Article (Scientific journals)
Notch signaling modulates the activation of microglial cells
Grandbarbe, Luc; Michelucci, Alessandro; Heurtaux, Tony et al.
2007In Glia, 55 (15), p. 1519-30
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Abstract :
[en] The Notch signaling pathway plays a crucial role in specifying cellular fate in metazoan development by regulating communication between adjacent cells. Correlative studies suggested an involvement of Notch in hematopoietic cell development. Here, we report that the Notch pathway is expressed and active in microglial cells. During inflammatory activation, the transcription of the Notch down-stream effector Hes1 is downregulated. When Notch1 transcription in microglia is inhibited, an upregulation of the expression of pro-inflammatory cytokines is observed. Notch stimulation in activated microglia, using a soluble form of its ligand Jagged1, induces a decrease in pro-inflammatory cytokines secretion and nitric oxide production as well as an increase in phagocytic activity. Notch-stimulation is accompanied by an increase in the rate of STAT3 phosphorylation and nuclear translocation. Our results show that the Notch pathway plays an important role in the control of inflammatory reactions in the CNS.
Disciplines :
Life sciences: Multidisciplinary, general & others
Identifiers :
UNILU:UL-ARTICLE-2012-462
Author, co-author :
Grandbarbe, Luc ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Michelucci, Alessandro ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Heurtaux, Tony ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Hemmer, Karin
Morga, Eleonora ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Heuschling, Paul ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)
External co-authors :
no
Language :
English
Title :
Notch signaling modulates the activation of microglial cells
Publication date :
2007
Journal title :
Glia
ISSN :
1098-1136
Publisher :
Wiley Liss, Inc., New York, United States - New York
Volume :
55
Issue :
15
Pages :
1519-30
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 01 April 2016

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