Profil

KRAUSE Roland

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core

ORCID
0000-0001-9938-7126
Main Referenced Co-authors
Lerche, Holger (36)
MAY, Patrick  (32)
Striano, Pasquale (23)
Helbig, Ingo (21)
Zara, Federico (21)
Main Referenced Keywords
Epilepsy (17); epilepsy (12); Genetics (9); Algorithms (4); Humans (4);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (34)
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) (15)
ULHPC - University of Luxembourg: High Performance Computing (4)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Chemical Biology (Crawford Group) (2)
Main Referenced Disciplines
Genetics & genetic processes (38)
Neurology (32)
Life sciences: Multidisciplinary, general & others (13)
Biochemistry, biophysics & molecular biology (6)
Human health sciences: Multidisciplinary, general & others (4)

Publications (total 76)

The most downloaded
1170 downloads
Lister, A. L., Datta, R. S., Hofmann, O., Krause, R., Kuhn, M., Roth, B., & Schneider, R. (2010). Live Coverage of Scientific Conferences Using Web Technologies. PLoS Computational Biology, 6 (1), 1-2. doi:10.1371/journal.pcbi.1000563 https://hdl.handle.net/10993/17064

The most cited

4069 citations (Scopus®)

Gavin, A.-C., Bosche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A.-M., Cruciat, C.-M., Remor, M., Hofert, C., Schelder, M., Brajenovic, M., Ruffner, H., Merino, A., Klein, K., Hudak, M., Dickson, D., ... Superti-Furga, G. (2002). Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature, 415 (6868), 141-7. doi:10.1038/415141a https://hdl.handle.net/10993/22134

Gomez Ramos, B., Ohnmacht, J., de Lange, N., VALCESCHINI, E., GINOLHAC, A., CATILLON, M., FERRANTE, D., Rakovic, A., HALDER, R., Massart, F., ARENA, G., ANTONY, P., BOLOGNIN, S., Klein, C., KRAUSE, R., Schulz, M. H., SAUTER, T., Krüger, R., & SINKKONEN, L. (2023). Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation. EMBO Reports. doi:10.1038/s44319-023-00024-2
Peer Reviewed verified by ORBi

Boothman, I., Clayton, L. M., McCormack, M., Driscoll, A. M., Stevelink, R., Moloney, P., KRAUSE, R., Kunz, W. S., Peter, S., O'Brien, T. J., Sills, G. J., de Haan, G.-J., Zara, F., Koeleman, B. P., Depondt, C., Marson, A. G., Stefansson, H., Stefansson, K., Craig, J., ... Cavalleri, G. L. (08 September 2023). Testing for pharmacogenomic predictors of ppRNFL thinning in individuals exposed to vigabatrin. Frontiers in Neuroscience, 17, 1156362. doi:10.3389/fnins.2023.1156362
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Stevelink, R., Campbell, C., Chen, S., Abou-Khalil, B., Adesoji, O. M., Afawi, Z., Amadori, E., Anderson, A., Anderson, J., Andrade, D. M., Annesi, G., Auce, P., Avbersek, A., Bahlo, M., Baker, M. D., Balagura, G., Balestrini, S., Barba, C., Barboza, K., ... Epilepsies, I. L. A. E. C. O. C. (2023). GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nature Genetics. doi:10.1038/s41588-023-01485-w
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Montanucci, L., Lewis-Smith, D., Collins, R. L., Niestroj, L.-M., Parthasarathy, S., Xian, J., Ganesan, S., Macnee, M., Brünger, T., Thomas, R. H., Talkowski, M., Krause, R., May, P., Helbig, I., Leu, C., & Lal, D. (20 July 2023). Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals. Nature Communications, 14 (1), 4392. doi:10.1038/s41467-023-39539-6
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Campbell, C., Lewis-Smith, D., Leu, C., Martins, H., Wolking, S., KRAUSE, R., O’Brien, T., Sill, G., Zara, F., Koeleman, B., Depondt, C., Marson, A., Stefánnson, H., Stefánnson, K., Craig, J., Johnson, M., Striano, P., Jorgensen, A., Lerche, H., ... Cavalleri, G. L. (2023). Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57188. doi:10.1101/2023.07.04.23292071

