic regulation of brain inflammatory responses. Cellular and Molecular Neurobiology, 23 (4-5), 625 - 635. doi:10.1023/a:1025084415833 Peer Reviewed verified by ORBi |
Klotz, L., Sastre, M., Kreutz, A., Gavrilyuk, V., Klockgether, T., Feinstein, D. L., & HENEKA, M. (August 2003). Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons. Journal of Neurochemistry, 86 (4), 907 - 916. doi:10.1046/j.1471-4159.2003.01909.x Peer Reviewed verified by ORBi |
HENEKA, M., Gavrilyuk, V., Landreth, G. E., O'Banion, M. K., Weinberg, G., & Feinstein, D. L. (April 2003). Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression. Journal of Neurochemistry, 85 (2), 387 - 398. doi:10.1046/j.1471-4159.2003.01694.x Peer Reviewed verified by ORBi |
Harzheim, M., Altenschmidt, M., HENEKA, M., Schröder, R., Klockgether, T., & Schmidt, S. (February 2003). IFN-beta1a (Rebif) modifies the expression of microfilament-associated cell-cell contacts in C6 glioma cells. Journal of Interferon and Cytokine Research, 23 (2), 83 - 89. doi:10.1089/107999003321455471 Peer Reviewed verified by ORBi |
Feinstein, D. L., HENEKA, M., Gavrilyuk, V., Dello Russo, C., Weinberg, G., & Galea, E. (November 2002). Noradrenergic regulation of inflammatory gene expression in brain. Neurochemistry International, 41 (5), 357 - 365. doi:10.1016/s0197-0186(02)00049-9 Peer Reviewed verified by ORBi |
Gavrilyuk, V., Dello Russo, C., HENEKA, M., Pelligrino, D., Weinberg, G., & Feinstein, D. L. (16 August 2002). Norepinephrine increases I kappa B alpha expression in astrocytes. Journal of Biological Chemistry, 277 (33), 29662 - 29668. doi:10.1074/jbc.M203256200 Peer Reviewed verified by ORBi |
Breidert, T., Callebert, J., HENEKA, M., Landreth, G., Launay, J. M., & Hirsch, E. C. (August 2002). Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. Journal of Neurochemistry, 82 (3), 615 - 624. doi:10.1046/j.1471-4159.2002.00990.x Peer Reviewed verified by ORBi |
Baltrons, M. A., Pedraza, C. E., HENEKA, M., & García, A. (July 2002). Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells. Neurobiology of Disease, 10 (2), 139 - 149. doi:10.1006/nbdi.2002.0492 Peer Reviewed verified by ORBi |
Feinstein, D. L., Galea, E., Gavrilyuk, V., Brosnan, C. F., Whitacre, C. C., Dumitrescu-Ozimek, L., Landreth, G. E., Pershadsingh, H. A., Weinberg, G., & HENEKA, M. (June 2002). Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Annals of Neurology, 51 (6), 694 - 702. doi:10.1002/ana.10206 Peer Reviewed verified by ORBi |
Zander, T., Kraus, J. A., Grommes, C., Schlegel, U., Feinstein, D., Klockgether, T., Landreth, G., Koenigsknecht, J., & HENEKA, M. (June 2002). Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. Journal of Neurochemistry, 81 (5), 1052 - 1060. doi:10.1046/j.1471-4159.2002.00899.x Peer Reviewed verified by ORBi |
HENEKA, M., Galea, E., Gavriluyk, V., Dumitrescu-Ozimek, L., Daeschner, J., O'Banion, M. K., Weinberg, G., Klockgether, T., & Feinstein, D. L. (01 April 2002). Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. Journal of Neuroscience, 22 (7), 2434 - 2442. doi:10.1523/JNEUROSCI.22-07-02434.2002 Peer Reviewed verified by ORBi |
Murphy, P., Sharp, A., Shin, J., Gavrilyuk, V., Dello Russo, C., Weinberg, G., Sharp, F. R., Lu, A., HENEKA, M., & Feinstein, D. L. (15 February 2002). Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis. Journal of Neuroscience Research, 67 (4), 461 - 470. doi:10.1002/jnr.10139 Peer Reviewed verified by ORBi |
HENEKA, M., Wiesinger, H., Dumitrescu-Ozimek, L., Riederer, P., Feinstein, D. L., & Klockgether, T. (September 2001). Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease. Journal of Neuropathology and Experimental Neurology, 60 (9), 906 - 916. doi:10.1093/jnen/60.9.906 Peer Reviewed verified by ORBi |
HENEKA, M., Sharp, A., Murphy, P., Lyons, J.-A., Dumitrescu, L., & Feinstein, D. L. (April 2001). The heat shock response reduces myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in mice. Journal of Neurochemistry, 77 (2), 568 - 579. doi:10.1046/j.1471-4159.2001.00260.x Peer Reviewed verified by ORBi |
HENEKA, M., & Feinstein, D. L. (01 March 2001). Expression and function of inducible nitric oxide synthase in neurons. Journal of Neuroimmunology, 114 (1-2), 8 - 18. doi:10.1016/s0165-5728(01)00246-6 Peer Reviewed verified by ORBi |
HENEKA, M., Landreth, G. E., & Feinstein, D. L. (February 2001). Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease. Annals of Neurology, 49 (2), 276. doi:10.1002/1531-8249(20010201)49:2 Peer Reviewed verified by ORBi |
