Article (Scientific journals)
Luxembourg Parkinson’s study -comprehensive baseline analysis of Parkinson’s disease and atypical parkinsonism
PAVELKA, Lukas; RAWAL, Rajesh; GHOSH, Soumyabrata et al.
2023In Frontiers in Neurology, 14
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Keywords :
Neurology (clinical); Neurology; Parkinson's disease; Parkinsonism; Clinical data; Luxembourg; Epidemiology
Abstract :
[en] Background: Deep phenotyping of Parkinson’s disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along with more than 800 control subjects have been recruited in the frame of the observational, monocentric, nation-wide, longitudinal-prospective Luxembourg Parkinson’s study.Objective: To profile the baseline dataset and to explore risk factors, comorbidities and clinical profiles associated with PD, atypical parkinsonism and controls.Methods: Epidemiological and clinical characteristics of all 1,648 participants divided in disease and control groups were investigated. Then, a cross-sectional group comparison was performed between the three largest groups: PD, progressive supranuclear palsy (PSP) and controls. Subsequently, multiple linear and logistic regression models were fitted adjusting for confounders.ResultsThe mean (SD) age at onset (AAO) of PD was 62.3 (11.8) years with 15% early onset (AAO < 50 years), mean disease duration 4.90 (5.16) years, male sex 66.5% and mean MDS-UPDRS III 35.2 (16.3). For PSP, the respective values were: 67.6 (8.2) years, all PSP with AAO > 50 years, 2.80 (2.62) years, 62.7% and 53.3 (19.5). The highest frequency of hyposmia was detected in PD followed by PSP and controls (72.9%; 53.2%; 14.7%), challenging the use of hyposmia as discriminating feature in PD vs. PSP. Alcohol abstinence was significantly higher in PD than controls (17.6 vs. 12.9%, p = 0.003).Conclusion: Luxembourg Parkinson’s study constitutes a valuable resource to strengthen the understanding of complex traits in the aforementioned neurodegenerative disorders. It corroborated several previously observed clinical profiles, and provided insight on frequency of hyposmia in PSP and dietary habits, such as alcohol abstinence in PD.Clinical trial registration: clinicaltrials.gov, NCT05266872.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Digital Medicine (Klucken Group)
Disciplines :
Neurology
Public health, health care sciences & services
Author, co-author :
PAVELKA, Lukas ;  University of Luxembourg
RAWAL, Rajesh ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
GHOSH, Soumyabrata  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
PAULY, Claire ;  University of Luxembourg
PAULY, Laure ;  University of Luxembourg
HANFF, Anne-Marie ;  University of Luxembourg
KOLBER, Pierre Luc ;  University of Luxembourg
JONSDOTTIR, Sonja ;  University of Luxembourg
MCINTYRE, Deborah ;  University of Luxembourg
AZAIZ, Kheira ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Translational Neuroscience
THIRY, Elodie ;  University of Luxembourg
Vilasboas, Liliana
SOBOLEVA, Ekaterina ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
GIRAITIS, Marijus ;  University of Luxembourg
TSURKALENKO, Olena ;  University of Luxembourg
SAPIENZA, Stefano ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine
DIEDERICH, Nico ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Scientific Central Services > Disease Modelling and Screening Platform
KLUCKEN, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine
GLAAB, Enrico  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science
Aguayo, Gloria A.
Jubal, Eduardo Rosales
PERQUIN, Magali ;  University of Luxembourg
Vaillant, Michel;  Luxembourg Institute of Health (LIH) > Translational Medicine Operations Hub
MAY, Patrick  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Gantenbein, Manon;  Luxembourg Institute of Health (LIH) > Translational Medicine Operations Hub
SATAGOPAM, Venkata ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
KRÜGER, Rejko ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Luxembourg Institute of Health (LIH) > Transversal Translational Medicine ; Centre Hospitalier de Luxembourg (CHL) > Parkinson Research Clinic
NCER-PD Consortium
More authors (18 more) Less
External co-authors :
no
Language :
English
Title :
Luxembourg Parkinson’s study -comprehensive baseline analysis of Parkinson’s disease and atypical parkinsonism
Publication date :
19 December 2023
Journal title :
Frontiers in Neurology
eISSN :
1664-2295
Publisher :
Frontiers Media SA
Volume :
14
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Development Goals :
3. Good health and well-being
European Projects :
H2020 - 692320 - CENTRE-PD - TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease
FnR Project :
FNR11264123 - Ncer-pd, 2015 (01/01/2015-30/11/2020) - Rejko Krüger
FNR14146272 - Digital Healthcare Solutions: Patient Management E-health Concepts, 2020 (01/07/2021-30/06/2026) - Jochen Klucken
Funders :
FNR - Fonds National de la Recherche [LU]
Union Européenne [BE]
Funding number :
FNR/P13/6682797; FNR/NCER13/BM/11264123; FNR/P13/6682797; INTER/22/17104370
Funding text :
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the Luxembourg National Research Fund (FNR) within the National Centre of Excellence in Research in Parkinson’s disease [NCER- PD; (FNR/NCER13/BM/11264123)] and the PEARL programme (FNR; FNR/P13/6682797 to RK) as well as by the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 692320 (WIDESPREAD; CENTRE-PD; Grant Agreement No. 692320; CENTRE-PD to RK); dHealthPD PEARL programme to JK (14146272); DIGIPD (ERAPERMED 2020-314) to EG, RECAST (INTER/22/17104370) to EG.
