Profil

BOBBILI Dheeraj Reddy

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core

Main Referenced Co-authors
MAY, Patrick  (32)
KRÜGER, Rejko  (13)
Sharma, Manu (10)
LANDOULSI, Zied  (8)
Schulte, Claudia (8)
Main Referenced Keywords
Parkinson's disease (12); Epilepsy (5); Genetics (5); GWAS (3); Alzheimer's disease (2);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (31)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) (13)
ULHPC - University of Luxembourg: High Performance Computing (8)
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) (6)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (5)
Main Referenced Disciplines
Genetics & genetic processes (27)
Neurology (22)
Oncology (4)
Cardiovascular & respiratory systems (2)
Biotechnology (2)

Publications (total 35)

The most downloaded
1456 downloads
BOBBILI, D. R. (2018). UNRAVELING THE COMPLEX GENETICS OF NEUROLOGICAL DISORDERS [Doctoral thesis, University du Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/35577 https://hdl.handle.net/10993/35577

The most cited

75 citations (Scopus®)

Fitzgerald, J. C., Zimprich, A., Carvajal-Berrio, D. A., Schindler, K. M., Maurer, B., Schulte, C., Bus, C., Hauser, A.-K., Kübler, M., Lewin, R., BOBBILI, D. R., Schwarz, L. M., Vartholomaiou, E., Brockmann, K., Wüst, R., Madlung, J., Nordheim, A., Riess, O., Martins, L. M., ... KRÜGER, R. (24 August 2017). Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease. Brain: a Journal of Neurology, 140 (9), 2444-2459. doi:10.1093/brain/awx202 https://hdl.handle.net/10993/31805

ARENA, G., LANDOULSI, Z., GROSSMANN, D., Payne, T., VITALI, A., DELCAMBRE, S., BARON, A., ANTONY, P., BOUSSAAD, I., BOBBILI, D. R., Sreelatha, A. A. K., PAVELKA, L., J Diederich, N., Klein, C., Seibler, P., GLAAB, E., Foltynie, T., Bandmann, O., Sharma, M., ... COURAGE‐PD Consortium. (2024). Polygenic Risk Scores Validated in Patient-Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease. Annals of Neurology. doi:10.1002/ana.26949
Peer Reviewed verified by ORBi

LANDOULSI, Z.* , PACHCHEK, S.* , BOBBILI, D. R., PAVELKA, L., MAY, P.* , KRÜGER, R.* , & NCER-PD consortium. (20 December 2023). Genetic landscape of Parkinson’s disease and related diseases in Luxembourg. Frontiers in Aging Neuroscience, 15. doi:10.3389/fnagi.2023.1282174
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Coppola, A., Krithika, S., Iacomino, M., BOBBILI, D. R., Balestrini, S., Bagnasco, I., Bilo, L., Buti, D., Casellato, S., Cuccurullo, C., Ferlazzo, E., Leu, C., Giordano, L., Gobbi, G., Hernandez-Hernandez, L., Lench, N., Martins, H., Meletti, S., Messana, T., ... Sisodiya, S. M. (2023). Dissecting the genetics of spectrum of Epilepsies with Eyelid Myoclonia by exome sequencing. Epilepsia. doi:10.1111/epi.17859
Peer Reviewed verified by ORBi

HASSANIN, E. S. F. E., Lee, K.-H., Hsieh, T.-C., Aldisi, R., Lee, Y.-L., BOBBILI, D. R., Krawitz, P., MAY, P., Chen, C.-Y., & Maj, C. (23 November 2023). Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis of the United Kingdom Biobank and Taiwan Biobank. Frontiers in Genetics, 14. doi:10.3389/fgene.2023.1286561
Peer Reviewed verified by ORBi

Stevelink, R., Campbell, C., Chen, S., Abou-Khalil, B., Adesoji, O. M., Afawi, Z., Amadori, E., Anderson, A., Anderson, J., Andrade, D. M., Annesi, G., Auce, P., Avbersek, A., Bahlo, M., Baker, M. D., Balagura, G., Balestrini, S., Barba, C., Barboza, K., ... Epilepsies, I. L. A. E. C. O. C. (2023). GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nature Genetics. doi:10.1038/s41588-023-01485-w
Peer Reviewed verified by ORBi

HASSANIN, E. S. F. S., MAY, P., & BOBBILI, D. R. (2023). Assessing the performance of European-derived cardiometabolic polygenic risk scores in South-Asians and their interplay with family history. BMC Medical Genomics. doi:10.1186/s12920-023-01598-5
Peer Reviewed verified by ORBi

