Reference : Altered infective competence of the human gut microbiome in COVID-19
Scientific journals : Article
Life sciences : Environmental sciences & ecology
Life sciences : Microbiology
Human health sciences : Immunology & infectious disease
Systems Biomedicine
http://hdl.handle.net/10993/54844
Altered infective competence of the human gut microbiome in COVID-19
English
de Nies, Laura [> >]
Galata, Valentina [> >]
Martin-Gallausiaux, Camille [> >]
Despotovic, Milena mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology]
Busi, Susheel Bhanu mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology]
Snoeck, Chantal J. []
Delacour, Lea mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations]
Budagavi, Deepthi Poornima [> >]
Laczny, Cedric Christian mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology]
Habier, Janine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Scientific Central Services]
Lupu, Paula-Cristina [> >]
Halder, Rashi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Scientific Central Services]
Fritz, Joëlle V. [> >]
Marques, Tainá mailto [University of Luxembourg > > >]
Sandt, Estelle [> >]
O'Sullivan, Marc Paul [> >]
Ghosh, Soumyabrata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Satagopam, Venkata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Consortium, CON-Vince [> >]
Krüger, Rejko mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Fagherazzi, Guy mailto [Luxembourg Institute of Health - LIH]
Ollert, Markus mailto [Luxembourg Institute of Health - LIH]
He, Feng mailto [Luxembourg Institute of Health - LIH]
May, Patrick mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology]
9-Mar-2023
Microbiome
11
1
46
Yes
International
2049-2618
[en] COVID-19 ; Gut microbiome ; Metagenomics ; Metatranscriptomics ; SARS-CoV-2
[en] BACKGROUND: Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection and healthy individuals have been reported, including the loss of commensal taxa. We aimed to understand if microbiome alterations including functional shifts are unique to severe cases or a common effect of COVID-19. We used high-resolution systematic multi-omic analyses to profile the gut microbiome in asymptomatic-to-moderate COVID-19 individuals compared to a control group. RESULTS: We found a striking increase in the overall abundance and expression of both virulence factors and antimicrobial resistance genes in COVID-19. Importantly, these genes are encoded and expressed by commensal taxa from families such as Acidaminococcaceae and Erysipelatoclostridiaceae, which we found to be enriched in COVID-19-positive individuals. We also found an enrichment in the expression of a betaherpesvirus and rotavirus C genes in COVID-19-positive individuals compared to healthy controls. CONCLUSIONS: Our analyses identified an altered and increased infective competence of the gut microbiome in COVID-19 patients. Video Abstract.
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Fonds National de la Recherche - FnR ; Fondation André Losch ; FEDER ; SBB ; ERC
Co-infectomics
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/54844
10.1186/s40168-023-01472-7
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-023-01472-7
FnR ; FNR14716281 > Rejko Krueger > CON-VINCE > > 01/04/2020 > 31/12/2021 > 2020

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