Landreth, G. E., & HENEKA, M. (2001). Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiology of Aging, 22 (6), 937 - 944. doi:10.1016/s0197-4580(01)00296-2 Peer Reviewed verified by ORBi |
HENEKA, M., Klockgether, T., & Feinstein, D. L. (15 September 2000). Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. Journal of Neuroscience, 20 (18), 6862 - 6867. doi:10.1523/JNEUROSCI.20-18-06862.2000 Peer Reviewed verified by ORBi |
HENEKA, M., Sharp, A., Klockgether, T., Gavrilyuk, V., & Feinstein, D. L. (May 2000). The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain. Journal of Cerebral Blood Flow and Metabolism, 20 (5), 800 - 811. doi:10.1097/00004647-200005000-00006 Peer Reviewed verified by ORBi |
HENEKA, M., Dumitrescu, L., Löschmann, P.-A., Wüllner, U., & Klockgether, T. (April 2000). Temporal, regional, and cell-specific changes of iNOS expression after intrastriatal microinjection of interferon gamma and bacterial lipopolysaccharide. Journal of Chemical Neuroanatomy, 18 (4), 167 - 179. doi:10.1016/s0891-0618(00)00041-7 Peer Reviewed verified by ORBi |
HENEKA, M., Feinstein, D. L., Galea, E., Gleichmann, M., Wüllner, U., & Klockgether, T. (December 1999). Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. Journal of Neuroimmunology, 100 (1-2), 156 - 168. doi:10.1016/s0165-5728(99)00192-7 Peer Reviewed verified by ORBi |
HENEKA, M., Schmidlin, A., & Wiesinger, H. (August 1999). Induction of argininosuccinate synthetase in rat brain glial cells after striatal microinjection of immunostimulants. Journal of Cerebral Blood Flow and Metabolism, 19 (8), 898 - 907. doi:10.1097/00004647-199908000-00009 Peer Reviewed verified by ORBi |
Roller, A., Bähr, O. R., Streffer, J., Winter, S., HENEKA, M., Deininger, M., Meyermann, R., Naumann, U., Gulbins, E., & Weller, M. (16 June 1999). Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP. Biochemical and Biophysical Research Communications, 259 (3), 600 - 605. doi:10.1006/bbrc.1999.0825 Editorial Reviewed verified by ORBi |
Wüllner, U., Seyfried, J., Groscurth, P., Beinroth, S., Winter, S., Gleichmann, M., HENEKA, M., Löschmann, P.-A., Schulz, J. B., Weller, M., & Klockgether, T. (24 April 1999). Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function. Brain Research, 826 (1), 53 - 62. doi:10.1016/s0006-8993(99)01228-7 Peer Reviewed verified by ORBi |
Rieger, J., Ständer, M., Löschmann, P. A., HENEKA, M., Dichgans, J., Klockgether, T., & Weller, M. (05 November 1998). Synthesis and biological effects of NO in malignant glioma cells: modulation by cytokines including CD95L and TGF-beta, dexamethasone, and p53 gene transfer. Oncogene, 17 (18), 2323 - 2332. doi:10.1038/sj.onc.1202154 Peer Reviewed verified by ORBi |
Schulz, J. B., Weller, M., Matthews, R. T., HENEKA, M., Groscurth, P., Martinou, J.-C., Lommatzsch, J., von Coelln, R., Wüllner, U., Löschmann, P.-A., Beal, M. F., Dichgans, J., & Klockgether, T. (October 1998). Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death and Differentiation, 5 (10), 847 - 857. doi:10.1038/sj.cdd.4400420 Peer Reviewed verified by ORBi |
Ständer, M., Naumann, U., Dumitrescu, L., HENEKA, M., Löschmann, P., Gulbins, E., Dichgans, J., & Weller, M. (September 1998). Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo. Gene Therapy, 5 (9), 1187 - 1194. doi:10.1038/sj.gt.3300709 Peer Reviewed verified by ORBi |
HENEKA, M., Löschmann, P.-A., Gleichmann, M., Weller, M., Schulz, J. B., Wüllner, U., & Klockgether, T. (July 1998). Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. Journal of Neurochemistry, 71 (1), 88 - 94. doi:10.1046/j.1471-4159.1998.71010088.x Peer Reviewed verified by ORBi |
Löschmann, P.-A., Wüllner, U., HENEKA, M., Schulz, J. B., Kunow, M., Wachtel, H., & Klockgether, T. (August 1997). Differential interaction of competitive NMDA and AMPA antagonists with selective dopamine D-1 and D-2 agonists in a rat model of Parkinson's disease. Synapse, 26 (4), 381 - 391. doi:10.1002/(SICI)1098-2396(199708)26:4 Peer Reviewed verified by ORBi |
HENEKA, M., Löschmann, P.-A., & Osswald, H. (01 January 1997). Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat. Journal of Clinical Investigation, 99 (1), 47 - 54. doi:10.1172/JCI119132 Peer Reviewed verified by ORBi |
Bokemeyer, C., Lampe, C., HENEKA, M., Schabet, M., Bamberg, M., & Kanz, L. (September 1996). Paclitaxel-induced radiation recall dermatitis. Annals of Oncology, 7 (7), 755 - 756. doi:10.1093/oxfordjournals.annonc.a010730 Peer Reviewed verified by ORBi |