  | GAVRIIL, M., PROIETTO, M., PACZIA, N., GINOLHAC, A., HALDER, R., VALCESCHINI, E., SAUTER, T., LINSTER, C., & SINKKONEN, L. (November 2023). 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition. Life Science Alliance, 7 (2), 202302333. doi:10.26508/lsa.202302333  Peer Reviewed verified by ORBi |
 | Zhang, J., Keibler, M. A., Dong, W., GHELFI, J., Cordes, T., Kanashova, T., Pailot, A., LINSTER, C., DITTMAR, G., Metallo, C. M., Lautenschlaeger, T., HILLER, K., & Stephanopoulos, G. (19 October 2023). Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines, 11 (10), 2842. doi:10.3390/biomedicines11102842 Peer Reviewed verified by ORBi |
 | FAVILLI, L., GRIFFITH, C., SCHYMANSKI, E.* , & LINSTER, C.*. (July 2023). High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted metabolomics. Analytical and Bioanalytical Chemistry, 415 (17), 3415 - 3434. doi:10.1007/s00216-023-04724-5 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | HEINS MARROQUIN, U., SINGH, R., PERATHONER, S., GAVOTTO, F., Ruiz, C. M., PATRASKAKI, M., Gomez-Giro, G., Borgmann, F. K., Meyer, M., Carpentier, A., WARMOES, M. O., JÄGER, C., MITTELBRONN, M., SCHWAMBORN, J. C., CORDERO MALDONADO, M. L., CRAWFORD, A., SCHYMANSKI, E., & LINSTER, C. (2023). CLN3 deficiency leads to neurological and metabolic perturbations during early development. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57737. doi:10.1101/2023.03.17.533107 |
  | Danileviciute, E., Zeng, N., Capelle, C. M., Paczia, N., Gillespie, M. A., Kurniawan, H., Benzarti, M., Merz, M. P., Coowar, D., Fritah, S., Vogt Weisenhorn, D. M., Gomez Giro, G., Grusdat, M., Baron, A., Guerin, C., Franchina, D. G., Léonard, C., Domingues, O., Delhalle, S., ... He, F. (26 May 2022). PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing. Nature Metabolism, 4 (5), 589-607. doi:10.1038/s42255-022-00576-y Peer Reviewed verified by ORBi |
 | Trezzi, J.-P., Aho, V., Jäger, C., Schade, S., Janzen, A., Hickl, O., Kunath, B., Thomas, M., Schmit, K., Garcia, P., Sciortino, A., Martin-Gallausiaux, C., Halder, R., Huarte, O. U., Heurtaux, T., Heins-Marroquin, U., Gomez-Giro, G., Weidenbach, K., Delacour, L., ... Wilmes, P. (2022). An archaeal compound as a driver of Parkinson’s disease pathogenesis. (1). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51987. doi:10.21203/rs.3.rs-1827631/v1 |
 | Vausort, M., Niedolistek, M., Lumley, A. I., Oknińska, M., Paterek, A., Mączewski, M., Dong, X., Jäger, C., Linster, C., Leszek, P., & Devaux, Y. (2022). Regulation of N6-Methyladenosine after Myocardial Infarction. Cells, 11 (15), 2271. doi:10.3390/cells11152271 Peer Reviewed verified by ORBi |
 | Griffith, C., Walvekar, A., & Linster, C. (09 September 2021). Approaches for completing metabolic networks through metabolite damage and repair discovery. Current Opinion in Systems Biology, 28. doi:10.1016/j.coisb.2021.100379 Peer reviewed |
 | Kentache, T., Thabault, L., Deumer, G., Haufroid, V., Frédéerick, R., Linster, C., Peracchi, A., Veiga-da-Cunha, M., Bommer, G., & van Schaftingen, E. (2021). The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate. Journal of Biological Chemistry. doi:10.1016/j.jbc.2021.100699 Peer Reviewed verified by ORBi |
 | Mencke, P., Boussaad, I., Romano, C., Kitami, T., Linster, C., & Krüger, R. (2021). The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease. Cells. doi:10.3390/cells10020347 Peer Reviewed verified by ORBi |