Bundalian, L., Su, Y.-Y., Chen, S., Velluva, A., Kirstein, A. S., Garten, A., Biskup, S., Battke, F., Lal, D., Heyne, H. O., Platzer, K., Lin, C.-C., Lemke, J. R., Duc, D. L., Krause, R., May, P., & Consortium, E. (2023). Epilepsies of presumed genetic etiology show enrichment of rare variants that occur in the general population. American Journal of Human Genetics. doi:10.1016/j.ajhg.2023.06.004
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Stevelink, R., Al-Toma, D., Jansen, F. E., Lamberink, H. J., Asadi-Pooya, A. A., Farazdaghi, M., Cação, G., Jayalakshmi, S., Patil, A., Özkara, Ç., Aydın, Ş., Gesche, J., Beier, C. P., Stephen, L. J., Brodie, M. J., Unnithan, G., Radhakrishnan, A., Höfler, J., Trinka, E., ... Braun, K. P. J. (2022). Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis. EClinicalMedicine, 101732. doi:10.1016/j.eclinm.2022.101732
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Krüger, J., Schubert, J., Kegele, J., Labalme, A., Mao, M., Heighway, J., Seebohm, G., Yan, P., Koko, M., Aslan-Kara, K., Caglayan, H., Steinhoff, B. J., Weber, Y. G., Keo-Kosal, P., Berkovic, S. F., Hildebrand, M. S., Petrou, S., Krause, R., May, P., ... Lerche, H. (08 September 2022). Loss-of-function variants in the KCNQ5 gene are implicated in genetic generalized epilepsies. EBioMedicine, 84, 104244. doi:10.1016/j.ebiom.2022.104244
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Adesoji, O. M., Schulz, H., May, P., Krause, R., Lerche, H., Nothnagel, M., & Epilepsies, I. C. O. C. (September 2022). Benchmarking of univariate pleiotropy detection methods applied to epilepsy. Human Mutation, 43 (9), 1314-1332. doi:10.1002/humu.24417
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Campbell, C., Leu, C., Feng, Y.-C. A., Wolking, S., Moreau, C., Ellis, C., Ganesan, S., Martins, H., Oliver, K., Boothman, I., Benson, K., Molloy, A., Brody, L., Michaud, J. L., Hamdan, F. F., Minassian, B. A., Lerche, H., Scheffer, I. E., Sisodiya, S., ... Krause, R. (July 2022). The role of common genetic variation in presumed monogenic epilepsies. EBioMedicine, 81, 104098. doi:10.1016/j.ebiom.2022.104098
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International League Against Epilepsy Consortium on Complex Epilepsies Krause, R., Landoulsi, Z., May, P., Krause, R., Berkovic, S. F., Cavalleri, G. L., & Koeleman, B. P. (2022). Genome-wide meta-analysis of over 29,000 people with epilepsy reveals 26 loci and subtype-specific genetic architecture. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51794. doi:10.1101/2022.06.08.22276120

