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MICHELUCCI Alessandro

University of Luxembourg

Main Referenced Co-authors
NICLOU, Simone  (11)
HEUSCHLING, Paul  (7)
SKUPIN, Alexander  (7)
BALLING, Rudolf  (6)
GRANDBARBE, Luc  (6)
Main Referenced Keywords
Animals (4); Mice (4); brain (3); Brain Neoplasms/pathology (3); Glioblastoma (3);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) (5)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Metabolomics (Hiller Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group) (2)
Main Referenced Disciplines
Life sciences: Multidisciplinary, general & others (13)
Oncology (8)
Biochemistry, biophysics & molecular biology (7)
Neurology (5)
Biotechnology (3)

Publications (total 30)

The most downloaded
1871 downloads
Cordes, T., Michelucci, A., & Hiller, K. (2015). Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite. Annual review of nutrition. doi:10.1146/annurev-nutr-071714-034243 https://hdl.handle.net/10993/26002

The most cited

713 citations (Scopus®)

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 https://hdl.handle.net/10993/2256

Turner, M. C., Radzikowska, U., Ferastraoaru, D. E., Pascal, M., Wesseling, P., McCraw, A., BACKES, C., Bax, H. J., Bergmann, C., Bianchini, R., Cari, L., de Las Vecillas, L., Izquierdo, E., Lind-Holm Mogensen, F., MICHELUCCI, A., NAZAROV, P., NICLOU, S. P., Nocentini, G., OLLERT, M., ... Poli, A. (2024). AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus-A joint EAACI-EANO position paper. Allergy. doi:10.1111/all.15994
Peer Reviewed verified by ORBi

Yabo, Y. A., Moreno-Sanchez, P. M., Pires-Afonso, Y., Kaoma, T., Nosirov, B., Scafidi, A., Ermini, L., Lipsa, A., Oudin, A., KYRIAKIS, D., GRZYB, K., POOVATHINGAL, S. K., Poli, A., Muller, A., TOTH, R., KLINK, B., BERCHEM, G. J. M. J., Berthold, C., HERTEL, F., ... GOLEBIEWSKA, A. (2023). Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/60199. doi:10.1101/2023.03.05.531162

Poli, A., Oudin, A., Muller, A., Salvato, I., Scafidi, A., Hunewald, O., Domingues, O., NAZAROV, P., Puard, V., Baus, V., AZUAJE, F., DITTMAR, G., ZIMMER, J., MICHEL, T., MICHELUCCI, A., NICLOU, S. P., & OLLERT, M. (March 2023). Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice. Allergy, 78 (3), 682-696. doi:10.1111/all.15545
Peer Reviewed verified by ORBi

Pires-Afonso, Y., Muller, A., GRZYB, K., Oudin, A., Yabo, Y. A., SOUSA, C., Scafidi, A., Poli, A., COSMA, A., HALDER, R., COOWAR, D., GOLEBIEWSKA, A., SKUPIN, A., NICLOU, S. P., & MICHELUCCI, A. (September 2022). Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency. Molecular Oncology, 16 (17), 3167 - 3191. doi:10.1002/1878-0261.13287
Peer Reviewed verified by ORBi

Garcia, P., Wemheuer, W., Uriarte, O., Michelucci, A., Masuch, A., Brioschi, S., Weihofen, A., Koncina, E., Coowar, D., Heurtaux, T., Glaab, E., Balling, R., Sousa, C., Kaoma, T., Nicot, N., Pfander, T., Schulz-Schaeffer, W., Allouche, A., Fischer, N., ... Buttini, M. (2022). Neurodegeneration and neuroinflammation are linked, but independent of a-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease. Glia. doi:10.1002/glia.24149
Peer Reviewed verified by ORBi

Oudin, A., Baus, V., Barthelemy, V., Fabian, C., KLEIN, E., Dieterle, M., Wantz, M., Hau, A.-C., DORDING, C., Bernard, A., MICHELUCCI, A., Yabo, Y. A., Kanli, G., Keunen, O., Bjerkvig, R., NICLOU, S. P., & GOLEBIEWSKA, A. (18 June 2021). Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors. STAR Protocols, 2 (2), 100534. doi:10.1016/j.xpro.2021.100534
Peer Reviewed verified by ORBi

Grandbarbe, L., Michelucci, A., Heuschling, P., Pavlou, M. A., & Ginolhac, A. (2021). NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells. Cells. doi:10.3390/cells10040840
Peer Reviewed verified by ORBi

Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., ... Niclou, S. (2020). Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica. doi:10.1007/s00401-020-02226-7
Peer Reviewed verified by ORBi

Gui, Y., Thomas, M. H., Garcia, P., Karout, M., Halder, R., Michelucci, A., Kollmus, H., Zhou, C., Melmed, S., Schughart, K., Balling, R., Mittelbronn, M., Nadeau, J. H., Williams, R. W., Sauter, T., Buttini, M., & Sinkkonen, L. (2020). Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging. Frontiers in Genetics. doi:10.3389/fgene.2020.566734
Peer Reviewed verified by ORBi

Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., ... Niclou, S. (2020). Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/43022. doi:10.1101/2020.04.24.057802

Pires-Afonso, Y., NICLOU, S. P., & MICHELUCCI, A. (21 January 2020). Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma. International Journal of Molecular Sciences, 21 (3). doi:10.3390/ijms21030689
Peer Reviewed verified by ORBi