 | Anso, I., Basso, L. G. M., Wang, L., Marina, A., Páez-Pérez, E. D., Jäger, C., gavotto, F., Tersa, M., Perrone, S., Contreras, F.-X., Prandi, J., Gilleron, M., Linster, C., Corzana, F., Lowary, T. L., Trastoy, B., & Guerin, M. E. (2021). Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA. Science Advances, 7 (42). doi:10.1126/sciadv.abj4565 Peer Reviewed verified by ORBi |
 | Soliman, R., Cordero Maldonado, M. L., Martins, T., Moein, M., Conrotte, J.-F., Warmack, R., Skupin, A., Crawford, A., Clarke, S., & Linster, C. (2020). L-Isoaspartyl methyltransferase deficiency in zebrafish leads to impaired calcium signaling in the brain. Frontiers in Genetics. doi:10.3389/fgene.2020.612343 Peer Reviewed verified by ORBi |
 | Van Bergen, N. J., Linster, C., & Christodoulou, J. (27 May 2020). Reply: NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness. Brain: a Journal of Neurology, 143 (7), 55. doi:10.1093/brain/awaa131 Peer Reviewed verified by ORBi |
 | Heins Marroquin, U., Jung, P., Cordero Maldonado, M. L., Crawford, A., & Linster, C. (27 September 2019). Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency. Brain Communications, 1 (1), 2-17. doi:10.1093/braincomms/fcz019 Peer Reviewed verified by ORBi |
 | Schymanski, E., Baker, N. C., Williams, A. J., Singh, R., Trezzi, J.-P., Kolber, P. L., Wilmes, P., Krüger, R., Paczia, N., Linster, C., & Balling, R. (2019). Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. Environmental Science. Processes and Impacts. doi:10.1039/C9EM00068B Peer Reviewed verified by ORBi |
 | Veiga-da-Cunha, M., Chevalier, N., Stephenne, X., Defour, J.-P., Paczia, N., Ferster, A., Achouri, Y., Dewulf, J. P., Linster, C., Bommer, G. T., & Van Schaftingen, E. (22 January 2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 116 (4), 1241-1250. doi:10.1073/pnas.1816143116 Peer Reviewed verified by ORBi |
 | Paczia, N.* , Becker-Kettern, J.* , Conrotte, J.-F., Cifuente, J. O., Guerin, M. E., & Linster, C. (2019). 3‑Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L‑Serine Synthesis. Biochemistry. doi:10.1021/acs.biochem.8b00990 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Van Bergen, N.* , Guo, Y.* , Rankin, J.* , Paczia, N.* , Becker-Kettern, J.* , Kremer, L., Pyle, A., Conrotte, J.-F., Ellaway, C., Procopis, P., Prelog, K., Homfray, T., Baptista, J., Baple, E., Wakeling, M., Massey, S., Kay, D., Shukla, A., Girisha, K., ... Hakonarson, H. (01 January 2019). NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. Brain: a Journal of Neurology, 142 (1), 50-58. doi:10.1093/brain/awy310 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Zhang, Z., Jung, P., Groues, V., May, P., Linster, C., & Glaab, E. (2019). BSA4Yeast: Web-based quantitative trait locus linkage analysis and bulk segregant analysis of yeast sequencing data. GigaScience, 8 (6), 060. doi:10.1093/gigascience/giz060 Peer Reviewed verified by ORBi |
 | Becker-Kettern, J., Paczia, N., Conrotte, J.-F., Zhu, C., Fiehn, O., Jung, P., Steinmetz, L., & Linster, C. (2018). NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS Journal. doi:10.1111/febs.14631 Peer Reviewed verified by ORBi |
