Article (Scientific journals)
Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map
Fujita, Kazuhiro A.; Ostaszewski, Marek; Matsuoka, Yukiko et al.
2014In Molecular Neurobiology
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Keywords :
Parkinson’s disease; Molecular neuropathology; Knowledge repository; Bioinformatics
Abstract :
[en] Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map .
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Life sciences: Multidisciplinary, general & others
Author, co-author :
Fujita, Kazuhiro A.;  The Systems Biology Institute, Minato-ku, Tokyo, Japan
Ostaszewski, Marek  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Integrated Biobank of Luxembourg
Matsuoka, Yukiko;  The Systems Biology Institute, Minato-ku, Tokyo, Japan
Ghosh, Samik;  The Systems Biology Institute, Minato-ku, Tokyo, Japan
Glaab, Enrico  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Trefois, Christophe ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Crespo, Isaac ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Perumal, Thanneer Malai ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Jurkowski, Wiktor ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Antony, Paul ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Diederich, Nico ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Buttini, Manuel ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kodama, Akihiko;  Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Satagopam, Venkata ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Eifes, Serge ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
del Sol Mesa, Antonio ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Schneider, Reinhard ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kitano, Hiroaki;  Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
More authors (9 more) Less
External co-authors :
yes
Language :
English
Title :
Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map
Publication date :
2014
Journal title :
Molecular Neurobiology
ISSN :
1559-1182
Publisher :
Humana Press, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 13 August 2013

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