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SMITS Lisa

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations > Fundraising

Main Referenced Co-authors
SCHWAMBORN, Jens Christian  (16)
BOLOGNIN, Silvia  (12)
ANTONY, Paul  (6)
GRZYB, Kamil  (5)
KRÜGER, Rejko  (5)
Main Referenced Keywords
midbrain organoids (1); Parkinson's disease (1); stem cells (1);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (5)
Biotechnology (4)
Life sciences: Multidisciplinary, general & others (4)
Genetics & genetic processes (3)
Neurology (1)

Publications (total 17)

The most downloaded
374 downloads
Smits, L. (2019). Generation of midbrain organoids as a model to study Parkinson's disease [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/40019 https://hdl.handle.net/10993/40019

The most cited

272 citations (Scopus®)

Monzel, A. S., Smits, L., Hemmer, K., Hachi, S., Lucumi Moreno, E., Van Wüllen, T. M., Jarazo, J., Walter, J., Werthschulte, I., Boussaad, I., Berger, E., Fleming, R. M., Bolognin, S., & Schwamborn, J. C. (2017). Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. doi:10.1016/j.stemcr.2017.03.010 https://hdl.handle.net/10993/30751

Zagare, A., Barmpa, K., Smajic, S., Smits, L., Grzyb, K., Grünewald, A., Skupin, A., Nickels, S. L., & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.12.009
Peer Reviewed verified by ORBi

Bolognin, S., Smits, L., Nickels, S. L., Magni, S., Antony, P., Grzyb, K., Krüger, R., Skupin, A., & Schwamborn, J. C. (2021). A new brain organoid model to study Parkinson’s Disease. Biomedical Science and Engineering.

Zanetti, C., Spitz, S., Berger, E., Bolognin, S., Smits, L., Crepaz, P., Rothbauer, M., Rosser, J. M., Marchetti'Deschmann, M., Schwamborn, J. C., & Ertl, P. (2021). Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson’s disease modeling and drug screening. Analyst. doi:10.1039/d0an02206c
Peer Reviewed verified by ORBi

Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L., Su, J., Arias-Fuenzalida, Walter, J., Gomez Giro, G., Monzel, A., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., ... Schwamborn, J. C. (2021). Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment. Movement Disorders. doi:10.1002/mds.28810
Peer Reviewed verified by ORBi

Walter, J., Bolognin, S., Poovathingal, S., Magni, S., Gerard, D., Antony, P., Nickels, S. L., Salamanca, L., Berger, E., Smits, L., Grzyb, K., Perfeito, R., Hoel, F., Qing, X., Ohnmacht, J., Bertacchi, M., Jarazo, J., Ignac, T., Monzel, A., ... Schwamborn, J. C. (2021). The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Reports. doi:10.1016/j.celrep.2021.109864
Peer Reviewed verified by ORBi

Smits, L., Magni, S., Kinugawa, K., Grzyb, K., Luginbühl, J., Sabaté Soler, S., Bolognin, S., Shin, J., Mori, E., Skupin, A., & Schwamborn, J. C. (2020). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and Tissue Research. doi:10.1007/s00441-020-03249-y
Peer Reviewed verified by ORBi

Smits, L., & Schwamborn, J. C. (2020). Midbrain organoids: A new tool to investigate Parkinson's disease. Frontiers in Cell and Developmental Biology. doi:10.3389/fcell.2020.00359
Peer Reviewed verified by ORBi

Monzel, A. S., Hemmer, K., Smits, L., Bolognin, S., Lucarelli, P., Rosety, I., Zagare, A., Antony, P., Nickels, S., Krüger, R., & Schwamborn, J. C. (2020). Machine learning-assisted neurotoxicity prediction in human midbrain organoids. Parkinsonism and Related Disorders. doi:10.1016/j.parkreldis.2020.05.011
Peer Reviewed verified by ORBi

Spitz, S., Zanetti, C., Bolognin, S., Muwanigwa, M. N., Smits, L., Berger, E., Jordan, C., Harasek, M., Schwamborn, J. C., & Ertl, P. (2019). Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/43479. doi:10.1101/869701

Smits, L. (2019). Generation of midbrain organoids as a model to study Parkinson's disease [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/40019

Smits, L., Magni, S., Grzyb, K., Antony, P., Krüger, R., Skupin, A., Bolognin, S., & Schwamborn, J. C. (2019). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/39342. doi:10.1101/589598

Smits, L., Reinhardt, L., Reinhardt, P., Glatza, M., Monzel, A. S., Stanslowsky, N., Rosato-Siri, M., Zanon, A., Antony, P., Bellmann, J., Nicklas, S., Hemmer, K., Qing, X., Berger, E., Kalmbach, N., Ehrlich, M., Bolognin, S., Hicks, A., Wegner, F., ... Schwamborn, J. C. (2019). Modeling Parkinson’s disease in midbrain-like organoids. NPJ Parkinson's Disease. doi:10.1038/s41531-019-0078-4
Peer Reviewed verified by ORBi

Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L., Negri, G. L., Schwamborn, J. C., Jensen, P., Mackenzie, I., Taubert, S., & Sorensen, P. (2018). Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. Acta Neuropathologica Communications. doi:10.1186/s40478-018-0554-9
Peer Reviewed verified by ORBi

Hemmer, K., Smits, L., Bolognin, S., & Schwamborn, J. C. (2018). In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading. Opera Medica et Physiologica.
Peer reviewed

Monzel, A. S., Smits, L., Hemmer, K., Hachi, S., Lucumi Moreno, E., Van Wüllen, T. M., Jarazo, J., Walter, J., Werthschulte, I., Boussaad, I., Berger, E., Fleming, R. M., Bolognin, S., & Schwamborn, J. C. (2017). Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. doi:10.1016/j.stemcr.2017.03.010
Peer Reviewed verified by ORBi

Spathis, A., Asvos, X., Ziavra, D., Karampelas, T., Topouzis, S., Cournia, Z., Qing, X., Alexakos, P., Smits, L., Dalla, C., Rideout, H., Schwamborn, J. C., Tamvakopoulos, C., Fokas, D., & Vassilatis, D. (2017). Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1616874114
Peer Reviewed verified by ORBi

Hemmer, K., Smits, L., Bolognin, S., & Schwamborn, J. C. (2017). In Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading. bioRxiv.

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