Article (Scientific journals)
Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease.
Crespo, Isaac; Rump, Kirsten; Jurkowski, Wiktor et al.
2012In BMC Systems Biology, 6 (132)
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Abstract :
[en] The activation of immune cells in the brain is believed to be one of the earliest events in prion disease development, where misfolded PrionSc protein deposits are thought to act as irritants leading to a series of events that culminate in neuronal cell dysfunction and death. The role of these events in prion disease though is still a matter of debate. To elucidate the mechanisms leading from abnormal protein deposition to neuronal injury, we have performed a detailed network analysis of genes differentially expressed in several mouse prion models
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2012-1247
Author, co-author :
Crespo, Isaac ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Rump, Kirsten  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Jurkowski, Wiktor ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kitano, H.
del Sol Mesa, Antonio ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
yes
Language :
English
Title :
Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease.
Publication date :
2012
Journal title :
BMC Systems Biology
ISSN :
1752-0509
Publisher :
BioMed Central
Volume :
6
Issue :
132
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 03 July 2013

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