Profil

LINSTER Carole

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Enzymology and Metabolism

ORCID
0000-0001-7143-0719
Main Referenced Co-authors
Van Schaftingen, Emile (11)
PACZIA, Nicole  (10)
Clarke, Steven G. (6)
Veiga-da-Cunha, Maria (6)
JÄGER, Christian  (5)
Main Referenced Keywords
metabolite repair (4); Saccharomyces cerevisiae (3); yeast (3); Animals (2); dehydrogenase (2);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Enzymology & Metabolism (Linster Group) (15)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (5)
Luxembourg Centre for Systems Biomedicine (LCSB) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (3)
ULHPC - University of Luxembourg: High Performance Computing (3)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (41)
Neurology (4)
Life sciences: Multidisciplinary, general & others (4)
Endocrinology, metabolism & nutrition (3)
Genetics & genetic processes (3)

Publications (total 47)

The most downloaded
267 downloads
Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 https://hdl.handle.net/10993/2256

The most cited

710 citations (Scopus®)

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 https://hdl.handle.net/10993/2256

HEINS MARROQUIN, U., SINGH, R., PERATHONER, S., GAVOTTO, F., Merino Ruiz, C., PATRASKAKI, M., Gomez-Giro, G., Kleine Borgmann, F., Meyer, M., Carpentier, A., WARMOES, M. O., Jäger, C., MITTELBRONN, M., SCHWAMBORN, J. C., Cordero-Maldonado, M. L., CRAWFORD, A., SCHYMANSKI, E., & LINSTER, C. (March 2024). CLN3 deficiency leads to neurological and metabolic perturbations during early development. Life Science Alliance, 7 (3). doi:10.26508/lsa.202302057
Peer Reviewed verified by ORBi

GAVRIIL, M., PROIETTO, M., PACZIA, N., GINOLHAC, A., HALDER, R., VALCESCHINI, E., SAUTER, T., LINSTER, C., & SINKKONEN, L. (November 2023). 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition. Life Science Alliance, 7 (2), 202302333. doi:10.26508/lsa.202302333
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Zhang, J., Keibler, M. A., Dong, W., GHELFI, J., Cordes, T., Kanashova, T., Pailot, A., LINSTER, C., DITTMAR, G., Metallo, C. M., Lautenschlaeger, T., HILLER, K., & Stephanopoulos, G. (19 October 2023). Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines, 11 (10), 2842. doi:10.3390/biomedicines11102842
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FAVILLI, L., GRIFFITH, C., SCHYMANSKI, E.* , & LINSTER, C.*. (July 2023). High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted metabolomics. Analytical and Bioanalytical Chemistry, 415 (17), 3415 - 3434. doi:10.1007/s00216-023-04724-5
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* These authors have contributed equally to this work.

HEINS MARROQUIN, U., SINGH, R., PERATHONER, S., GAVOTTO, F., Ruiz, C. M., PATRASKAKI, M., Gomez-Giro, G., Borgmann, F. K., Meyer, M., Carpentier, A., WARMOES, M. O., JÄGER, C., MITTELBRONN, M., SCHWAMBORN, J. C., CORDERO MALDONADO, M. L., CRAWFORD, A., SCHYMANSKI, E., & LINSTER, C. (2023). CLN3 deficiency leads to neurological and metabolic perturbations during early development. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57737. doi:10.1101/2023.03.17.533107

Danileviciute, E., Zeng, N., Capelle, C. M., Paczia, N., Gillespie, M. A., Kurniawan, H., Benzarti, M., Merz, M. P., Coowar, D., Fritah, S., Vogt Weisenhorn, D. M., Gomez Giro, G., Grusdat, M., Baron, A., Guerin, C., Franchina, D. G., Léonard, C., Domingues, O., Delhalle, S., ... He, F. (26 May 2022). PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing. Nature Metabolism, 4 (5), 589-607. doi:10.1038/s42255-022-00576-y
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Trezzi, J.-P., Aho, V., Jäger, C., Schade, S., Janzen, A., Hickl, O., Kunath, B., Thomas, M., Schmit, K., Garcia, P., Sciortino, A., Martin-Gallausiaux, C., Halder, R., Huarte, O. U., Heurtaux, T., Heins-Marroquin, U., Gomez-Giro, G., Weidenbach, K., Delacour, L., ... Wilmes, P. (2022). An archaeal compound as a driver of Parkinson’s disease pathogenesis. (1). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51987. doi:10.21203/rs.3.rs-1827631/v1

