Reference : Mitochondria interaction networks show altered topological patterns in Parkinson's di...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/45728

Title :	Mitochondria interaction networks show altered topological patterns in Parkinson's disease.
Language :	English
Author, co-author :	Zanin, Massimiliano [Instituto de Física Interdisciplinar y Sistemas Complejos IFISC > Center for Biomedical Technology, Universidad Politécnica de Madrid,]
	Santos, Bruno F. R. [Luxembourg Institute of Health - LIH > Transversal Translational Medicine]
	Antony, Paul [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
	Berenguer-Escuder, Clara [> >]
	Larsen, Simone B. [> >]
	Hanss, Zoé [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience >]
	Barbuti, Peter [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Baumuratov, Aidos [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Grossmann, Dajana [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Capelle, Christophe M. [Luxembourg Institute of Health - LIH > Department of Infection and Immunity]
	Weber, Joseph [Centre Hospitalier de Luxembourg (CHL)]
	Balling, Rudolf [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Ollert, Markus [Luxembourg Institute of Health - LIH > Department of Infection and Immunity]
	Krüger, Rejko [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
	Diederich, Nico J. [Centre Hospitalier de Luxembourg (CHL)]
	He, Feng [Luxembourg Institute of Health - LIH > Department of Infection and Immunity]
Publication date :	10-Nov-2020
Journal title :	NPJ systems biology and applications
Volume :	6
Issue/season :	1
Pages :	38
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
ISSN :	2056-7189
e-ISSN :	2056-7189
Keywords :	[en] Parkinson’s disease ; Mitochondrial dysfunction
Abstract :	[en] Mitochondrial dysfunction is linked to pathogenesis of Parkinson's disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria interaction networks (MINs). Here we show that MINs formed nonclassical scale-free supernetworks in colonic ganglia both from healthy controls and PD patients; however, altered network topological patterns were observed in PD patients. These patterns were highly correlated with PD clinical scores and a machine-learning approach based on the MIN features alone accurately distinguished between patients and controls with an area-under-curve value of 0.989. The MINs of midbrain dopaminergic neurons (mDANs) derived from several genetic PD patients also displayed specific changes. CRISPR/CAS9-based genome correction of alpha-synuclein point mutations reversed the changes in MINs of mDANs. Our organelle-interaction network analysis opens another critical dimension for a deeper characterization of various complex diseases with mitochondrial dysregulation.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/10993/45728
DOI :	10.1038/s41540-020-00156-4
Other URL :	https://www.nature.com/articles/s41540-020-00156-4

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