[en] DJ-1, also known as PARK7, as its name suggests, is one of the familial Parkinson’s disease (PD) genes. Defects in human DJ-1 are the cause of autosomal recessive early-onset PD. DJ-1 is a redox-responsive protein and is long thought to mainly play an essential protective role in neurons. DJ-1 is ubiquitously expressed throughout the body rather than only in brain and is involved in several biological functions. We here seek to characterize a novel role of DJ-1 in regulatory T cells, currently recognized as CD4+CD25+FOXP3+ regulatory T-cells (Tregs), which are well-known immune suppressor cells in many peripheral diseases and emerging to play a role in several neurodegenerative diseases.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
DANILEVICIUTE, Egle ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Language :
English
Title :
CHARACTERIZATION OF PARKINSON’S DISEASE GENE DJ-1/PARK7 IN CD4+CD25+FOXP3+ REGULATORY T-CELLS
Alternative titles :
[en] CHARACTERIZATION OF PARKINSON’S DISEASE GENE DJ-1/PARK7 IN CD4+CD25+FOXP3+ REGULATORY T-CELLS
Defense date :
04 September 2017
Number of pages :
105
Institution :
Unilu - University of Luxembourg, Esch-sur-Alzette, Luxembourg
