MAZEIN, Alexander ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Ivanova, Olga; European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
BALAUR, Irina-Afrodita ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France
OSTASZEWSKI, Marek ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Berzhitskaya, Valeriya; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia
Serebriyskaya, Tatiana; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia
Ligon, Thomas; Faculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-Universität, Munich, Germany
Hasenauer, Jan; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, Faculty of Mathematics and Natural Sciences, University of Bonn, Endenicher, Bonn, Germany
De Meulder, Bertrand; European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France
Overall, Rupert W; Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany, German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany
Roy, Ludovic; European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France
Knowles, Richard G; Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom
Wheelock, Craig E; Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Dahlen, Sven-Erik; Unit for Experimental Asthma and Allergy Research, Institute of Environmental Medicine (IMM), Karolinska Institutet, Solna, Sweden
Chung, Kian Fan; National Heart & Lung Institute, Imperial College London, London, United Kingdom
Adcock, Ian M; National Heart & Lung Institute, Imperial College London, London, United Kingdom
Roberts, Graham; Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton Biomedical Research Centre, Southampton, United Kingdom
Djukanovic, Ratko; Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom
Pellet, Johann; European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France
GAWRON, Piotr ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Visualisation
Balling, Rudi; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg
Maitland-van der Zee, Anke H; Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
SCHNEIDER, Reinhard ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Sterk, Peter J; Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Auffray, Charles; European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France
This was funded in part by the Innovative Medicines Initiative funded by the European Union and the European Federation of Pharmaceutical Industry Associations through U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes, no. 115010) and eTRIKS (European Translational Information and Knowledge Management Services, Innovative Medicines Initiative no. 115446), the French National Center for Scientific Research (CNRS), the European Institute for Systems Biology and Medicine (EISBM), and the Luxembourg Center for Systems Biomedicine.Disclosure of potential conflict of interest: S.-E. Dahlen reports personal fees from AstraZeneca, Boehringer-Ingelheim, Cayman Chemicals, GlaxoSmithKline (GSK), Novartis, Regeneron, Roche, Sanofi, and Teva outside the submitted work. K. F. Chung has received honoraria for participating in advisory board meetings of GSK, AstraZeneca, Roche, Novartis, Merck, BI, TEVA, and Shionogi regarding treatments for asthma, chronic obstructive pulmonary disease, and chronic cough and has also been remunerated for speaking engagements. R. Balling is a founder and a shareholder of MEGENO S.A. and a shareholder of ITTM S.A. R. Djukanovic reports receiving fees for lectures at symposia organized by Novartis, AstraZeneca, and TEVA; consultation for TEVA and Novartis as member of advisory boards; participation in a scientific discussion about asthma organized by GSK; and is a cofounder and current consultant and has shares in Synairgen, a University of Southampton spin-out company. A. H. Maitland-van der Zee reports grants and personal fees from Boehringer Ingelheim and GSK, grants from Vertex, and personal fees from AstraZeneca, all paid to her institution, and, in a public-private partnership, sponsored by Health Holland matching grants from Boehringer Ingelheim, Breathomix, Fluidda, Ortec Logiqcare, Philips, Quantib-U, Smartfish, SODAQ, Thirona, TopMD, and Novartis outside the submitted work. R. Schneider is a founder and a shareholder of MEGENO S.A. and ITTM S.A. P. J. Sterk is a scientific adviser and officially has a nonsubstantial interest in the start-up company Breathomix BV, which produces eNoses and accompanying cloud algorithms. The rest of the authors declare that they have no relevant conflicts of interest.The AsthmaMap project progresses in alliance with the efforts of the Disease Maps Community (https://disease-maps.org). Disclosure of potential conflict of interest: S.-E. Dahlen reports personal fees from AstraZeneca, Boehringer-Ingelheim, Cayman Chemicals, GlaxoSmithKline (GSK), Novartis, Regeneron, Roche, Sanofi, and Teva outside the submitted work. K. F. Chung has received honoraria for participating in advisory board meetings of GSK, AstraZeneca, Roche, Novartis, Merck, BI, TEVA, and Shionogi regarding treatments for asthma, chronic obstructive pulmonary disease, and chronic cough and has also been remunerated for speaking engagements. R. Balling is a founder and a shareholder of MEGENO S.A. and a shareholder of ITTM S.A. R. Djukanovic reports receiving fees for lectures at symposia organized by Novartis, AstraZeneca, and TEVA; consultation for TEVA and Novartis as member of advisory boards; participation in a scientific discussion about asthma organized by GSK; and is a cofounder and current consultant and has shares in Synairgen, a University of Southampton spin-out company. A. H. Maitland-van der Zee reports grants and personal fees from Boehringer Ingelheim and GSK, grants from Vertex, and personal fees from AstraZeneca, all paid to her institution, and, in a public-private partnership, sponsored by Health Holland matching grants from Boehringer Ingelheim, Breathomix, Fluidda, Ortec Logiqcare, Philips, Quantib-U, Smartfish, SODAQ, Thirona, TopMD, and Novartis outside the submitted work. R. Schneider is a founder and a shareholder of MEGENO S.A. and ITTM S.A. P. J. Sterk is a scientific adviser and officially has a nonsubstantial interest in the start-up company Breathomix BV, which produces eNoses and accompanying cloud algorithms. The rest of the authors declare that they have no relevant conflicts of interest.A collective effort, initiated within the European Union–funded U-BIOPRED project ( https://www.europeanlung.org/en/projects-and-research/projects/u-biopred ) and further developed within the eTRIKS project ( https://www.etriks.org ), has led to the creation of the AsthmaMap resource, a map for a computational description of the mechanisms relevant to asthma development, progression, and treatment. The data for the map construction come from the published biomedical literature and from high-quality pathway databases. The search was focused on mechanisms that exist in the cell types included and have been shown to be part of asthma pathogenesis. The building of the resource is supported by experts in the field of asthma from the Amsterdam University Medical Centers, the University of Amsterdam, the National Heart & Lung Institute of Imperial College London, the Karolinska Institute Stockholm, and the University of Southampton ( http://asthma-map.org/team ).
Mazein, A., Knowles, R.G., Adcock, I., Chung, K.F., Wheelock, C.E., Maitland-van der Zee, A.H., et al. AsthmaMap: an expert-driven computational representation of disease mechanisms. Clin Exp Allergy 48 (2018), 916–918.
Mazein, A., Ostaszewski, M., Kuperstein, I., Watterson, S., Le Novère, N., Lefaudeux, D., et al. Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms. Npj Syst Biol Appl, 4, 2018.
Singh V, Kalliolias GD, Ostaszewski M, Veyssiere M, Pilalis E, Gawron P, et al. RA-map: building a state-of-the-art interactive knowledge base for rheumatoid arthritis [published online ahead of print April 20, 2020]. Database J Biol Databases Curation. https://doi.org/10.1093/database/baaa017.
Parton, A., McGilligan, V., Chemaly, M., O'Kane, M., Watterson, S., New models of atherosclerosis and multi-drug therapeutic interventions. Bioinforma Oxf Engl 35 (2019), 2449–2457.
Ravel, J.-M., Monraz Gomez, L.C., Sompairac, N., Calzone, L., Zhivotovsky, B., Kroemer, G., et al. Comprehensive map of the regulated cell death signaling network: a powerful analytical tool for studying diseases. Cancers (Basel), 12, 2020, 990.
Monraz Gomez, L.C., Kondratova, M., Ravel, J.-M., Barillot, E., Zinovyev, A., Kuperstein, I., Application of Atlas of Cancer Signalling Network in preclinical studies. Brief Bioinform 20 (2019), 701–716.
Ostaszewski, M., Gebel, S., Kuperstein, I., Mazein, A., Zinovyev, A., Dogrusoz, U., et al. Community-driven roadmap for integrated disease maps. Brief Bioinform, 20, 2019 659:70.
Gawron, P., Ostaszewski, M., Satagopam, V., Gebel, S., Mazein, A., Kuzma, M., et al. MINERVA – a platform for visualization and curation of molecular interaction networks. NPJ Syst Biol Appl, 2, 2016, 16020.
De Meulder, B., Lefaudeux, D., Bigler, J., Loza, M.J., Wheelock, C.E., Sousa, A.R., et al. The first U-BIOPRED blood handprint of severe asthma. Eur Respir J, 46, 2015, PA4889.
Ostaszewski, M., Mazein, A., Gillespie, M.E., Kuperstein, I., Niarakis, A., Hermjakob, H., et al. COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms. Sci Data, 7, 2020, 136.
