[en] A multitude of factors contribute to complex diseases and can be measured with ‘omics’ methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic Human (VMH, www.vmh.life) database encapsulating current knowledge of human metabolism within five interlinked resources ‘Human metabolism’, ‘Gut microbiome’, ‘Disease’, ‘Nutrition’, and ‘ReconMaps’. The VMH captures 5180 unique metabolites, 17 730 unique reactions, 3695 human genes, 255 Mendelian diseases, 818 microbes, 632 685 microbial genes and 8790 food items. The VMH’s unique features are (i) the hosting of the metabolic reconstructions of human and gut microbes amenable for metabolic modeling; (ii) seven human metabolic maps for data visualization; (iii) a nutrition designer; (iv) a user-friendly webpage and application-programming interface to access its content; (v) user feedback option for community engagement and (vi) the connection of its entities to 57 other web resources. The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community.
Luxembourg National Research Fund (FNR) through the ATTRACT program [FNR/A12/01] ; FNR CORE program [C16/BM/11332722]; FNR OPEN grant [FNR/O16/11402054] ; FNR National Centre of Excellence in Research (NCER) on Parkinson's disease ; European Union's Horizon 2020 research and innovation program under grant agreement [668738] ; European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [757922] ; Art2Cure ASBL
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