 | Jung, P., Zhang, Z., Paczia, N., Jäger, C., Ignac, T., May, P., & Linster, C. (12 March 2018). Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. npj Aging and Mechanisms of Disease, 4 (3). doi:10.1038/s41514-018-0022-6 Peer Reviewed verified by ORBi |
 | Berger, E., Magliaro, C., Paczia, N., Monzel, A. S., Antony, P., Linster, C., Bolognin, S., Ahluwalia, A., & Schwamborn, J. C. (2018). Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a Chip - Miniaturisation for Chemistry and Biology. doi:10.1039/c8lc00206a Peer reviewed |
 | Ellens, K. W., Christian, N., Satagopam, V., May, P., & Linster, C. (16 November 2017). Confronting the catalytic dark matter encoded by sequenced genomes. Nucleic Acids Research, 45 (20), 11495-11514. doi:10.1093/nar/gkx937 Peer Reviewed verified by ORBi |
 | Peracchi, A., Veiga-da-Cunha, M., Kuhara, T., Ellens, K. W., Paczia, N., Stroobant, V., Seliga, A. K., Marlaire, S., Jaisson, S., Bommer, G. T., Sun, J., Huebner, K., Linster, C., Cooper, A. J. L., & Van Schaftingen, E. (03 April 2017). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proceedings of the National Academy of Sciences of the United States of America, 1613736114, 3233-3242. doi:10.1073/pnas.1613736114 Peer Reviewed verified by ORBi |
 | Singh, C., Glaab, E., & Linster, C. (2017). Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals. Journal of Biological Chemistry, 292 (3), 1005-1028. doi:10.1074/jbc.M116.760744 Peer Reviewed verified by ORBi |
 | Collard, F., Baldin, F., Gerin, I., Bolsée, J., Noël, G., Graff, J., Veiga-da-Cunha, M., Stroobant, V., Vertommen, D., Houddane, A., Rider, M. H., Linster, C., Van Schaftingen, E., & Bommer, G. T. (August 2016). A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nature Chemical Biology, 12 (8), 601-607. doi:10.1038/nchembio.2104 Peer Reviewed verified by ORBi |
 | Becker-Kettern, J., Paczia, N., Conrotte, J.-F., Kay, D., Guignard, C., Jung, P., & Linster, C. (2016). Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. The Journal of Biological Chemistry. doi:10.1074/jbc.M115.704494 Peer reviewed |
 | Van Schaftingen, E., Veiga-da-Cunha, M., & Linster, C. (July 2015). Enzyme complexity in intermediary metabolism. Journal of Inherited Metabolic Disease, 38 (4), 721-7. doi:10.1007/s10545-015-9821-0 Peer Reviewed verified by ORBi |
 | Jung, P., Christian, N., Kay, D., Skupin, A., & Linster, C. (30 March 2015). Protocols and programs for high-throughput growth and aging phenotyping in yeast. PLoS ONE, 10 (3), 0119807. doi:10.1371/journal.pone.0119807 Peer Reviewed verified by ORBi |
 | Marbaix, A. Y., Tyteca, D., Niehaus, T. D., Hanson, A. D., Linster, C., & Van Schaftingen, E. (15 May 2014). Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals. The Biochemical journal, 460 (1), 49-58. doi:10.1042/BJ20131482 Peer reviewed |
 | Van Schaftingen, E., Rzem, R., Marbaix, A., Collard, F., Veiga-da-Cunha, M., & Linster, C. (May 2013). Metabolite proofreading, a neglected aspect of intermediary metabolism. Journal of Inherited Metabolic Disease, 36 (3), 427-34. doi:10.1007/s10545-012-9571-1 Peer Reviewed verified by ORBi |
 | Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 Peer Reviewed verified by ORBi |
 | Linster, C., Van Schaftingen, E., & Hanson, A. D. (February 2013). Metabolite damage and its repair or pre-emption. Nature Chemical Biology, 9 (2), 72-80. doi:10.1038/nchembio.1141 Peer Reviewed verified by ORBi |
