Abstract :
[en] Neurodegenerative disease is attributed in roughly equal parts to genetic risks present at birth and modifiable risk factors, such as air pollution or brain injury, which differ between age groups and populations. Risk factors can interact, but the calculation of synergistic risk is complicated, so the standard approach is to present the marginal risk as partitioned between the individual causative factors. The Lancet Commission on dementia prevention, intervention, and care established 12 modifiable risk factors and described bidirectional interactions between delirium (which can arise from infectious disease) and dementia. It also outlined dementia as a risk factor for COVID-19 mortality, but could not investigate the risk of dementia after SARS-CoV-2 infection. Here, we discuss evidence of neurodegenerative disease risk from SARS-CoV-2 infection.
Funding text :
The publication is a report of the Covaminf workgroup, which was funded as part of the EU-JPND program (EU Joint Programme on Neurodegenerative Disease) of the European Commission. The funding for the workgroup was delivered in Luxembourg via the "INTER" instrument of the FNR. There were no publication charges, so in the strictest sense the publication itself was not directly funded by anybody.
Commentary :
Summary: SARS-CoV-2 infection should be considered as a risk factor for Alzheimer's disease, even though the distinction between causation versus disease acceleration is not clear at the time of writing. The severity of this risk is comparable to several other infections of wide incidence. More discussion in uni.lu news article: https://www.uni.lu/lcsb-en/news/current-research-on-covid-19/
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