Title : Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture Language : English Author, co-author : Chia, Ruth [> >] Sabir, Marya S. [> >] Bandres-Ciga, Sara [> >] Saez-Atienzar, Sara [> >] Reynolds, Regina H. [> >] Gustavsson, Emil [> >] Walton, Ronald L. [> >] Ahmed, Sarah [> >] Viollet, Coralie [> >] Ding, Jinhui [> >] Makarious, Mary B. [> >] Diez-Fairen, Monica [> >] Portley, Makayla K. [> >] Shah, Zalak [> >] Abramzon, Yevgeniya [> >] Hernandez, Dena G. [> >] Blauwendraat, Cornelis [> >] Stone, David J. [> >] Eicher, John [> >] Parkkinen, Laura [> >] Ansorge, Olaf [> >] Clark, Lorraine [> >] Honig, Lawrence S. [> >] Marder, Karen [> >] Lemstra, Afina [> >] St George-Hyslop, Peter [> >] Londos, Elisabet [> >] Morgan, Kevin [> >] Lashley, Tammaryn [> >] Warner, Thomas T. [> >] Jaunmuktane, Zane [> >] Galasko, Douglas [> >] Santana, Isabel [> >] Tienari, Pentti J. [> >] Myllykangas, Liisa [> >] Oinas, Minna [> >] Cairns, Nigel J. [> >] Morris, John C. [> >] Halliday, Glenda M. [> >] Van Deerlin, Vivianna M. [> >] Trojanowski, John Q. [> >] Grassano, Maurizio [> >] Calvo, Andrea [> >] Mora, Gabriele [> >] Canosa, Antonio [> >] Floris, Gianluca [> >] Bohannan, Ryan C. [> >] Brett, Francesca [> >] Gan-Or, Ziv [> >] Geiger, Joshua T. [> >] Moore, Anni [> >] May, Patrick [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core] Krüger, Rejko [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience] Goldstein, David S. [> >] Lopez, Grisel [> >] Tayebi, Nahid [> >] Sidransky, Ellen [> >] Sotis, Anthony R. [> >] Sukumar, Gauthaman [> >] Alba, Camille [> >] Lott, Nathaniel [> >] Martinez, Elisa Mcgrath [> >] Tuck, Meila [> >] Singh, Jatinder [> >] Bacikova, Dagmar [> >] Zhang, Xijun [> >] Hupalo, Daniel N. [> >] Adeleye, Adelani [> >] Wilkerson, Matthew D. [> >] Pollard, Harvey B. [> >] Norcliffe-Kaufmann, Lucy [> >] Palma, Jose-Alberto [> >] Kaufmann, Horacio [> >] Shakkottai, Vikram G. [> >] Perkins, Matthew [> >] Newell, Kathy L. [> >] Gasser, Thomas [> >] Schulte, Claudia [> >] Landi, Francesco [> >] Salvi, Erika [> >] Cusi, Daniele [> >] Masliah, Eliezer [> >] Kim, Ronald C. [> >] Caraway, Chad A. [> >] Monuki, Edwin S. [> >] Brunetti, Maura [> >] Dawson, Ted M. [> >] Rosenthal, Liana S. [> >] Albert, Marilyn S. [> >] Pletnikova, Olga [> >] Troncoso, Juan C. [> >] Flanagan, Margaret E. [> >] Mao, Qinwen [> >] Bigio, Eileen H. [> >] Rodríguez-Rodríguez, Eloy [> >] Infante, Jon [> >] Lage, Carmen [> >] González-Aramburu, Isabel [> >] Sanchez-Juan, Pascual [> >] Ghetti, Bernardino [> >] Keith, Julia [> >] Black, Sandra E. [> >] Masellis, Mario [> >] Rogaeva, Ekaterina [> >] Duyckaerts, Charles [> >] Brice, Alexis [> >] Lesage, Suzanne [> >] Xiromerisiou, Georgia [> >] Barrett, Matthew J. [> >] Tilley, Bension S. [> >] Gentleman, Steve [> >] Logroscino, Giancarlo [> >] Serrano, Geidy E. [> >] Beach, Thomas G. [> >] McKeith, Ian G. [> >] Thomas, Alan J. [> >] Attems, Johannes [> >] Morris, Christopher M. [> >] Palmer, Laura [> >] Love, Seth [> >] Troakes, Claire [> >] Al-Sarraj, Safa [> >] Hodges, Angela K. [> >] Aarsland, Dag [> >] Klein, Gregory [> >] Kaiser, Scott M. [> >] Woltjer, Randy [> >] Pastor, Pau [> >] Bekris, Lynn M. [> >] Leverenz, James B. [> >] Besser, Lilah M. [> >] Kuzma, Amanda [> >] Renton, Alan E. [> >] Goate, Alison [> >] Bennett, David A. [> >] Scherzer, Clemens R. [> >] Morris, Huw R. [> >] Ferrari, Raffaele [> >] Albani, Diego [> >] Pickering-Brown, Stuart [> >] Faber, Kelley [> >] Kukull, Walter A. [> >] Morenas-Rodriguez, Estrella [> >] Lleó, Alberto [> >] Fortea, Juan [> >] Alcolea, Daniel [> >] Clarimon, Jordi [> >] Nalls, Mike A. [> >] Ferrucci, Luigi [> >] Resnick, Susan M. [> >] Tanaka, Toshiko [> >] Foroud, Tatiana M. [> >] Graff-Radford, Neill R. [> >] Wszolek, Zbigniew K. [> >] Ferman, Tanis [> >] Boeve, Bradley F. [> >] Hardy, John A. [> >] Topol, Eric J. [> >] Torkamani, Ali [> >] Singleton, Andrew B. [> >] Ryten, Mina [> >] Dickson, Dennis W. [> >] Chiò, Adriano [> >] Ross, Owen A. [> >] Gibbs, J. Raphael [> >] Dalgard, Clifton L. [> >] Traynor, Bryan J. [> >] Scholz, Sonja W. [> >] Publication date : 15-Feb-2021 Journal title : Nature Genetics Publisher : Nature Publishing Group Peer reviewed : Yes (verified by ORBilu ) Audience : International ISSN : 1061-4036 e-ISSN : 1546-1718 City : New York Country : United Kingdom Keywords : [en] Genetics research ; Genomics ; Neurodegenerative diseasesAbstract : [en] The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s disease and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition.Research centres : Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) Funders : Fonds National de la Recherche - FnR Target : Researchers Permalink : http://hdl.handle.net/10993/46268 DOI : 10.1038/s41588-021-00785-3 Other URL : https://www.nature.com/articles/s41588-021-00785-3 FnR project : FnR ; FNR11264123 > Rejko Krüger > > Ncer-pd > 01/01/2015 > 30/11/2020 > 2015 
