Biomarkers of postoperative delirium and cognitive dysfunction

Androsova, Ganna; Krause, Roland; Winterer, Georg; Schneider, Reinhard

doi:10.3389/fnagi.2015.00112

Reference : Biomarkers of postoperative delirium and cognitive dysfunction


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others Human health sciences : Neurology Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/10993/22380

Title :	Biomarkers of postoperative delirium and cognitive dysfunction
Language :	English
Author, co-author :	Androsova, Ganna [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
	Krause, Roland [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
	Winterer, Georg [> >]
	Schneider, Reinhard [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Publication date :	2015
Journal title :	Frontiers in Aging Neuroscience
Volume :	7
Issue/season :	112
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
ISSN :	1663-4365
Abstract :	[en] Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.
Target :	Researchers
Permalink :	http://hdl.handle.net/10993/22380
DOI :	10.3389/fnagi.2015.00112
Other URL :	http://www.frontiersin.org/aging_neuroscience/10.3389/fnagi.2015.00112/abstract
Framework Programme / European Project :	FP7 ; BioCog

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