Reference : DJ-1 depletion slows down immunoaging in T-cell compartments
Reports : Other
Life sciences : Genetics & genetic processes
Systems Biomedicine
http://hdl.handle.net/10993/50270
DJ-1 depletion slows down immunoaging in T-cell compartments
English
Zeng, Ni [> >]
Capelle, Christophe [> >]
Baron, Alexandre [> >]
Cire, Severine [> >]
Leonard, Cathy [> >]
Coowar, Djalil mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Scientific Central Services]
Koseki, Haruhiko [> >]
Westendorf, Astrid [> >]
Buer, Jan [> >]
Brenner, Dirk mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Krüger, Rejko mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Balling, Rudi [> >]
Ollert, Markus mailto [University of Luxembourg > >]
He, Feng mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
May-2021
bioRxiv
[en] DJ-1 ; Parkinson’s disease ; immune
[en] Decline in immune function during aging increases susceptibility to different aging related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance of naïve/memory T-cell subpopulations, still remain largely elusive. Here we show that loss of DJ-1 encoded by PARK7 /DJ-1, causing early-onset familial Parkinson’s disease (PD), unexpectedly delayed immunoaging in both human and mice. Compared with two gender-matched unaffected sibling carriers of similar ages, the index PD patient with DJ-1 deficiency showed a decline in many critical immunoaging features, including almost doubled frequencies of non-senescent T cells. The observation of a ‘younger’ immune system in the index patient was further consolidated by the results in aged DJ-1 knockout mice. Our data from bone marrow chimera models and adoptive transfer experiments demonstrated that DJ-1 regulates several immunoaging features via hematopoietic-intrinsic and naïve-CD8-intrinsic mechanisms. Our finding suggests an unrecognized critical role of DJ-1 in regulating immunoaging, discovering a potent target to interfere with immunoaging- and aging-associated diseases.
Researchers
http://hdl.handle.net/10993/50270
10.1101/2021.05.21.445139
https://doi.org/10.1101/2021.05.21.445139
Open Access
FnR ; FNR8231540 > Jorge Gonçalves > GeDES > Genome-wide Dynamical Modelling Differentially-regulated Systems With Application To The Human T Cell Response > 01/09/2015 > 31/08/2018 > 2014

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