Commentary :
Group members of [NCER-PD Consortium] Geeta Acharya2, Gloria Aguayo2, Myriam Alexandre2, Muhammad Ali1, Wim Ammerlann2, Giuseppe Arena1, Rudi Balling1, Michele Bassis1, Roxane Batutu3, Katy Beaumont2, Regina Becker1, Camille Bellora2, Guy Berchem3, Daniela Berg11, Alexandre Bisdorff5, Ibrahim Boussaad1, Kathrin Brockmann11, Jessica Calmes2, Lorieza Castillo2, Gessica Contesotto2, Nancy De Bremaeker3, Nico Diederich3, Rene Dondelinger5, Daniela Esteves2, Guy Fagherazzi2, Jean-Yves Ferrand2, Manon Gantenbein2, Thomas Gasser11, Piotr Gawron1, Soumyabrata Ghosh1, Marijus Giraitis2,3, Enrico Glaab1, Elisa Gómez De Lope1, Jérôme Graas2, Mariella Graziano17, Valentin Groues1, Anne Grünewald1, Wei Gu1, Gaël Hammot2, Anne-Marie Hanff2,20,21, Linda Hansen1,3, Michael Heneka1, Estelle Henry2, Sylvia Herbrink6, Sascha Herzinger1, Michael Heymann2, Michele Hu8, Alexander Hundt2, Nadine Jacoby18, Jacek Jaroslaw Lebioda1, Yohan Jarosz1, Sonja Jónsdóttir2, Quentin Klopfenstein1, Jochen Klucken1,2,3, Rejko Krüger1,2,3, Pauline Lambert2, Zied Landoulsi1, Roseline Lentz7, Inga Liepelt11, Robert Liszka14, Laura Longhino3, Victoria Lorentz2, Paula Cristina Lupu2, Tainá M. Marques1, Clare Mackay10, Walter Maetzler15, Katrin Marcus13, Guilherme Marques2, Patricia Martins Conde1, Patrick May1, Deborah Mcintyre2, Chouaib Mediouni2, Francoise Meisch1, Myriam Menster2, Maura Minelli2, Michel Mittelbronn1,4, Brit Mollenhauer12, Friedrich Mühlschlegel4, Romain Nati3, Ulf Nehrbass2, Sarah Nickels1, Beatrice Nicolai3, Jean-Paul Nicolay19, Fozia Noor2, Marek Ostaszewski1, Clarissa P. C. Gomes1, Sinthuja Pachchek1, Claire Pauly1,3, Laure Pauly2, 20, Lukas Pavelka1,2,3, Magali Perquin2, Nancy E. Ramia1, Rosalina Ramos Lima2, Armin Rauschenberger1, Rajesh Rawal1, Dheeraj Reddy Bobbili1, Kirsten Roomp1, Eduardo Rosales2, Isabel Rosety1, Estelle Sandt2, Stefano Sapienza1, Venkata Satagopam1, Margaux Schmitt2, Sabine Schmitz1, Reinhard Schneider1, Jens Schwamborn1, Amir Sharify2, Ekaterina Soboleva1, Kate Sokolowska2, Hermann Thien2, Elodie Thiry1,3, Rebecca Ting Jiin Loo1, Christophe Trefois1, Johanna Trouet2, Olena Tsurkalenko2, Michel Vaillant2, Mesele Valenti2, Gilles Van Cutsem1,3, Carlos Vega1, Liliana Vilas Boas3, Maharshi Vyas1, Richard Wade-Martins9, Paul Wilmes1, Evi Wollscheid-Lengeling1, Gelani Zelimkhano3. 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. 2Luxembourg Institute of Health, Strassen, Luxembourg. 3Centre Hospitalier de Luxembourg, Strassen, Luxembourg. 4Laboratoire National de Santé, Dudelange, Luxembourg. 5Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg. 6Centre Hospitalier du Nord, Ettelbrück, Luxembourg. 7Parkinson Luxembourg Association, Leudelange, Luxembourg. 8Oxford Parkinson’s Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. 9Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, United Kingdom. 10Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, United Kingdom. 11Center of Neurology and Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University Hospital Tübingen, Germany. 12Paracelsus-Elena-Klinik, Kassel, Germany. 13 Ruhr-University of Bochum, Bochum, Germany. 14Westpfalz-Klinikum GmbH, Kaiserslautern, Germany. 15Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany. 16Department of Neurology Philipps, University Marburg, Marburg, Germany. 17Association of Physiotherapists in Parkinson’s Disease Europe, Esch-sur-Alzette, Luxembourg. 18Private Practice, Ettelbruck, Luxembourg. 19 Private Practice, Luxembourg, Luxembourg. 20Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. 21Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre+, Maastricht, Netherlands. Funding The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the Luxembourg National Research Fund (FNR) within the National Centre of Excellence in Research in Parkinson’s disease [NCER- PD; (FNR/NCER13/BM/11264123)] and the PEARL programme (FNR; FNR/P13/6682797 to RK) as well as by the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 692320 (WIDESPREAD; CENTRE-PD; Grant Agreement No. 692320; CENTRE-PD to RK); dHealthPD PEARL programme to JK (14146272); DIGIPD (ERAPERMED 2020-314) to EG, RECAST (INTER/22/17104370) to EG. Acknowledgments We would like to give special thanks to all the study participants. Additionally, we are very grateful for all the funding and private donations that enabled us to carry out the project. Furthermore, we acknowledge the joint effort of the NCER-PD consortium members generally contributing to the Luxembourg Parkinson’s study. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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