![]() ![]() | KONCINA, E., NURMIK, M., POZDEEV, V., GILSON, C., TSENKOVA, M., BEGAJ, R., Stang, S., GAIGNEAUX, A., Weindorfer, C., RODRIGUEZ, F., SCHMOETTEN, M., KLEIN, E., KARTA, J., Atanasova, V. S., GRZYB, K., ULLMANN, P., HALDER, R., Hengstschläger, M., Graas, J., ... LETELLIER, E. (17 July 2023). IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer. Nature Communications, 14 (1), 4251. doi:10.1038/s41467-023-39953-w ![]() |
![]() ![]() | Bonetti, L., Horkova, V., Longworth, J., Guerra, L., Kurniawan, H., Franchina, D. G., Soriano-Baguet, L., Grusdat, M., Spath, S., Koncina, E., Ewen, A., Binsfeld, C., Verschueren, C., Gérardy, J.-J., Kobayashi, T., Dostert, C., Farinelle, S., Härm, J., Chen, Y., ... BRENNER, D. (2023). A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/58027. doi:10.1101/2023.07.06.547932 |
![]() ![]() | Lesur, A., Bernardin, F., KONCINA, E., LETELLIER, E., Kruppa, G., Schmit, P.-O., & DITTMAR, G. (02 June 2023). Quantification of 782 Plasma Peptides by Multiplexed Targeted Proteomics. Journal of Proteome Research, 22 (6), 1630 - 1638. doi:10.1021/acs.jproteome.2c00575 ![]() |
![]() ![]() | Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A.-S., Loseva, O., Mortusewicz, O., MEYERS, M., VIRY, E., ... MEISER, J. (April 2023). Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism, 5 (4), 642 - 659. doi:10.1038/s42255-023-00771-5 ![]() |
![]() ![]() | Peiffer, R., Boumahd, Y., Gullo, C., Crake, R., LETELLIER, E., Bellahcène, A., & Peulen, O. (2023). Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic CancerCancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer. Cancers. doi:10.3390/cancers15010061 ![]() |
![]() ![]() | TERNES, D., TSENKOVA, M., POZDEEV, V., MEYERS, M., KONCINA, E., ATATRI, S., SCHMITZ, M., KARTA, J., SCHMOETTEN, M., Heinken, A., RODRIGUEZ, F., Delbrouck, C., GAIGNEAUX, A., GINOLHAC, A., Dan Nguyen, T. T., Grandmougin, L., Frachet-Bour, A., Martin-Gallausiaux, C., PIRES PACHECO, M. I., ... LETELLIER, E. (2022). The gut microbial metabolite formate exacerbates colorectal cancer progression. Nature Metabolism. doi:10.1038/s42255-022-00558-0 ![]() |
![]() ![]() | Kiweler, N., Delbrouck, C., POZDEEV, V., Neises, L., Soriano-Bague, L., Eiden, K., Xian, F., Benzarti, M., Haase, L., KONCINA, E., SCHMOETTEN, M., JÄGER, C., Zaeem Noman, M., Vazquez, A., Janji, B., DITTMAR, G., BRENNER, D., LETELLIER, E., & Meiser, J. (2022). Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis. Nature Communications. doi:10.1038/s41467-022-30363-y ![]() |
![]() ![]() | Iglesias-González, A., Schweitzer, M., Palazzi, P., Peng, F., HAAN, S., LETELLIER, E., & Appenzeller, B. (2022). Investigating children's chemical exposome - Description and possible determinants of exposure in the region of Luxembourg based on hair analysisInvestigating children's chemical exposome - Description and possible determinants of exposure in the region of Luxembourg based on hair analysis. Water and Environmental International. doi:10.1016/j.envint.2022.107342 ![]() |
![]() ![]() | DE NIES, L., BUSI, S. B., TSENKOVA, M., HALDER, R., LETELLIER, E., & WILMES, P. (2022). Evolution of the murine gut resistome following broad-spectrum antibiotic treatment. Nature Communications, 13 (1), 2296. doi:10.1038/s41467-022-29919-9 ![]() |
