Lessons learned from the COVID-19 pandemic: identifying hesitant groups and exploring reasons for vaccination hesitancy, from adolescence to late adulthood.
[en] INTRODUCTION: The COVID-19 (COronaVIrus Disease-2019) pandemic highlighted the importance of assessing the rationales behind vaccine hesitancy for the containment of pandemics. In this nationwide study, representative of the Luxembourgish population, we identified hesitant groups from adolescence to late adulthood and explored motivations both for and against vaccination.
METHODS: We combined data collected via online surveys for the CON-VINCE (COvid-19 National survey for assessing VIral spread by Non-affected CarriErs) study, 1865 respondents aged 18-84, and for the YAC (Young people And Covid-19) study, 3740 respondents aged 12-29. Data from both studies were harmonized and weighted to ensure a sample representative of Luxembourg's resident population. The surveys included information on demographic and socio-economic factors as well as vaccination hesitancy.
RESULTS: At the time of the survey, 67.0% of respondents had been vaccinated against SARS-CoV-2 (Severe Acute Respiratory Syndrome COronaVirus-2), while 33.0% of the respondents had not yet been vaccinated. Of those not yet vaccinated, 41.8% of respondents were vaccine hesitant. The most important concerns against vaccination were that the vaccine had not been tested sufficiently (59.4%) and the fear of side effects (52.4%). The most frequent reasons for vaccination were to help society overcome the pandemic (74.8%), and to protect oneself from the consequences of infection with the virus (69.3%). The proportion of unvaccinated respondents unwilling or undecided to get vaccinated was higher in the younger age groups compared to the higher age groups.
CONCLUSION: Our findings contribute to improving public health policy communications, not only for future pandemics but also for routine vaccination campaigns. This will help reach those who are unwilling (26.7%) or undecided (15.1%) about vaccination and reinforce strategies that have successfully increased vaccination willingness.
Disciplines :
Social & behavioral sciences, psychology: Multidisciplinary, general & others
Author, co-author :
PAULY, Laure ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality ; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg ; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Strassen, Luxembourg
BULUT, Hamid ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Centre for Childhood and Youth Research
Bulaev, Dmitry; Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, Strassen, Luxembourg
GHOSH, Soumyabrata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
O'Sullivan, Marc P; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg
Fritz, Joëlle V; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg
Vaillant, Michel; Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, Strassen, Luxembourg
ROMMES, Basile ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Translational Informatics
SAMUEL, Robin ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Centre for Childhood and Youth Research
SATAGOPAM, Venkata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
KRÜGER, Rejko ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
LEIST, Anja ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
Lessons learned from the COVID-19 pandemic: identifying hesitant groups and exploring reasons for vaccination hesitancy, from adolescence to late adulthood.
World Health Organization. Seventy-third world health assembly: COVID-19 response. Geneva: WHO (2020).
Collatuzzo G Visci G Violante FS Porru S Spiteri G Lourdes Monaco MG et al. Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers – ORCHESTRA project. Front Immunol. (2022) 13:986085. doi: 10.3389/fimmu.2022.986085
Meslé MMI Brown J Mook P Katz MA Hagan J Pastore R et al. Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European region from December, 2020, to march, 2023: a retrospective surveillance study. Lancet Respir Med. (2024) 12:714–27. doi: 10.1016/S2213-2600(24)00179-6, PMID: 39127051
The Luxembourg Government. First people vaccinated against COVID-19 in Luxembourg [internet] (2020). Available at: https://gouvernement.lu/en/actualites/toutes_actualites/communiques/2020/12-decembre/28-vaccin-covid.html (accessed October 20, 2021)
The Luxembourg Government. Vaccination – Coronavirus – Official information – Luxembourg [Internet] (2020). Available at: https://covid19.public.lu/en/vaccination.html (accessed December 9, 2022)
The Luxembourg Government – Ministry of Health. Invitations for COVID-19 vaccination launched for adolescents aged 12-17 years, with priority given to the most vulnerable (2021). Available at: http://msan.gouvernement.lu/en/actualites.html (accessed November 21, 2022)
Borga L Kornadt A Seguel JCC Gentile N Lepinteur A Lutz A et al. Vaccine reluctance in Luxembourg France and Germany [internet] (2021). Available at: https://pandemic.uni.lu
D’Ambrosio Conchita Greiff Samuel Ratti Luca Vögele Claus. Pandemic life in Luxembourg in 2021 – PANDEMIC Research News [Internet] (2021). Available at: https://pandemic.uni.lu
Trust in Science: key to Covid-19 vaccination. STATNEWS [Internet] (2021). Available at: https://statistiques.public.lu/dam-assets/en/actualites/conditions-sociales/sante-secu/2021/07/20210727/STN40_Trust_Covid_v07_EN.pdf (accessed October 20, 2021)
COVID-19 Vaccine Tracker. European Centre for Disease Prevention and Control [Internet] (2021). Available at: https://vaccinetracker.ecdc.europa.eu/public/extensions/COVID-19/vaccine-tracker.html#uptake-tab (accessed May 4, 2023)
MacDonald NE Eskola J Liang X Chaudhuri M Dube E Gellin B et al. Vaccine hesitancy: definition, scope and determinants. Vaccine. (2015) 33:4161–4. doi: 10.1016/j.vaccine.2015.04.036, PMID: 25896383
Schomaker L Residori C Samuel R. Young people and COVID-19: Social, economic, and health consequences of infection prevention and control measures among young people in Luxembourg (2022).