Celli, R., Striano, P., Citraro, R., Di Menna, L., Cannella, M., Imbriglio, T., Koko, M., Consortium, E.-C., May, P., Krause, R., De Sarro, G., Monn, J. A., Battaglia, G., van Luitjelaar, G., Nicoletti, F., Russo, E., & Leo, A. (2022). mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data. Current Neuropharmacology. doi:10.2174/1570159X20666220509160511
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Campbell, C., McCormack, M., Patel, S., Stapleton, C., Bobbili, D. R., Krause, R., Depondt, C., Sills, G. J., Koeleman, B. P., Striano, P., Zara, F., Sander, J. W., Lerche, H., Kunz, W. S., Stefansson, K., Stefansson, H., Doherty, C. P., Heinzen, E. L., Scheffer, I. E., ... Cavalleri, G. L. (2022). A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam. Epilepsia, 63 (6), 1563-1570. doi:10.1111/epi.17228
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Czarnewski, P., Mahfouz, A., Calogero, R. A., Palagi, P. M., Portell-Silva, L., Gonzalez-Uriarte, A., Soneson, C., Burdett, T., Szomolay, B., Videm, P., Hotz, H. R., Papatheodorou, I., Hancock, J. M., Gruening, B., Haerty, W., Krause, R., Capella-Gutierrez, S., Lesko?ek, B., Alessandri, L., ... Korpelainen, E. (2022). Community-driven ELIXIR activities in single-cell omics [version 1; peer review: awaiting peer review]. F1000Research, 11 (869). doi:10.12688/f1000research.122312.1

Koko, M., Krause, R., Sander, T., Bobbili, D. R., Nothnagel, M., May, P., Lerche, H., & Epi25 Collaborative. (24 September 2021). Distinct gene-set burden patterns underlie common generalized and focal epilepsies. EBioMedicine, 72, 103588. doi:10.1016/j.ebiom.2021.103588
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Wolking, S., Campbell, C., Stapleton, C., McCormack, M., Delanty, N., Depondt, C., Johnson, M. R., Koeleman, B. P. C., Krause, R., Kunz, W. S., Marson, A. G., Sander, J. W., Sills, G. J., Striano, P., Zara, F., Sisodiya, S. M., Cavalleri, G. L., Lerche, H., & Epipgx Consortium. (09 June 2021). Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications. Frontiers in Pharmacology, 12, 1291. doi:10.3389/fphar.2021.688386
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Wolking, S., Moreau, C., McCormack, M., Krause, R., Krenn, M., Consortium, E., Berkovic, S., Cavalleri, G. L., Delanty, N., Depondt, C., Johnson, M. R., Koeleman, B. P. C., Kunz, W. S., Lerche, H., Marson, A. G., O’Brien, T. J., Petrovski, S., Sander, J. W., Sills, G. J., ... Cossette, P. (21 May 2021). Assessing the role of rare genetic variants in drug-resistant, non-lesional focal epilepsy. Annals of Clinical and Translational Neurology, n/a (n/a). doi:10.1002/acn3.51374
Peer reviewed

Stevelink, R., Luykx, J. J., Lin, B. D., Leu, C., Lal, D., Smith, A. W., Schijven, D., Carpay, J. A., Rademaker, K., Rodrigues Baldez, R. A., Devinsky, O., Braun, K. P. J., Jansen, F. E., Smit, D. J. A., Koeleman, B. P. C., International League Against Epilepsy Consortium On ComplexEpilepsies, Epi25 Collaborative, May, P., & Krause, R. (18 May 2021). Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. Epilepsia, 62 (7), 1518-1527. doi:10.1111/epi.16922
Peer reviewed

Lewis-Smith, D., Galer, P. D., Balagura, G., Kearney, H., Ganesan, S., Cosico, M., O'Brien, M., Vaidiswaran, P., Krause, R., Ellis, C. A., Thomas, R. H., Robinson, P. N., & Helbig, I. (05 May 2021). Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable. Epilepsia, n/a (n/a). doi:10.1111/epi.16908
Peer reviewed

Motelow, J. E., Povysil, G., Dhindsa, R. S., Stanley, K. E., Allen, A. S., Feng, Y.-C. A., Howrigan, D. P., Abbott, L. E., Tashman, K., Cerrato, F., Cusick, C., Singh, T., Heyne, H., Byrnes, A. E., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., Gupta, N., ... Goldstein, D. B. (2021). Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. The American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.04.009
Peer reviewed

Krueger, J., Schubert, J., Kegele, J., Labalme, A., Mao, M., Heighway, J., Seebohm, G., Yan, P., Koko, M., Aslan, K., Caglayan, H., Steinhoff, B. J., Weber, Y. G., Keo-Kosal, P., Berkovic, S. F., Hildebrand, M. S., Petrou, S., Krause, R., May, P., ... Lerche, H. (2021). Loss of function variants in the KCNQ5 gene are associated with genetic generalized epilepsies. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/46849. doi:10.1101/2021.04.20.21255696