![]() ![]() | Stadler, M., Pudelko, K., Biermeier, A., Walterskirchen, N., GAIGNEAUX, A., Weindorfer, C., Harrer, N., Klett, H., Hengstschläger, M., Schüler, J., Sommergruber, W., Oehler, R., Bergmann, M., LETELLIER, E., & Dolznig, H. (2021). Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages. Cancer Letters. doi:10.1016/j.canlet.2021.07.006 ![]() |
![]() ![]() | KARTA, J., BOSSICARD, Y., KOTZAMANIS, K., Dolznig, H., & LETELLIER, E. (2021). Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts. Cells. doi:10.3390/cells10020304 ![]() |
![]() ![]() | Lesur, A., Schmit, P.-O., Bernardin, F., LETELLIER, E., Brehmer, S., Decker, J., & Dittmar, G. (2021). Highly Multiplexed Targeted Proteomics Acquisition on a TIMS-QTOF. Analytical Chemistry. doi:10.1021/acs.analchem.0c03180 ![]() |
![]() ![]() | TERNES, D., KARTA, J., TSENKOVA, M., KONCINA, E., SCHMITZ, M., GRANDMOUGIN, L., GINOLHAC, A., GAIGNEAUX, A., RAMIRO GARCIA, J., WILMES, P., HAAN, S., & LETELLIER, E. (22 February 2020). Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression [Poster presentation]. The Microbiome, Viruses, and Cancer, Orlando, United States. |
![]() ![]() | TERNES, D., KARTA, J., TSENKOVA, M., WILMES, P., HAAN, S., & LETELLIER, E. (2020). Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism? Trends in Microbiology. doi:10.1016/j.tim.2020.01.001 ![]() |
![]() ![]() | KONCINA, E., HAAN, S., Rauh, S., & LETELLIER, E. (2020). Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges. Cancers. doi:10.3390/cancers12020319 ![]() |
![]() ![]() | LETELLIER, E., & KONCINA, E. (2020). Myosins: Driving us towards novel targets and biomarkers in cancer. In Actin Cytoskeleton in Cancer Progression and Metastasis - Part B (pp. 291-322). Elsevier. doi:10.1016/bs.ircmb.2020.06.004 ![]() |
![]() ![]() | Qureshi-Baig, K., Kuhn, Viry, E., POZDEEV, V., SCHMITZ, M., RODRIGUEZ, F., Ullmann, P., KONCINA, E., NURMIK, M., Frasquilho, S., Nazarov, P. V., Zuegel, N., Boulmont, M., Karapetyan, Y., Antunes, L., Val, D., MITTELBRONN, M., Janji, B., HAAN, S., & LETELLIER, E. (2019). Hypoxia-induced Autophagy Drives Colorectal Cancer Initiation and Progression by Activating the PRKC/PKC-EZR (Ezrin) Pathway. Autophagy. doi:10.1080/15548627.2019.1687213 ![]() |
![]() ![]() | Ullmann, P., NURMIK, M., BEGAJ, R., HAAN, S., & LETELLIER, E. (01 June 2019). Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells. Cells, 8 (6). doi:10.3390/cells8060528 ![]() |
![]() ![]() | PACHECO, M., BINTENER, T. J. R., TERNES, D., Kulms, D., HAAN, S., LETELLIER, E., & SAUTER, T. (May 2019). Identifying and targeting cancer-specific metabolism with network-based drug target prediction. EBioMedicine, 43 (May 2019), 98-106. doi:10.1016/j.ebiom.2019.04.046 ![]() |
![]() ![]() | ULLMANN, P., NURMIK, M., SCHMITZ, M., RODRIGUEZ, F., Weilerr, J., BAIG, K., FELTEN, P., Nazarov, P., NICOT, N., Zuegel, N., HAAN, S., & LETELLIER, E. (May 2019). Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity. Cancer Letters, 450, 32-41. doi:10.1016/j.canlet.2019.02.030 ![]() |
![]() ![]() | GREENHALGH, K., RAMIRO GARCIA, J., Heinken, Ullmann, P., BINTENER, T. J. R., PACHECO, M., Baginska, J., SHAH, P., FRACHET BOUR, A., HALDER, R., FRITZ, J., SAUTER, T., Thiele, I., HAAN, S., LETELLIER, E., & WILMES, P. (30 April 2019). Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells. Cell Reports, 27, 1621–1632. doi:10.1016/j.celrep.2019.04.001 ![]() |
