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HEURTAUX Tony

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

Main Referenced Co-authors
HEUSCHLING, Paul  (8)
BUTTINI, Manuel  (6)
GLAAB, Enrico  (6)
GRANDBARBE, Luc  (6)
MICHELUCCI, Alessandro  (6)
Main Referenced Keywords
inflammation (3); neurodegeneration (3); brain (2); gene expression (2); mouse models (2);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (4)
Luxembourg Centre for Systems Biomedicine (LCSB) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group) (2)
LIH - Luxembourg Institute of Health (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (1)
Main Referenced Disciplines
Life sciences: Multidisciplinary, general & others (16)
Neurology (6)
Biotechnology (3)
Biochemistry, biophysics & molecular biology (2)
Immunology & infectious disease (1)

Publications (total 21)

The most downloaded
364 downloads
Grandbarbe, L., Michelucci, A., Heurtaux, T., Hemmer, K., Morga, E., & Heuschling, P. (2007). Notch signaling modulates the activation of microglial cells. Glia, 55 (15), 1519-30. doi:10.1002/glia.20553 https://hdl.handle.net/10993/26406

The most cited

317 citations (Scopus®)

Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009). Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta. Journal of Neuroimmunology, 210 (1-2), 3-12. doi:10.1016/j.jneuroim.2009.02.003 https://hdl.handle.net/10993/26405

SCHMIT, K.* , GARCIA, P.* , SCIORTINO, A., AHO, V., Pardo Rodriguez, B., THOMAS, M., GERARDY, J.-J., Bastero Acha, I., HALDER, R., CIALINI, C., HEURTAUX, T., Ostahi, I., BUSI, S. B., Grandmougin, L., LOWNDES, T., Singh, Y., Martens, E. C., MITTELBRONN, M., BUTTINI, M.* , & WILMES, P. (26 September 2023). Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson's disease. Cell Reports, 42 (9), 113071. doi:10.1016/j.celrep.2023.113071
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

ALI, M.* , GARCIA, P.* , Laetitia P. Lunkes, SCIORTINO, A., THOMAS, M., HEURTAUX, T., GRZYB, K., HALDER, R., SKUPIN, A., MITTELBRONN, M., BUTTINI, M., & GLAAB, E. (12 May 2023). Gene Regulatory Network Analysis of Single-Cell Transcriptomes from THY-Tau22 Mice Reveals Sex-Dependent Immune Dysregulation associated with Alzheimer-like pathology [Poster presentation]. The 7th Venusberg Meeting on Neuroinflammation, Belval, Luxembourg.
* These authors have contributed equally to this work.

Heurtaux, T., Bouvier, D. S., Benani, A., Helgueta Romero, S., Frauenknecht, K. B. M., Mittelbronn, M., & Sinkkonen, L. (July 2022). Normal and Pathological NRF2 Signalling in the Central Nervous System. Antioxidants, 11 (8), 1426. doi:10.3390/antiox11081426
Peer reviewed

Salvi, J., Andreoletti, P., Audinat, E., Balland, E., Ben Fradj, S., Cherkaoui-Malki, M., Heurtaux, T., Lienard, F., Nedelec, E., Rovere, C., Savary, S., Vejux, A., Trompier, D., & Benani, A. (2022). Microgliosis: a double-edged sword in the control of food intake. FEBS Journal. doi:10.1111/febs.16583
Peer Reviewed verified by ORBi

Bouvier, D. S., Fixemer, S., Heurtaux, T., Jeannelle, F., Frauenknecht, K. B. M., & Mittelbronn, M. (2022). The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective. Frontiers in Physiology. doi:10.3389/fphys.2022.814889
Peer Reviewed verified by ORBi

Kishk, A., Pires Pacheco, M. I., Heurtaux, T., Sinkkonen, L., Pang, J., Fritah, S., Niclou, S., & Sauter, T. (2022). Review of Current Human Genome-Scale Metabolic Models for Brain Cancer and Neurodegenerative Diseases. Cells, 11 (16). doi:10.3390/cells11162486
Peer Reviewed verified by ORBi

Trezzi, J.-P., Aho, V., Jäger, C., Schade, S., Janzen, A., Hickl, O., Kunath, B., Thomas, M., Schmit, K., Garcia, P., Sciortino, A., Martin-Gallausiaux, C., Halder, R., Huarte, O. U., Heurtaux, T., Heins-Marroquin, U., Gomez-Giro, G., Weidenbach, K., Delacour, L., ... Wilmes, P. (2022). An archaeal compound as a driver of Parkinson’s disease pathogenesis. (1). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51987. doi:10.21203/rs.3.rs-1827631/v1

Garcia, P., Wemheuer, W., Uriarte, O., Michelucci, A., Masuch, A., Brioschi, S., Weihofen, A., Koncina, E., Coowar, D., Heurtaux, T., Glaab, E., Balling, R., Sousa, C., Kaoma, T., Nicot, N., Pfander, T., Schulz-Schaeffer, W., Allouche, A., Fischer, N., ... Buttini, M. (2022). Neurodegeneration and neuroinflammation are linked, but independent of a-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease. Glia. doi:10.1002/glia.24149
Peer Reviewed verified by ORBi