Koko, M., Krause, R., Sander, T., Bobbili, D. R., Nothnagel, M., May, P., Lerche, H., & ???. (2021). Ultra-rare constrained missense variants in the epilepsies: Shared and specific enrichment patterns in neuronal gene-sets 2021.04.18.440264. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/46851. doi:10.1101/2021.04.18.440264

Gulcebi, M. I., Bartolini, E., Lee, O., Lisgaras, C. P., Onat, F., Mifsud, J., Striano, P., Vezzani, A., Hildebrand, M. S., Jimenez-Jimenez, D., Junck, L., Lewis-Smith, D., Scheffer, I. E., Thijs, R. D., Zuberi, S. M., Blenkinsop, S., Fowler, H. J., Foley, A., Balestrini, S., ... Sisodiya, S. M. (2021). Climate change and epilepsy: Insights from clinical and basic science studies. Epilepsy and Behavior, 116, 107791. doi:10.1016/j.yebeh.2021.107791
Peer reviewed

Crawford, K., Xian, J., Helbig, K. L., Galer, P. D., Parthasarathy, S., Lewis-Smith, D., Kaufman, M. C., Fitch, E., Ganesan, S., O'Brien, M., Codoni, V., Ellis, C. A., Conway, L. J., Taylor, D., Krause, R., & Helbig, I. (2021). Computational analysis of 10,860 phenotypic annotations in individuals with SCN2A-related disorders. Genetics in medicine : official journal of the American College of Medical Genetics, 23 (7), 1263-1272. doi:10.1038/s41436-021-01120-1
Peer reviewed

Heyne, H. O., Baez-Nieto, D., Iqbal, S., Palmer, D. S., Brunklaus, A., May, P., EPI25 Collaborative, Krause, R., Johannesen, K. M., Lauxmann, S., Lemke, J. R., Møller, R. S., Pérez-Palma, E., Scholl, U. I., Syrbe, S., Lerche, H., Lal, D., Campbell, A. J., Wang, H.-R., ... Daly, M. J. (12 August 2020). Predicting functional effects of missense variants in voltage-gated sodium and calcium channels. Science Translational Medicine, 12 (556), 6848. doi:10.1126/scitranslmed.aay6848
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Gurwitz, K. T., Singh Gaur, P., Bellis, L. J., Larcombe, L., Alloza, E., Balint, B. L., Botzki, A., Dimec, J., Dominguez Del Angel, V., Fernandes, P. L., Korpelainen, E., Krause, R., Kuzak, M., Le Pera, L., Leskošek, B., Lindvall, J. M., Marek, D., Martinez, P. A., Muyldermans, T., ... Rustici, G. (23 July 2020). A framework to assess the quality and impact of bioinformatics training across ELIXIR. PLoS Computational Biology, 16 (7), 1007976. doi:10.1371/journal.pcbi.1007976
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Wolking, S., Schulz, H., Nies, A. T., McCormack, M., Schaeffeler, E., Auce, P., Avbersek, A., Becker, F., Klein, K. M., Krenn, M., Møller, R. S., Nikanorova, M., Weckhuysen, S., Consortium, E., Cavalleri, G. L., Delanty, N., Depondt, C., Johnson, M. R., Koeleman, B. P. C., ... Lerche, H. (20 April 2020). Pharmacoresponse in genetic generalized epilepsy: a genome-wide association study. Pharmacogenomics, 0 (0). doi:10.2217/pgs-2019-0179
Peer Reviewed verified by ORBi