Tsurkalenko O Bulaev D O’Sullivan MP Snoeck C Ghosh S Kolodkin A et al. Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE). BMC Infect Dis [Internet]. (2024) 24:179. doi: 10.1186/s12879-024-09055-z
STATEC. Population by Age and Sex (2021) Available at: https://lustat.statec.lu/vis?lc=en&pg=0&tm=age%20and%20sex&df[ds]=ds-release&df[id]=DF_B1102&df[ag]=LU1&df[vs]=1.0&pd=2015%2C2021&dq=A.&ly[rw]=AGE&ly[cl]=SEX&lo=1
Riedel S. Edward Jenner and the History of Smallpox and Vaccination. Baylor University Medical Center Proceedings. 18:21–5. Available at: bumc0018-0021
World Health Organisation. Ten threats to global health in 2019 (2019).
De Figueiredo A Eagan RL Hendrickx G Karafillakis E Van Damme P Larson HJ. State of vaccine confidence in the European Union, Luxembourg; (2022).
Avelino-Silva VI Ferreira-Silva SN Soares MEM Vasconcelos R Fujita L Medeiros T et al. Say it right: measuring the impact of different communication strategies on the decision to get vaccinated. BMC Public Health. (2023) 23:1162. doi: 10.1186/s12889-023-16047-2
Najjar M Albuaini S Fadel M Mohsen F. Covid-19 vaccination reported side effects and hesitancy among the Syrian population: a cross-sectional study. Ann Med. (2023) 55:2241351. doi: 10.1080/07853890.2023.2241351, PMID: 37544017
Mogensen I Ekström S Hallberg J Georgelis A Melén E Bergström A et al. Post COVID-19 symptoms are common, also among young adults in the general population. Sci Rep. (2023) 13:11300. doi: 10.1038/s41598-023-38315-2, PMID: 37438424
Viner RM Ward JL Hudson LD Ashe M Patel SV Hargreaves D et al. Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents. Arch Dis Child. (2021) 106:802–7. doi: 10.1136/archdischild-2020-320972
Plaisime M Robertson-James C Mejia L Núñez A Wolf J Reels S. Social media and teens: a needs assessment exploring the potential role of social media in promoting health. Soc Media Soc. (2020) 6. doi: 10.1177/2056305119886025
Eagan RL Larson HJ de Figueiredo A. Recent trends in vaccine coverage and confidence: a cause for concern. Hum Vaccin Immunother. (2023) 19:2237374. doi: 10.1080/21645515.2023.2237374, PMID: 37526111
Chan AKM Nickson CP Rudolph JW Lee A Joynt GM. Social media for rapid knowledge dissemination: early experience from the COVID-19 pandemic. Anaesthesia [Internet]. (2020) 75:1579–82. doi: 10.1111/anae.15057, PMID: 32227594
Shahi GK Dirkson A Majchrzak TA. An exploratory study of COVID-19 misinformation on twitter. Online Soc Netw Media. (2021) 22:100104. doi: 10.1016/j.osnem.2020.100104
Fact Check. Agence France-Presse (AFP) [Internet]. (2022). Available at: https://factcheck.afp.com/ (accessed December 13, 2022)
Vögele C Lutz A Yin R Ambrosio CD. How do different confinement measures affect people in Luxembourg and Sweden? COME-HERE: First Report [Internet]. (2020). Available at: https://wwwen.uni.lu/research/fhse/dbcs/pandemic/research_publications
Finney Rutten LJ Zhu X Leppin AL Ridgeway JL Swift MD Griffin JM et al. Evidence-based strategies for clinical organizations to address COVID-19 vaccine hesitancy. Mayo Clin Proc. (2021) 96:699–707. doi: 10.1016/j.mayocp.2020.12.024, PMID: 33673921
OECD. Evaluation of Luxembourg’s COVID-19 response: Learning from the crisis to increase resilience (2022).
Trucchi C Costantino C Restivo V Bertoncello C Fortunato F Tafuri S et al. Immunization campaigns and strategies against human papillomavirus in Italy: the results of a survey to regional and local health units representatives. Biomed Res Int. (2019) 2019:1–8. doi: 10.1155/2019/6764154, PMID: 31355274
Kukreti S Lu MY Lin YH Strong C Lin CY Ko NY et al. Willingness of Taiwan’s healthcare workers and outpatients to vaccinate against COVID-19 during a period without community outbreaks. Vaccines (Basel) [Internet]. (2021) 9:246. doi: 10.3390/vaccines9030246
Akel KB Noppert GA Rajamoorthy Y Lu Y Singh A Harapan H et al. A study of COVID-19 vaccination in the US and Asia: the role of media, personal experiences, and risk perceptions. PLOS Global Public Health. (2022) 2:e0000734. doi: 10.1371/journal.pgph.0000734, PMID: 36962371
Mills MC Rüttenauer T. The effect of mandatory COVID-19 certificates on vaccine uptake: synthetic-control modelling of six countries. Lancet Public Health. (2022) 7:e15–22. doi: 10.1016/S2468-2667(21)00273-5, PMID: 34914925
Stefanizzi P Martinelli A Bianchi FP Migliore G Tafuri S. Acceptability of the third dose of anti-SARS-CoV-2 vaccine co-administered with influenza vaccine: preliminary data in a sample of Italian HCWs. Hum Vaccin Immunother. (2022) 18:1–2. doi: 10.1080/21645515.2021.2011652, PMID: 34893012
De Figueiredo A Karafillakis E PHJ Larson. State of vaccine confidence in the EU+UK 2020 (2020); Available at: http://ec.europa.eu/dgs/health_food-safety/index_en.htm (accessed May 3, 2022)
Larson HJ de Figueiredo A Xiahong Z Schulz WS Verger P Johnston IG et al. The state of vaccine confidence 2016: global insights through a 67-country survey. EBioMedicine [Internet]. (2016) 12:295–301. doi: 10.1016/j.ebiom.2016.08.042