Yabo, Y. A., Moreno-Sanchez, P. M., Pires-Afonso, Y., Kaoma, T., Nosirov, B., Scafidi, A., Ermini, L., Lipsa, A., Oudin, A., KYRIAKIS, D., GRZYB, K., POOVATHINGAL, S. K., Poli, A., Muller, A., TOTH, R., KLINK, B., BERCHEM, G. J. M. J., Berthold, C., HERTEL, F., ... GOLEBIEWSKA, A. (2023). Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/60199. doi:10.1101/2023.03.05.531162 |
  | Capelle, C. M., Ciré, S., Hedin, F., HANSEN, M., PAVELKA, L., GRZYB, K., KYRIAKIS, D., Hunewald, O., Konstantinou, M., Revets, D., TSLAF, V., Marques, T. M., GOMES, C., BARON, A., Domingues, O., Gomez, M., Zeng, N., BETSOU, F., MAY, P., ... Hefeng, F. Q. (20 November 2023). Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females. Nature Communications, 14 (1), 7461. doi:10.1038/s41467-023-43053-0  Peer Reviewed verified by ORBi |
  | RANDIC, T., MAGNI, S., PHILIPPIDOU, D., Margue, C., GRZYB, K., PREIS, J. R., WROBLEWSKA, J. P., NAZAROV, P., MITTELBRONN, M., FRAUENKNECHT, K., SKUPIN, A., & KREIS, S. (25 July 2023). Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response. Cell Reports, 42 (7), 112696. doi:10.1016/j.celrep.2023.112696 Peer Reviewed verified by ORBi |
 | KONCINA, E., NURMIK, M., POZDEEV, V., GILSON, C., TSENKOVA, M., BEGAJ, R., Stang, S., GAIGNEAUX, A., Weindorfer, C., RODRIGUEZ, F., SCHMOETTEN, M., KLEIN, E., KARTA, J., Atanasova, V. S., GRZYB, K., ULLMANN, P., HALDER, R., Hengstschläger, M., Graas, J., ... LETELLIER, E. (17 July 2023). IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer. Nature Communications, 14 (1), 4251. doi:10.1038/s41467-023-39953-w Peer Reviewed verified by ORBi |
ALI, M.* , GARCIA, P.* , Laetitia P. Lunkes, SCIORTINO, A., THOMAS, M., HEURTAUX, T., GRZYB, K., HALDER, R., SKUPIN, A., MITTELBRONN, M., BUTTINI, M., & GLAAB, E. (12 May 2023). Gene Regulatory Network Analysis of Single-Cell Transcriptomes from THY-Tau22 Mice Reveals Sex-Dependent Immune Dysregulation associated with Alzheimer-like pathology [Poster presentation]. The 7th Venusberg Meeting on Neuroinflammation, Belval, Luxembourg. * These authors have contributed equally to this work. |
 | Pires-Afonso, Y., Muller, A., GRZYB, K., Oudin, A., Yabo, Y. A., SOUSA, C., Scafidi, A., Poli, A., COSMA, A., HALDER, R., COOWAR, D., GOLEBIEWSKA, A., SKUPIN, A., NICLOU, S. P., & MICHELUCCI, A. (September 2022). Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency. Molecular Oncology, 16 (17), 3167 - 3191. doi:10.1002/1878-0261.13287 Peer Reviewed verified by ORBi |
 | ZAGARE, A., BARMPA, K., SMAJIC, S., SMITS, L., GRZYB, K., GRÜNEWALD, A., SKUPIN, A., NICKELS, S. L., & SCHWAMBORN, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.12.009 Peer Reviewed verified by ORBi |
 | Capelle, C. M., Ciré, S., Domingues, O., ERNENS, I., Hedin, F., Fischer, A., Snoeck, C. J., Ammerlaan, W., Konstantinou, M., GRZYB, K., SKUPIN, A., Carty, C. L., HILGER, C., Gilson, G., Celebic, A., WILMES, P., Del Sol, A., Kaplan, I. M., BETSOU, F., ... HE, F. (2022). Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients. Cell Reports Medicine, 3 (4), 100600. doi:10.1016/j.xcrm.2022.100600 Peer reviewed |
 | Capelle, C. M., Chen, A., Zeng, N., Baron, A., GRZYB, K., ARNS, T., SKUPIN, A., OLLERT, M., & HE, F. (2022). Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1. Immunology, 165 (4), 428--444. doi:10.1111/imm.13448 Peer Reviewed verified by ORBi |
 | Novak, G., KYRIAKIS, D., GRZYB, K., BERNINI, M., Rodius, S., DITTMAR, G., Finkbeiner, S., & SKUPIN, A. (2022). Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson’s disease. Communications Biology, 5 (1), 1--19. doi:10.1038/s42003-021-02973-7 Peer reviewed |
