In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading
SMITS, Lisa ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
BOLOGNIN, Silvia ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
SCHWAMBORN, Jens Christian ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Co-auteurs externes :
no
Langue du document :
Anglais
Titre :
In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading
Postuma RB, Lang AE, Gagnon JF, Pelletier A, Montplaisir JY: How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain 2012, 135(Pt 6):1860-1870.
Klein C, Westenberger A: Genetics of Parkinson's disease. Cold Spring Harb Perspect Med 2012, 2(1):a008888.
Kalinderi K, Bostantjopoulou S, Fidani L: The genetic background of Parkinson's disease: Current progress and future prospects. Acta Neurol Scand 2016, 134(5):314-326.
Braak H, Del Tredici K: Neuroanatomy and pathology of sporadic Parkinson's disease. Adv Anat Embryol Cell Biol 2009, 201:1-119.
Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM: Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 2011, 72(1):57-71.
Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126(4):663-676.
Yu J, Vodyanik MA, Smuga-Otto K, AntosiewiczBourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R et al: Induced pluripotent stem cell lines derived from human somatic cells. Science (New York, NY) 2007, 318(5858):1917-1920.
Hillje AL, Schwamborn JC: Utilization of stem cells to model Parkinson's disease – current state and future challenges. Future Neurology 2016, 11(2):171-186.
Sanchez-Danes A, Richaud-Patin Y, Carballo-Carbajal I, Jimenez-Delgado S, Caig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A et al: Disease-specific phenotypes in dopamine neurons from human iPSbased models of genetic and sporadic Parkinson's disease. EMBO Mol Med 2012, 4(5):380-395.
Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, Glatza M, Hoing S, Hargus G, Heck SA, Dhingra A et al: Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Cell stem cell 2013, 12(3):354-367.
Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel CS, Hoing S, Moritz S, Parga JA, Wagner L, Bruder JM et al: Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PloS one 2013, 8:e59252.
Hemmer K, Zhang M, van Wullen T, Sakalem M, Tapia N, Baumuratov A, Kaltschmidt C, Kaltschmidt B, Scholer HR, Zhang W et al: Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain. Stem cell reports 2014, 3(3):423-431.
Proukakis C, Houlden H, Schapira AH: Somatic alpha-synuclein mutations in Parkinson's disease: Hypothesis and preliminary data. Movement Disorders 2013, 28:705-712.
Van Broeckhoven C: The future of genetic research on neurodegeneration. Nat Med 2010, 16(11):1215-1217.
Schneider SA, Johnson MR: Monozygotic twins with LRRK2 mutations: Genetically identical but phenotypically discordant. Movement Disorders 2012, 27:1203-1204.
Luk KC, Song C, Brien PO, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM: Exogenous alphasynuclein fibrils seed the formation of Lewy bodylike intracellular inclusions in cultured cells. PNAS 2009, 106.
Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM: Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. The Journal of experimental medicine 2012, 209(5):975-986.
Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman VL, Masliah E, Lashuel HA: Induction of de novo alpha-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 2016, 113(7):E912-921.
Rochet JC, Conway KA, Lansbury PT, Jr.: Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alphasynuclein. Biochemistry 2000, 39(35):10619-10626.
Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Goke J, Tan ZY, Saw TY, Tan CP, Lokman H et al: Midbrainlike Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell stem cell 2016, 19(2):248-257.
Monzel AS, Smits LM, Hemmer K, Hachi S, E. LM, van Wuellen T, Jarazo J, Walter J, Brüggemann I, Boussaad I et al: Derivation of human midbrainspecific organoids from neuroepithelial stem cells. Stem cell reports 2017, 8.