ARENA, G., LANDOULSI, Z., Grossmann, D., Vitali, A., DELCAMBRE, S., BARON, A., ANTONY, P., BOUSSAAD, I., BOBBILI, D. R., Sreelatha, A. A. K., PAVELKA, L., Klein, C., Seibler, P., GLAAB, E., Sharma, M., KRÜGER, R., MAY, P., & GRÜNEWALD, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05.12.23289877. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55367. doi:10.1101/2023.05.12.23289877

PEIRIS, S., LANDOULSI, Z., PAVELKA, L., Schulte, C., Buena-Atienza, E., Gross, C., Hauser, A.-K., BOBBILI, D. R., Casadei, N., MAY, P., KRÜGER, R., & Consortium, T. N.-P. (2023). Accurate long-read sequencing identified GBA variants as a major genetic risk factor in the Luxembourg Parkinson\textquoterights study 2023.03.29.23287880. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55244. doi:10.1101/2023.03.29.23287880

HASSANIN, E. S. F. S., Spier, I., BOBBILI, D. R., Aldisi, R., Klinkhammer, H., David, F., Dueñas, N., Hüneburg, R., Perne, C., Brunet, J., Capella, G., Nöthen, M. M., Forstner, A. J., Mayr, A., Krawitz, P., MAY, P., Aretz, S., & Maj, C. (23 March 2023). Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence. BMC Medical Genomics, 16 (1), 42. doi:10.1186/s12920-023-01469-z
Peer Reviewed verified by ORBi

HASSANIN, E. S. F. S., Maj, C., Krawitz, P., MAY, P., & BOBBILI, D. R. (2023). Transferability of European-derived cardiometabolic polygenic risk scores in the South Asians and their interplay with family history 2023.03.20.23287470. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55242. doi:10.1101/2023.03.20.23287470

Sugier, P.-E., Lucotte, E. A., Domenighetti, C., Law, M. H., Iles, M. M., Brown, K., Amos, C., McKay, J. D., Hung, R. J., Karimi, M., Bacq-Daian, D., Boland-Augé, A., Olaso, R., Deleuze, J.-F., Lesueur, F., Ostroumova, E., Kesminiene, A., de Vathaire, F., Guénel, P., ... Elbaz, A. (14 February 2023). Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers. Movement Disorders, n/a (n/a). doi:10.1002/mds.29337
Peer Reviewed verified by ORBi

Domenighetti, C., Douillard, V., Sugier, P.-E., Sreelatha, A. A. K., Schulte, C., Grover, S., MAY, P., BOBBILI, D. R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Gourraud, P.-A., Mellick, G. D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A. E., ... Consortium, E. I. P. S. D. C.-P. D. (2022). The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited. Movement Disorders. doi:10.1002/mds.29133
Peer reviewed

Grover, S., Ashwin, A. K. S., Pihlstrom, L., Domenighetti, C., Schulte, C., Sugier, P.-E., Radivojkov-Blagojevic, M., Lichtner, P., Mohamed, O., Portugal, B., LANDOULSI, Z., MAY, P., BOBBILI, D. R., Edsall, C., Bartusch, F., Hanussek, M., Krüger, J., Hernandez, D. G., Blauwendraat, C., ... consortium, E. I. P. T. D. C.-P. D. (2022). Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson Disease: Evidence From COURAGE-PD Consortium 10.1212/WNL.0000000000200699. Neurology. doi:10.1212/WNL.0000000000200699
Peer reviewed

Liu, H., Dehestani, M., Blauwendraat, C., Makarious, M. B., Leonard, H., Kim, J. J., Schulte, C., Noyce, A., Jacobs, B. M., Foote, I., Sharma, M., International Parkinson's Disease Genomics Consortium, Comprehensive Unbiased Risk Factor Assessment For Environment in Parkinson's Disease Consortium, LANDOULSI, Z., KRÜGER, R., MAY, P., BOBBILI, D. R., PAVELKA, L., Nalls, M., Singleton, A., ... Bandres-Ciga, S. (2022). Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors. Annals of Neurology. doi:10.1002/ana.26416
Peer Reviewed verified by ORBi

Hassanin, E., Spier, I., BOBBILI, D. R., Aldisi, R., Klinkhammer, H., David, F., Dueñas, N., Hüneburg, R., Perne, C., Brunet, J., Capella, G., Nöthen, M. M., Forstner, A. J., Mayr, A., Krawitz, P., MAY, P., Aretz, S., & Maj, C. (2022). Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence 2022.01.20.22269585. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/50410. doi:10.1101/2022.01.20.22269585