Lal, D., May, P., Perez-Palma, E., Samocha, K. E., Kosmicki, J. A., Robinson, E. B., Møller, R. S., Krause, R., Nürnberg, P., Weckhuysen, S., De Jonghe, P., Guerrini, R., Niestroj, L. M., Du, J., Marini, C., EuroEPINOMICS-RES Consortium, Ware, J. S., Kurki, M., Gormley, P., ... Daly, M. J. (17 March 2020). Gene family information facilitates variant interpretation and identification of disease-associated genes in neurodevelopmental disorders. Genome Medicine, 12 (28). doi:10.1186/s13073-020-00725-6
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Wolking, S., Moreau, C., Nies, A. T., Schaeffeler, E., McCormack, M., Auce, P., Avbersek, A., Becker, F., Krenn, M., Møller, R. S., Nikanorova, M., Weber, Y. G., Weckhuysen, S., Cavalleri, G. L., Delanty, N., Depondt, C., Johnson, M. R., Koeleman, B. P. C., Kunz, W. S., ... EpiPGX Consortium. (2020). Testing association of rare genetic variants with resistance to three common antiseizure medications. Epilepsia, 61 (n/a), 657-666. doi:10.1111/epi.16467
Peer reviewed

Köhler, S., Gargano, M., Matentzoglu, N., Carmody, L. C., Lewis-Smith, D., Vasilevsky, N. A., Danis, D., Balagura, G., Baynam, G., Brower, A. M., Callahan, T. J., Chute, C. G., Est, J. L., Galer, P. D., Ganesan, S., Griese, M., Haimel, M., Pazmandi, J., Hanauer, M., ... Robinson, P. N. (2020). The Human Phenotype Ontology in 2021. Nucleic Acids Research. doi:10.1093/nar/gkaa1043
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Galer, P. D., Ganesan, S., Lewis-Smith, D., McKeown, S. E., Pendziwiat, M., Helbig, K. L., Ellis, C. A., Rademacher, A., Smith, L., Poduri, A., Seiffert, S., Spiczak, S. V., Muhle, H., Baalen, A. V., Thomas, R. H., Krause, R., Weber, Y., & Helbig, I. (2020). Semantic Similarity Analysis Reveals Robust Gene-Disease Relationships in Developmental and Epileptic Encephalopathies. The American Journal of Human Genetics, 107 (4), 683 - 697. doi:10.1016/j.ajhg.2020.08.003
Peer reviewed

Garcia, L., Batut, B., Burke, M. L., Kuzak, M., Psomopoulos, F., Arcila, R., Attwood, T. K., Beard, N., Carvalho-Silva, D., Dimopoulos, A. C., Del Angel, V. D., Dumontier, M., Gurwitz, K. T., Krause, R., McQuilton, P., Le Pera, L., Morgan, S. L., Rauste, P., Via, A., ... Palagi, P. M. (2020). Ten simple rules for making training materials FAIR. PLoS Computational Biology, 16 (5), 1007854. doi:10.1371/journal.pcbi.1007854
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Tanevski, J., Nguyen, T., Truong, B., Karaiskos, N., Eren, M., Zhang, X., Shu, C., Hu, Y., Pham, H. V. V., Li, X., Le, T., Tarca, A., Bhatti, G., Romero, R., Karathanasis, N., Loher, P., Chen, Y., Ouyang, Z., Mao, D., ... Saez-Rodriguez, J. (2020). Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics. Life Science Alliance, 3 (11), 202000867. doi:10.26508/LSA.202000867
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Feng, Y.-C. A., Howrigan, D. P., Abbott, L. E., Tashman, K., Cerrato, F., Singh, T., Heyne, H., Byrnes, A., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., Heinzen, E. L., Dhindsa, R. S., Stanley, K. E., Cavalleri, G. L., Hakonarson, H., Helbig, I., Krause, R., ... Neale, B. M. (2019). Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals. American Journal of Human Genetics. doi:10.1016/j.ajhg.2019.05.020
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Helbig, I., Lopez-Hernandez, T., Shor, O., Galer, P., Ganesan, S., Pendziwiat, M., Rademacher, A., Ellis, C. A., Humpfer, N., Schwarz, N., Seiffert, S., Peeden, J., Shen, J., Sterbova, K., Hammer, T. B., Moller, R. S., Shinde, D. N., Tang, S., Smith, L., ... GRIN consortium. (2019). A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy. American Journal of Human Genetics. doi:10.1016/j.ajhg.2019.04.001
Peer Reviewed verified by ORBi

