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PACZIA Nicole

Main Referenced Co-authors
LINSTER, Carole  (10)
BECKER-KETTERN, Julia  (4)
CONROTTE, Jean-François  (3)
JUNG, Paul  (3)
Bommer, Guido T (2)
Main Referenced Keywords
metabolite repair (4); dehydrogenase (2); transhydrogenase (2); yeast (2); 1,5-anhydroglucitol (1);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Enzymology & Metabolism (Linster Group) (4)
ULHPC - University of Luxembourg: High Performance Computing (2)
Luxembourg Centre for Systems Biomedicine (LCSB) (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (8)
Endocrinology, metabolism & nutrition (2)
Neurology (1)
Biotechnology (1)
Genetics & genetic processes (1)

Publications (total 10)

The most downloaded
134 downloads
Veiga-da-Cunha, M., Chevalier, N., Stephenne, X., Defour, J.-P., Paczia, N., Ferster, A., Achouri, Y., Dewulf, J. P., Linster, C., Bommer, G. T., & Van Schaftingen, E. (22 January 2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 116 (4), 1241-1250. doi:10.1073/pnas.1816143116 https://hdl.handle.net/10993/38260

The most cited

91 citations (Scopus®)

Veiga-da-Cunha, M., Chevalier, N., Stephenne, X., Defour, J.-P., Paczia, N., Ferster, A., Achouri, Y., Dewulf, J. P., Linster, C., Bommer, G. T., & Van Schaftingen, E. (22 January 2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 116 (4), 1241-1250. doi:10.1073/pnas.1816143116 https://hdl.handle.net/10993/38260

GAVRIIL, M., PROIETTO, M., PACZIA, N., GINOLHAC, A., HALDER, R., VALCESCHINI, E., SAUTER, T., LINSTER, C., & SINKKONEN, L. (November 2023). 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition. Life Science Alliance, 7 (2), 202302333. doi:10.26508/lsa.202302333
Peer Reviewed verified by ORBi

Schymanski, E., Baker, N. C., Williams, A. J., Singh, R., Trezzi, J.-P., Kolber, P. L., Wilmes, P., Krüger, R., Paczia, N., Linster, C., & Balling, R. (2019). Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. Environmental Science. Processes and Impacts. doi:10.1039/C9EM00068B
Peer Reviewed verified by ORBi

Veiga-da-Cunha, M., Chevalier, N., Stephenne, X., Defour, J.-P., Paczia, N., Ferster, A., Achouri, Y., Dewulf, J. P., Linster, C., Bommer, G. T., & Van Schaftingen, E. (22 January 2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 116 (4), 1241-1250. doi:10.1073/pnas.1816143116
Peer Reviewed verified by ORBi

Van Bergen, N.* , Guo, Y.* , Rankin, J.* , Paczia, N.* , Becker-Kettern, J.* , Kremer, L., Pyle, A., Conrotte, J.-F., Ellaway, C., Procopis, P., Prelog, K., Homfray, T., Baptista, J., Baple, E., Wakeling, M., Massey, S., Kay, D., Shukla, A., Girisha, K., ... Hakonarson, H. (01 January 2019). NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. Brain: a Journal of Neurology, 142 (1), 50-58. doi:10.1093/brain/awy310
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Paczia, N.* , Becker-Kettern, J.* , Conrotte, J.-F., Cifuente, J. O., Guerin, M. E., & Linster, C. (2019). 3‑Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L‑Serine Synthesis. Biochemistry. doi:10.1021/acs.biochem.8b00990
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Becker-Kettern, J., Paczia, N., Conrotte, J.-F., Zhu, C., Fiehn, O., Jung, P., Steinmetz, L., & Linster, C. (2018). NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS Journal. doi:10.1111/febs.14631
Peer Reviewed verified by ORBi

Jung, P., Zhang, Z., Paczia, N., Jäger, C., Ignac, T., May, P., & Linster, C. (12 March 2018). Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. npj Aging and Mechanisms of Disease, 4 (3). doi:10.1038/s41514-018-0022-6
Peer Reviewed verified by ORBi

Berger, E., Magliaro, C., Paczia, N., Monzel, A. S., Antony, P., Linster, C., Bolognin, S., Ahluwalia, A., & Schwamborn, J. C. (2018). Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a Chip - Miniaturisation for Chemistry and Biology. doi:10.1039/c8lc00206a
Peer reviewed

Peracchi, A., Veiga-da-Cunha, M., Kuhara, T., Ellens, K. W., Paczia, N., Stroobant, V., Seliga, A. K., Marlaire, S., Jaisson, S., Bommer, G. T., Sun, J., Huebner, K., Linster, C., Cooper, A. J. L., & Van Schaftingen, E. (03 April 2017). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proceedings of the National Academy of Sciences of the United States of America, 1613736114, 3233-3242. doi:10.1073/pnas.1613736114
Peer Reviewed verified by ORBi

Becker-Kettern, J., Paczia, N., Conrotte, J.-F., Kay, D., Guignard, C., Jung, P., & Linster, C. (2016). Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. The Journal of Biological Chemistry. doi:10.1074/jbc.M115.704494
Peer reviewed

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