Reference : CHARACTERIZATION OF PARKINSON’S DISEASE GENE DJ-1/PARK7 IN CD4+CD25+FOXP3+ REGULATORY...
Dissertations and theses : Doctoral thesis
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/32767
CHARACTERIZATION OF PARKINSON’S DISEASE GENE DJ-1/PARK7 IN CD4+CD25+FOXP3+ REGULATORY T-CELLS
English
[en] CHARACTERIZATION OF PARKINSON’S DISEASE GENE DJ-1/PARK7 IN CD4+CD25+FOXP3+ REGULATORY T-CELLS
Danileviciute, Egle mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
4-Sep-2017
University of Luxembourg, ​Esch-sur-Alzette, ​​Luxembourg
DOCTEUR DE L’UNIVERSITÉ DU LUXEMBOURG EN BIOLOGIE
105
Balling, Rudi mailto
Schwamborn, Jens Christian mailto
He, Feng mailto
Ollert, Markus mailto
[en] Treg ; DJ-1/PARK7 ; Parkinson's disease
[en] DJ-1, also known as PARK7, as its name suggests, is one of the familial Parkinson’s disease (PD) genes. Defects in human DJ-1 are the cause of autosomal recessive early-onset PD. DJ-1 is a redox-responsive protein and is long thought to mainly play an essential protective role in neurons. DJ-1 is ubiquitously expressed throughout the body rather than only in brain and is involved in several biological functions. We here seek to characterize a novel role of DJ-1 in regulatory T cells, currently recognized as CD4+CD25+FOXP3+ regulatory T-cells (Tregs), which are well-known immune suppressor cells in many peripheral diseases and emerging to play a role in several neurodegenerative diseases.
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Fonds National de la Recherche - FnR
Researchers ; Students
http://hdl.handle.net/10993/32767
FnR ; FNR7603621 > Egle Danileviciute > DJTreg > Characterization Of A Parkinson’S Disease Gene Dj-1 In Regulatory T Cells > 01/03/2014 > 31/10/2017 > 2014

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