Poster (Scientific congresses, symposiums and conference proceedings)
Design principles study of ROS management and ROS-induced mitophagy with a kinetic model
Kolodkin, Alexey; Ignatenko, Andrew; Sangar, Vineet et al.
20132013 BMES Annual Meeting
 

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Keywords :
ROS management; kinetic model
Abstract :
[en] In vivo evidence demonstrates three fundamental interconnected adaptive survival mechanisms , which protect against excessive ROS that is generated during mitochondrial dysfunction: (i) autophagy/mitophagy, (ii) adaptive antioxidant response and (iii) NFkB signaling in cancer and neurodegeneration. We have been expanding a kinetic model which recapitulates the consensus understanding of the mechanisms responsible for cellular ROS – management system and performed modular analysis to analyze emergent behavior. We started with the simplest model and added stepwise new modules. We identify the qualitative role (certain emergent behavior) attributed to each module and thus understand the design principles of the system. We propose a detailed, mechanistic, kinetic model for studying how mutations relevant for diseases such as PD and cancer affect the emergent behavior of ROS management network.
Disciplines :
Mathematics
Biochemistry, biophysics & molecular biology
Author, co-author :
Kolodkin, Alexey ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Ignatenko, Andrew ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Engineering Research Unit
Sangar, Vineet;  Institute for Systems Biology - ISB
Simeonidis, Vangelis ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Peters, Bernhard ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Engineering Research Unit
Brady, Nathan;  German Cancer Research Center
Price, Nathan;  Institute for Systems Biology - ISB
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Language :
English
Title :
Design principles study of ROS management and ROS-induced mitophagy with a kinetic model
Publication date :
27 September 2013
Event name :
2013 BMES Annual Meeting
Event place :
Seattle, United States
Event date :
September 25-28, 2013
Audience :
International
Focus Area :
Computational Sciences
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since 26 September 2013

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