Ali, M., Huarte, O., Heurtaux, T., Garcia, P., Rodriguez, B. P., Grzyb, K., Halder, R., Skupin, A., Buttini, M., & Glaab, E. (2022). Single-cell transcriptional profiling and gene regulatory network modeling in Tg2576 mice reveal gender-dependent molecular features preceding Alzheimer-like pathologies. Molecular Neurobiology, in press (doi:10.1007/s12035-022-02985-2) (in press). doi:10.1007/s12035-022-02985-2
Peer Reviewed verified by ORBi

Heurtaux, T., Kirchmeyer, M., Koncina, E., Richart, L., Uriarte Huarte, O., Schohn, H., & Mittelbronn, M. (2021). Apomorphine Reduces A53T α‑Synuclein‑Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway. Cellular and Molecular Neurobiology. doi:10.1007/s10571-021-01131-1
Peer Reviewed verified by ORBi

Uriarte Huarte, O., Kyriakis, D., Heurtaux, T., Pires-Afonso, Y., Grzyb, K., Halder, R., Buttini, M., Skupin, A., Mittelbronn, M., & Michelucci, A. (2021). Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway. Frontiers in Immunology. doi:10.3389/fimmu.2021.639613
Peer Reviewed verified by ORBi

Nuzzaci, D., Cansell, C., Liénard, F., Nédélec, E., Ben Fradj, S., Castel, J., Foppen, E., Denis, R., Grouselle, D., Laderrière, A., Lemoine, A., Mathou, A., Tolle, V., Heurtaux, T., Fioramonti, X., Audinat, E., Pénicaud, L., Nahon, J.-L., Rovère, C., & Benani, A. (03 March 2020). Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal. Cell Reports, 30, 3067-3078. doi:10.1016/j.celrep.2020.02.029
Peer Reviewed verified by ORBi

Hoenen, C., Gustin, A., Birck, C., Kirchmeyer, M., Beaume, N., Felten, P., Grandbarbe, L., Heuschling, P., & Heurtaux, T. (2016). Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant. PLoS ONE. doi:10.1371/journal.pone.0162717
Peer Reviewed verified by ORBi

Birck, C., Koncina, E., Heurtaux, T., Glaab, E., Michelucci, A., Heuschling, P., & Grandbarbe, L. (10 November 2015). Transcriptomic analyses of primary astrocytes under TNFα treatment. Genomics Data, 7, 7-11. doi:10.1016/j.gdata.2015.11.005
Peer Reviewed verified by ORBi

Gabel, S., Koncina, E., Dorban, G., Heurtaux, T., Birck, C., Glaab, E., Michelucci, A., Heuschling, P., & Grandbarbe, L. (17 September 2015). Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation. Molecular Neurobiology, 53 (8), 5041-5055. doi:10.1007/s12035-015-9428-3
Peer reviewed

Gustin, A., Kirchmeyer, M., Koncina, E., Felten, P., Losciuto, S., Heurtaux, T., Tardivel, A., Heuschling, P., & Dostert, C. (19 June 2015). NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PLoS ONE, 10 (6). doi:10.1371/journal.pone.0130624
Peer Reviewed verified by ORBi

Blanchard, B., Heurtaux, T., & Nait Oumesmar, B. (10 July 2013). Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis. Journal of Neuroscience, 33 (28), 11633-42. doi:10.1523/JNEUROSCI.0774-13.2013
Peer Reviewed verified by ORBi

Losciuto, S., Dorban, G., Gabel, S., Gustin, A., Hoenen, C., Grandbarbe, L., Heuschling, P., & Heurtaux, T. (30 May 2012). An efficient method to limit microglia-dependent effects in astroglial cultures. Journal of Neuroscience Methods, 207 (1), 59-71. doi:10.1016/j.jneumeth.2012.03.010
Peer Reviewed verified by ORBi

Heurtaux, T., Michelucci, A., Losciuto, S., Gallotti, C., Felten, P., Dorban, G., Grandbarbe, L., Morga, E., & Heuschling, P. (July 2010). Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2. Journal of Neurochemistry, 114 (2), 576-586. doi:10.1111/j.1471-4159.2010.06783.x
Peer Reviewed verified by ORBi

Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009). Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta. Journal of Neuroimmunology, 210 (1-2), 3-12. doi:10.1016/j.jneuroim.2009.02.003
Peer reviewed

Grandbarbe, L., Michelucci, A., Heurtaux, T., Hemmer, K., Morga, E., & Heuschling, P. (2007). Notch signaling modulates the activation of microglial cells. Glia, 55 (15), 1519-30. doi:10.1002/glia.20553
Peer Reviewed verified by ORBi

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