Article (Scientific journals)
Community-driven roadmap for integrated disease maps.
Ostaszewski, Marek; Gebel, Stephan; Kuperstein, Inna et al.
2018In Briefings in Bioinformatics
Peer Reviewed verified by ORBi
 

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Abstract :
[en] The Disease Maps Project builds on a network of scientific and clinical groups that exchange best practices, share information and develop systems biomedicine tools. The project aims for an integrated, highly curated and user-friendly platform for disease-related knowledge. The primary focus of disease maps is on interconnected signaling, metabolic and gene regulatory network pathways represented in standard formats. The involvement of domain experts ensures that the key disease hallmarks are covered and relevant, up-to-date knowledge is adequately represented. Expert-curated and computer readable, disease maps may serve as a compendium of knowledge, allow for data-supported hypothesis generation or serve as a scaffold for the generation of predictive mathematical models. This article summarizes the 2nd Disease Maps Community meeting, highlighting its important topics and outcomes. We outline milestones on the roadmap for the future development of disease maps, including creating and maintaining standardized disease maps; sharing parts of maps that encode common human disease mechanisms; providing technical solutions for complexity management of maps; and Web tools for in-depth exploration of such maps. A dedicated discussion was focused on mathematical modeling approaches, as one of the main goals of disease map development is the generation of mathematically interpretable representations to predict disease comorbidity or drug response and to suggest drug repositioning, altogether supporting clinical decisions.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Ostaszewski, Marek  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Gebel, Stephan ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kuperstein, Inna
Mazein, Alexander
Zinovyev, Andrei
Dogrusoz, Ugur
Hasenauer, Jan
Fleming, Ronan MT ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Le Novere, Nicolas
Gawron, Piotr ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Ligon, Thomas
Niarakis, Anna
Nickerson, David
Weindl, Daniel
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Barillot, Emmanuel
Auffray, Charles
Schneider, Reinhard ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
More authors (8 more) Less
External co-authors :
yes
Language :
English
Title :
Community-driven roadmap for integrated disease maps.
Publication date :
2018
Journal title :
Briefings in Bioinformatics
ISSN :
1477-4054
Publisher :
Oxford University Press, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Available on ORBilu :
since 14 August 2018

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