![]() ![]() | GARCIA, P., Wemheuer, W., Uriarte, O., MICHELUCCI, A., Masuch, A., Brioschi, S., Weihofen, A., KONCINA, E., COOWAR, D., HEURTAUX, T., GLAAB, E., BALLING, R., Sousa, C., Kaoma, T., Nicot, N., Pfander, T., Schulz-Schaeffer, W., Allouche, A., Fischer, N., ... BUTTINI, M. (2022). Neurodegeneration and neuroinflammation are linked, but independent of a-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease. Glia. doi:10.1002/glia.24149 ![]() |
![]() ![]() | KRÜGER, R., Kern, F., Fehlmann, T., Violich, I., Hutchins, E., Alsop, E., Kahraman, M., Grammes, N., BALLING, R., GEFFERS, L., & Keller, A. (2021). Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression. Nature Aging. doi:10.1038/s43587-021-00042-6 ![]() |
![]() ![]() | Iftekhar, E. N., Priesemann, V., BALLING, R., Bauer, S., Beutels, P., Valdez, A. C., Cuschieri, S., Czypionka, T., Dumpis, U., GLAAB, E., Grill, E., Hanson, C., Hotulainen, P., Klimek, P., Kretzschmar, M., Krüger, T., Krutzinna, J., Low, N., Machado, H., ... Willeit, P. (2021). A look into the future of the COVID-19 pandemic in Europe: an expert consultation. The Lancet Regional Health. Europe, 8 (100185). doi:10.1016/j.lanepe.2021.100185 ![]() |
![]() ![]() | Priesemann, V., BALLING, R., Bauer, S., Beutels, P., Valdez, A. C., Cuschieri, S., Czypionka, T., Dumpis, U., GLAAB, E., Grill, E., Hotulainen, P., Iftekhar, E. N., Krutzinna, J., Lionis, C., Machado, H., Martins, C., McKee, M., Pavlakis, G. N., Perc, M., ... Willeit, P. (2021). The benefits of low COVID-19 incidence in Europe. The Lancet, 398 (10303), 838-839. doi:10.1016/S0140-6736(21)01808-0 ![]() |
![]() ![]() | Fehlmann, T., Lehallier, B., Schaum, N., Hahn, O., Kahraman, M., Li, Y., Grammes, N., Geffers, L., Backes, C., BALLING, R., Kern, F., KRÜGER, R., Lammert, F., Ludwig, N., Meder, B., Fromm, B., Maetzler, W., Berg, D., Brockmann, K., ... Keller, A. (24 November 2020). Common diseases alter the physiological age-related blood microRNA profile. Nature Communications, 11 (1), 5958. doi:10.1038/s41467-020-19665-1 ![]() |
![]() ![]() | Zanin, M., Santos, B. F. R., ANTONY, P., Berenguer-Escuder, C., Larsen, S. B., HANSS, Z., BARBUTI, P., BAUMURATOV, A., GROSSMANN, D., Capelle, C. M., Weber, J., BALLING, R., Ollert, M., KRÜGER, R., Diederich, N. J., & HE, F. (10 November 2020). Mitochondria interaction networks show altered topological patterns in Parkinson's disease. NPJ Systems Biology and Applications, 6 (1), 38. doi:10.1038/s41540-020-00156-4 ![]() |
![]() ![]() | KOLODKIN, A., Colangelo, A., Ignatenko, A., Martorana, F., Jennen, D., Briedé, J., Brady, N., Barberis, M., Mondeel, T., Papa, M., Kumar, V., PETERS, B., SKUPIN, A., Alberghina, L., BALLING, R., & Westerhoff, H. (2020). ROS networks: designs, aging, Parkinson's disease and precision therapies. NPJ Systems Biology and Applications. doi:10.1038/s41540-020-00150-w ![]() |
![]() ![]() | GUI, Y., Thomas, M. H., Garcia, P., Karout, M., HALDER, R., MICHELUCCI, A., Kollmus, H., Zhou, C., Melmed, S., Schughart, K., BALLING, R., MITTELBRONN, M., Nadeau, J. H., Williams, R. W., SAUTER, T., BUTTINI, M., & SINKKONEN, L. (2020). Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging. Frontiers in Genetics. doi:10.3389/fgene.2020.566734 ![]() |
![]() ![]() | Stover, P., & BALLING, R. (2020). Nutrition and the 2020 Pandemic. Annual Review Of Nutrition. doi:10.1146/annurev-nu-40-082120-100001 ![]() |
![]() ![]() | Hartl, D.* , MAY, P.* , GU, W.* , Mayhaus, M., Pichler, S., Spaniol, C., GLAAB, E., BOBBILI, D. R., ANTONY, P., Köglsberger, S., Kurz, A., Grimmer, T., Morgan, K., Vardarajan, B. N., Reitz, C., Hardy, J., Bras, J., Guerreiro, R., AESG, ... Riemenschneider, M. (09 July 2020). A rare loss-of function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Molecular Psychiatry, 25 (3), 629-639. doi:10.1038/s41380-018-0091-8 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Kern, F., Fehlmann, T., Violich, I., Alsop, E., Hutchins, E., Kahraman, M., Grammes, N. L., Guimarães, P., Backes, C., Poston, K., Casey, B., BALLING, R., GEFFERS, L., KRÜGER, R., Galasko, D., Mollenhauer, B., Meese, E., Wyss-Coray, T., Craig, D. W., ... Keller, A. (2020). Deep sncRNA-seq of the PPMI cohort to study Parkinson’s disease progression. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/44658. doi:10.1101/2020.06.01.127092 |
![]() ![]() | OSTASZEWSKI, M., MAZEIN, A., Gillespie, M., Kuperstein, I., Niarakis, A., Hermjakob, H., Pico, A., Willinghagen, E., Evelo, C., Hasenauer, J., Schreiber, F., Dräger, A., Demir, E., Wolkenhauer, O., Furlong, L., Barillot, E., Dopazo, J., Orta-Resendiz, A., Messina, F., ... SCHNEIDER, R. (2020). COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms. Scientific Data. doi:10.1038/s41597-020-0477-8 ![]() |
![]() ![]() | Fehlmann, T., Kahraman, M., Backes, C., Galata, V., Keller, V., GEFFERS, L., Mercaldo, N., Hornung, D., Keller, A., KRÜGER, R., & BALLING, R. (2020). Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. JAMA Oncology. doi:10.1001/jamaoncol.2020.0001 ![]() |
![]() ![]() | Kollmus, F., Fuchs, H., Lengger, C., Haselimashhadi, H., Bogue, M., Östereicher, M., Horsch, M., Aguilar-Pimentel, J., Amarie, O., Becker, L., Beckers, J., Calzada-Wack, J., Garrett, L., Hans, W., Hölter, S., Klein-Rodewald, T., Maier, H., Mayer-Kuckuk, P., Miller, G., ... Hrabě de Angelis, M. (2020). A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mammalian Genome. doi:10.1007/s00335-020-09827-3 ![]() |
![]() ![]() | Aarestrup, F., Albeyatti, A., Armitage, W., Auffray, C., Augello, L., & BALLING, R. (2020). Towards a European health research and innovation cloud (HRIC). Genome Medicine. doi:10.1186/s13073-020-0713-z ![]() |
![]() ![]() | KRÜGER, R., BALLING, R., ANTONY, P., KONDRATYEVA, O., OSTASZEWSKI, M., BAUMURATOV, A., GROSSMANN, D., Mommaerts, K., Sokolowska, K., LONGHINO, L., Poulain, J. F., & Diederich, N. J. (2020). Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization. Scientific Reports. doi:10.1038/s41598-020-58505-6 ![]() |
![]() ![]() | SCHYMANSKI, E., Baker, N. C., Williams, A. J., SINGH, R., TREZZI, J.-P., KOLBER, P. L., WILMES, P., KRÜGER, R., PACZIA, N., LINSTER, C., & BALLING, R. (2019). Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. Environmental Science. Processes and Impacts. doi:10.1039/C9EM00068B ![]() |
![]() ![]() | BALLING, R., & Stover, P. (2019). Addressing the Increased Expectations of Nutrition. Annual Review of Nutrition. doi:10.1146/annurev-nu-39-190619-100001 ![]() |
BALLING, R., GONCALVES, J., MAGNI, S., MOMBAERTS, L., OLDANO, A., & SKUPIN, A. (2019). From Diagnosing Diseases to Predicting Diseases. In U. A. K. Betz (Ed.), Curious2018 (pp. 95-103). Springer, Cham. doi:10.1007/978-3-030-16061-6_11 |
![]() ![]() | Helbig, I., Lopez-Hernandez, T., Shor, O., Galer, P., Ganesan, S., Pendziwiat, M., Rademacher, A., Ellis, C. A., Humpfer, N., Schwarz, N., Seiffert, S., Peeden, J., Shen, J., Sterbova, K., Hammer, T. B., Moller, R. S., Shinde, D. N., Tang, S., Smith, L., ... GRIN consortium. (2019). A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy. American Journal of Human Genetics. doi:10.1016/j.ajhg.2019.04.001 ![]() |
![]() ![]() | Overall, R., BALLING, R., Kempermann, G., & Williams, R. (2019). Workshop Report: Systems Genetics of Neurodegenerative Disease, a Summer School in Systems Medicine, 25th August-1st September 2017. Frontiers In Genetics. doi:10.3389/fgene.2019.00029 ![]() |
![]() ![]() | Lerche, H., Berkovic, S. F., Lowenstein, D. H., EuroEPINOMICS-CoGIE, MAY, P., BOBBILI, D. R., KRAUSE, R., BALLING, R., EpiPGX consortium, Peter, S., & Epi4K Consortium/Epilepsy Phenome/Genome. (18 April 2019). Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy [letter to the editor]. New England Journal of Medicine, 380 (16), 24. doi:10.1056/NEJMc1805100 ![]() |
![]() ![]() | Bohler, S., Krauskopf, J., Espín-Pérez, A., Gebel, S., Palli, D., Rantakokko, P., Kiviranta, H., Kyrtopoulos, S., BALLING, R., & Kleinjans, J. (2019). Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females. Environmental Pollution. doi:10.1016/j.envpol.2019.04.005 ![]() |
![]() ![]() | Salamanca, L., Mechawar, N., Murai, K. K., BALLING, R., BOUVIER, D., & SKUPIN, A. (2019). MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples. Glia. doi:10.1002/glia.23623 ![]() |
![]() ![]() | Siekierska, A., Stamberger, H., Deconinck, T., Oprescu, S. N., Partoens, M. L., Sourbron, J., Zhang, Y., Adriaenssens, E., Mullen, P., Wiencek, P., Hardies, K., Lee, J.-S., Giong, H.-K., Distelmaier, F., Elpeleg, O., Helbig, K. L., Hersh, J., Isikay, S., Jordan, E., ... De Jonghe, P. (12 February 2019). Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish. Nature Communications, 10 (1), 708. doi:10.1038/s41467-018-07953-w ![]() |
![]() ![]() | Berghuis, B., Stapleton, C., Sonsma, A., Hulst, J., de Haan, G., Lindhout, D., Demurtas, R., BALLING, R., SCHNEIDER, R., EpiPGX Consortium, & KRAUSE, R. (2019). A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine. Epilepsia Open. doi:10.1002/epi4.12297 ![]() |