Vausort, M., Niedolistek, M., Lumley, A. I., Oknińska, M., Paterek, A., Mączewski, M., Dong, X., Jäger, C., Linster, C., Leszek, P., & Devaux, Y. (2022). Regulation of N6-Methyladenosine after Myocardial Infarction. Cells, 11 (15), 2271. doi:10.3390/cells11152271
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Griffith, C., Walvekar, A., & Linster, C. (09 September 2021). Approaches for completing metabolic networks through metabolite damage and repair discovery. Current Opinion in Systems Biology, 28. doi:10.1016/j.coisb.2021.100379
Peer reviewed

Kentache, T., Thabault, L., Deumer, G., Haufroid, V., Frédéerick, R., Linster, C., Peracchi, A., Veiga-da-Cunha, M., Bommer, G., & van Schaftingen, E. (2021). The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate. Journal of Biological Chemistry. doi:10.1016/j.jbc.2021.100699
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Mencke, P., Boussaad, I., Romano, C., Kitami, T., Linster, C., & Krüger, R. (2021). The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease. Cells. doi:10.3390/cells10020347
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Anso, I., Basso, L. G. M., Wang, L., Marina, A., Páez-Pérez, E. D., Jäger, C., gavotto, F., Tersa, M., Perrone, S., Contreras, F.-X., Prandi, J., Gilleron, M., Linster, C., Corzana, F., Lowary, T. L., Trastoy, B., & Guerin, M. E. (2021). Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA. Science Advances, 7 (42). doi:10.1126/sciadv.abj4565
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Soliman, R., Cordero Maldonado, M. L., Martins, T., Moein, M., Conrotte, J.-F., Warmack, R., Skupin, A., Crawford, A., Clarke, S., & Linster, C. (2020). L-Isoaspartyl methyltransferase deficiency in zebrafish leads to impaired calcium signaling in the brain. Frontiers in Genetics. doi:10.3389/fgene.2020.612343
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Van Bergen, N. J., Linster, C., & Christodoulou, J. (27 May 2020). Reply: NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness. Brain: a Journal of Neurology, 143 (7), 55. doi:10.1093/brain/awaa131
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Heins Marroquin, U., Jung, P., Cordero Maldonado, M. L., Crawford, A., & Linster, C. (27 September 2019). Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency. Brain Communications, 1 (1), 2-17. doi:10.1093/braincomms/fcz019
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Schymanski, E., Baker, N. C., Williams, A. J., Singh, R., Trezzi, J.-P., Kolber, P. L., Wilmes, P., Krüger, R., Paczia, N., Linster, C., & Balling, R. (2019). Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. Environmental Science. Processes and Impacts. doi:10.1039/C9EM00068B
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Veiga-da-Cunha, M., Chevalier, N., Stephenne, X., Defour, J.-P., Paczia, N., Ferster, A., Achouri, Y., Dewulf, J. P., Linster, C., Bommer, G. T., & Van Schaftingen, E. (22 January 2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 116 (4), 1241-1250. doi:10.1073/pnas.1816143116
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Zhang, Z., Jung, P., Groues, V., May, P., Linster, C., & Glaab, E. (2019). BSA4Yeast: Web-based quantitative trait locus linkage analysis and bulk segregant analysis of yeast sequencing data. GigaScience, 8 (6), 060. doi:10.1093/gigascience/giz060
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Paczia, N.* , Becker-Kettern, J.* , Conrotte, J.-F., Cifuente, J. O., Guerin, M. E., & Linster, C. (2019). 3‑Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L‑Serine Synthesis. Biochemistry. doi:10.1021/acs.biochem.8b00990
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* These authors have contributed equally to this work.

