Reference : Characterization of the microglial phenotype under specific pro-inflammatory and ant...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/26405

Title :	Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta
Language :	English
Author, co-author :	Michelucci, Alessandro [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Heurtaux, Tony [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Grandbarbe, Luc [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Morga, Eleonora [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Heuschling, Paul [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)]
Publication date :	2009
Journal title :	Journal of Neuroimmunology
Publisher :	Elsevier Science
Volume :	210
Issue/season :	1-2
Pages :	3-12
Peer reviewed :	Yes (verified by ORBilu)
ISSN :	0165-5728
City :	Amsterdam
Country :	The Netherlands
Abstract :	[en] M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differentiate microglia towards a M2-deactivated or M2-alternatively-activated phenotype respectively. These differentiation processes also affect the Notch pathway. In order to study the polarization induced by Abeta, microglia was stimulated with different forms of the peptide. The oligomeric Abeta is a stronger M1-inductor than the fibrillar form. Moreover, a cytokine-induced anti-inflammatory environment reduces the microglial reactivity towards oligomeric Abeta.
Permalink :	http://hdl.handle.net/10993/26405
DOI :	10.1016/j.jneuroim.2009.02.003

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	Fulltext file(s): File Commentary Version Size Access Open access 2009 - Journal of Neuroimmunology (Michelucci).pdf Publisher postprint 1.09 MB View/Open

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