Reference : PredictProtein - Predicting Protein Structure and Function for 29 Years
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/47520
PredictProtein - Predicting Protein Structure and Function for 29 Years
English
Bernhofer, Michael [> >]
Dallago, Christian [> >]
Karl, Tim [> >]
Satagopam, Venkata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Heinzinger, Michael [> >]
Littmann, Maria [> >]
Olenyi, Tobias [> >]
Qiu, Jiajun [> >]
Schütze, Konstantin [> >]
Yachdav, Guy [> >]
Ashkenazy, Haim [> >]
Ben-Tal, Nir [> >]
Bromberg, Yana [> >]
Goldberg, Tatyana [> >]
Kajan, Laszlo [> >]
O’Donoghue, Sean [> >]
Sander, Chris [> >]
Schafferhans, Andrea [> >]
Schlessinger, Avner [> >]
Vriend, Gerrit [> >]
Mirdita, Milot [> >]
Gawron, Piotr mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Gu, Wei mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Jarosz, Yohan mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Trefois, Christophe mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Steinegger, Martin [> >]
Schneider, Reinhard mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Rost, Burkhard [> >]
2021
Nucleic Acids Research
Yes
0305-1048
[en] Since 1992 PredictProtein (https://predictprotein.org) is a one-stop online resource for protein sequence analysis with its main site hosted at the Luxembourg Centre for Systems Biomedicine (LCSB) and queried monthly by over 3,000 users in 2020. PredictProtein was the first Internet server for protein predictions. It pioneered combining evolutionary information and machine learning. Given a protein sequence as input, the server outputs multiple sequence alignments, predictions of protein structure in 1D and 2D (secondary structure, solvent accessibility, transmembrane segments, disordered regions, protein flexibility, and disulfide bridges) and predictions of protein function (functional effects of sequence variation or point mutations, Gene Ontology (GO) terms, subcellular localization, and protein-, RNA-, and DNA binding). PredictProtein's infrastructure has moved to the LCSB increasing throughput; the use of MMseqs2 sequence search reduced runtime five-fold (apparently without lowering performance of prediction methods); user interface elements improved usability, and new prediction methods were added. PredictProtein recently included predictions from deep learning embeddings (GO and secondary structure) and a method for the prediction of proteins and residues binding DNA, RNA, or other proteins. PredictProtein.org aspires to provide reliable predictions to computational and experimental biologists alike. All scripts and methods are freely available for offline execution in high-throughput settings.
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
S-STR-4029 > LCSB ELIXIR > 01/01/2016 - 31/12/2018 > SCHNEIDER Reinhard
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/47520
10.1093/nar/gkab354
https://doi.org/10.1093/nar/gkab354
gkab354

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