Reference : Connecting environmental exposure and neurodegeneration using cheminformatics and hig...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/42314
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges
English
Schymanski, Emma mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Baker, Nancy C. [Leidos, Research Triangle Park, North Carolina, USA]
Williams, Antony J [United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA > National Centre for Computational Toxicity (NCCT)]
Singh, Randolph mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Trezzi, Jean-Pierre mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kolber, Pierre Luc mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Paczia, Nicole [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Linster, Carole mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Balling, Rudi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
1-Sep-2019
Environmental Science. Processes and Impacts
Royal Society of Chemistry
Yes (verified by ORBilu)
International
2050-7887
2050-7895
Cambridge
United Kingdom
[en] neurodegenerative diseases ; chemical exposures ; mass spectrometry
[en] Connecting chemical exposures over a lifetime to complex chronic diseases with multifactorial causes such as neurodegenerative diseases is an immense challenge requiring a long-term, interdisciplinary approach. Rapid developments in analytical and data technologies, such as non-target high resolution mass spectrometry (NT-HR-MS), have opened up new possibilities to accomplish this, inconceivable 20 years ago. While NT-HR-MS is being applied to increasingly complex research questions, there are still many unidentified chemicals and uncertainties in linking exposures to human health outcomes and environmental impacts. In this perspective, we explore the possibilities and challenges involved in using cheminformatics and NT-HR-MS to answer complex questions that cross many scientific disciplines, taking the identification of potential (small molecule) neurotoxicants in environmental or biological matrices as a case study. We explore capturing literature knowledge and patient exposure information in a form amenable to high-throughput data mining, and the related cheminformatic challenges. We then briefly cover which sample matrices are available, which method(s) could potentially be used to detect these chemicals in various matrices and what remains beyond the reach of NT-HR-MS. We touch on the potential for biological validation systems to contribute to mechanistic understanding of observations and explore which sampling and data archiving strategies may be required to form an accurate, sustained picture of small molecule signatures on extensive cohorts of patients with chronic neurodegenerative disorders. Finally, we reflect on how NT-HR-MS can support unravelling the contribution of the environment to complex diseases.
http://hdl.handle.net/10993/42314
10.1039/C9EM00068B
https://pubs.rsc.org/en/content/articlelanding/2019/em/c9em00068b#!divAbstract
Open Access
FnR ; FNR12341006 > Emma Schymanski > ECHIDNA > Environmental Cheminformatics to Identify Unknown Chemicals and their Effects > 01/10/2018 > 30/09/2023 > 2018

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