[en] [en] BACKGROUND: During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.
METHODS: A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.
RESULTS: One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.
CONCLUSION: The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research.
TRIAL REGISTRATION: Trial registration number: NCT04379297, 10 April 2020.
Disciplines :
Immunology & infectious disease Public health, health care sciences & services
Author, co-author :
TSURKALENKO, Olena ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg. olena.tsurkalenko@lih.lu
Bulaev, Dmitry; Luxembourg Institute of Health, Strassen, Luxembourg
O'Sullivan, Marc Paul; Luxembourg Institute of Health, Strassen, Luxembourg
Snoeck, Chantal; Luxembourg Institute of Health, Strassen, Luxembourg
GHOSH, Soumyabrata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
KOLODKIN, Alexey ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
ROMMES, Basile ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Translational Informatics
GAWRON, Piotr ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Visualisation
Moreno, Carlos Vega; University of Luxembourg, Esch-Belval, Luxembourg
GOMES, Clarissa ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
KAYSEN, Anne ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
OHNMACHT, Jochen ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
Schröder, Valerie E; University of Luxembourg, Esch-Belval, Luxembourg ; Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
PAVELKA, Lukas ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
Meyers, Guilherme Ramos; Luxembourg Institute of Health, Strassen, Luxembourg ; University of Luxembourg, Esch-Belval, Luxembourg
PAULY, Laure ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
PAULY, Claire ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
HANFF, Anne-Marie ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg ; Maastricht University Medical Centre, Maastricht, The Netherlands
MEYRATH, Max Marc Roger ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Translational Neuroscience > Team Rejko KRÜGER ; Luxembourg Institute of Health, Strassen, Luxembourg
LEIST, Anja ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
Sandt, Estelle; Luxembourg Institute of Health, Strassen, Luxembourg
Aguayo, Gloria A; Luxembourg Institute of Health, Strassen, Luxembourg
PERQUIN, Magali ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
Gantenbein, Manon; Luxembourg Institute of Health, Strassen, Luxembourg
Abdelrahman, Tamir; Laboratoire National de Santé, Dudelange, Luxembourg
KLUCKEN, Jochen ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine ; Luxembourg Institute of Health, Strassen, Luxembourg
SATAGOPAM, Venkata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
HILGER, Christiane ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
TURNER, Jonathan ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
Vaillant, Michel; Luxembourg Institute of Health, Strassen, Luxembourg
Fritz, Joëlle V; Luxembourg Institute of Health, Strassen, Luxembourg
OLLERT, Markus ; University of Luxembourg ; Luxembourg Institute of Health, Strassen, Luxembourg
Krüger, Rejko; Luxembourg Institute of Health, Strassen, Luxembourg ; University of Luxembourg, Esch-Belval, Luxembourg ; Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
CON-VINCE consortium and the ORCHESTRA working group
Fonds National de la Recherche Luxembourg Horizon 2020 André Losch Fondation
Funding text :
We would like to give special thanks to all participants of the CON-VINCE study and to each volunteer that helped in sample processing or sample kit preparation. Additionally, we are very grateful for the financial support by the Fonds National de la Recherche and the André Losch Foundation, which enabled us to carry out the project. The funders had no role in the design and conduct of the study, nor in the decision to prepare and submit the manuscript for publication. We also would like to thank the Ministry of Health of Luxembourg as well as the Directorate of Health of Luxembourg for their support.The CON-VINCE Study is funded by the National Research Fund Luxembourg (14716281/ CONVINCE/ Kruger) and the André Losch Foundation (Luxembourg). This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101016167. The views expressed in this paper are the sole responsibility of the authors and the Commission is not responsible for any use that may be made of the information it contains.We would like to give special thanks to all participants of the CON-VINCE study and to each volunteer that helped in sample processing or sample kit preparation. Additionally, we are very grateful for the financial support by the Fonds National de la Recherche and the André Losch Foundation, which enabled us to carry out the project. The funders had no role in the design and conduct of the study, nor in the decision to prepare and submit the manuscript for publication. We also would like to thank the Ministry of Health of Luxembourg as well as the Directorate of Health of Luxembourg for their support. We acknowledge