Profil

GINOLHAC Aurélien

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

ORCID
0000-0001-7665-9547
Main Referenced Co-authors
Orlando, Ludovic (13)
Willerslev, Eske (11)
HAAN, Serge  (8)
SAUTER, Thomas  (8)
SINKKONEN, Lasse  (8)
Main Referenced Keywords
Animals (8); Fossils (7); Phylogeny (7); Evolution, Molecular (4); Humans (4);
Main Referenced Unit & Research Centers
ULHPC - University of Luxembourg: High Performance Computing (15)
University of Luxembourg (2)
LuXDEM - University of Luxembourg: Luxembourg XDEM Research Centre (1)
University of Luxembourg:DLSM (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (28)
Biotechnology (3)
Life sciences: Multidisciplinary, general & others (3)
Computer science (2)
Oncology (2)

Publications (total 40)

The most downloaded
596 downloads
Linnartz-Gerlach, B., Bodea, L.-G., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., & Neumann, H. (2018). TREM2 triggers microglial density and age‐related neuronal loss. Glia. doi:10.1002/glia.23563 https://hdl.handle.net/10993/37706

The most cited

947 citations (OpenCitations)

Jonsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F., & Orlando, L. (2013). mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Bioinformatics, 29 (13), 1682-4. doi:10.1093/bioinformatics/btt193 https://hdl.handle.net/10993/24786

Gomez Ramos, B., Ohnmacht, J., de Lange, N., VALCESCHINI, E., GINOLHAC, A., CATILLON, M., FERRANTE, D., Rakovic, A., HALDER, R., Massart, F., ARENA, G., ANTONY, P., BOLOGNIN, S., Klein, C., KRAUSE, R., Schulz, M. H., SAUTER, T., Krüger, R., & SINKKONEN, L. (2023). Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation. EMBO Reports. doi:10.1038/s44319-023-00024-2
Peer Reviewed verified by ORBi

GAVRIIL, M., PROIETTO, M., PACZIA, N., GINOLHAC, A., HALDER, R., VALCESCHINI, E., SAUTER, T., LINSTER, C., & SINKKONEN, L. (November 2023). 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition. Life Science Alliance, 7 (2), 202302333. doi:10.26508/lsa.202302333
Peer Reviewed verified by ORBi

BESSERON, X., & GINOLHAC, A. (2023). Result Verification of Multi-physics Simulations and Transcriptomics Analyses on Processor AWS Graviton3.

Ternes, D., Tsenkova, M., Pozdeev, V., Meyers, M., Koncina, E., Atatri, S., Schmitz, M., Karta, J., Schmoetten, M., Heinken, A., Rodriguez, F., Delbrouck, C., Gaigneaux, A., Ginolhac, A., Dan Nguyen, T. T., Grandmougin, L., Frachet-Bour, A., Martin-Gallausiaux, C., Pires Pacheco, M. I., ... Letellier, E. (2022). The gut microbial metabolite formate exacerbates colorectal cancer progression. Nature Metabolism. doi:10.1038/s42255-022-00558-0
Peer reviewed

Del Mistro, G., Riemann, S., Schindler, S., Beissert, S., Kontermann, R. E., Ginolhac, A., Halder, R., Presta, L., Sinkkonen, L., Sauter, T., & Kulms, D. (2022). Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma. Cell Death and Disease. doi:10.1038/s41419-022-04502-8
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Grandbarbe, L., Michelucci, A., Heuschling, P., Pavlou, M. A., & Ginolhac, A. (2021). NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells. Cells. doi:10.3390/cells10040840
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Kirchmeyer, M., Servais, F., Ginolhac, A., Nazarov, P. V., Margue, C., Philippidou, D., Nicot, N., Behrmann, I., Haan, C., & Kreis, S. (2020). Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types. Journal of Molecular Biology. doi:10.1016/j.jmb.2020.09.011
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Shahraz, A., Wißfeld, J., Ginolhac, A., Matthews, M., Sinkkonen, L., & Neumann, H. (2020). Phagocytosis‐related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. Glia. doi:10.1002/glia.23890
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Ternes, D., Karta, J., Tsenkova, M., Koncina, E., Schmitz, M., Grandmougin, L., Ginolhac, A., Gaigneaux, A., Ramiro Garcia, J., Wilmes, P., Haan, S., & Letellier, E. (22 February 2020). Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression [Poster presentation]. The Microbiome, Viruses, and Cancer, Orlando, United States.

