Age-related differences in functional connectivity associated with pain modulation.

Aging; Descending pain control system; Functional connectivity; Pain modulation; Periaqueductal gray; Resting state fMRI; Humans; Male; Aged; Female; Adult; Young Adult; Middle Aged; Amygdala/physiopathology; Amygdala/diagnostic imaging; Cerebral Cortex/physiopathology; Cerebral Cortex/diagnostic imaging; Periaqueductal Gray/physiopathology; Periaqueductal Gray/diagnostic imaging; Insular Cortex/diagnostic imaging; Insular Cortex/physiopathology; Neural Pathways/physiopathology; Neural Pathways/diagnostic imaging; Aging/physiology; Pain/physiopathology; Magnetic Resonance Imaging; Gyrus Cinguli/physiopathology; Gyrus Cinguli/diagnostic imaging; Amygdala; Cerebral Cortex; Gyrus Cinguli; Insular Cortex; Neural Pathways; Pain; Neuroscience (all); Neurology (clinical); Developmental Biology; Geriatrics and Gerontology

Résumé :

[en] Growing evidence suggests that aging is associated with impaired endogenous pain modulation, and that this likely underlies the increased transition from acute to chronic pain in older individuals. Resting-state functional connectivity (rsFC) offers a valuable tool to examine the neural mechanisms behind these age-related changes in pain modulation. RsFC studies generally observe decreased within-network connectivity due to aging, but its relevance for pain modulation remains unknown. We compared rsFC within a set of brain regions involved in pain modulation between young and older adults and explored the relationship with the efficacy of distraction from pain. This revealed several age-related increases and decreases in connectivity strength. Importantly, we found a significant association between lower pain relief and decreased strength of three connections in older adults, namely between the periaqueductal gray and right insula, between the anterior cingulate cortex (ACC) and right insula, and between the ACC and left amygdala. These findings suggest that the functional integrity of the pain control system is critical for effective pain modulation, and that its function is compromised by aging.

Disciplines :

Neurosciences & comportement

Auteur, co-auteur :

VAN DER MEULEN, Marian ; University of Luxembourg

RISCHER, Katharina Miriam ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences > Department of Behavioural and Cognitive Sciences > Team Marian VAN DER MEULEN

González Roldán, Ana María; Cognitive and Affective Neuroscience and Clinical Psychology, University of the Balearic Islands, Palma, Spain

Terrasa, Juan Lorenzo; Cognitive and Affective Neuroscience and Clinical Psychology, University of the Balearic Islands, Palma, Spain

Montoya, Pedro; Cognitive and Affective Neuroscience and Clinical Psychology, University of the Balearic Islands, Palma, Spain

ANTON, Fernand ; University of Luxembourg

Co-auteurs externes :

yes

Langue du document :

Anglais

Titre :

Age-related differences in functional connectivity associated with pain modulation.

Date de publication/diffusion :

août 2024

Titre du périodique :

Neurobiology of Aging

ISSN :

0197-4580

eISSN :

1558-1497

Maison d'édition :

Elsevier Inc., Etats-Unis

Volume/Tome :

140

Pagination :

1 - 11

Peer reviewed :

Peer reviewed vérifié par ORBi

URL complémentaire :

https://api.elsevier.com/content/article/PII:S0197458024000794?httpAccept=text/xml

Organisme subsidiant :

Fonds National de la Recherche

Subventionnement (détails) :

We are very grateful to the management and staff of the H\u00F4pitaux Robert Schuman for their support in acquiring the functional neuroimaging data. We would also like to thank Martine Hoffmann from \u201CGERO \u2013 Kompetenzzenter fir den Alter\u201D for her help with participant recruitment. This work was supported by the Luxembourg National Research Fund (FNR) (grant number: C16/BM/11266318/ACHE). The FNR had no involvement in any stage of the research. The authors report no declarations of interest. The authors have no financial or personal relationships that could influence this work. During their preparation of this work the authors have not used any AI technologies, except for use of Google Scholar to search literature. This work has not been published previously in any form and it is not under consideration for publication elsewhere. Its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright holder.

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depuis le 14 mars 2025

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