 | ALI, M., Huarte, O., HEURTAUX, T., GARCIA, P., Rodriguez, B. P., GRZYB, K., HALDER, R., SKUPIN, A., BUTTINI, M., & GLAAB, E. (2022). Single-cell transcriptional profiling and gene regulatory network modeling in Tg2576 mice reveal gender-dependent molecular features preceding Alzheimer-like pathologies. Molecular Neurobiology, in press (doi:10.1007/s12035-022-02985-2) (in press). doi:10.1007/s12035-022-02985-2 Peer Reviewed verified by ORBi |
BOLOGNIN, S., SMITS, L., NICKELS, S. L., MAGNI, S., ANTONY, P., GRZYB, K., KRÜGER, R., SKUPIN, A., & SCHWAMBORN, J. C. (2021). A new brain organoid model to study Parkinson’s Disease. Biomedical Science and Engineering. |
 | Gui, Y., GRZYB, K., THOMAS, M., OHNMACHT, J., GARCIA, P., BUTTINI, M., SKUPIN, A., SAUTER, T., & SINKKONEN, L. (2021). Single‑nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell‑type‑specific gene regulatory variation. Epigenetics and Chromatin. doi:10.1186/s13072-021-00418-3 Peer Reviewed verified by ORBi |
 | URIARTE HUARTE, O., KYRIAKIS, D., HEURTAUX, T., Pires-Afonso, Y., GRZYB, K., HALDER, R., BUTTINI, M., SKUPIN, A., MITTELBRONN, M., & Michelucci, A. (2021). Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway. Frontiers in Immunology. doi:10.3389/fimmu.2021.639613 Peer Reviewed verified by ORBi |
 | Walter, J., BOLOGNIN, S., Poovathingal, S., MAGNI, S., GERARD, D., ANTONY, P., NICKELS, S. L., Salamanca, L., Berger, E., SMITS, L., GRZYB, K., Perfeito, R., Hoel, F., Qing, X., OHNMACHT, J., Bertacchi, M., Jarazo, J., Ignac, T., Monzel, A., ... SCHWAMBORN, J. C. (2021). The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Reports. doi:10.1016/j.celrep.2021.109864 Peer Reviewed verified by ORBi |
 | GOLEBIEWSKA, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., MICHELUCCI, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., AZUAJE, F., De Falco, A., Flies, B., ... NICLOU, S. (2020). Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica. doi:10.1007/s00401-020-02226-7 Peer Reviewed verified by ORBi |
 | GOLEBIEWSKA, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., MICHELUCCI, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., AZUAJE, F., De Falco, A., Flies, B., ... NICLOU, S. (2020). Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/43022. doi:10.1101/2020.04.24.057802 |
 | Tiraboschi, E., MARTINA, S., van der Ent, W., GRZYB, K., Gawel, K., Cordero-Maldonado, M. L., Poovathingal, S. K., Heintz, S., Satheesh, S. V., Brattespe, J., SKUPIN, A., & Esguerra, C. (2020). New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome. Epilepsia. doi:10.1111/epi.16456 Peer reviewed |
 | SMITS, L., MAGNI, S., Kinugawa, K., GRZYB, K., Luginbühl, J., SABATÉ SOLER, S., BOLOGNIN, S., Shin, J., Mori, E., SKUPIN, A., & SCHWAMBORN, J. C. (2020). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and Tissue Research. doi:10.1007/s00441-020-03249-y Peer Reviewed verified by ORBi |
 | GRZYB, K. (2019). The Effect of ATP INDUCED CALCIUM DYNAMICS ON EPITHELIAL TO MESENCHYMAL TRANSITIONS [Doctoral thesis, University of Luxembourg - LCSB]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/39636 |
SMITS, L., MAGNI, S., GRZYB, K., ANTONY, P., KRÜGER, R., SKUPIN, A., BOLOGNIN, S., & SCHWAMBORN, J. C. (2019). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/39342. doi:10.1101/589598 |
 | MOEIN, M., GRZYB, K., Gonçalves Martins, T., Komoto, S., Peri, F., CRAWFORD, A. D., Fouquier d’Herouel, A., & SKUPIN, A. (2018). CaSiAn: a Calcium Signaling Analyzer tool. Bioinformatics, 1, 3. doi:10.1093/bioinformatics/bty281 Peer reviewed |
Dataset: