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Prevalence of SARS-CoV-2 infection in the Luxembourgish population: the CON-VINCE study.
Snoeck, Chantal J.; Vaillant, Michel; Abdelrahman, Tamir et al.
2020
 

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Keywords :
SARS-CoV-2; rRT-PCR; population cohort
Abstract :
[en] BACKGROUND: After the World Health Organization declared the outbreak of coronavirus disease to be a public health emergency of international concern on January 30, 2020, the first SARS-CoV-2 infection was detected in Luxembourg on February 29, 2020. Representative population-based data, including asymptomatic individuals for assessing the viral spread and immune response were, however, lacking worldwide. METHODS: Using a panel-based method, we implemented a representative sample of the Luxembourgish population based on age, gender and residency for testing for SARS-CoV-2 infection and antibody status in order to define prevalence irrespective of clinical symptoms. Participants were contacted via email to fill an online questionnaire before biosampling at local laboratories. All participants provided information related to clinical symptoms, epidemiology, socioeconomic and psychological assessments and underwent biosampling, rRT-PCR testing and serology for SARS-CoV-2. RESULTS: We included a total of 1862 individuals in our representative sample of the general Luxembourgish population. Of these, 5 individuals had a current positive result for infection with SARS-CoV-2 based on rRT-PCR. Four of these individuals were oligosymptomatic and one was asymptomatic. Overall we found a positive IgG antibody status in 35 individuals (1.97%), of which 11 reported to be tested positive by rRT-PCR for SARS-CoV-2 previously and showed in addition their IgG positive status also a positive status for IgA. Our data indicate a prevalence of 0.3% for active SARS-CoV-2 infection and an infection rate of 2.15% in the Luxembourgish population between 18 and 79 years of age. CONCLUSIONS: Luxembourgish residents show a low rate of acute infections after 7 weeks of confinement and present with an antibody profile indicative of a more recent immune response to SARS-CoV-2. All infected individuals were oligo- or asymptomatic. Bi-weekly follow-up visits over the next 2 months will inform about the viral spread by a- and oligosymptomatic carriers and the individual changes in the immune profile.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT04379297Funding StatementThe CON-VINCE Study is funded by the Research Fund Luxembourg (FNR; CON-VINCE) and the André Losch Foundation (Luxembourg).Author DeclarationsAll relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.YesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesDue to ethical concerns, supporting data cannot be made openly available.
Disciplines :
Immunology & infectious disease
Author, co-author :
Snoeck, Chantal J.;  Luxembourg Institute of Health - LIH > Department of Infection and Immunity
Vaillant, Michel;  Luxembourg Institute of Health - LIH > Competence Center for Methodology and Statistics
Abdelrahman, Tamir;  Luxembourg Institute of Health - LIH
Satagopam, Venkata ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Turner, Jonathan ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)
Beaumont, Katy;  Integrated Biobank of Luxembourg
Gomes, Clarissa ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Fritz, Joelle ;  Luxembourg Institute of Health - LIH
Schröder, Valerie ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Kaysen, Anne ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Pavelka, Lukas ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Stute, Lara ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Ramos Meyers, Guilherme ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Pauly, Laure
Hansen, Maxime ;  Luxembourg Institute of Health - LIH
Pauly, Claire ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Aguayo, Gloria A.
Perquin, Magali ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE)
Hanff, Anne-Marie ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Ghosh, Soumyabrata  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Gantenbein, Manon
Huiart, Laetitia ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)
Ollert, Markus
Krüger, Rejko ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
More authors (14 more) Less
Language :
English
Title :
Prevalence of SARS-CoV-2 infection in the Luxembourgish population: the CON-VINCE study.
Publication date :
18 May 2020
Publisher :
Cold Spring Harbor Laboratory, Woodbury, NY, United States
Focus Area :
Systems Biomedicine
Name of the research project :
CONVINCE
Funders :
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 10 December 2020

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