Lerche, H., Berkovic, S. F., Lowenstein, D. H., EuroEPINOMICS-CoGIE, May, P., Bobbili, D. R., Krause, R., Balling, R., EpiPGX consortium, Peter, S., & Epi4K Consortium/Epilepsy Phenome/Genome. (18 April 2019). Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy [letter to the editor]. New England Journal of Medicine, 380 (16), 24. doi:10.1056/NEJMc1805100
Peer Reviewed verified by ORBi

Berghuis, B., Stapleton, C., Sonsma, A., Hulst, J., de Haan, G., Lindhout, D., Demurtas, R., Balling, R., Schneider, R., EpiPGX Consortium, & Krause, R. (2019). A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine. Epilepsia Open. doi:10.1002/epi4.12297
Peer reviewed

Silvennoinen, K., de Lange, N. M., Zagaglia, S., Balestrini, S., Androsova, G., Wassenaar, M., Auce, P., Avbersek, A., Becker, F., Berghuis, B., Campbell, E., Coppola, A., Francis, B., Wolking, S., Cavalleri, G. L., Craig, J., Delanty, N., Johnson, M. R., Koeleman, B. P. C., ... Consortium, T. E. (2019). Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy. Epilepsia Open, 0 (0). doi:10.1002/epi4.12349
Peer reviewed

Heavin, S. B., McCormack, M., Wolking, S., Slattery, L., Walley, N., Avbersek, A., Novy, J., Sinha, S. R., Radtke, R., Doherty, C., Auce, P., Craig, J., Johnson, M. R., Koeleman, B. P. C., Krause, R., Kunz, W. S., Marson, A. G., O'Brien, T. J., Sander, J. W., ... Delanty, N. (2019). Genomic and clinical predictors of lacosamide response in refractory epilepsies. Epilepsia Open, 0 (0). doi:10.1002/epi4.12360
Peer Reviewed verified by ORBi

The International League Against Epilepsy Consortium on Complex Epilepsies, & Krause, R. (2018). Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nature Communications. doi:10.1038/s41467-018-07524-z
Peer Reviewed verified by ORBi

Jabbari, K., Bobbili, D. R., Lal, D., Reinthaler, E. M., Schubert, J., Wolking, S., Sinha, V., Motameny, S., Thiele, H., Kawalla, A., Altmüller, J., Toliat, M. R., Kraaij, R., van Rooij, J., Uitterlinden, A. G., Ikram, M. A., EuroEPINOMICS CoGIE Consortium, Balling, R., Zara, F., ... Nürnberg, P. (2018). Rare gene deletions in genetic generalized and Rolandic epilepsies. PLoS ONE. doi:10.1371/journal.pone.0202022
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May, P., Girard, S., Harrer, M., Bobbili, D. R., Schubert, J., Wolking, S., Becker, F., Lachance-Touchette, P., Meloche, C., Gravel, M., Niturad, C. E., Knaus, J., De Kovel, C., Toliat, M., Polvi, A., Iacomino, M., Guerrero-López, R., Baulac, S., Marini, C., ... Lerche, H. (18 August 2018). Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study. The Lancet Neurology, 17 (8), 699-708. doi:10.1016/S1474-4422(18)30215-1
Peer Reviewed verified by ORBi

