Reference : Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Gene...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/43842

Title :	Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research.
Language :	English
Author, co-author :	Rajan, Roopa [Department of Neurology, All India Institute of Medical Sciences, New Delhi, India]
	Divya, K. P. [Sree Chitra Tirunal Institute for Medical Sciences, Trivandrum, India]
	Kandadai, Rukmini Mridula [Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India]
	Yadav, Ravi [National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India]
	Satagopam, Venkata [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
	Madhusoodanan, U. K. [Sree Chitra Tirunal Institute for Medical Sciences, Trivandrum, IndiaSree Chitra Tirunal Institute for Medical Sciences, Trivandrum, India]
	Agarwal, Pankaj [Movement Disorders Clinic, Global Hospitals, Mumbai, India]
	Kumar, Niraj [All India Institute of Medical Sciences, Rishikesh, India]
	Ferreira, Teresa [Goa Medical College, Panaji, India]
	Kumar, Hrishikesh [Institute of Neurosciences, Kolkata, India]
	Sreeram Prasad, A. V. [Lourdes Hospital, Kochi, India]
	Shetty, Kuldeep [Narayana Hrudayalaya Multispeciality Hospital, Bangalore, India]
	Mehta, Sahil [Department of Neurology, PGIMER, Chandigarh, India]
	Desai, Soaham [Shree Krishna Hospital and Pramukhswami Medical College, Karamsad, India]
	Kumar, Suresh [> >]
	Prashanth, L. K. [> >]
	Bhatt, Mohit [> >]
	Wadia, Pettarusp [> >]
	Ramalingam, Sudha [> >]
	Wali, G. M. [> >]
	Pandey, Sanjay [> >]
	Bartusch, Felix [> >]
	Hannussek, Maximilian [> >]
	Krüger, Jens [> >]
	Kumar-Sreelatha, Ashwin [> >]
	Grover, Sandeep [> >]
	Lichtner, Peter [> >]
	Sturm, Marc [> >]
	Roeper, Jochen [> >]
	Busskamp, Volker [> >]
	Chandak, Giriraj R. [> >]
	Schwamborn, Jens Christian [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Life Science Research Unit]
	Seth, Pankaj [National Brain Research Centre, Gurugram, India]
	Gasser, Thomas [Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
	Riess, Olaf [Institute for Medical Genetics and Applied Genomics, University of Tubingen, Tübingen, Germany]
	Goyal, Vinay [> >]
	Pal, Pramod Kumar [> >]
	Borgohain, Rupam [> >]
	Krüger, Rejko [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
	Kishore, Asha [Sree Chitra Tirunal Institute for Medical Sciences, Trivandrum, India]
	Sharma, Manu [Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany]
Publication date :	18-Jun-2020
Journal title :	Frontiers in neurology
Volume :	11
Pages :	524
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
ISSN :	1664-2295
e-ISSN :	1664-2295
Keywords :	[en] Parkinson's disease ; biobank ; common genetic variation ; genetic diversity ; genome-wide association study
Abstract :	[en] Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of genetic discoveries to other ethnically diverse populations are unknown. The Indian population has been under-represented in PD research. The Genetic Architecture of PD in India (GAP-India) project aims to develop one of the largest clinical/genomic bio-bank for PD in India. Specifically, GAP-India project aims to: (1) develop a pan-Indian deeply phenotyped clinical repository of Indian PD patients; (2) perform whole-genome sequencing in 500 PD samples to catalog Indian genetic variability and to develop an Indian PD map for the scientific community; (3) perform a genome-wide association study to identify novel loci for PD and (4) develop a user-friendly web-portal to disseminate results for the scientific community. Our "hub-spoke" model follows an integrative approach to develop a pan-Indian outreach to develop a comprehensive cohort for PD research in India. The alignment of standard operating procedures for recruiting patients and collecting biospecimens with international standards ensures harmonization of data/bio-specimen collection at the beginning and also ensures stringent quality control parameters for sample processing. Data sharing and protection policies follow the guidelines established by local and national authorities.We are currently in the recruitment phase targeting recruitment of 10,200 PD patients and 10,200 healthy volunteers by the end of 2020. GAP-India project after its completion will fill a critical gap that exists in PD research and will contribute a comprehensive genetic catalog of the Indian PD population to identify novel targets for PD.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/10993/43842
DOI :	10.3389/fneur.2020.00524
Other URL :	https://www.frontiersin.org/articles/10.3389/fneur.2020.00524/full
Mentions required by the publisher for OA :	OA
Commentary :	Copyright © 2020 Rajan, Divya, Kandadai, Yadav, Satagopam, Madhusoodanan, Agarwal, Kumar, Ferreira, Kumar, Sreeram Prasad, Shetty, Mehta, Desai, Kumar, Prashanth, Bhatt, Wadia, Ramalingam, Wali, Pandey, Bartusch, Hannussek, Krüger, Kumar-Sreelatha, Grover, Lichtner, Sturm, Roeper, Busskamp, Chandak, Schwamborn, Seth, Gasser, Riess, Goyal, Pal, Borgohain, Krüger, Kishore, Sharma and the Lux-GIANT Consortium.
FnR project :	FnR ; FNR11264123 > Rejko Krüger > NCER-PD > > 01/01/2015 > 30/11/2020 > 2013

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	Fulltext file(s): File Commentary Version Size Access Open access Rajan-2020-Genetic Architecture of Parkinson's.pdf Publisher postprint 1.35 MB View/Open

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