Article (Scientific journals)
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
Hipp Epouse D'amico, Géraldine; Vaillant, Michel; Diederich, Nico J. et al.
2018In Frontiers in Aging Neuroscience, 10, p. 326
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Keywords :
parkinsonism; cohort; longitudinal; stratification; deep phenotyping
Abstract :
[en] While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson’s study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB)
Disciplines :
Life sciences: Multidisciplinary, general & others
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Hipp Epouse D'amico, Géraldine ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Vaillant, Michel
Diederich, Nico J.
Roomp, Kirsten  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Satagopam, Venkata ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Banda, Peter ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Sandt, Estelle
Mommaerts, Kathleen
Schmitz, Sabine ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Longhino, Laura
Schweicher, Alexandra
Hanff, Anne-Marie
Nicolai, Béatrice
Kolber, Pierre Luc ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Reiter, Dorothea ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Pavelka, Lukas ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Binck, Sylvia ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Pauly, Claire ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Geffers, Lars ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Betsou, Fay
Gantenbein, Manon
Klucken, Jochen
Gasser, Thomas
Hu, Michele
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Krüger, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
More authors (16 more) Less
External co-authors :
yes
Language :
English
Title :
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
Publication date :
29 October 2018
Journal title :
Frontiers in Aging Neuroscience
ISSN :
1663-4365
Publisher :
Frontiers Media S.A., Lausanne, Switzerland
Volume :
10
Pages :
326
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
FnR Project :
NCER13/BM/11264123
Name of the research project :
National Centre of Excellence in Research on Parkinson’s disease
Available on ORBilu :
since 13 December 2018

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