Van Bergen, N.* , Guo, Y.* , Rankin, J.* , Paczia, N.* , Becker-Kettern, J.* , Kremer, L., Pyle, A., Conrotte, J.-F., Ellaway, C., Procopis, P., Prelog, K., Homfray, T., Baptista, J., Baple, E., Wakeling, M., Massey, S., Kay, D., Shukla, A., Girisha, K., ... Hakonarson, H. (01 January 2019). NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. Brain: a Journal of Neurology, 142 (1), 50-58. doi:10.1093/brain/awy310
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Becker-Kettern, J., Paczia, N., Conrotte, J.-F., Zhu, C., Fiehn, O., Jung, P., Steinmetz, L., & Linster, C. (2018). NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS Journal. doi:10.1111/febs.14631
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Jung, P., Zhang, Z., Paczia, N., Jäger, C., Ignac, T., May, P., & Linster, C. (12 March 2018). Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. npj Aging and Mechanisms of Disease, 4 (3). doi:10.1038/s41514-018-0022-6
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Berger, E., Magliaro, C., Paczia, N., Monzel, A. S., Antony, P., Linster, C., Bolognin, S., Ahluwalia, A., & Schwamborn, J. C. (2018). Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a Chip - Miniaturisation for Chemistry and Biology. doi:10.1039/c8lc00206a
Peer reviewed

Ellens, K. W., Christian, N., Satagopam, V., May, P., & Linster, C. (16 November 2017). Confronting the catalytic dark matter encoded by sequenced genomes. Nucleic Acids Research, 45 (20), 11495-11514. doi:10.1093/nar/gkx937
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Peracchi, A., Veiga-da-Cunha, M., Kuhara, T., Ellens, K. W., Paczia, N., Stroobant, V., Seliga, A. K., Marlaire, S., Jaisson, S., Bommer, G. T., Sun, J., Huebner, K., Linster, C., Cooper, A. J. L., & Van Schaftingen, E. (03 April 2017). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proceedings of the National Academy of Sciences of the United States of America, 1613736114, 3233-3242. doi:10.1073/pnas.1613736114
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Singh, C., Glaab, E., & Linster, C. (2017). Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals. Journal of Biological Chemistry, 292 (3), 1005-1028. doi:10.1074/jbc.M116.760744
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Collard, F., Baldin, F., Gerin, I., Bolsée, J., Noël, G., Graff, J., Veiga-da-Cunha, M., Stroobant, V., Vertommen, D., Houddane, A., Rider, M. H., Linster, C., Van Schaftingen, E., & Bommer, G. T. (August 2016). A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nature Chemical Biology, 12 (8), 601-607. doi:10.1038/nchembio.2104
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Becker-Kettern, J., Paczia, N., Conrotte, J.-F., Kay, D., Guignard, C., Jung, P., & Linster, C. (2016). Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. The Journal of Biological Chemistry. doi:10.1074/jbc.M115.704494
Peer reviewed

Van Schaftingen, E., Veiga-da-Cunha, M., & Linster, C. (July 2015). Enzyme complexity in intermediary metabolism. Journal of Inherited Metabolic Disease, 38 (4), 721-7. doi:10.1007/s10545-015-9821-0
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Jung, P., Christian, N., Kay, D., Skupin, A., & Linster, C. (30 March 2015). Protocols and programs for high-throughput growth and aging phenotyping in yeast. PLoS ONE, 10 (3), 0119807. doi:10.1371/journal.pone.0119807
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Marbaix, A. Y., Tyteca, D., Niehaus, T. D., Hanson, A. D., Linster, C., & Van Schaftingen, E. (15 May 2014). Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals. The Biochemical journal, 460 (1), 49-58. doi:10.1042/BJ20131482
Peer reviewed

Van Schaftingen, E., Rzem, R., Marbaix, A., Collard, F., Veiga-da-Cunha, M., & Linster, C. (May 2013). Metabolite proofreading, a neglected aspect of intermediary metabolism. Journal of Inherited Metabolic Disease, 36 (3), 427-34. doi:10.1007/s10545-012-9571-1
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Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110
Peer Reviewed verified by ORBi