![]() ![]() | Keller, A., Fehlmann, T., Laufer, T., Backes, C., Kahramann, M., Alles, J., Fischer, U., Minet, M., Ludwig, N., Kern, F., Kehl, T., Galata, V., Dusterloh, A., Schrors, H., Kohlhaas, J., Bals, R., Huwer, H., GEFFERS, L., KRÜGER, R., ... Meese, E. (2018). Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity. RNA Biology. doi:10.1080/15476286.2018.1559689 ![]() |
![]() ![]() | HIPP EPOUSE DU0027AMICO, G., Vaillant, M., Diederich, N. J., ROOMP, K., SATAGOPAM, V., BANDA, P., Sandt, E., Mommaerts, K., SCHMITZ, S., Longhino, L., Schweicher, A., Hanff, A.-M., Nicolai, B., KOLBER, P. L., REITER, D., PAVELKA, L., BINCK, S., PAULY, C., GEFFERS, L., ... KRÜGER, R. (29 October 2018). The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis. Frontiers in Aging Neuroscience, 10, 326. doi:10.3389/fnagi.2018.00326 ![]() |
![]() ![]() | SOUSA, C., Golebiewska, A., Poovathingal, S. K., Kaoma, T., Pires-Afonso, Y., Martina, S., COOWAR, D., Azuaje, F., SKUPIN, A., BALLING, R., Biber, K., NICLOU, S., & MICHELUCCI, A. (2018). Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Reports. doi:10.15252/embr.201846171 ![]() |
![]() ![]() | Jabbari, K., BOBBILI, D. R., Lal, D., Reinthaler, E. M., Schubert, J., Wolking, S., Sinha, V., Motameny, S., Thiele, H., Kawalla, A., Altmüller, J., Toliat, M. R., Kraaij, R., van Rooij, J., Uitterlinden, A. G., Ikram, M. A., EuroEPINOMICS CoGIE Consortium, BALLING, R., Zara, F., ... Nürnberg, P. (2018). Rare gene deletions in genetic generalized and Rolandic epilepsies. PLoS ONE. doi:10.1371/journal.pone.0202022 ![]() |
![]() ![]() | MAY, P., Girard, S., Harrer, M., BOBBILI, D. R., Schubert, J., Wolking, S., Becker, F., Lachance-Touchette, P., Meloche, C., Gravel, M., Niturad, C. E., Knaus, J., De Kovel, C., Toliat, M., Polvi, A., Iacomino, M., Guerrero-López, R., Baulac, S., Marini, C., ... Lerche, H. (18 August 2018). Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study. The Lancet Neurology, 17 (8), 699-708. doi:10.1016/S1474-4422(18)30215-1 ![]() |
![]() ![]() | MAY, P.* , Pichler, S.* , Hartl, D., BOBBILI, D. R., Mayhaus, M., Spaniol, C., Kurz, A., BALLING, R., SCHNEIDER, J., & Riemenschneider, M. (01 April 2018). Rare ABCA7 variants in 2 German families with Alzheimer disease. Neurology. Genetics, 4 (2). doi:10.1212/NXG.0000000000000224 ![]() * These authors have contributed equally to this work. |
![]() ![]() | BOBBILI, D. R.* , Lal, D.* , MAY, P.* , Reinthaler, E. M., Jabbari, K., Thiele, H., Nothnagel, M., Jurkowski, W., EuroEPINOMICS COGIE Consortium, BALLING, R., Feucht, M., Nürnberg, P., Lerche, H., Zimprich, F., KRAUSE, R., & Neubauer, B. A. (2018). Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic Epilepsy. European Journal of Human Genetics. doi:10.1038/s41431-017-0034-x ![]() * These authors have contributed equally to this work. |
![]() ![]() | Delhalle, S., Bode, S. F. N., BALLING, R., Ollert, M., & He, F. Q. (2018). A roadmap towards personalized immunology. NPJ Systems Biology and Applications, 4, 9. doi:10.1038/s41540-017-0045-9 ![]() |
![]() ![]() | OSTASZEWSKI, M., GEBEL, S., Kuperstein, I., Mazein, A., Zinovyev, A., Dogrusoz, U., Hasenauer, J., FLEMING, R. M., Le Novere, N., GAWRON, P., Ligon, T., Niarakis, A., Nickerson, D., Weindl, D., BALLING, R., Barillot, E., Auffray, C., & SCHNEIDER, R. (2018). Community-driven roadmap for integrated disease maps. Briefings in Bioinformatics. doi:10.1093/bib/bby024 ![]() |
![]() ![]() | Mazein, A., OSTASZEWSKI, M., Kuperstein, I., Watterson, S., Le Novere, N., Lefaudeux, D., De Meulder, B., Pellet, J., Balaur, I., Saqi, M., Nogueira, M. M., He, F., Parton, A., Lemonnier, N., GAWRON, P., GEBEL, S., Hainaut, P., Ollert, M., Dogrusoz, U., ... Auffray, C. (2018). Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms. NPJ Systems Biology and Applications, 4, 21. doi:10.1038/s41540-018-0059-y ![]() |
![]() ![]() | Barbosa-Silva, A., Bratfalean, D., GU, W., SATAGOPAM, V., Houston, P., Becnel, L. B., Eifes, S., Richard, F., Tielmann, A., HERZINGER, S., REGE, K., BALLING, R., Peeters, P., & SCHNEIDER, R. (2018). Presenting and Sharing Clinical Data using the eTRIKS Standards Master Tree for tranSMART. Bioinformatics, 809. doi:10.1093/bioinformatics/bty809 ![]() |
![]() ![]() | Niturad, E. C., Lev, D., Kalscheuer, V. M., Charzewska, A., Schubert, J., Lerman-Sagie, T., Kroes, H. Y., Oegema, R., Traverso, M., Specchio, N., Lassota, M., Chelly, J., Bennett-Back, O., Carmi, N., Koffler-Brill, T., Iacomino, M., Trivisano, M., Capovilla, G., Striano, P., ... Leshinsky-Silver, E. (01 November 2017). Rare GABRA3 variants are associated with epileptic seizures, encephalopathy and dysmorphic features. Brain: a Journal of Neurology, 140 (11), 2879-2894. doi:10.1093/brain/awx236 ![]() |
![]() ![]() | Santolini, I., Celli, R., Cannella, M., Imbriglio, T., Guiducci, M., Parisi, P., Schubert, J., Iacomino, M., Zara, F., Lerche, H., EuroEPINOMICS CoGIE Consortium, MAY, P., KRAUSE, R., BALLING, R., Genetic Commission of Italian League Against Epilepsy (LICE), Moyanova, S., Ngomba, R. T., van Luijtellar, G., Battaglia, G., ... Nicoletti, F. (2017). Alterations in the α2δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies. Epilepsia. doi:10.1111/epi.13898 ![]() |
![]() ![]() | OLIVEIRA, M., BALLING, R., Smidt, M., & FLEMING, R. M. (26 June 2017). Embryonic development of selectively vulnerable neurons in Parkinson’s disease. NPJ Parkinson's Disease, 3. doi:10.1038/s41531-017-0022-4 ![]() |
![]() ![]() | Allen, A. S., Berkovic, S. F., Bridgers, J., Cossette, P., Dlugos, D., Epstein, M. P., Glauser, T., Goldstein, D. B., Heinzen, E. L., Jiang, Y., Johnson, M. R., Kuzniecky, R., Lowenstein, D. H., Marson, A. G., Mefford, H. C., O'Brien, T. J., Ottman, R., Petrou, S., Petrovski, S., ... Winawer, M. R. (2017). Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data. European Journal of Human Genetics. doi:10.1038/ejhg.2017.61 ![]() |
![]() ![]() | Blauwendraat, C., Faghri, F., Pihlstrom, L., Geiger, J. T., Elbaz, A., Lesage, S., MAY, P., Aude, N., Abramzon, Y., Murphy, N. A., Gibbs, J. R., Ryten, M., Ferrari, R., Bras, J., Guerreiro, R., Williams, J., Sims, R., Lubbe, S., Hernandez, D. G., ... Scholz, S. W. (2017). NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2017.05.009 ![]() |
![]() ![]() | Santiago-Sim, T., Burrage, L. C., Ebstein, F., Tokita, M. J., Miller, M., Bi, W., Braxton, A. A., Rosenfeld, J. A., Shahrour, M., Lehmann, A., Cogne, B., Küry, S., Besnard, T., Isidor, B., Bézieau, S., Hazert, I., Nagakura, H., Immken, L. L., Littlejohn, R. O., ... Walkiewicz, M. A. (06 April 2017). Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. American Journal of Human Genetics, 100 (4), 676-688. doi:10.1016/j.ajhg.2017.03.001 ![]() |
![]() ![]() | Marini, C., Hardies, K., Pisano, T., MAY, P., Weckhuysen, S., Cellini, E., Suls, A., Mei, D., BALLING, R., De Jonghe, P., Helbig, I., Garozzo, D., EuroEPINOMICS consortium AR working group, & Guerrini, R. (April 2017). Recessive mutations in SLC35A3 cause early onset epileptic encephalopathy with skeletal defects. American Journal of Medical Genetics. Part A, 173 (4), 1119-1123. doi:10.1002/ajmg.a.38112 ![]() |
![]() ![]() | Appenzeller, S., BALLING, R., Barisic, N., Baulac, S., Caglayan, H., Craiu, D., Jonghe, P. D., Depienne, C., Dimova, P., Djémié, T., Gormley, P., Guerrini, R., Helbig, I., Hjalgrim, H., Hoffman-Zacharska, D., Jähn, J., Klein, K. M., Koeleman, B., Komarek, V., ... Sherr, E. (05 January 2017). De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies. American Journal of Human Genetics, 100 (1), 179. doi:10.1016/j.ajhg.2016.12.012 ![]() |
![]() ![]() | Sagner, M., McNeil, A., Puska, P., Auffray, C., Price, N. D., Hood, L., Lavie, C. J., Han, Z.-G., Chen, Z., Brahmachari, S. K., McEwen, B. S., Soares, M. B., BALLING, R., Epel, E., & Arena, R. (2017). The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan. Progress in cardiovascular diseases, 59 (5), 506-521. doi:10.1016/j.pcad.2016.08.002 ![]() |
![]() ![]() | Hartl, D., MAY, P., GU, W., Mayhaus, M., GLAAB, E., ANTONY, P., BOBBILI, D. R., Köglsberger, S., Pichler, S., Spaniol, C., Kurz, A., BALLING, R., SCHNEIDER, J., & Riemenschneider, M. (2017). IDENTIFICATION OF A RARE GENE VARIANT THAT IS ASSOCIATED WITH FAMILIAL ALZHEIMER DISEASE AND REGULATES APP EXPRESSION. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 13 (7, Supplement), 648. doi:10.1016/j.jalz.2017.06.758 ![]() |
![]() ![]() | Gawron, P., OSTASZEWSKI, M., SATAGOPAM, V., GEBEL, S., Mazein, A., Kuzma, M., Zorzan, S., McGee, F., Otjacques, B., BALLING, R., & SCHNEIDER, R. (2016). MINERVA—a platform for visualization and curation of molecular interaction networks. NPJ Systems Biology and Applications. doi:10.1038/npjsba.2016.20 ![]() |
![]() ![]() | de Kovel, C. G. F., Brilstra, E. H., van Kempen J.A., van't Slot, R., Nijman, I. J., Afawi, Z., De Jonghe, P., Djemie, T., Guerrini, R., Hardies, K., Helbig, I., Hendrickx, R., Kanaan, M., Kramer, U., Lehesjoki, A.-E. E., Lemke, J. R., Marini, C., Mei, D., Moller, R. S., ... Koeleman, B. P. C. (30 July 2016). Targeted sequencing of 351 candidate genes for epileptic encephalopathy in a large cohort of patients. Molecular Genetics and Genomic Medicine, 4 (5), 568-80. doi:10.1002/mgg3.235 ![]() |