![]() ![]() | MARGUE, C., PHILIPPIDOU, D., KOZAR, I., CESI, G., FELTEN, P., Kulms, D., LETELLIER, E., HAAN, C., & KREIS, S. (February 2019). Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells. Journal of Experimental and Clinical Cancer Research, 38 (1). doi:10.1186/s13046-019-1038-x ![]() |
![]() ![]() | NURMIK, M., ULLMANN, P., RODRIGUEZ, F., HAAN, S., & LETELLIER, E. (2019). In search of definitions: Cancer-associated fibroblasts and their markers. International Journal of Cancer. doi:10.1002/ijc.32193 ![]() |
![]() ![]() | Dostert, C., Grustat, M., LETELLIER, E., & Brenner, D. (01 January 2019). The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond. Physiological Reviews, 99 (1). doi:10.1152/physrev.00045.2017 ![]() |
![]() ![]() | Cesi, G., PHILIPPIDOU, D., KOZAR, I., Kim, Y. J., Bernardin, F., Van Niel, G., Wienecke-Baldacchino, A., FELTEN, P., LETELLIER, E., Dengler, S., Nashan, D., HAAN, C., & KREIS, S. (2018). A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells. Molecular Cancer, (17:145). doi:10.1186/s12943-018-0886-x ![]() |
![]() ![]() | GREENHALGH, K., RAMIRO GARCIA, J., HEINKEN, A. K., BAGINSKA, J., LETELLIER, E., HALDER, R., FRACHET BOUR, A., ULLMANN, P., THIELE, I., HAAN, S., & WILMES, P. (16 February 2018). Cominatorial effect of dietary fibre and Lactobacillus rhamnosus in the context of colorectal cancer therapy [Poster presentation]. Cell Immunology symposium. |
![]() ![]() | ULLMANN, P., RODRIGUEZ, F., SCHMITZ, M., Meurer, S. K., Qureshi-Baig, K., FELTEN, P., GINOLHAC, A., Antunes, L., Frasquilho, S., Zugel, N., Weiskirchen, R., HAAN, S., & LETELLIER, E. (2018). The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Research. doi:10.1158/0008-5472.CAN-17-3003 ![]() |
LETELLIER, E., GINOLHAC, A., Schmitz Martine, & HAAN, S. (2018). NOVEL BIOMARKERS FOR CANCER DIAGNOSIS, PREDICTION OR STAGING. |
![]() ![]() | LETELLIER, E., SCHMITZ, M., GINOLHAC, A., RODRIGUEZ, F., ULLMANN, P., Qureshi-Baig, K., Frasquilho, S., Antunes, L., & HAAN, S. (21 November 2017). Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence. British Journal of Cancer, 117 (11), 1689-1701. doi:10.1038/bjc.2017.352 ![]() |
![]() ![]() | ROLVERING, C., Zimmer, A., KOZAR, I., Hermanns, LETELLIER, E., Vallar, L., Nazarov, P., Nicot, N., GINOLHAC, A., HAAN, S., BEHRMANN, I., & HAAN, C. (2017). Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines. BBA Molecular Cell Research, 516-526. doi:10.1016/J.BBAMCR.2016.12.006 ![]() |
![]() ![]() | BAIG, K., ULLMANN, P., HAAN, S., & LETELLIER, E. (2017). Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies. Molecular Cancer. doi:10.1186/s12943-017-0602-2 ![]() |
![]() ![]() | TERNES, D., WILMES, P., LETELLIER, E., & HAAN, S. (05 February 2017). From meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer [Poster presentation]. Keystone symposia: Microbiome in Health and Disease (J8), Keystone, Colorado, United States. |
![]() ![]() | Bahlawane, C., SCHMITZ, M., LETELLIER, E., Arumugam, K., Nicot, N., Nazarov, P., & HAAN, S. (2017). Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling. Cell Signal. doi:10.1016/j.cellsig.2016.10.009 ![]() |
GREENHALGH, K., FRITZ, J., LETELLIER, E., RAMIRO GARCIA, J., HALDER, R., FRACHET BOUR, A., BAGINSKA, J., TERNES, D., Jäger, C., HAAN, S., & WILMES, P. (2017). A study of the molecular mechanisms underlying teh response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics [Poster presentation]. ISAPP conference. |