Linster, C., Van Schaftingen, E., & Hanson, A. D. (February 2013). Metabolite damage and its repair or pre-emption. Nature Chemical Biology, 9 (2), 72-80. doi:10.1038/nchembio.1141
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Urzica, E. I., Adler, L. N., Page, M. D., Linster, C., Arbing, M. A., Casero, D., Pellegrini, M., Merchant, S. S., & Clarke, S. G. (20 April 2012). Impact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-L-galactose phosphorylase. Journal of Biological Chemistry, 287 (17), 14234-45. doi:10.1074/jbc.M112.341982
Peer Reviewed verified by ORBi

Linster, C., Noël, G., Stroobant, V., Vertommen, D., Vincent, M.-F., Bommer, G. T., Veiga-da-Cunha, M., & Van Schaftingen, E. (16 December 2011). Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. Journal of Biological Chemistry, 286 (50), 42992-3003. doi:10.1074/jbc.M111.281527
Peer Reviewed verified by ORBi

Marbaix, A. Y., Noël, G., Detroux, A. M., Vertommen, D., Van Schaftingen, E., & Linster, C. (02 December 2011). Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Journal of Biological Chemistry, 286 (48), 41246-52. doi:10.1074/jbc.C111.310847
Peer Reviewed verified by ORBi

Adler, L. N., Gomez, T. A., Clarke, S. G., & Linster, C. (17 June 2011). A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. Journal of Biological Chemistry, 286 (24), 21511-23. doi:10.1074/jbc.M111.238774
Peer Reviewed verified by ORBi

Khare, S., Linster, C., & Clarke, S. G. (2011). The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans. PLoS ONE, 6 (6), 20850. doi:10.1371/journal.pone.0020850
Peer Reviewed verified by ORBi

Khare, S., Gomez, T., Linster, C., & Clarke, S. G. (October 2009). Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Mechanisms of Ageing and Development, 130 (10), 670-80. doi:10.1016/j.mad.2009.08.002
Peer Reviewed verified by ORBi

Linster, C., & Clarke, S. G. (November 2008). L-Ascorbate biosynthesis in higher plants: the role of VTC2. Trends in Plant Science, 13 (11), 567-73. doi:10.1016/j.tplants.2008.08.005
Peer reviewed

Linster, C., Adler, L. N., Webb, K., Christensen, K. C., Brenner, C., & Clarke, S. G. (04 July 2008). A second GDP-L-galactose phosphorylase in Arabidopsis en route to vitamin C covalent intermediate and substrate requirements for the conserved reaction. Journal of Biological Chemistry, 283 (27), 18483-92. doi:10.1074/jbc.M802594200
Peer Reviewed verified by ORBi

Linster, C., Gomez, T. A., Christensen, K. C., Adler, L. N., Young, B. D., Brenner, C., & Clarke, S. G. (29 June 2007). Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants. Journal of Biological Chemistry, 282 (26), 18879-85. doi:10.1074/jbc.M702094200
Peer Reviewed verified by ORBi

Linster, C., & Van Schaftingen, E. (January 2007). Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS Journal, 274 (1), 1-22. doi:10.1111/j.1742-4658.2006.05607.x
Peer reviewed

Linster, C., & Van Schaftingen, E. (April 2006). Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver. FEBS Journal, 273 (7), 1516-27. doi:10.1111/j.1742-4658.2006.05172.x
Peer reviewed

Linster, C., & Van Schaftingen, E. (October 2004). A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomerase and mannonate dehydrogenase. Protein Expression and Purification, 37 (2), 352-60. doi:10.1016/j.pep.2004.06.015
Peer Reviewed verified by ORBi

Linster, C., & Van Schaftingen, E. (19 September 2003). Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes. Journal of Biological Chemistry, 278 (38), 36328-33. doi:10.1074/jbc.M306593200
Peer Reviewed verified by ORBi

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