Dirkse, A., Golebiewska, A., Buder, T., Nazarov, P. V., Muller, A., Poovathingal, S., Brons, N. H. C., Leite, S., Sauvageot, N., Sarkisjan, D., Seyfrid, M., Fritah, S., Stieber, D., Michelucci, A., Herold-Mende, C., Bjerkvig, R., Azuaje, F., Skupin, A., Deutsch, A., ... Hertel, F. (2019). Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. Nature communications, 10 (1), 1787. doi:10.1038/s41467-019-09853-z
Peer reviewed

Pavlou, M. A., Grandbarbe, L., Buckley, N., Niclou, S., & Michelucci, A. (2018). Transcriptional and epigenetic mechanisms underlying astrocyte identity. Progress in Neurobiology. doi:10.1016/j.pneurobio.2018.12.007
Peer Reviewed verified by ORBi

Sousa, C., Golebiewska, A., Poovathingal, S. K., Kaoma, T., Pires-Afonso, Y., Martina, S., Coowar, D., Azuaje, F., Skupin, A., Balling, R., Biber, K., Niclou, S., & Michelucci, A. (2018). Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Reports. doi:10.15252/embr.201846171
Peer Reviewed verified by ORBi

del Sol Mesa, A., Ravichandran, S., & Michelucci, A. (2018). Integrative Computational Network Analysis Reveals Site-Specific Mediators of Inflammation in Alzheimer's Disease. Frontiers in Physiology.
Peer Reviewed verified by ORBi

Sousa, C., Biber, K., & Michelucci, A. (2017). Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population. Frontiers in Immunology, 8, 198. doi:10.3389/fimmu.2017.00198
Peer Reviewed verified by ORBi

Antony, P., Tallam, A., Perumal, T. M., Jäger, C., Fritz, J., Balling, R., del Sol Mesa, A., Michelucci, A., & Vallar, L. (2016). Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. PLoS ONE. doi:10.1371/journal.pone.0149050
Peer Reviewed verified by ORBi

Cordes, T., Wallace, M., Michelucci, A., Divakaruni, A. S., Sapcariu, S. C., Sousa, C., Koseki, H., Cabrales, P., Murphy, A. N., Hiller, K., & Metallo, C. M. (2016). Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. The Journal of biological chemistry, 291 (27), 14274-84. doi:10.1074/jbc.m115.685792
Peer reviewed

Meiser, J., Delcambre, S., Wegner, A., Jäger, C., Ghelfi, J., Fouquier d'Hérouël, A., Dong, X., Weindl, D., Stautner, C., Nonnenmacher, Y., Michelucci, A., Popp, O., Giesert, F., Schildknecht, S., Kraemer, L., Schneider, J. G., Woitalla, D., Wurst, W., Skupin, A., ... Hiller, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019
Peer Reviewed verified by ORBi

Birck, C., Koncina, E., Heurtaux, T., Glaab, E., Michelucci, A., Heuschling, P., & Grandbarbe, L. (10 November 2015). Transcriptomic analyses of primary astrocytes under TNFα treatment. Genomics Data, 7, 7-11. doi:10.1016/j.gdata.2015.11.005
Peer Reviewed verified by ORBi

Gabel, S., Koncina, E., Dorban, G., Heurtaux, T., Birck, C., Glaab, E., Michelucci, A., Heuschling, P., & Grandbarbe, L. (17 September 2015). Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation. Molecular Neurobiology, 53 (8), 5041-5055. doi:10.1007/s12035-015-9428-3
Peer reviewed

Michelucci, A., Bithell, A., Burney, M., Johnston, C., Wong, K.-Y., Teng, S.-W., Desai, J., Gumbleton, N., Anderson, G., Stanton, L., Williams, B., & Buckley, N. (2015). The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals. Molecular Neurobiology. doi:10.1007/s12035-015-9296-x
Peer Reviewed verified by ORBi

Jäger, C.* , Glaab, E.* , Michelucci, A.* , Binz, T., Köglsberger, S., Garcia, P., Trezzi, J.-P., Ghelfi, J., Balling, R., & Buttini, M. (2015). The Mouse Brain Metabolome: Region-Specific Signatures and Response to Excitotoxic Neuronal Injury. American Journal of Pathology, 185 (6), 1699-1712. doi:10.1016/j.ajpath.2015.02.016
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Cordes, T., Michelucci, A., & Hiller, K. (2015). Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite. Annual review of nutrition. doi:10.1146/annurev-nutr-071714-034243
Peer reviewed

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110
Peer Reviewed verified by ORBi

Wegner, A., Cordes, T., Michelucci, A., & Hiller, K. (2012). The Application of Stable Isotope Assisted Metabolomics in Biomedicine. Current Biotechnology, 1, 88-97.
Peer Reviewed verified by ORBi

Heurtaux, T., Michelucci, A., Losciuto, S., Gallotti, C., Felten, P., Dorban, G., Grandbarbe, L., Morga, E., & Heuschling, P. (July 2010). Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2. Journal of Neurochemistry, 114 (2), 576-586. doi:10.1111/j.1471-4159.2010.06783.x
Peer Reviewed verified by ORBi

Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009). Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta. Journal of Neuroimmunology, 210 (1-2), 3-12. doi:10.1016/j.jneuroim.2009.02.003
Peer reviewed

Grandbarbe, L., Michelucci, A., Heurtaux, T., Hemmer, K., Morga, E., & Heuschling, P. (2007). Notch signaling modulates the activation of microglial cells. Glia, 55 (15), 1519-30. doi:10.1002/glia.20553
Peer Reviewed verified by ORBi

Hauss, F., Liu, J., Michelucci, A., Coowar, D., Morga, E., Heuschling, P., & Luu, B. (2007). Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation. Bioorganic & Medicinal Chemistry Letters, 17 (15), 4218-4222. doi:10.1016/j.bmcl.2007.05.037
Peer reviewed

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