![]() ![]() | Hardies, K., Cai, Y., Jardel, C., Jansen, A. C., Cao, M., MAY, P., Djémié, T., Hachon Le Camus, C., Keymolen, K., Deconinck, T., Bhambhani, V., Long, C., Sajan, S. A., Helbig, K. L., Suls, A., BALLING, R., Helbig, I., De Jonghe, P., Depienne, C., ... Weckhuysen, S. (2016). Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline. Brain: a Journal of Neurology. doi:10.1093/brain/aww180 ![]() |
![]() ![]() | Lal, D., Reinthaler, E., Dejanovic, MAY, P., Thiele, H., Lehesjoki, A.-E., Schwarz, G., Riesch, E., Ikram, A., van Duijn, C., Uitterlinden, A., Steinböck, H., Gruber-Sedlmayr, U., Neophytou, B., Zara, F., Hahn, A., Genetic Commission of the Italian League against Epilepsy, EuroEPINOMICS CoGIE Consortium, BALLING, R., ... Neubauer, B. (2016). Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes. PLoS ONE. doi:10.1371/journal.pone.0150426 ![]() |
![]() ![]() | ANTONY, P., TALLAM, A., PERUMAL, T. M., Jäger, C., FRITZ, J., BALLING, R., DEL SOL MESA, A., MICHELUCCI, A., & Vallar, L. (2016). Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. PLoS ONE. doi:10.1371/journal.pone.0149050 ![]() |
![]() ![]() | Auffray, C., BALLING, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., Del Signore, S., Delogne, C., Devilee, P., Di Meglio, A., Eijkemans, M., Flicek, P., Graf, N., Grimm, V., Guchelaar, H.-J., ... Zanetti, G. (2016). Making sense of big data in health research: Towards an EU action plan. Genome Medicine, 8 (1), 71. doi:10.1186/s13073-016-0323-y ![]() |
![]() ![]() | SATAGOPAM, V., GU, W., Eifes, S., Gawron, P., OSTASZEWSKI, M., GEBEL, S., Barbosa-Silva, A., BALLING, R., & SCHNEIDER, R. (2016). Integration and Visualization of Translational Medicine Data for Better Understanding of Human Diseases. Big Data, 4 (2), 97-108. doi:10.1089/big.2015.0057 ![]() |
![]() ![]() | Maes, Nowak, G., Caso, J., Leza, J. C., Song, C., Kubera, M., Klein, H., Galecki, P., Noto, C., GLAAB, E., BALLING, R., & Berk, M. (2016). Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research. Molecular Neurobiology, 53 (5), 2927-2935. doi:10.1007/s12035-015-9183-5 ![]() |
![]() ![]() | Leist, S. R., Pilzner, C., van den Brand, J. M. A., Dengler, L., Geffers, R., Kuiken, T., BALLING, R., Kollmus, H., & Schughart, K. (2016). Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics, 17 (1), 143. doi:10.1186/s12864-016-2483-y ![]() |
![]() ![]() | ANTONY, P., FORSTER, J., Köglsberger, S., TREFOIS, C., BOYD, O., BAUMURATOV, A., BALLING, R., & Buck, L. (2016). Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability. Journal of Biomolecular Screening. doi:10.1177/1087057115625190 ![]() |
![]() ![]() | OSTASZEWSKI, M., SKUPIN, A., & BALLING, R. (2016). Neurological Diseases from a Systems Medicine Point of View. Methods in Molecular Biology, 1386, 221-50. doi:10.1007/978-1-4939-3283-2_11 ![]() |
![]() ![]() | Ameziane, N., MAY, P., Van de Vrugt, H. J., Van Rossum-Fikkert, S. E., Ristic, D., Williams, G. J., Balk, J., Rockx, D., Li, H., Rooimans, M. A., Oostra, A. B., Velleuer, E., Dietrich, R., Bleijerveld, O. B., Altelaar, A. F. M., Meijers-Heijboer, H., Joenje, H., Glusman, G., Roach, J. C., ... Dorsman, J. C. (18 December 2015). A novel Fanconi anemia subtype associated with a dominant-negative mutation in RAD51. Nature Communications, 6 (8829). doi:10.1038/ncomms9829 ![]() |
![]() ![]() | Hardies, K., de Kovel, C. G. F., Weckhuysen, S., Asselbergh, B., Geuens, T., Deconnick, T., Azmi, A., MAY, P., Brilstra, E., Becker, F., Barisic, N., Craiu, D., Braun, K., Lal, D., Thiele, H., Schubert, J., Weber, Y., van't Slot, R., Autosomal recessive working group of the EuroEPINOMICS RES Consortium, ... De Jonghe, P. (2015). Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia. Brain: a Journal of Neurology. doi:10.1093/brain/awv263 ![]() |
![]() ![]() | TREFOIS, C., ANTONY, P., GONCALVES, J., SKUPIN, A., & BALLING, R. (August 2015). Critical transitions in chronic disease: transferring concepts from ecology to systems medicine. Current Opinion in Biotechnology, 34, 48-55. doi:10.1016/j.copbio.2014.11.020 ![]() |
ANTONY, P., Antunes, L., Frasquilho, S., OSTASZEWSKI, M., Weber, J., Longhino, L., BAUMURATOV, A., Derkinderen, P., BALLING, R., & DIEDERICH, N. (June 2015). Staining for unphosphorylated alpha-synuclein in the colon mucosa. No difference between patients with Parkinson's disease and healthy controls [Paper presentation]. 19th International Congress of Parkinson's Disease and Movement. |
![]() ![]() | Syrbe, S., Hedrich, U. B. S., Riesch, E., Djémié, T., Müller, S., Møller, R. S., Maher, B., Hernandez-Hernandez, L., Synofzik, M., Caglayan, H. S., Arslan, M., Serratosa, J. M., Nothnagel, M., MAY, P., KRAUSE, R., Löffler, H., Detert, K., Dorn, T., Vogt, H., ... Lemke, J. R. (09 March 2015). De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nature Genetics, 47 (4), 393-9. doi:10.1038/ng.3239 ![]() |
![]() ![]() | Thomas, R. H., Zhang, L. M., Carvill, G. L., Archer, J. S., Heavin, S. B., Mandelstam, S. A., Craiu, D., Berkovic, S. F., Gill, D. S., Mefford, H. C., Scheffer, I. E., Paalotie, A., Lehesjoki, A.-E., Koeleman, B., Marini, C., Depienne, C., Pal, D., Hoffman-Zacharska, D., Leguern, E., ... Weber, Y. (03 March 2015). CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures. Neurology, 84 (9), 951-958. doi:10.1212/WNL.0000000000001305 ![]() |
![]() ![]() | Larsen, J., Carvill, G. L., Gardella, E., Kluger, G., Schmiedel, G., Barisic, N., Depienne, C., Brilstra, E., Mang, Y., Nielsen, J. E. K., Kirkpatrick, M., Goudie, D., Goldman, R., Jähn, J. A., Jepsen, B., Gill, D., Döcker, M., Biskup, S., McMahon, J. M., ... EuroEPINOMICS RES Consortium CRP. (03 February 2015). The phenotypic spectrum of SCN8A encephalopathy. Neurology, 84 (5), 480-489. doi:10.1212/WNL.0000000000001211 ![]() |
![]() ![]() | Hardies, K., MAY, P., Djémié, T., Tarta-Arsene, O., Deconinck, T., Craiu, D., EuroEPINOMICS RES Consortium, Helbig, I., Suls, A., BALLING, R., Weckhuysen, S., De Jonghe, P., & Hirst, J. (2015). Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly. Human Molecular Genetics, 24 (8), 2218-2227. doi:10.1093/hmg/ddu740 ![]() |
![]() ![]() | Jäger, C.* , GLAAB, E.* , MICHELUCCI, A.* , Binz, T., Köglsberger, S., GARCIA, P., TREZZI, J.-P., GHELFI, J., BALLING, R., & BUTTINI, M. (2015). The Mouse Brain Metabolome: Region-Specific Signatures and Response to Excitotoxic Neuronal Injury. American Journal of Pathology, 185 (6), 1699-1712. doi:10.1016/j.ajpath.2015.02.016 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Manolio, T. A., Abramowicz, M., Al-Mulla, F., Anderson, W., BALLING, R., Berger, A. C., Bleyl, S., Chakravarti, A., Chantratita, W., Chisholm, R. L., Dissanayake, V. H. W., Dunn, M., Dzau, V. J., Han, B.-G., Hubbard, T., Kolbe, A., Korf, B., Kubo, M., Lasko, P., ... Ginsburg, G. S. (2015). Global implementation of genomic medicine: We are not alone. Science Translational Medicine, 7 (290), 290ps13. doi:10.1126/scitranslmed.aab0194 ![]() |
![]() ![]() | ANTONY, P., BOYD, O., TREFOIS, C., Ammerlaan, W., OSTASZEWSKI, M., Baumuratov, A. S., Longhino, L., Antunes, L., Koopman, W., BALLING, R., & Diederich, N. J. (2015). Platelet mitochondrial membrane potential in Parkinson's disease. Annals of Clinical and Translational Neurology, 2 (1), 67-73. doi:10.1002/acn3.151 ![]() |
![]() ![]() | KRISHNA, A., BIRYUKOV, M., TREFOIS, C., ANTONY, P., Hussong, R., LIN, J., Heinäniemi, M., Glusman, G., Köglsberger, S., BOYD, O., van den Berg, B. H. J., Linke, D., Huang, D., Wang, K., Hood, L., Tholey, A., SCHNEIDER, R., GALAS, D. J., BALLING, R., & MAY, P. (20 December 2014). Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease. BMC Genomics, 15 (1154). doi:10.1186/1471-2164-15-1154 ![]() |
![]() ![]() | KOLODKIN, A., IGNATENKO, A., Sangar, V., SIMEONIDIS, V., PETERS, B., Westerhoff, H., SKUPIN, A., Yilmaz, N., Barberis, M., Mondeel, T., Price, N., Brady, N., & BALLING, R. (December 2014). ROS homeostasis in a dynamic model: How to save PD neuron? [Poster presentation]. Benelux Bioinformatics conference, Luxembourg, Luxembourg. |
![]() ![]() | Schubert, J., Siekierska, A., LANGLOIS, M., MAY, P., Huneau, C., Becker, F., Muhle, H., Suls, A., Lemke, J. R., de Kovel, C. G. F., Thiele, H., Konrad, K., Kawalia, A., Toliat, M. R., Sander, T., Ruschendorf, F., Caliebe, A., Nagel, I., Kohl, B., ... Lerche, H. (02 November 2014). Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nature Genetics, 46 (12), 1327-32. doi:10.1038/ng.3130 ![]() |
KOLODKIN, A., IGNATENKO, A., Sangar, V., SIMEONIDIS, V., GLAAB, E., PETERS, B., Brady, N., Price, N., & BALLING, R. (October 2014). ROS-management in Parkinson’s disease: Dynamic blue-print domino-based model and design principles study. Dynamic modelling of ROS management and ROS-induced mitophagy [Poster presentation]. GFG Neurogenetics Conference & PD Symposium, Munsbach, Luxembourg. |