![]() ![]() | Bahlawane, C., SCHMITZ, M., LETELLIER, E., Arumugam, K., Nicot, N., Nazarov, P., & HAAN, S. (2016). Data on quantification of signaling pathways activated by KIT and PDGFRA mutants. Data in Brief, (9), 828-838. doi:10.1016/j.dib.2016.10.026 ![]() |
![]() ![]() | ULLMANN, P., qureshi-baig, K., RODRIGUEZ, F., GINOLHAC, A., nonnenmacher, Y., TERNES, D., Weiler, J., Gaebler, K., bahlawane, C., hiller, K., HAAN, S., & LETELLIER, E. (04 October 2016). Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production. Oncotarget, 7 (40), 97-114. doi:10.18632/oncotarget.11772 ![]() |
![]() ![]() | GREENHALGH, K., FRITZ, J., LETELLIER, E., FRACHET BOUR, A., BAGINSKA, J., SHAH, P., DESAI, M., GLAAB, E., Jäger, C., HAAN, S., & WILMES, P. (June 2016). A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics [Poster presentation]. ISAPP conference. |
![]() ![]() | LETELLIER, E., & HAAN, S. (2016). SOCS2: physiological and pathological functions. Frontiers in Bioscience (Elite Edition), 8, 189-204. doi:10.2741/760 ![]() |
![]() ![]() | BAIG, K., ULLMANN, P., RODRIGUEZ, F., Frasquilho, S., Nazarov, P. V., HAAN, S., & LETELLIER, E. (January 2016). What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. PLoS ONE, 11. doi:10.1371/JOURNAL.PONE.0146052 ![]() |
![]() ![]() | LETELLIER, E., SCHMITZ, M., BAIG, K., BEAUME, N., Schwartz, C., Frasquilho, S., Antunes, L., Marcon, N., Nazarov, P. V., Vallar, L., Even, J., & HAAN, S. (2014). Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer. British Journal of Cancer, 111 (4), 726-35. doi:10.1038/bjc.2014.377 ![]() |
![]() ![]() | Pitzer, C., Klussmann, S., Krüger, C., LETELLIER, E., Plaas, C., Dittgen, T., Kirsch, F., Stieltjes, B., Weber, D., Laage, R., Martin-Villalba, A., & Schneider, A. (May 2010). The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury. Journal of Neurochemistry, 113, 930-942. doi:10.1111/j.1471-4159.2010.06659.x ![]() |
![]() ![]() | LETELLIER, E., Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S, Konecki K, Klussmann S, Corsini NS, Kleber S, Drost N, Neumann A, Lévi-Strauss M, Brors B, Gretz N, Edler L, Fischer C, Hill O, Thiemann M, ... Martin-Villalba A. (February 2010). CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity, 32. doi:10.1016/j.immuni.2010.01.011 ![]() |
![]() ![]() | Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, LETELLIER, E., Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B,, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, ... Martin-Villalba A. (07 August 2009). The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell, 5. doi:10.1016/j.stem.2009.05.004 ![]() |
![]() ![]() | Kleber, S., Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, schreglmann n, LETELLIER, E., Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, ... Martin-Villalba A., A. (March 2008). Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell, 13. doi:10.1016/j.ccr.2008.02.003 ![]() |
LETELLIER, E., & Martin-Villalba, A. (June 2007). Spinal cord injuries entering the Fas(t) lane. Neurosurgery, 6. ![]() |
![]() ![]() | Stieltjes B,, Klussmann S, Bock M, Umathum R, Mangalathu J, LETELLIER, E., Rittgen W, Edler L, & martin-villalba, A. (May 2006). Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice. Magn Reson Med, 5. ![]() |