Klaus, C., Hansen, J. N., Ginolhac, A., GERARD, D., Gnanapragassam, V. S., Horstkorte, R., Rossdam, C., Buettner, F. F. R., Sauter, T., Sinkkonen, L., Neumann, H., & Linnartz-Gerlach, B. (2020). Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2020.01.008
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Becker, J. C., Gerard, D., Ginolhac, A., Sauter, T., & Sinkkonen, L. (2019). Identification of genes under dynamic post-transcriptional regulation from time-series epigenomic data. Epigenomics. doi:10.2217/epi-2018-0084
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Cappellini, E., Welker, F., Pandolfi, L., Ramos-Madrigal, J., Samodova, D., Ruther, P. L., Fotakis, A. K., Lyon, D., Moreno-Mayar, J. V., Bukhsianidze, M., Rakownikow Jersie-Christensen, R., Mackie, M., Ginolhac, A., Ferring, R., Tappen, M., Palkopoulou, E., Dickinson, M. R., Stafford, T. W. J., Chan, Y. L., ... Willerslev, E. (2019). Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny. Nature. doi:10.1038/s41586-019-1555-y
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Gerard, D., Schmidt, F., Ginolhac, A., Schmitz, M., Halder, R., Ebert, P., Schulz, M., Sauter, T., & Sinkkonen, L. (2018). Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency. Nucleic Acids Research. doi:10.1093/nar/gky1240
Peer Reviewed verified by ORBi

Linnartz-Gerlach, B., Bodea, L.-G., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., & Neumann, H. (2018). TREM2 triggers microglial density and age‐related neuronal loss. Glia. doi:10.1002/glia.23563
Peer Reviewed verified by ORBi

Ginolhac, A., Emeras, J., Varrette, S., Plugaru, V., Diehl, S., Parisot, C., Cartiaux, H., & Bouvry, P. (June 2018). UL HPC Tutorial: Statistical Computing with R [Paper presentation]. 7th High Performance Computing School, University of Luxembourg, Luxembourg.

Rolvering, C., Zimmer, A. D., Ginolhac, A., Margue, C., Kirchmeyer, M., Servais, F., Hermanns, H. M., Hergovits, S., Nazarov, P. V., Nicot, N., Kreis, S., Haan, S., Behrmann, I., & Haan, C. (2018). The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies. Journal of Leukocyte Biology, 104, 969-985. doi:10.1002/JLB.MA1217-495R
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Kirchmeyer, M., Servais, F., Hamdorf, M., Nazarov, P. V., Ginolhac, A., Halder, R., Vallar, L., Glanemann, M., Rubie, C., Lammert, F., Kreis, S., & Behrmann, I. (2018). Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets. Journal of Leukocyte Biology. doi:10.1002/JLB.MA1217-499RR
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Ullmann, P., Rodriguez, F., Schmitz, M., Meurer, S. K., Qureshi-Baig, K., Felten, P., Ginolhac, A., Antunes, L., Frasquilho, S., Zugel, N., Weiskirchen, R., Haan, S., & Letellier, E. (2018). The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Research. doi:10.1158/0008-5472.CAN-17-3003
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LETELLIER, E., GINOLHAC, A., Schmitz Martine, & HAAN, S. (2018). NOVEL BIOMARKERS FOR CANCER DIAGNOSIS, PREDICTION OR STAGING.