![]() ![]() | Appenzeller, S., BALLING, R., Barisic, N., Baulac, S., Caglayan, H., Craiu, D., De Jonghe, P., Depienne, C., Dimova, P., Djemie, T., Gormly, P., Guerrini, R., Helbig, I., Hjalgrim, H., Hoffman-Zacharska, D., Jähn, Klein, K. M., Koeleman, B., Komarek, V., ... Epi4K Consortium. (25 September 2014). De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies. American Journal of Human Genetics, 4, 360-370. doi:10.1016/j.ajhg.2014.08.013 ![]() |
![]() ![]() | Bodea, L.-G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., SINKKONEN, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D., BALLING, R., & Neumann, H. (18 June 2014). Neurodegeneration by Activation of the Microglial Complement–Phagosome Pathway. Journal of Neuroscience, 34 (25), 8546-8556. doi:10.1523/JNEUROSCI.5002-13.2014 ![]() |
ANTONY, P., BOYD, O., TREFOIS, C., OSTASZEWSKI, M., BAUMURATOV, A., BALLING, R., & DIEDERICH, N. (12 June 2014). Analysis of mitochondrial membrane potential in idiopathic Parkinson's disease: A case-control study [Paper presentation]. 18th International Congress of Parkinson's Disease and Movement. |
ANTONY, P., OSTASZEWSKI, M., Gawron, P., TREFOIS, C., Fujita, K. A., MOSCH, S., & BALLING, R. (12 June 2014). Curation of complex molecular pathways of Parkinson's disease as a collaborative scientific community effort [Paper presentation]. 18th International Congress of Parkinson's Disease and Movement. |
KOLODKIN, A., IGNATENKO, A., Sangar, V., GLAAB, E., PETERS, B., Price, N., Brady, N., & BALLING, R. (June 2014). Dynamic modelling of ROS management and ROS-induced mitophagy [Poster presentation]. Gordon workshop on Cell Death Mechanisms, West Dover, United States. |
KOLODKIN, A., IGNATENKO, A., Sangar, V., SIMEONIDIS, V., PETERS, B., Sahin, N., Price, N., Brady, N., BALLING, R., & Westerhoff, H. (June 2014). ROS-activated signaling network: dynamic modelling and design principles study [Poster presentation]. Interdisciplinary Signalling Workshop, Vizegrad, Hungary. |
![]() ![]() | IGNATENKO, A., KOLODKIN, A., PETERS, B., & BALLING, R. (2014). Comparison of ODE-based models for reactive oxygen species regulation system. Proceedings of ICCSA 2014, 199-203. ![]() |
![]() ![]() | Nava, C., Dalle, C., Rastetter, A., Striano, P., de Kovel, C. G. F., Nabbout, R., Cancès, C., Ville, D., Brilstra, E. H., Gobbi, G., Raffo, E., Bouteiller, D., Marie, Y., Trouillard, O., Robbiano, A., Keren, B., Agher, D., Roze, E., Lesage, S., ... Zara, F. (Other coll.). (2014). De novo mutations in HCN1 cause early infantile epileptic encephalopathy. Nature Genetics. doi:10.1038/ng.2952 ![]() |
![]() ![]() | Fujita, K. A., OSTASZEWSKI, M., Matsuoka, Y., Ghosh, S., GLAAB, E., TREFOIS, C., CRESPO, I., PERUMAL, T. M., JURKOWSKI, W., ANTONY, P., DIEDERICH, N., BUTTINI, M., Kodama, A., SATAGOPAM, V., EIFES, S., DEL SOL MESA, A., SCHNEIDER, R., Kitano, H., & BALLING, R. (2014). Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map. Molecular Neurobiology. doi:10.1007/s12035-013-8489-4 ![]() |
![]() ![]() | Bousquet, J., Jorgensen, C., Dauzat, M., Cesario, A., Camuzat, T., Bourret, R., Best, N., Anto, J. M., Abecassis, F., Aubas, P., Avignon, A., Badin, M., Bedbrook, A., Blain, H., Bourdin, A., Bringer, J., Camu, W., Cayla, G., Costa, D. J., ... Mercier, J. (2014). Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies. Current Pharmaceutical Design, 20 (38), 5928-44. doi:10.2174/1381612820666140314115505 ![]() |
![]() ![]() | KOLODKIN, A., IGNATENKO, A., Sangar, V., SIMEONIDIS, V., PETERS, B., Brady, N., Price, N., & BALLING, R. (27 September 2013). Design principles study of ROS management and ROS-induced mitophagy with a kinetic model [Poster presentation]. 2013 BMES Annual Meeting, Seattle, United States. |
SIMEONIDIS, V., KOLODKIN, A., IGNATENKO, A., Sangar, V., BALLING, R., & Brady, N. (22 July 2013). Modeling cellular ROS defense in mitochondrial-related diseases [Poster presentation]. 21st Annual International Conference on Intelligent Systemsfor Molecular Biology and 12th European Conference on Computational Biology, Berlin, Germany. |
![]() ![]() | ANTONY, P., DIEDERICH, N., KRÜGER, R., & BALLING, R. (2013). The hallmarks of Parkinson's disease. FEBS Journal, 13. doi:10.1111/febs.12335 ![]() |
![]() ![]() | KOLODKIN, A., IGNATENKO, A., SIMEONIDIS, V., Sangar, V., Choe, C., PETERS, B., Price, N., BALLING, R., & Brady, N. (May 2013). ROS-induced regulation of mitophagy and its failure in Parkinson’s disease [Poster presentation]. Mitochondria: from Signaling to Disease, Lisbon, Portugal. |
![]() ![]() | MICHELUCCI, A., CORDES, T., GHELFI, J., PAILOT, A., Reiling, N., Goldmann, O., Binz, T., WEGNER, A., TALLAM, A., Rausell, A., BUTTINI, M., LINSTER, C., Medina, E., BALLING, R., & HILLER, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 ![]() |
![]() ![]() | OSTASZEWSKI, M., Fujita, K., Matsuoka, Y., Ghosh, S., GLAAB, E., TREFOIS, C., CRESPO, I., PERUMAL, T. M., JURKOWSKI, W., ANTONY, P., DIEDERICH, N., BUTTINI, M., KOLODKIN, A., Kodama, A., SATAGOPAM, V., BIRYUKOV, M., EIFES, S., DEL SOL MESA, A., SCHNEIDER, R., ... BALLING, R. (09 March 2013). The Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of Disease-related Pathways [Poster presentation]. The 11th International Conference on Alzheimer's & Parkinson's Diseases, Florence, Italy. |
ANTONY, P., KRISHNA, A., MAY, P., TREFOIS, C., BOYD, O., Köglsberger, S., BAUMURATOV, A., GALAS, D. J., & BALLING, R. (2013). Differentiated SH-SY5Y Cells as PD Model for Mitochondrial Dysfunction: From Whole Genome Sequencing to an Educated Design of High-Throughput Experiments [Poster presentation]. The 11th International Conference on Alzheimer's & Parkinson's Diseases, Florence, Italy. |
![]() ![]() | Chaiboonchoe, A., JURKOWSKI, W., Pellet, J., GLAAB, E., KOLODKIN, A., Raussel, A., LE BÉCHEC, A., Meyniel, L., Ballereau, S., CRESPO, I., Ahmed, H., Volpert, V., Lotteau, V., Baliga, N., HOOD, L., del Sol, A., BALLING, R., & Auffray, C. (2013). Network analysis for systems biology. In A. Prokop & Csukás (Eds.), Springer book in Systems Biology, Vol.1: Systems Biology:, Integrative Biology and Simulation Tools (Springer book in Systems Biology, Vol.1). Springer. doi:10.1007/978-94-007-6803-1 ![]() |
![]() ![]() | Ballereau, S., GLAAB, E., KOLODKIN, A., Chaiboonchoe, A., BIRYUKOV, M., VLASSIS, N., Ahmed, H., Pellet, J., Baliga, N., HOOD, L., SCHNEIDER, R., BALLING, R., & Auffray, C. (2013). Functional Genomics, Proteomics, Metabolomics and Bioinformatics for Systems Biology. In A. Prokop & B. Csukás (Eds.), Systems Biology: Integrative Biology and Simulation Tools. Springer. doi:10.1007/978-94-007-6803-1_1 ![]() |
![]() ![]() | Chaiboonchoe, A., JURKOWSKI, W., Pellet, J., GLAAB, E., KOLODKIN, A., Raussel, A., LE BÉCHEC, A., Ballereau, S., Meyniel, L., CRESPO, I., Ahmed, H., Volpert, V., Lotteau, V., Baliga, N., Hood, L., Sol, A. D., BALLING, R., & Auffray, C. (2013). On different aspects of network analysis in systems biology. Systems Biology, 1, 181-207. doi:10.1007/978-94-007-6803-1_6 ![]() |
![]() ![]() | HE, F., & BALLING, R. (2013). The role of regulatory T cells in neurodegenerative diseases. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 5 (2), 153-80. doi:10.1002/wsbm.1187 ![]() |
![]() ![]() | Schughart, K., Libert, C., Kas, M. J., Andreux, P., Aransay, A. M., Auwerx, J., BALLING, R., Banerjee, S., Bezerianos, A., Bragonzi, A. D., Brockmann, G. A., Brown, S., Campbell-Tofte, J., Cendelin, J., Chatziioannou, A., Chen, D., Crusio, W., Dimitrakopoulou, K., Falcon, J. M., ... Zatloukal, K. (2013). Controlling complexity: the clinical relevance of mouse complex genetics. European Journal of Human Genetics, 21 (11), 1191-6. doi:10.1038/ejhg.2013.79 ![]() |
![]() ![]() | GEORGATOS, F., Ballereau, S., Pellet, J., Ghanem, M., Price, N., HOOD, L., Guo, Y. K., Boutigny, D., Auffray, C., BALLING, R., & SCHNEIDER, R. (2013). Computational infrastructures for data and knowledge management in systems biology. In A. Prokop & B. Csukás (Eds.), Systems Biology: Integrative Biology and Simulation Tools. Springer. doi:10.1007/978-94-007-6803-1_13 ![]() |
TREFOIS, C., Fujita, A. K., OSTASZEWSKI, M., Matsuoka, Y., Ghosh, S., GLAAB, E., Crespo, I., Perumal, T. M., Jurkowski, W., ANTONY, P., DIEDERICH, N., BUTTINI, M., Kodama, A., SATAGOPAM, V., EIFES, S., DEL SOL MESA, A., SCHNEIDER, R., Kitano, H., & BALLING, R. (August 2012). Constructing a comprehensive map of Parkinson’s disease to elucidate underlying mechanisms of its multifaceted molecular pathology [Poster presentation]. The 13th International Conference on Systems Biology. |
![]() ![]() | KOLODKIN, A., SIMEONIDIS, V., Brady, N., & BALLING, R. (August 2012). A kinetic model and design principles study of cellular ROS defence and its failure in Parkinson’s disease [Poster presentation]. ICSB 2013 - 13th International Conference on Systems Biology, Toronto, Canada. |
![]() ![]() | KOLODKIN, A., SIMEONIDIS, E., BALLING, R., & Westerhoff, H. V. (2012). Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence. Frontiers in Physiology, 3, 291. doi:10.3389/fphys.2012.00291 ![]() |