 | Urzica, E. I., Adler, L. N., Page, M. D., Linster, C., Arbing, M. A., Casero, D., Pellegrini, M., Merchant, S. S., & Clarke, S. G. (20 April 2012). Impact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-L-galactose phosphorylase. Journal of Biological Chemistry, 287 (17), 14234-45. doi:10.1074/jbc.M112.341982 Peer Reviewed verified by ORBi |
 | Linster, C., Noël, G., Stroobant, V., Vertommen, D., Vincent, M.-F., Bommer, G. T., Veiga-da-Cunha, M., & Van Schaftingen, E. (16 December 2011). Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. Journal of Biological Chemistry, 286 (50), 42992-3003. doi:10.1074/jbc.M111.281527 Peer Reviewed verified by ORBi |
 | Marbaix, A. Y., Noël, G., Detroux, A. M., Vertommen, D., Van Schaftingen, E., & Linster, C. (02 December 2011). Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Journal of Biological Chemistry, 286 (48), 41246-52. doi:10.1074/jbc.C111.310847 Peer Reviewed verified by ORBi |
 | Adler, L. N., Gomez, T. A., Clarke, S. G., & Linster, C. (17 June 2011). A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. Journal of Biological Chemistry, 286 (24), 21511-23. doi:10.1074/jbc.M111.238774 Peer Reviewed verified by ORBi |
 | Khare, S., Linster, C., & Clarke, S. G. (2011). The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans. PLoS ONE, 6 (6), 20850. doi:10.1371/journal.pone.0020850 Peer Reviewed verified by ORBi |
 | Khare, S., Gomez, T., Linster, C., & Clarke, S. G. (October 2009). Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Mechanisms of Ageing and Development, 130 (10), 670-80. doi:10.1016/j.mad.2009.08.002 Peer Reviewed verified by ORBi |
 | Linster, C., & Clarke, S. G. (November 2008). L-Ascorbate biosynthesis in higher plants: the role of VTC2. Trends in Plant Science, 13 (11), 567-73. doi:10.1016/j.tplants.2008.08.005 Peer reviewed |
 | Linster, C., Adler, L. N., Webb, K., Christensen, K. C., Brenner, C., & Clarke, S. G. (04 July 2008). A second GDP-L-galactose phosphorylase in Arabidopsis en route to vitamin C covalent intermediate and substrate requirements for the conserved reaction. Journal of Biological Chemistry, 283 (27), 18483-92. doi:10.1074/jbc.M802594200 Peer Reviewed verified by ORBi |
 | Linster, C., Gomez, T. A., Christensen, K. C., Adler, L. N., Young, B. D., Brenner, C., & Clarke, S. G. (29 June 2007). Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants. Journal of Biological Chemistry, 282 (26), 18879-85. doi:10.1074/jbc.M702094200 Peer Reviewed verified by ORBi |
 | Linster, C., & Van Schaftingen, E. (January 2007). Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS Journal, 274 (1), 1-22. doi:10.1111/j.1742-4658.2006.05607.x Peer reviewed |
 | Linster, C., & Van Schaftingen, E. (April 2006). Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver. FEBS Journal, 273 (7), 1516-27. doi:10.1111/j.1742-4658.2006.05172.x Peer reviewed |
 | Linster, C., & Van Schaftingen, E. (October 2004). A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomerase and mannonate dehydrogenase. Protein Expression and Purification, 37 (2), 352-60. doi:10.1016/j.pep.2004.06.015 Peer Reviewed verified by ORBi |
 | Linster, C., & Van Schaftingen, E. (19 September 2003). Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes. Journal of Biological Chemistry, 278 (38), 36328-33. doi:10.1074/jbc.M306593200 Peer Reviewed verified by ORBi |