Letellier, E., Schmitz, M., Ginolhac, A., Rodriguez, F., Ullmann, P., Qureshi-Baig, K., Frasquilho, S., Antunes, L., & Haan, S. (21 November 2017). Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence. British Journal of Cancer, 117 (11), 1689-1701. doi:10.1038/bjc.2017.352
Peer Reviewed verified by ORBi

Rolvering, C., Zimmer, A., Kozar, I., Hermanns, Letellier, E., Vallar, L., Nazarov, P., Nicot, N., Ginolhac, A., Haan, S., Behrmann, I., & Haan, C. (2017). Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines. BBA Molecular Cell Research, 516-526. doi:10.1016/J.BBAMCR.2016.12.006
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Ullmann, P., qureshi-baig, K., Rodriguez, F., Ginolhac, A., nonnenmacher, Y., Ternes, D., Weiler, J., Gaebler, K., bahlawane, C., hiller, K., Haan, S., & Letellier, E. (04 October 2016). Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production. Oncotarget, 7 (40), 97-114. doi:10.18632/oncotarget.11772
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Reinsbach, S., Wienecke, A., Ginolhac, A., Vallar, L., Krishna, Krishna, A., Nazarov, P., May, P., & Kreis, S. (2016). “Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients. European Journal of Cancer, 61 (Suppl.1), 32. doi:10.1016/S0959-8049(16)61101-2

Dorosz, S. A., Ginolhac, A., Kähne, T., Naumann, M., Sauter, T., Salsmann, A., & Bueb, J.-L. (2015). Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells. Mediators of Inflammation, 2015, 1-16. doi:10.1155/2015/737310
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Der Sarkissian, C., Ermini, L., Schubert, M., Yang, M. A., Librado, P., Fumagalli, M., Jonsson, H., Bar-Gal, G. K., Albrechtsen, A., Vieira, F. G., Petersen, B., Ginolhac, A., Seguin-Orlando, A., Magnussen, K., Fages, A., Gamba, C., Lorente-Galdos, B., Polani, S., Steiner, C., ... Orlando, L. (2015). Evolutionary Genomics and Conservation of the Endangered Przewalski's Horse. Current Biology, 25 (19), 2577-83. doi:10.1016/j.cub.2015.08.032
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Jonsson, H., Schubert, M., Seguin-Orlando, A., Ginolhac, A., Petersen, L., Fumagalli, M., Albrechtsen, A., Petersen, B., Korneliussen, T. S., Vilstrup, J. T., Lear, T., Myka, J. L., Lundquist, J., Miller, D. C., Alfarhan, A. H., Alquraishi, S. A., Al-Rasheid, K. A. S., Stagegaard, J., Strauss, G., ... Orlando, L. (2014). Speciation with gene flow in equids despite extensive chromosomal plasticity. Proceedings of the National Academy of Sciences of the United States of America, 111 (52), 18655-60. doi:10.1073/pnas.1412627111
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Schubert, M., Jonsson, H., Chang, D., Der Sarkissian, C., Ermini, L., Ginolhac, A., Albrechtsen, A., Dupanloup, I., Foucal, A., Petersen, B., Fumagalli, M., Raghavan, M., Seguin-Orlando, A., Korneliussen, T. S., Velazquez, A. M. V., Stenderup, J., Hoover, C. A., Rubin, C.-J., Alfarhan, A. H., ... Orlando, L. (2014). Prehistoric genomes reveal the genetic foundation and cost of horse domestication. Proceedings of the National Academy of Sciences of the United States of America, 111 (52), 5661-9. doi:10.1073/pnas.1416991111
Peer Reviewed verified by ORBi

Schubert, M., Ermini, L., Der Sarkissian, C., Jonsson, H., Ginolhac, A., Schaefer, R., Martin, M. D., Fernandez, R., Kircher, M., McCue, M., Willerslev, E., & Orlando, L. (2014). Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX. Nature Protocols, 9 (5), 1056-82. doi:10.1038/nprot.2014.063
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Orlando, L.* , Ginolhac, A.* , Zhang, G., Froese, D., Albrechtsen, A., Stiller, M., Schubert, M., Cappellini, E., Petersen, B., Moltke, I., Johnson, P. L. F., Fumagalli, M., Vilstrup, J. T., Raghavan, M., Korneliussen, T., Malaspinas, A.-S., Vogt, J., Szklarczyk, D., Kelstrup, C. D., ... Willerslev, E. (2013). Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature, 499 (7456), 74-8. doi:10.1038/nature12323
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* These authors have contributed equally to this work.