![]() ![]() | HE, F., Chen, H., Probst-Kepper, M., Geffers, R., EIFES, S., Del Sol, A., Schughart, K., Zeng, A.-P., & BALLING, R. (2012). PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells. Molecular Systems Biology, 8, 624. doi:10.1038/msb.2012.56 ![]() |
![]() ![]() | HOOD, L., BALLING, R., & Auffray, C. (2012). Revolutionizing medicine in the 21(st) century through systems approaches. Biotechnology Journal, 7 (8), 937-1054. doi:10.1002/biot.201100306 ![]() |
![]() ![]() | KOLODKIN, A., Boogerda, F. C., Plantb, N., Bruggemana, F. J., Goncharuke, V., Lunshofa, J., Moreno-Sanchezi, R., Yilmaza, N., Bakkerk, B. M., Snoepa, J. L., BALLING, R., & Westerhoff, H. V. (2012). Emergence of the silicon human and network targeting drugs. European Journal of Pharmaceutical Sciences, 46 (4), 190-197. doi:10.1016/j.ejps.2011.06.006 ![]() |
![]() ![]() | ANTONY, P., BALLING, R., & VLASSIS, N. (2012). From Systems Biology to Systems Biomedicine. Current Opinion in Biotechnology, 23 (4), 604-8. doi:10.1016/j.copbio.2011.11.009 ![]() |
TREFOIS, C., ANTONY, P., BAUMURATOV, A., BOYD, O., Köglsberger, S., & BALLING, R. (12 December 2011). Analysis of critical transitions in Parkinson's disease [Poster presentation]. BeNeLux Bioinformatics Conference, Luxembourg, Luxembourg. |
![]() ![]() | SIMEONIDIS, V., Roach, J., Brunkow, M., Glusman, G., Reynolds, S., BALLING, R., HOOD, L., GALAS, D. J., Wichmann, H.-E., Grimm, S., & Gelinas, R. (July 2011). Candidate mutations for early-onset lung cancer by family genome sequencing [Poster presentation]. ISMB/ECCB 2011 - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology, Vienna, Austria. |
![]() ![]() | BALLING, R. (2011). Fighting the Diseases of the Future. In Our Common Future Conference Summary Report (pp. 63-65). Volkswagen Stiftung Germany. |
![]() ![]() | Abrahams, J. P., Apweiler, R., BALLING, R., Bertero, M. G., Bujnicki, J. M., Chayen, N. E., Chène, P., Corthals, G. L., Dylag, T., Förster, F., Heck, A. J., Henderson, P. J., Herwig, R., Jehenson, P., Kokalj, S. J., Laue, E., Legrain, P., Martens, L., Migliorini, C., ... Taussig, M. J. (2011). 4D Biology for health and disease. New Biotechnology, 28 (4), 291-293. doi:10.1016/j.nbt.2010.10.003 ![]() |
![]() ![]() | Bousquet, J., Anto, J. M., Sterk, P. J., Adcock, I. M., Chung, K. F., Roca, J., Agusti, A., Brightling, C., Cambon-Thomsen, A., Cesario, A., Abdelhak, S., Antonarakis, S. E., Avignon, A., Ballabio, A., Baraldi, E., Baranov, A., Bieber, T., Bockaert, J., Brahmachari, S., ... Auffray, C. (2011). Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Medicine, 3 (7), 43-47. doi:10.1186/gm259 ![]() |
![]() ![]() | ANTONY, P., DIEDERICH, N., & BALLING, R. (2011). Parkinson’s disease mouse models in translational research. Mammalian Genome, 22 (7-8), 401-19. doi:10.1007/s00335-011-9330-x ![]() |
![]() ![]() | Smedley, D., Schofield, P., Chen, C. K., Aidinis, V., Ainali, C., Bard, J., BALLING, R., Birney, E., Blake, A., Bongcam-Rudloff, E., Brookes, A. J., Cesareni, G., Chandras, C., Eppig, J., Flicek, P., Gkoutos, G., Greenaway, S., Gruenberger, M., Heriche, J. K., ... Hancock, J. M. (2010). Finding and sharing: new approaches to registries of databases and services for the biomedical sciences. Database: The Journal of Biological Databases and Curation, Jul 6, 1758-0463. doi:10.1093/database/baq014 ![]() |
![]() ![]() | Probst-Kepper, M., BALLING, R., & Buer, J. (2010). FOXP3: required but not sufficient. the role of GARP (LRRC32) as a safeguard of the regulatory phenotype. Current Molecular Medicine, 10 (6), 533-539. doi:10.2174/1566524011009060533 ![]() |
![]() ![]() | DEL SOL MESA, A., BALLING, R., HOOD, L., & GALAS, D. J. (2010). Diseases as network perturbations. Current Opinion in Biotechnology, 21 (4), 566-571. doi:10.1016/j.copbio.2010.07.010 ![]() |
![]() ![]() | BALLING, R., & BECKER, R. (2010). EATRIS Infrastructure Accelerates Translation. BIOforum Europe, (1-2), 14-16. ![]() |
![]() ![]() | Erben, R. G., Zeitz, U., Weber, K., Stierstorfer, B., Wolf, G., Schmahl, W., BALLING, R., & Quintanilla-Martinez, L. (2010). A non-functioning vitamin D receptor predisposes to leukaemoid reactions in mice. Hematological Oncology, 28 (4), 185-191. doi:10.1002/hon.938 ![]() |
![]() ![]() | Morgan, H., Beck, T., Blake, A., Gates, H., Adams, N., Debouzy, G., Leblanc, S., Lengger, C., Maier, H., Melvin, D., Meziane, H., Richardson, D., Wells, S., White, J., Wood, J., Eumodic, C., Hrabé de Angelis, M., Hrabé de Angelis, M., Brown, S. D. M., ... BALLING, R. (2010). EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Research, 38 (1), 577-585. doi:10.1093/nar/gkp1007 ![]() |
![]() ![]() | Phillips, R. A., & BALLING, R. (2010). The bumpy road to personalized healthcare. European Biotechnology Science and Industry News, 9 (7-8). ![]() |
![]() ![]() | Schughart, K., Arends, D., Andreux, P., BALLING, R., Beyer, A., Bezerianos, A., Brockmann, G. A., Crusio, W. E., Campbell-Tofte, J., Denny, P., Falcon-Perez, J. M., Forejt, J., Franken, P., Hovatta, I., Iraqi, F., Jansen, R. C., Kaczmarek, L., Kas, M. J., Kashofer, K., ... Zatloukal, K. (2010). SYSGENET: a meeting report from a new European network for systems genetics. Mammalian Genome, 21 (7-8), 331-6. doi:10.1007/s00335-010-9273-7 ![]() |
![]() ![]() | HE, F., BALLING, R., & Zeng, A.-P. (2009). Reverse engineering and verification of gene networks: principles, assumptions, and limitations of present methods and future perspectives. Journal of Biotechnology, 144 (3), 190-203. doi:10.1016/j.jbiotec.2009.07.013 ![]() |
![]() ![]() | Legrand, N., Ploss, A., BALLING, R., Becker, P. D., Borsotti, C., Brezillon, N., Debarry, J., de Jong, Y., Deng, H., Di Santo, J. P., Eisenbarth, S., Eynon, E., Flavell, R. A., Guzman, C. A., Huntington, N. D., Kremsdorf, D., Manns, M. P., Manz, M. G., Mention, J.-J., ... Ziegler, P. (2009). Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host and Microbe, 6 (1), 5-9. doi:10.1016/j.chom.2009.06.006 ![]() |
![]() ![]() | Probst-Kepper, M., Geffers, R., Kröger, A., Viegas, N., Erck, C., Hecht, H. J., Lünsdorf, H., Roubin, R., Moharregh-Khiabani, D., Wagner, K., Ocklenburg, F., Jeron, A., Garritsen, H., Arstila, T. P., Kekäläinen, E., BALLING, R., Hauser, H., Buer, J., & Weiss, S. (2009). GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal of Cellular and Molecular Medicine, 13 (9B), 3343-57. doi:10.1111/j.1582-4934.2009.00782.x ![]() |
Altman, R. B., BALLING, R., Brinkley, J. F., Coiera, E., Consorti, F., Dhansay, M. A., Geissbuhler, A., Hersh, W., Kwankam, S. Y., Lorenzi, N. M., Martin-Sanchez, F., Mihalas, G. I., Shahar, Y., Takabayashi, K., & Wiederhold, G. (2008). Commentaries on "Informatics and medicine: from molecules to populations". Methods of Information in Medicine, 47 (4), 296-317. doi:10.1055/s-0038-1627413 ![]() |
Kappen, C., Neubuser, A., BALLING, R., & Finnell, R. (2007). Molecular basis for skeletal variation: insights from developmental genetic studies in mice. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 80 (6), 425-50. doi:10.1002/bdrb.20136 ![]() |
BALLING, R. (2007). Sudden and unexpected. Nature Genetics, 39 (12), 1422-3. doi:10.1038/ng1207-1422 ![]() |
![]() ![]() | HE, F., Buer, J., Zeng, A.-P., & BALLING, R. (2007). Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation. Genome Biology, 8 (9), 181. doi:10.1186/gb-2007-8-9-r181 ![]() |
BALLING, R. (2007). From mouse genetics to systems biology. Mammalian Genome, 18 (6-7), 383-8. doi:10.1007/s00335-007-9044-2 ![]() |
Lengeling, A., Müller, W., & BALLING, R. (2006). Phenotyping of host-pathogen interactions in mice. In Standards of Mouse Model Phenotyping. In M. Harbe de Angelis, P. Chambon, ... S. Brown (Eds.), Phenotyping of host-pathogen interactions in mice. In Standards of Mouse Model Phenotyping (pp. 201-219). Wiley-VCH, Weinheim. ![]() |
Helming, L., Bose, J., Ehrchen, J., Schiebe, S., Frahm, T., Geffers, R., Probst-Kepper, M., BALLING, R., & Lengeling, A. (2005). 1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation. Blood, 106 (13), 4351-8. doi:10.1182/blood-2005-03-1029 ![]() |
Brown, S. D., Chambon, P., De Angelis, M. H., Eumorphia Consortium, & BALLING, R. (Other coll.). (2005). EMPReSS: standardized phenotype screens for functional annotation of the mouse genome. Nature Genetics, (37), 1155. doi:10.1038/ng1105-1155 ![]() |
Luckow, B., Joergensen, J., Chilla, S., Li, J.-P., Henger, A., Kiss, E., Wieczorek, G., Roth, L., Hartmann, N., Hoffmann, R., Kretzler, M., Nelson, P. J., Perez de Lema, G., Maier, H., Wurst, W., BALLING, R., Pfeffer, K., Grone, H.-J., Schlondorff, D., & Zerwes, H.-G. (2004). Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. European Journal of Immunology, 34 (9), 2568-78. doi:10.1002/eji.200324776 ![]() |
Auwerx, J., Avner, P., Baldock, R., Ballabio, A., BALLING, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies, K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., de Angelis, M. H., ... Wurst, W. (2004). The European dimension for the mouse genome mutagenesis program. Nature Genetics, 36 (9), 925-7. doi:10.1038/ng0904-925 ![]() |
