Article (Scientific journals)
Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
Fitzgerald, Julia C.; Zimprich, Alexander; Bobbili, Dheeraj Reddy et al.
2018In Brain: a Journal of Neurology
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Keywords :
Parkinson's disease; TRAP1; Mutations
Abstract :
[en] Sir, In their letter in this issue, Gaare and colleagues (2018) state that TRAP1 may not be a Parkinson’s disease gene because of lack of genetic association. In response, we welcome their data analyses and we welcome any further genetic analyses of TRAP1 variants in additional Parkinson’s disease genetic datasets, including the reanalysis of open access datasets such as the Parkinson’s Progressive Markers Initiative (PPMI). Our point of view is that TRAP1 is an interesting effector protein that our study unequivocally showed is relevant to Parkinson’s disease signaling in the context of mitochondrial regulation. Furthermore, the overall contribution of TRAP1 genetic variants to Parkinson’s disease was not the focus of our recent paper in Brain (Fitzgerald et al., 2017).
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
ULHPC - University of Luxembourg: High Performance Computing
Disciplines :
Neurology
Genetics & genetic processes
Author, co-author :
Fitzgerald, Julia C.
Zimprich, Alexander
Bobbili, Dheeraj Reddy ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Sharma, Manu
May, Patrick  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Krüger, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
yes
Language :
English
Title :
Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
Publication date :
24 January 2018
Journal title :
Brain: a Journal of Neurology
ISSN :
1460-2156
Publisher :
Oxford University Press, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Available on ORBilu :
since 25 January 2018

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