the joint effort of the CON-VINCE team involved in sample and data collection. We would like to thank the Research Luxembourg COVID-19 Task Force (Frank Glod, Paul Wilmes, Lars Geffers, Jasmin Schulz, Henry-Michel Cauchie, Ulf Nehrbass, Rudi Balling) for their overall support of the CON-VINCE study. A special thanks also to the data protection officers Sandrine Munoz and Laurent Prévotat. Furthermore, we would like to acknowledge the whole Communication teams involved within CON-VINCE, especially Sabine Schmitz, Arnaud D’Agostini, Didier Gossens, Hélène Jacuszin for their excellent work and support during the implementation and execution of CON-VINCE. We would like to thank Monica Marchese for her support and thank Philippe Lamesch for important and successful fundraising for research on COVID-19 in Luxembourg. We would like to express our appreciation to the Charité Universitätsmedizin Berlin for providing Viral RNA from BetaCoV/Germany/BavPat1/2020 strain (Ref 026N-03889) through the European Virus Archive GLOBAL (EVA-GLOBAL) project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 871029. We express our gratitude for an opportunity to continue the follow-up of the CON-VINCE cohort within the framework of the collaboration ORCHESTRA Europe project. The questionnaires at Visits 5 and 6 described within this manuscript have been adjusted in order to be homogenous with the questionnaires used by other ORCHESTRA Europe cohorts. Sections on psychological scales, vaccine hesitancy, long COVID, unmet healthcare needs, mental health of household members, children and work family balance, trust, sleep, lifestyle factors, and short demographics were created and shared with ORCHESTRA partners in order to allow the collection of data relevant for analysing the impact of the pandemic on health. CON-VINCE consortium and ORCHESTRA working group Tamir Abdelrahman5; Geeta Acharya1; Gloria Aguayo1; Pinar Alper10; Wim Ammerlaan1; François Ancien10; Ariane Assele-Kama1; Christelle Bahlawane1; Katy Beaumont1; Nadia Beaupain1; Lucrèce Beckers1; Camille Bellora1; Fay Betsou1; Luc Biver8; Sandie Boly1; Dirk Brenner1; Henry-Michel Cauchie11; Eleftheria Charalambous1; Emilie Charpentier1; Estelle Coibion5; Sylvie Coito6; Delphine Collart11; Manuel Counson1; Brian De Witt1; Antonelle Di Pasquale8; Olivia Domingues1; Claire Dording1; Jean-Luc Dourson7; Bianca Dragomir1; Tessy Fautsch1; Jean-Yves Ferrand1; Thibault Ferrandon7; Ana Festas Lopes1; Guillaume Fournier5; Joëlle Véronique Fritz1; Manon Gantenbein1; Piotr Gawron10; Laura Georges1; Soumyabrata Ghosh10; Stéphane Gidenne6; Enrico Glaab10; Clarissa Gomes10; Borja Gomez Ramos10; Vyron Gorgogietas10; Jérôme Graas1; Valentin Groues10; Wei Gu10; Gael Hamot1; Anne-Marie Hanff1; Maxime Hansen1; Linda Hansen3; Lisa Hefele1; Laurent Heirendt10; Ahmed Hemedan10; Estelle Henry1; Margaux Henry1; Eve Herkenne1; Sascha Herzinger10; Christiane Hilger1; Laetitia Huiart1; Alexander Hundt1; Judith Hübschen1; Gilles Iserentant1; Philipp Jägi9; Anne Kaysen10; Piyapong Khurmin10; Fédéric Klein7; Tommy Klein8; Stéphanie Kler1; Alexey Kolodkin1; Rejko Krüger1; Pauline Lambert1; Jacek Jaroslaw Lebioda10; Sabine Lehmann1; Marie Leick5; Anja Leist2; Morgane Lemaire1; Andrew Lumley1; Annika Lutz2; João Manuel Loureiro3; Monica Marchese1; Tainà Marques10; François Massart10; Patrick May10; Maura Minelli1; Alessandra Mousel1; Maeva Munsch1; Sophie Mériaux1; Friedrich Mühlschlegel5; Mareike Neumann1; Trang Nguyen1; Beatrice Nicolai3; Marc Paul O’Sullivan1; Leslie Ogorzaly11; Jochen Ohnmacht1; Christiane Olesky10; Markus Ollert1; Claire Pauly10; Laure Pauly10; Lukas Pavelka10; Christian Penny11; Magali Perquin1; Achilleas Pexaras1; Palma di Pinto6; Marie France Pirard5; Jean-Marc Plesseria1; Guilherme Ramos Meyers10; Armin Rauschenberger10; Lucie Remark1; Antonio Rodriguez8; Basile Rommes10; Kirsten Rump10; Estelle Sandt1; Bruno Santos1; Venkata P. Satagopam10; Aurélie Sausy1; Margaux Schmitt1; Christiane Schmitt9; Reinhard Schneider10; Valerie Schröder10; Serge Schumacher8; Alexandra Schweicher3; Sneeha Seal1; Jean-Yves Servais1; Florian Simon1; Amna Skrozic10; Chantal Snoeck1; Kate Sokolowska1; Lara Stute10; Hermann Thien1; Stéphane Toll9; Noua Toukourou10; Christophe Trefois10; Johanna Trouet1; Nguyen Trung5; Jonathan Turner1; Michel Vaillant1; Daniela Valoura Esteves1; Carlos Vega Moreno10; Charlène Verschueren1; Maharshi Vyas10; Claus Vögele2; Cécile Walczak11; Xinhui Wang10; Femke Wauters3; Bernard Weber9; Emilie Weibel7; Tania Zamboni.1 1: Luxembourg Institute of Health, Strassen, Luxembourg. 2: University of Luxembourg, Esch-sur-Alzette, Luxembourg. 3: Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg. 5: Laboratoire National de Santé, Dudelange, Luxembourg. 6: Ketterthill, Belvaux, Luxembourg. 7: BioNeXt, Leudelange, Luxembourg. 8: TNS-ILRES, Bertrange, Luxembourg. 9: Laboratoire Réunis, Junglinster, Luxembourg. 10: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg. 11: Luxembourg Institute of Science and Technology, Luxembourg, Luxembourg.
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