Wollscheid-Lengeling, E., Muller, R.-J., BALLING, R., & Schughart, K. (2004). Maintaining your immune system--one method for enhanced longevity. Science of Aging Knowledge Environment, 2004 (1), 2. doi:10.1126/sageke.2004.1.pe2 ![]() |
Zeitz, U., Weber, K., Soegiarto, D. W., Wolf, E., BALLING, R., & Erben, R. G. (2003). Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB Journal, 17 (3), 509-11. doi:10.1096/fj.02-0424fje ![]() |
Rodrigo, I., Hill, R. E., BALLING, R., Munsterberg, A., & Imai, K. (2003). Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Development, 130 (3), 473-82. doi:10.1242/dev.00240 ![]() |
Buer, J., & BALLING, R. (2003). Mice, microbes and models of infection. Nature Reviews. Genetics, 4 (3), 195-205. doi:10.1038/nrg1019 ![]() |
Rubio-Aliaga, I., Frey, I., Boll, M., Groneberg, D. A., Eichinger, H. M., BALLING, R., & Daniel, H. (2003). Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Molecular and Cellular Biology, 23 (9), 3247-52. doi:10.1128/MCB.23.9.3247-3252.2003 ![]() |
Vreugde, S., Erven, A., Kros, C. J., Marcotti, W., Fuchs, H., Kurima, K., Wilcox, E. R., Friedman, T. B., Griffith, A. J., BALLING, R., Hrabe De Angelis, M., Avraham, K. B., & Steel, K. P. (2002). Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nature Genetics, 30 (3), 257-8. doi:10.1038/ng848 ![]() |
Schulz, H., Johner, C., Eder, G., Ziesenis, A., Reitmeier, P., Heyder, J., & BALLING, R. (2002). Respiratory mechanics in mice: strain and sex specific differences. Acta Physiologica Scandinavica, 174 (4), 367-75. doi:10.1046/j.1365-201x.2002.00955.x ![]() |
Jansen, W. T. M., Bolm, M., BALLING, R., Chhatwal, G. S., & Schnabel, R. (2002). Hydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes. Infection and Immunity, 70 (9), 5202-7. doi:10.1128/IAI.70.9.5202-5207.2002 ![]() |
Hetzer-Egger, C., Schorpp, M., Haas-Assenbaum, A., BALLING, R., Peters, H., & Boehm, T. (2002). Thymopoiesis requires Pax9 function in thymic epithelial cells. European Journal of Immunology, 32 (4), 1175-81. doi:10.1002/1521-4141(200204)32:4<1175::AID-IMMU1175>3.0.CO;2-U ![]() |
Gerber, J.-K., Richter, T., Kremmer, E., Adamski, J., Hofler, H., BALLING, R., & Peters, H. (2002). Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. Journal of Pathology, 197 (3), 293-7. doi:10.1002/path.1115 ![]() |
Kist, R., Schrewe, H., BALLING, R., & Scherer, G. (2002). Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis, 32 (2), 121-3. doi:10.1002/gene.10050 ![]() |
Stoeger, T., Proetzel, G. E., Welzel, H., Papadimitriou, A., Dony, C., BALLING, R., & Hofmann, C. (2002). In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Growth Factors, 20 (4), 197-210. doi:10.1080/0897719021000069579 ![]() |
Ernest, S., Christensen, B., Gilfix, B. M., Mamer, O. A., Hosack, A., Rodier, M., Colmenares, C., McGrath, J., Bale, A., BALLING, R., Sankoff, D., Rosenblatt, D. S., & Nadeau, J. H. (2002). Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mammalian Genome, 13 (5), 259-67. doi:10.1007/s00335-001-3054-2 ![]() |
Graw, J., Loster, J., Soewarto, D., Fuchs, H., Reis, A., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (2002). V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice. Mammalian Genome, 13 (8), 452-5. doi:10.1007/s00335-002-3021-6 ![]() |
Erben, R. G., Soegiarto, D. W., Weber, K., Zeitz, U., Lieberherr, M., Gniadecki, R., Moller, G., Adamski, J., & BALLING, R. (2002). Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Molecular Endocrinology, 16 (7), 1524-37. doi:10.1210/mend.16.7.0866 ![]() |
Nadeau, J. H., BALLING, R., Barsh, G., Beier, D., Brown, S. D., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W. N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J. L., Hicks, G., Hrabe de Angelis, M., Jackson, I., ... ZIMMER, A. D. (2001). Sequence interpretation. Functional annotation of mouse genome sequences. Science, 291 (5507), 1251-5. doi:10.1126/science.1058244 ![]() |
BALLING, R. (2001). ENU mutagenesis: analyzing gene function in mice. Annual Review of Genomics & Human Genetics, 2, 463-92. doi:10.1146/annurev.genom.2.1.463 ![]() |
Kiernan, A. E., Ahituv, N., Fuchs, H., BALLING, R., Avraham, K. B., Steel, K. P., & Hrabe de Angelis, M. (2001). The Notch ligand Jagged1 is required for inner ear sensory development. Proceedings of the National Academy of Sciences of the United States of America, 98 (7), 3873-8. doi:10.1073/pnas.071496998 ![]() |
Graw, J., Klopp, N., Loster, J., Soewarto, D., Fuchs, H., Becker-Follmann, J., Reis, A., Wolf, E., BALLING, R., & Habre de Angelis, M. (2001). Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts. Genetics, 157 (3), 1313-20. ![]() |
Graw, J., Loster, J., Soewarto, D., Fuchs, H., Meyer, B., Reis, A., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (2001). Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. Experimental Eye Research, 73 (6), 867-76. doi:10.1006/exer.2001.1096 ![]() |
Brown, S. D., & BALLING, R. (2001). Systematic approaches to mouse mutagenesis. Current Opinion in Genetics and Development, 11 (3), 268-73. doi:10.1016/S0959-437X(00)00189-1 ![]() |
Graw, J., Loster, J., Soewarto, D., Fuchs, H., Reis, A., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (2001). Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse. Investigative Ophthalmology and Visual Science, 42 (7), 1574-80. ![]() |
Graw, J., Loster, J., Soewarto, D., Fuchs, H., Meyer, B., Reis, A., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (2001). Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Investigative Ophthalmology and Visual Science, 42 (12), 2909-15. ![]() |
Alessandrini, F., Jakob, T., Wolf, A., Wolf, E., BALLING, R., Hrabe de Angelis, M., Ring, J., & Behrendt, H. (2001). Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. International Archives of Allergy and Applied Immunology, 124 (1-3), 25-8. doi:10.1159/000053659 ![]() |
Lengeling, A., Pfeffer, K., & BALLING, R. (2001). The battle of two genomes: genetics of bacterial host/pathogen interactions in mice. Mammalian Genome, 12 (4), 261-71. doi:10.1007/s003350040001 ![]() |
Santagati, F., Gerber, J. K., Blusch, J. H., Kokubu, C., Peters, H., Adamski, J., Werner, T., BALLING, R., & Imai, K. (2001). Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes. Mammalian Genome, 12 (3), 232-7. doi:10.1007/s003350010267 ![]() |
Faiella, A., Wernig, M., Consalez, G. G., Hostick, U., Hofmann, C., Hustert, E., Boncinelli, E., BALLING, R., & Nadeau, J. H. (2000). A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression. Human Molecular Genetics, 9 (2), 227-36. doi:10.1093/hmg/9.2.227 ![]() |
Rathkolb, B., Fuchs, E., Kolb, H. J., Renner-Muller, I., Krebs, O., BALLING, R., Hrabe de Angelis, M., & Wolf, E. (2000). Large-scale N-ethyl-N-nitrosourea mutagenesis of mice--from phenotypes to genes. Experimental Physiology, 85 (6), 635-44. doi:10.1111/j.1469-445x.2000.02094.x ![]() |
BALLING, R., & Hrabe de Angelis, M. (2000). From developmental biology to developmental toxicology. Annals of the New York Academy of Sciences, 919, 239-45. doi:10.1111/j.1749-6632.2000.tb06884.x ![]() |
BALLING, R., & Erben, R. G. (2000). From parathyroid to thymus, via glial cells. Nature Medicine, 6 (8), 860-1. doi:10.1038/78607 ![]() |
Hrabe de Angelis, M. H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., ... BALLING, R. (2000). Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genetics, 25 (4), 444-7. doi:10.1038/78146 ![]() |
Rolinski, B., Arnecke, R., Dame, T., Kreischer, J., Olgemoller, B., Wolf, E., BALLING, R., Hrabe de Angelis, M., & Roscher, A. A. (2000). The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry. Mammalian Genome, 11 (7), 547-51. doi:10.1007/s003350010105 ![]() |
Rathkolb, B., Decker, T., Fuchs, E., Soewarto, D., Fella, C., Heffner, S., Pargent, W., Wanke, R., BALLING, R., Hrabe de Angelis, M., Kolb, H. J., & Wolf, E. (2000). The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes. Mammalian Genome, 11 (7), 543-6. doi:10.1007/s003350010104 ![]() |
Soewarto, D., Fella, C., Teubner, A., Rathkolb, B., Pargent, W., Heffner, S., Marschall, S., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (2000). The large-scale Munich ENU-mouse-mutagenesis screen. Mammalian Genome, 11 (7), 507-10. doi:10.1007/s003350010097 ![]() |
Fuchs, H., Schughart, K., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (2000). Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants. Mammalian Genome, 11 (7), 528-30. doi:10.1007/s003350010101 ![]() |
Peters, H., & BALLING, R. (1999). Teeth. Where and how to make them. Trends in Genetics, 15 (2), 59-65. doi:10.1016/S0168-9525(98)01662-X ![]() |
Peters, H., Wilm, B., Sakai, N., Imai, K., Maas, R., & BALLING, R. (1999). Pax1 and Pax9 synergistically regulate vertebral column development. Development, 126 (23), 5399-408. ![]() |
