Reference : Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiati...

	Document type :	Scientific congresses, symposiums and conference proceedings : Poster
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	Focus Areas :	Computational Sciences; Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/46298

Title :	Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression
Language :	English
Author, co-author :	Ternes, Dominik [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Karta, Jessica [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Tsenkova, Mina [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Koncina, Eric [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Schmitz, Martine [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Grandmougin, Léa [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
	Ginolhac, Aurélien [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Gaigneaux, Anthoula [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Ramiro Garcia, Javier [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
	Wilmes, Paul [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
	Haan, Serge [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Letellier, Elisabeth [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Publication date :	22-Feb-2020
Number of pages :	A0
Peer reviewed :	No
Audience :	International
Event name :	The Microbiome, Viruses, and Cancer
Event date :	from 21-01-2020 to 24-02-2020
Event organizer :	AACR
Event place (city) :	Orlando
Event country :	USA
Keywords :	[en] Microbiome ; Colorectal cancer ; Systems Biology
Abstract :	[en] Accumulating evidence suggests that dysbiosis, a state of pathological imbalance in the human gut microbiome, is present in patients suffering from colorectal cancer (CRC). 16S rRNA gene sequencing, as well as metagenomic and metatranscriptomic analyses, identified specific bacteria being associated with CRC. Among others, Fusobacterium ssp. have been found to directly interact with cancer or immune cells of their host. However, only a limited number of CRC-associated microbes have been examined for host-microbial interactions and, as such, the role of bacteria in the etiology of the disease remains largely elusive. Our aim is the development of predictive and experimental models that allow to not only study the host-microbiota interactions but are also amenable to high-throughput experimentation and large-scale omics-data integration. Ultimately, such models should help to get from meta-omics to cellular mechanism and, moreover, serve as tools for reproducible analyses of host-microbial interaction mechanisms of on a transcriptomic, proteomic, and metabolomic level. Our research proposes an integrative study approach allowing us to bridge meta-omics with functional mechanisms by focusing on the interaction taking place between F. nucleatum and patient-derived CRC cells.
Funders :	Fonds National de la Recherche - FnR ; Fondation du Pélican de Mie et Pierre Hippert-Faber
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/10993/46298

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