Vilstrup, J. T., Seguin-Orlando, A., Stiller, M., Ginolhac, A., Raghavan, M., Nielsen, S. C. A., Weinstock, J., Froese, D., Vasiliev, S. K., Ovodov, N. D., Clary, J., Helgen, K. M., Fleischer, R. C., Cooper, A., Shapiro, B., & Orlando, L. (2013). Mitochondrial phylogenomics of modern and ancient equids. PLoS ONE, 8 (2), 55950. doi:10.1371/journal.pone.0055950
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Jonsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F., & Orlando, L. (2013). mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Bioinformatics, 29 (13), 1682-4. doi:10.1093/bioinformatics/btt193
Peer reviewed

Cappellini, E., Jensen, L. J., Szklarczyk, D., Ginolhac, A., da Fonseca, R. A. R., Stafford, T. W., Holen, S. R., Collins, M. J., Orlando, L., Willerslev, E., Gilbert, M. T. P., & Olsen, J. V. (2012). Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins. Journal of Proteome Research, 11 (2), 917-26. doi:10.1021/pr200721u
Peer Reviewed verified by ORBi

Schubert, M., Ginolhac, A., Lindgreen, S., Thompson, J. F., Al-Rasheid, K. A. S., Willerslev, E., Krogh, A., & Orlando, L. (2012). Improving ancient DNA read mapping against modern reference genomes. BMC Genomics, 13, 178. doi:10.1186/1471-2164-13-178
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Ginolhac, A., Vilstrup, J., Stenderup, J., Rasmussen, M., Stiller, M., Shapiro, B., Zazula, G., Froese, D., Steinmann, K. E., Thompson, J. F., Al-Rasheid, K. A. S., Gilbert, T. M. P., Willerslev, E., & Orlando, L. (2012). Improving the performance of true single molecule sequencing for ancient DNA. BMC Genomics, 13, 177. doi:10.1186/1471-2164-13-177
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Orlando, L., Ginolhac, A., Raghavan, M., Vilstrup, J., Rasmussen, M., Magnussen, K., Steinmann, K. E., Kapranov, P., Thompson, J. F., Zazula, G., Froese, D., Moltke, I., Shapiro, B., Hofreiter, M., Al-Rasheid, K. A. S., Gilbert, M. T. P., & Willerslev, E. (2011). True single-molecule DNA sequencing of a pleistocene horse bone. Genome Research, 21 (10), 1705-19. doi:10.1101/gr.122747.111
Peer Reviewed verified by ORBi

Ginolhac, A., Rasmussen, M., Gilbert, M. T. P., Willerslev, E., & Orlando, L. (2011). mapDamage: testing for damage patterns in ancient DNA sequences. Bioinformatics, 27 (15), 2153-5. doi:10.1093/bioinformatics/btr347
Peer reviewed

Lefevre, F., Robe, P., Jarrin, C., GINOLHAC, A., Zago, C., Auriol, D., Vogel, T. M., Simonet, P., & Nalin, R. (April 2008). Drugs from hidden bugs: their discovery via untapped resources. Research in Microbiology, 159 (3), 153-61. doi:10.1016/j.resmic.2007.12.011
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GINOLHAC, A., Jarrin, C., Robe, P., Perrière, G., Vogel, T. M., Simonet, P., & Nalin, R. (June 2005). Type I polyketide synthases may have evolved through horizontal gene transfer. Journal of Molecular Evolution, 60 (6), 716-25. doi:10.1007/s00239-004-0161-1
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GINOLHAC, A.* , Jarrin, C.* , Gillet, B., Robe, P., Pujic, P., Tuphile, K., Bertrand, H., Vogel, T. M., Perrière, G., Simonet, P., & Nalin, R. (September 2004). Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones. Applied and Environmental Microbiology, 70 (9), 5522-7. doi:10.1128/AEM.70.9.5522-5527.2004
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* These authors have contributed equally to this work.

Armengaud, C., Causse, N., Aït-Oubah, J., GINOLHAC, A., & Gauthier, M. (24 March 2000). Functional cytochrome oxidase histochemistry in the honeybee brain. Brain Research, 859 (2), 390-3. doi:10.1016/s0006-8993(00)02016-3
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