Koko, M., Motelow, J. E., Stanley, K. E., BOBBILI, D. R., Dhindsa, R. S., MAY, P., Network, C. E., Consortium, E. K., Project, E. P. G., Consortium, E., & Consortium, E.-C. (2022). Association of ultra-rare coding variants with genetic generalized epilepsy: A case–control whole exome sequencing study. Epilepsia. doi:10.1111/epi.17166
Peer Reviewed verified by ORBi

Domenighetti, C., Sugier, P.-E., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., Portugal, B., MAY, P., BOBBILI, D. R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Mellick, G. D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A. E., ... Consortium, E. I. P. S. D. C.-P. D. (2022). Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. Movement Disorders. doi:10.1002/mds.28902
Peer Reviewed verified by ORBi

Campbell, C., McCormack, M., Patel, S., Stapleton, C., BOBBILI, D. R., KRAUSE, R., Depondt, C., Sills, G. J., Koeleman, B. P., Striano, P., Zara, F., Sander, J. W., Lerche, H., Kunz, W. S., Stefansson, K., Stefansson, H., Doherty, C. P., Heinzen, E. L., Scheffer, I. E., ... Cavalleri, G. L. (2022). A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam. Epilepsia, 63 (6), 1563-1570. doi:10.1111/epi.17228
Peer Reviewed verified by ORBi

Hassanin, E., MAY, P., Aldisi, R., Spier, I., Forstner, A. J., Nöthen, M. M., Aretz, S., Krawitz, P., BOBBILI, D. R., & Maj, C. (2021). Breast and prostate cancer risk: the interplay of polygenic risk, rare pathogenic germline variants, and family history. Genetics in Medicine. doi:10.1016/j.gim.2021.11.009
Peer reviewed

Domenighetti, C., Sugier, P. E., Sreelatha, A. A. K., Schulte, C., Grover, S., Mohamed, O., Portugal, B., MAY, P., BOBBILI, D. R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Mellick, G. D., Zimprich, A., Pirker, W., Rogaieva, E., Lang, A. E., ... Elbaz, A. (2021). Mendelian randomization study of smoking, alcohol, and coffee drinking in relation to Parkinso's disease. Journal of Parkinson's Disease, 1-16. doi:10.3233/JPD-212851
Peer Reviewed verified by ORBi

Koko, M., KRAUSE, R., Sander, T., BOBBILI, D. R., Nothnagel, M., MAY, P., Lerche, H., & Epi25 Collaborative. (24 September 2021). Distinct gene-set burden patterns underlie common generalized and focal epilepsies. EBioMedicine, 72, 103588. doi:10.1016/j.ebiom.2021.103588
Peer Reviewed verified by ORBi

Hassanin, E., MAY, P., Aldisi, R., Krawitz, P., Maj, C., & BOBBILI, D. R. (2021). Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson\textquoterights disease. 2021.06.06.21253270. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/47448. doi:10.1101/2021.06.06.21253270

Hassanin, E., MAY, P., Aldisi, R., Spier, I., Forstner, A. J., Nothen, M. M., Aretz, S., Krawitz, P., BOBBILI, D. R., & Maj, C. (2021). Breast and prostate cancer risk: the interplay of polygenic risk, high-impact monogenic variants, and family history 2021.06.04.21258277. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/47445. doi:10.1101/2021.06.04.21258277

Hartl, D.* , MAY, P.* , GU, W.* , Mayhaus, M., Pichler, S., Spaniol, C., GLAAB, E., BOBBILI, D. R., ANTONY, P., Köglsberger, S., Kurz, A., Grimmer, T., Morgan, K., Vardarajan, B. N., Reitz, C., Hardy, J., Bras, J., Guerreiro, R., AESG, ... Riemenschneider, M. (09 July 2020). A rare loss-of function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Molecular Psychiatry, 25 (3), 629-639. doi:10.1038/s41380-018-0091-8
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Lerche, H., Berkovic, S. F., Lowenstein, D. H., EuroEPINOMICS-CoGIE, MAY, P., BOBBILI, D. R., KRAUSE, R., BALLING, R., EpiPGX consortium, Peter, S., & Epi4K Consortium/Epilepsy Phenome/Genome. (18 April 2019). Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy [letter to the editor]. New England Journal of Medicine, 380 (16), 24. doi:10.1056/NEJMc1805100
Peer Reviewed verified by ORBi

