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Mild cognitive impairment is not associated with gut microbiota alterations in Parkinson’s disease
AHO, Velma; KLEE, Matthias; LANDOULSI, Zied et al.
2023
 

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Keywords :
Mild cognitive impairment; Parkinson's disease; Gut microbiome
Abstract :
[en] Abstract Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n=58) to cognitively unimpaired PD (n=60) and control subjects (n=90) without MCI. Our results did not support a specific microbiome signature related to MCI in PD.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Disciplines :
Neurology
Psychiatry
Genetics & genetic processes
Microbiology
Author, co-author :
AHO, Velma  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Systems Ecology > Team Paul WILMES ; Norwegian University of Life Sciences (NMBU)
KLEE, Matthias ;  University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
LANDOULSI, Zied  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Heintz-Buschart, Anna;  University of Amsterdam
PAVELKA, Lukas ;  University of Luxembourg
LEIST, Anja   ;  University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
Krüger, Rejko  ;  Luxembourg Institute of Health
MAY, Patrick   ;  University of Luxembourg
WILMES, Paul   ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology
 These authors have contributed equally to this work.
Language :
English
Title :
Mild cognitive impairment is not associated with gut microbiota alterations in Parkinson’s disease
Publication date :
29 September 2023
Publisher :
Research Square R&D LLC, Durham, United States - North Carolina
Version :
v1
Focus Area :
Systems Biomedicine
Development Goals :
3. Good health and well-being
European Projects :
H2020 - 863664 - ExpoBiome - Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease
FnR Project :
FNR11264123 - Ncer-pd, 2015 (01/01/2015-30/11/2020) - Rejko Krüger
FNR11250962 - Reduced Penetrance In Hereditary Movement Disorders: Elucidating Mechanisms Of Endogenous Disease Protection P1: Markers And Mechanisms Of Reduced Penetrance In Lrrk2 Mutation Carriers, 2016 (01/01/2017-30/06/2020) - Anne Grünewald
FNR6682797 - Comprehensive Assessment Of Endophenotypes In Neurodegenerative Diseases - Translating Impaired Molecular Signalling Pathways Into Novel Therapeutic Strategies For Parkinson’S Disease, 2013 (01/06/2014-31/05/2019) - Rejko Krüger
Name of the research project :
R-AGR-3870 - IAS - MCI-BIOME (01/01/2020 - 31/12/2023) - WILMES Paul
Funders :
Unilu - University of Luxembourg
Union Européenne
Funding number :
MCI-BIOME_2019
Available on ORBilu :
since 20 November 2023

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