Graw, J., Jung, M., Loster, J., Klopp, N., Soewarto, D., Fella, C., Fuchs, H., Reis, A., Wolf, E., BALLING, R., & Hrabe de Angelis, M. (1999). Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse. Genomics, 62 (1), 67-73. doi:10.1006/geno.1999.5974 ![]() |
Kiernan, A. E., Zalzman, M., Fuchs, H., Hrabe de Angelis, M., BALLING, R., Steel, K. P., & Avraham, K. B. (1999). Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival. Journal of Neurocytology, 28 (10-11), 969-85. doi:10.1023/a:1007090626294 ![]() |
Furumoto, T. A., Miura, N., Akasaka, T., Mizutani-Koseki, Y., Sudo, H., Fukuda, K., Maekawa, M., Yuasa, S., Fu, Y., Moriya, H., Taniguchi, M., Imai, K., Dahl, E., BALLING, R., Pavlova, M., Gossler, A., & Koseki, H. (1999). Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Developmental Biology, 210 (1), 15-29. doi:10.1006/dbio.1999.9261 ![]() |
Dietz, U. H., Ziegelmeier, G., Bittner, K., Bruckner, P., & BALLING, R. (1999). Spatio-temporal distribution of chondromodulin-I mRNA in the chicken embryo: expression during cartilage development and formation of the heart and eye. Developmental Dynamics : An Official Publication of the American Association of Anatomists, 216 (3), 233-43. doi:10.1002/(SICI)1097-0177(199911)216:3<233::AID-DVDY2>3.0.CO;2-G ![]() |
Munz, B., Smola, H., Engelhardt, F., Bleuel, K., Brauchle, M., Lein, I., Evans, L. W., Huylebroeck, D., BALLING, R., & Werner, S. (1999). Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO Journal, 18 (19), 5205-15. doi:10.1093/emboj/18.19.5205 ![]() |
Aruga, J., Mizugishi, K., Koseki, H., Imai, K., BALLING, R., Noda, T., & Mikoshiba, K. (1999). Zic1 regulates the patterning of vertebral arches in cooperation with Gli3. Mechanisms of Development, 89 (1-2), 141-50. doi:10.1016/S0925-4773(99)00220-8 ![]() |
Markus, M. A., Reichmuth, C., Atkinson, M. J., Reich, U., Hoffmann, I., BALLING, R., Anderer, U., & Hofler, H. (1999). Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro. Journal of Pathology, 187 (2), 164-72. doi:10.1002/(SICI)1096-9896(199901)187:2<164::AID-PATH208>3.0.CO;2-3 ![]() |
Marschall, S., Huffstadt, U., BALLING, R., & Hrabe de Angelis, M. (1999). Reliable recovery of inbred mouse lines using cryopreserved spermatozoa. Mammalian Genome, 10 (8), 773-6. doi:10.1007/s003359901090 ![]() |
BALLING, R. (1998). Whose law for sharing research tools? Nature, 396 (6711), 509. doi:10.1038/24971 ![]() |
Hofmann, C., Drossopoulou, G., McMahon, A., BALLING, R., & Tickle, C. (1998). Inhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development. Developmental Dynamics : An Official Publication of the American Association of Anatomists, 213 (2), 199-206. doi:10.1002/(SICI)1097-0177(199810)213:2<199::AID-AJA5>3.0.CO;2-B ![]() |
Peters, H., Neubuser, A., & BALLING, R. (1998). Pax genes and organogenesis: Pax9 meets tooth development. European Journal of Oral Sciences, 106 Suppl 1, 38-43. doi:10.1111/j.1600-0722.1998.tb02151.x ![]() |
Wilm, B., Dahl, E., Peters, H., BALLING, R., & Imai, K. (1998). Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proceedings of the National Academy of Sciences of the United States of America, 95 (15), 8692-7. doi:10.1073/pnas.95.15.8692 ![]() |
Pusch, C., Hustert, E., Pfeifer, D., Sudbeck, P., Kist, R., Roe, B., Wang, Z., BALLING, R., Blin, N., & Scherer, G. (1998). The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Human Genetics, 103 (2), 115-23. doi:10.1007/s004390050793 ![]() |
BALLING, R. (1998). Die Maus. In Seyffert (Ed.), Lehrbuch der Genetik (pp. 15, 309-322). Gustav Fischer Verlag, Stuttgart. ![]() |
Hrabe de Angelis, M., & BALLING, R. (1998). Large scale ENU screens in the mouse: genetics meets genomics. Mutation research, 400 (1-2), 25-32. doi:10.1016/S0027-5107(98)00061-X ![]() |
BALLING, R., Hrabe de Angelis, M., Schughart, K., & Wolf, E. (1998). We need more mutants: Plans for a large scale ENU mouse mutagenesis screen. OECD Economics Department Working Papers, (98), 103-111. ![]() |
Peters, H., Neubuser, A., Kratochwil, K., & BALLING, R. (1998). Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes and Development, 12 (17), 2735-47. doi:10.1101/gad.12.17.2735 ![]() |
Hillebrandt, S., Streffer, C., Montagutelli, X., & BALLING, R. (1998). A locus for radiation-induced gastroschisis on mouse Chromosome 7. Mammalian Genome, 9 (12), 995-7. doi:10.1007/s003359900913 ![]() |
Neubuser, A., Peters, H., BALLING, R., & Martin, G. R. (1997). Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell, 90 (2), 247-55. doi:10.1016/S0092-8674(00)80333-5 ![]() |
Peters, H., Neubüser, A., Wallin, J., Hostik, U., & BALLING, R. (1997). The Genetics of Vertebral Column Development. In Thiel & Klug (Eds.), Methods in Developmental Toxicology (pp. 135-149). Blackwell. ![]() |
BALLING, R. (1997). Transgenic technology as a tool. In P. Thorogood (edt.) Embryos, Genes and Birth (pp. 4: 49-67). John Wiley & Sons Ltd., Baffins Lane, Chichester. ![]() |
Dahl, E., Willecke, K., & BALLING, R. (1997). Segment-specific expression of the gap junction gene connexin 31 during hindbrain development. Development Genes & Evolution, (207), 359-361. doi:10.1007/s004270050123 ![]() |
Dahl, E., Koseki, H., & BALLING, R. (1997). Pax genes and organogenesis. BioEssays, 19 (9), 755-65. doi:10.1002/bies.950190905 ![]() |
Peters, H., Schuster, G., Neubuser, A., Richter, T., Hofler, H., & BALLING, R. (1997). Isolation of the Pax9 cDNA from adult human esophagus. Mammalian Genome, 8 (1), 62-4. doi:10.1007/s003359900351 ![]() |
Akasaka, T., Kanno, M., BALLING, R., Mieza, M. A., Taniguchi, M., & Koseki, H. (1996). A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development, 122 (5), 1513-22. ![]() |
Wallin, J., Eibel, H., Neubuser, A., Wilting, J., Koseki, H., & BALLING, R. (1996). Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation. Development, 122 (1), 23-30. ![]() |
Hofmann, C., Luo, G., BALLING, R., & Karsenty, G. (1996). Analysis of limb patterning in BMP-7-deficient mice. Developmental Genetics, 19 (1), 43-50. doi:10.1002/(SICI)1520-6408(1996)19:1<43::AID-DVG5>3.0.CO;2-0 ![]() |
MULLER, T., Ebensperger, C., Neubuser, A., Koseki, H., BALLING, R., Christ, B., & Wilting, J. (1996). Expression of avian Pax1 and Pax9 is intrinsically regulated in the pharyngeal endoderm, but depends on environmental influences in the paraxial mesoderm. Developmental Biology, 178 (2), 403-17. doi:10.1006/dbio.1996.0227 ![]() |
Hol, F. A., Geurds, M. P., Chatkupt, S., Shugart, Y. Y., BALLING, R., Schrander-Stumpel, C. T., Johnson, W. G., Hamel, B. C., & Mariman, E. C. (1996). PAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida. Journal of Medical Genetics, 33 (8), 655-60. doi:10.1136/jmg.33.8.655 ![]() |
BALLING, R., Helwig, U., Nadeau, J., Neubuser, A., Schmahl, W., & Imai, K. (1996). Pax genes and skeletal development. Annals of the New York Academy of Sciences, 785, 27-33. doi:10.1111/j.1749-6632.1996.tb56240.x ![]() |
BALLING, R. (1996). Von Knick- und Ringelschwänzen - Mäuse als Modellorganismus. Forschung-Mitteilungen der DFG, (2), 13-14. ![]() |
Wilting, J., Müller, T. S., Ebensperger, C., Brand-Saberi, B., Christ, B., Neubüser, A., BALLING, R., & Koseki, H. (1996). Development of the vertebral column: Morphogenesis and genes. In R. Vorgel, J. Fanghaenel, ... J. Giebel (Eds.), Aspects of Teratologie. Tectum Verlag. ![]() |
BALLING, R. (1996). Drug Toxicity in Embryonic Development; Chapter 4: Axial Skeleton. In R. Kavlock & G. Daston (Eds.), Handbook of Experimental Pharmacology (pp. 77-112). Springer. ![]() |
Hustert, E., Scherer, G., Olowson, M., Guenet, J. L., & BALLING, R. (1996). Rbt (Rabo torcido), a new mouse skeletal mutation involved in anteroposterior patterning of the axial skeleton, maps close to the Ts (tail-short) locus and distal to the Sox9 locus on chromosome 11. Mammalian Genome, 7 (12), 881-5. doi:10.1007/s003359900261 ![]() |
BALLING, R., Neubüser, A., & Christ, B. (1996). Pax genes and sclerotome induction. Seminars in Cell and Developmental Biology, (7), 129-136. doi:10.1006/scdb.1996.0018 ![]() |
Ebensperger, C., Wilting, J., Brand-Saberi, B., Mizutani, Y., Christ, B., BALLING, R., & Koseki, H. (1995). Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos. Anatomy & Embryology, 191 (4), 297-310. doi:10.1007/BF00534682 ![]() |
Lynch, S. A., Bond, P. M., Copp, A. J., Kirwan, W. O., Nour, S., BALLING, R., Mariman, E., Burn, J., & Strachan, T. (1995). A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36. Nature Genetics, 11 (1), 93-5. doi:10.1038/ng0995-93 ![]() |
Neubuser, A., Koseki, H., & BALLING, R. (1995). Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Developmental Biology, 170 (2), 701-16. doi:10.1006/dbio.1995.1248 ![]() |
Helwig, U., Imai, K., Schmahl, W., Thomas, B. E., Varnum, D. S., Nadeau, J. H., & BALLING, R. (1995). Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice. Nature Genetics, 11 (1), 60-3. doi:10.1038/ng0995-60 ![]() |
Hoffmann, I., & BALLING, R. (1995). Cloning and expression analysis of a novel mesodermally expressed cadherin. Developmental Biology, 169 (1), 337-46. doi:10.1006/dbio.1995.1148 ![]() |