Jabbari, K., BOBBILI, D. R., Lal, D., Reinthaler, E. M., Schubert, J., Wolking, S., Sinha, V., Motameny, S., Thiele, H., Kawalla, A., Altmüller, J., Toliat, M. R., Kraaij, R., van Rooij, J., Uitterlinden, A. G., Ikram, M. A., EuroEPINOMICS CoGIE Consortium, BALLING, R., Zara, F., ... Nürnberg, P. (2018). Rare gene deletions in genetic generalized and Rolandic epilepsies. PLoS ONE. doi:10.1371/journal.pone.0202022
Peer Reviewed verified by ORBi

MAY, P., Girard, S., Harrer, M., BOBBILI, D. R., Schubert, J., Wolking, S., Becker, F., Lachance-Touchette, P., Meloche, C., Gravel, M., Niturad, C. E., Knaus, J., De Kovel, C., Toliat, M., Polvi, A., Iacomino, M., Guerrero-López, R., Baulac, S., Marini, C., ... Lerche, H. (18 August 2018). Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study. The Lancet Neurology, 17 (8), 699-708. doi:10.1016/S1474-4422(18)30215-1
Peer Reviewed verified by ORBi

BOBBILI, D. R. (2018). UNRAVELING THE COMPLEX GENETICS OF NEUROLOGICAL DISORDERS [Doctoral thesis, University du Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/35577

MAY, P.* , Pichler, S.* , Hartl, D., BOBBILI, D. R., Mayhaus, M., Spaniol, C., Kurz, A., BALLING, R., SCHNEIDER, J., & Riemenschneider, M. (01 April 2018). Rare ABCA7 variants in 2 German families with Alzheimer disease. Neurology. Genetics, 4 (2). doi:10.1212/NXG.0000000000000224
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Fitzgerald, J. C., Zimprich, A., BOBBILI, D. R., Sharma, M., MAY, P., & KRÜGER, R. (2018). Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease. Brain: a Journal of Neurology. doi:10.1093/brain/awx380
Peer Reviewed verified by ORBi

BOBBILI, D. R.* , Lal, D.* , MAY, P.* , Reinthaler, E. M., Jabbari, K., Thiele, H., Nothnagel, M., Jurkowski, W., EuroEPINOMICS COGIE Consortium, BALLING, R., Feucht, M., Nürnberg, P., Lerche, H., Zimprich, F., KRAUSE, R., & Neubauer, B. A. (2018). Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic Epilepsy. European Journal of Human Genetics. doi:10.1038/s41431-017-0034-x
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Fitzgerald, J. C., Zimprich, A., Carvajal-Berrio, D. A., Schindler, K. M., Maurer, B., Schulte, C., Bus, C., Hauser, A.-K., Kübler, M., Lewin, R., BOBBILI, D. R., Schwarz, L. M., Vartholomaiou, E., Brockmann, K., Wüst, R., Madlung, J., Nordheim, A., Riess, O., Martins, L. M., ... KRÜGER, R. (24 August 2017). Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease. Brain: a Journal of Neurology, 140 (9), 2444-2459. doi:10.1093/brain/awx202
Peer Reviewed verified by ORBi

BOBBILI, D. R., MAY, P., & KRÜGER, R. (02 June 2017). Rare variant analysis of the PPMI dataset to uncover the complex genetic architecture of Parkinson’s disease. Movement Disorders, 322 (Supplement S2), 405. doi:10.1002/mds.27087
Peer Reviewed verified by ORBi

Hartl, D., MAY, P., GU, W., Mayhaus, M., GLAAB, E., ANTONY, P., BOBBILI, D. R., Köglsberger, S., Pichler, S., Spaniol, C., Kurz, A., BALLING, R., SCHNEIDER, J., & Riemenschneider, M. (2017). IDENTIFICATION OF A RARE GENE VARIANT THAT IS ASSOCIATED WITH FAMILIAL ALZHEIMER DISEASE AND REGULATES APP EXPRESSION. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 13 (7, Supplement), 648. doi:10.1016/j.jalz.2017.06.758
Peer reviewed

ALEX NAMASIVAYAM, A., Morales, A. F., Lacave, A. M. F., Tallam, A., Simovic, B., Alfaro, D. G., BOBBILI, D. R., Martin, F., ANDROSOVA, G., Shvydchenko, I., Park, J., Calvo, J. V., Hoeng, J., Peitsch, M. C., Racero, M. G. V., BIRYUKOV, M., Talikka, M., Perez, M. B., Rohatgi, N., ... Xiang, Y. (2016). Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications. Gene Regulation and Systems Biology, 10, 51-66. doi:10.4137/GRSB.S39076
Peer Reviewed verified by ORBi

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