Reference : Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiati...
Scientific congresses, symposiums and conference proceedings : Poster
Life sciences : Biochemistry, biophysics & molecular biology
Computational Sciences; Systems Biomedicine
http://hdl.handle.net/10993/46298
Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression
English
Ternes, Dominik mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Karta, Jessica mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Tsenkova, Mina mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Koncina, Eric mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Schmitz, Martine mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Grandmougin, Léa mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
Ginolhac, Aurélien mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Gaigneaux, Anthoula mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Ramiro Garcia, Javier mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
Haan, Serge mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Letellier, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
22-Feb-2020
A0
No
International
The Microbiome, Viruses, and Cancer
from 21-01-2020 to 24-02-2020
AACR
Orlando
USA
[en] Microbiome ; Colorectal cancer ; Systems Biology
[en] Accumulating evidence suggests that dysbiosis, a state of pathological imbalance in the human gut microbiome, is present in patients suffering from colorectal cancer (CRC). 16S rRNA gene sequencing, as well as metagenomic and metatranscriptomic analyses, identified specific bacteria being associated with CRC. Among others, Fusobacterium ssp. have been found to directly interact with cancer or immune cells of their host. However, only a limited number of CRC-associated microbes have been examined for host-microbial interactions and, as such, the role of bacteria in the etiology of the disease remains largely elusive.
Our aim is the development of predictive and experimental models that allow to not only study the host-microbiota interactions but are also amenable to high-throughput experimentation and large-scale omics-data integration. Ultimately, such models should help to get from meta-omics to cellular mechanism and, moreover, serve as tools for reproducible analyses of host-microbial interaction mechanisms of on a transcriptomic, proteomic, and metabolomic level. Our research proposes an integrative study approach allowing us to bridge meta-omics with functional mechanisms by focusing on the interaction taking place between F. nucleatum and patient-derived CRC cells.
Fonds National de la Recherche - FnR ; Fondation du Pélican de Mie et Pierre Hippert-Faber
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/46298

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Poster_Ternes_version_2.pdfAuthor postprint1.54 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.