BALLING, R. (1995). Von Mäusen und Menschen In: “Genetische Determinierung: Schicksal aus den Genen?”. GSF-Mensch und Umwelt, (10), 17-23. ![]() |
Otsen, M., BALLING, R., Den Bieman, M., & Van Zutphen, L. F. (1995). Assignment of the paired box gene Pax1 to rat chromosome 3. Mammalian Genome, 6 (9), 666-7. doi:10.1007/BF00352378 ![]() |
Hoffman, I., & BALLING, R. (1995). Chromosomal localization of the murine cadherin-11. Mammalian Genome, 6 (4), 304. doi:10.1007/BF00352423 ![]() |
Timmons, P. M., Wallin, J., Rigby, P. W., & BALLING, R. (1994). Expression and function of Pax 1 during development of the pectoral girdle. Development, 120 (10), 2773-85. ![]() |
Wallin, J., Wilting, J., Koseki, H., Fritsch, R., Christ, B., & BALLING, R. (1994). The role of Pax-1 in axial skeleton development. Development, 120 (5), 1109-21. ![]() |
Bober, E., Brand-Saberi, B., Ebensperger, C., Wilting, J., BALLING, R., Paterson, B. M., Arnold, H. H., & Christ, B. (1994). Initial steps of myogenesis in somites are independent of influence from axial structures. Development, 120 (11), 3073-82. ![]() |
BALLING, R. (1994). The undulated mouse and the development of the vertebral column. Is there a human PAX-1 homologue? Clinical Dysmorphology, 3 (3), 185-91. doi:10.1097/00019605-199407000-00001 ![]() |
BALLING, R. (1994). [Transgenic mice--biological fundamentals, practices and applications]. DTW. Deutsche tierarztliche Wochenschrift, 101 (3), 94-5. ![]() |
BALLING, R., Koseki, H., Wallin, J., Ebensperger, C., Wilting, J., & Christ, B. (1994). Mouse genetics and the development of vertebral column development. Proceedings Greenwood Genetics Center, (13), 58-60. ![]() |
Koseki, H., Wallin, J., Wilting, J., Mizutani, Y., Kispert, A., Ebensperger, C., Herrmann, B. G., Christ, B., & BALLING, R. (1993). A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae. Development, 119 (3), 649-60. ![]() |
Brand-Saberi, B., Ebensperger, C., Wilting, J., BALLING, R., & Christ, B. (1993). The ventralizing effect of the notochord on somite differentiation in chick embryos. Anatomy & Embryology, 188 (3), 239-45. doi:10.1007/BF00188215 ![]() |
Goulding, M., Sterrer, S., Fleming, J., BALLING, R., Nadeau, J., Moore, K. J., Brown, S. D., Steel, K. P., & Gruss, P. (1993). Analysis of the Pax-3 gene in the mouse mutant splotch. Genomics, 17 (2), 355-63. doi:10.1006/geno.1993.1332 ![]() |
BALLING, R., Ebensperger, C., Hoffmann, I., Imai, K., Koseki, H., Mizutani, Y., & Wallin, J. (1993). The genetics of skeletal development. Annales de Génétique, 36 (1), 56-62. ![]() |
Wallin, J., Mizutani, Y., Imai, K., Miyashita, N., Moriwaki, K., Taniguchi, M., Koseki, H., & BALLING, R. (1993). A new Pax gene, Pax-9, maps to mouse chromosome 12. Mammalian Genome, 4 (7), 354-8. doi:10.1007/BF00360584 ![]() |
Koseki, H., Zachgo, J., Mizutani, Y., Simon-Chazottes, D., Guenet, J. L., BALLING, R., & Gossler, A. (1993). Fine genetic mapping of the proximal part of mouse chromosome 2 excludes Pax-8 as a candidate gene for Danforth's short tail (Sd). Mammalian Genome, 4 (6), 324-7. doi:10.1007/BF00357091 ![]() |
Nass, S. J., Olowson, M., Miyashita, N., Moriwaki, K., BALLING, R., & Imai, K. (1993). Mapping of the Mod-1 locus on mouse chromosome 9. Mammalian Genome, 4 (6), 333-7. doi:10.1007/BF00357093 ![]() |
Imai, K., Nass, S. J., Olowson, M., & BALLING, R. (1993). The genetic map around the tail kinks (tk) locus on mouse chromosome 9. Mammalian Genome, 4 (10), 560-4. doi:10.1007/BF00361385 ![]() |
Schnittger, S., Rao, V. V., Deutsch, U., Gruss, P., BALLING, R., & Hansmann, I. (1992). Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH). Genomics, 14 (3), 740-4. doi:10.1016/S0888-7543(05)80177-6 ![]() |
Tassabehji, M., Read, A. P., Newton, V. E., Harris, R., BALLING, R., Gruss, P., & Strachan, T. (1992). Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature, 355 (6361), 635-6. doi:10.1038/355635a0 ![]() |
Gossler, A., & BALLING, R. (1992). The molecular and genetic analysis of mouse development. European Journal of Biochemistry, 204 (1), 5-11. doi:10.1111/j.1432-1033.1992.tb16599.x ![]() |
BALLING, R., Lau, C. F., Dietrich, S., Wallin, J., & Gruss, P. (1992). Development of the skeletal system. Ciba Foundation Symposium, 165, 132-40; discussion 140-3. ![]() |
Puschel, A. W., BALLING, R., & Gruss, P. (1991). Separate elements cause lineage restriction and specify boundaries of Hox-1.1 expression. Development, 112 (1), 279-87. ![]() |
Walther, C., Guenet, J. L., Simon, D., Deutsch, U., Jostes, B., Goulding, M. D., Plachov, D., BALLING, R., & Gruss, P. (1991). Pax: a murine multigene family of paired box-containing genes. Genomics, 11 (2), 424-34. doi:10.1016/0888-7543(91)90151-4 ![]() |
Yeom, Y. I., Ha, H. S., BALLING, R., Scholer, H. R., & Artzt, K. (1991). Structure, expression and chromosomal location of the Oct-4 gene. Mechanisms of Development, 35 (3), 171-9. doi:10.1016/0925-4773(91)90016-Y ![]() |
BALLING, R. (1991). CRABP and the teratogenic effects of retinoids. Trends in Genetics, (7), 279-287. doi:10.1016/0168-9525(91)90224-E ![]() |
Puschel, A. W., BALLING, R., & Gruss, P. (1990). Position-specific activity of the Hox1.1 promoter in transgenic mice. Development, 108 (3), 435-42. ![]() |
Theuring, F., Gotz, W., BALLING, R., Korf, H. W., Schulze, F., Herken, R., & Gruss, P. (1990). Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen. Oncogene, 5 (2), 225-32. ![]() |
Kessel, M., BALLING, R., & Gruss, P. (1990). Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell, 61 (2), 301-8. doi:10.1016/0092-8674(90)90810-2 ![]() |
BALLING, R., & Kessel, M. (1990). Development(s) in mouse genetics. Biochemistry & Cell Biology, 68 (2), 404-7. doi:10.1139/o90-058 ![]() |
Kessel, M., BALLING, R., & Gruss, P. (1990). The role of homeobox genes in mammalian development. Developmental Endocrinology. ![]() |
Püschel, A., BALLING, R., & Gruss, P. (1990). Analysis of the spatial and temporal control of Hox 1.1 in transgenic mice. Development, (108), 435-442. ![]() |
Schöler, H. R., Dressler, G. R., BALLING, R., Rohdewohld, H., & Gruss, P. (1990). Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO journal, (9), 2185-2195. doi:10.1002/j.1460-2075.1990.tb07388.x ![]() |
Scholer, H. R., Hatzopoulos, A. K., BALLING, R., Suzuki, N., & Gruss, P. (1989). A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO Journal, 8 (9), 2543-50. doi:10.1002/j.1460-2075.1989.tb08392.x ![]() |
Chowdhury, K., Dietrich, S., BALLING, R., Guenet, J. L., & Gruss, P. (1989). Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Nucleic Acids Research, 17 (24), 10427-38. doi:10.1093/nar/17.24.10427 ![]() |
Scholer, H. R., BALLING, R., Hatzopoulos, A. K., Suzuki, N., & Gruss, P. (1989). Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO Journal, 8 (9), 2551-7. doi:10.1002/j.1460-2075.1989.tb08393.x ![]() |
BALLING, R., Mutter, G., Gruss, P., & Kessel, M. (1989). Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. Cell, 58 (2), 337-47. doi:10.1016/0092-8674(89)90848-9 ![]() |
Schöler, H. R., BALLING, R., Hatzopoulos, A. K., Suzuki, N., & Gruss, P. (1989). Transcriptional activity of the octamer motif in embryonic stem cells and preimplantation embryos. Hormones and Cell Regulation, 198 (14), 91-95. ![]() |
BALLING, R., Deutsch, U., & Gruss, P. (1988). undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell, 55 (3), 531-5. doi:10.1016/0092-8674(88)90039-6 ![]() |
Dressler, G. R., Deutsch, U., BALLING, R., Simon, D., Guenet, J. L., & Gruss, P. (01 January 1988). Murine Genes with homology to Drosophila segmentation genes. Development, 0 (104), 181-186. ![]() |
Duprey, P., Chowdhury, K., Dressler, G. R., BALLING, R., Simon, D., Guenet, J. L., & Gruss, P. (1988). A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes and Development, 2 (12A), 1647-54. doi:10.1101/gad.2.12a.1647 ![]() |
Sapienza, C., Peterson, A. C., Rossant, J., & BALLING, R. (1987). Degree of methylation of transgenes is dependent on gamete of origin. Nature, 328 (6127), 251-4. doi:10.1038/328251a0 ![]() |
BALLING, R., & Beier, H. M. (1985). Direct effects of nicotine on rabbit preimplantation embryos. Toxicology, 34 (4), 309-13. doi:10.1016/0300-483X(85)90141-6 ![]() |
Huszar, D., BALLING, R., Kothary, R., Magli, M. C., Hozumi, N., Rossant, J., & Bernstein, A. (1985). Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector. Proceedings of the National Academy of Sciences of the United States of America, 82 (24), 8587-91. doi:10.1073/pnas.82.24.8587 ![]() |
BALLING, R., Haaf, H., Maydl, R., Metzler, M., & Beier, H. M. (1985). Oxidative and conjugative metabolism of diethylstilbestrol by rabbit preimplantation embryos. Developmental Biology, 109 (2), 370-4. doi:10.1016/0012-1606(85)90462-2 ![]() |
Coon, C., & BALLING, R. (1984). Asparagine and glutamine metabolism in chicks. Poultry Science, 63 (4), 717-29. doi:10.3382/ps.0630717 ![]() |
BALLING, R., & Coon, C. (1981). Effect Of Dietary Asparagine And Protein-Equivalents In Crystalline Amino-Acid Diets On Asparagine Metabolism In Chicks. Journal of Nutrition, 111 (10), 1749-1756. doi:10.1093/jn/111.10.1749 ![]() |