Bobbili, D. R.* , Lal, D.* , May, P.* , Reinthaler, E. M., Jabbari, K., Thiele, H., Nothnagel, M., Jurkowski, W., EuroEPINOMICS COGIE Consortium, Balling, R., Feucht, M., Nürnberg, P., Lerche, H., Zimprich, F., Krause, R., & Neubauer, B. A. (2018). Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic Epilepsy. European Journal of Human Genetics. doi:10.1038/s41431-017-0034-x
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Winterer, G., Androsova, G., Bender, O., Boraschi, D., Borchers, F., Dschietzig, T. B., Feinkohl, I., Fletcher, P., Gallinat, J., Hadzidiakos, D., Haynes, J. D., Heppner, F., Hetzer, S., Hendrikse, J., Ittermann, B., Kant, I. M. J., Kraft, A., Krannich, A., Krause, R., ... Zacharias, N. (2018). Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project. European Psychiatry, 50, 34-39. doi:10.1016/j.eurpsy.2017.10.004
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McCormack, M., Gui, H., Ingason, A., Speed, D., Wright, G. E. B., Zhang, E. J., Secolin, R., Yasuda, C., Kwok, M., Wolking, S., Becker, F., Rau, S., Avbersek, A., Heggeli, K., Leu, C., Depondt, C., Sills, G. J., Marson, A. G., Auce, P., ... Cavalleri, G. L. (2017). Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients. Neurology. doi:10.1212/WNL.0000000000004853
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Niturad, E. C., Lev, D., Kalscheuer, V. M., Charzewska, A., Schubert, J., Lerman-Sagie, T., Kroes, H. Y., Oegema, R., Traverso, M., Specchio, N., Lassota, M., Chelly, J., Bennett-Back, O., Carmi, N., Koffler-Brill, T., Iacomino, M., Trivisano, M., Capovilla, G., Striano, P., ... Leshinsky-Silver, E. (01 November 2017). Rare GABRA3 variants are associated with epileptic seizures, encephalopathy and dysmorphic features. Brain: a Journal of Neurology, 140 (11), 2879-2894. doi:10.1093/brain/awx236
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Santolini, I., Celli, R., Cannella, M., Imbriglio, T., Guiducci, M., Parisi, P., Schubert, J., Iacomino, M., Zara, F., Lerche, H., EuroEPINOMICS CoGIE Consortium, May, P., Krause, R., Balling, R., Genetic Commission of Italian League Against Epilepsy (LICE), Moyanova, S., Ngomba, R. T., van Luijtellar, G., Battaglia, G., ... Nicoletti, F. (2017). Alterations in the α2δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies. Epilepsia. doi:10.1111/epi.13898
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Androsova, G.* , Krause, R.* , Borghei, M., Wassenaar, M., Auce, P., Avbersek, A., Becker, F., Berghuis, B., Campbell, E., Coppola, A., Francis, B., Wolking, S., Cavalleri, G. L., Craig, J., Delanty, N., Koeleman, B. P. C., Kunz, W. S., Lerche, H., Marson, A. G., ... the EpiPGX Consortium. (2017). Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia, 1-8. doi:10.1111/epi.13871
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* These authors have contributed equally to this work.

Keck, M., Androsova, G., Gualtieri, F., Walker, A., von Ruden, E.-L., Russmann, V., Deeg, C. A., Hauck, S. M., Krause, R., & Potschka, H. (30 May 2017). A systems level analysis of epileptogenesis-associated proteome alterations. Neurobiology of Disease, 105, 164-178. doi:10.1016/j.nbd.2017.05.017
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Allen, A. S., Berkovic, S. F., Bridgers, J., Cossette, P., Dlugos, D., Epstein, M. P., Glauser, T., Goldstein, D. B., Heinzen, E. L., Jiang, Y., Johnson, M. R., Kuzniecky, R., Lowenstein, D. H., Marson, A. G., Mefford, H. C., O'Brien, T. J., Ottman, R., Petrou, S., Petrovski, S., ... Winawer, M. R. (2017). Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data. European Journal of Human Genetics. doi:10.1038/ejhg.2017.61
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Appenzeller, S., Balling, R., Barisic, N., Baulac, S., Caglayan, H., Craiu, D., Jonghe, P. D., Depienne, C., Dimova, P., Djémié, T., Gormley, P., Guerrini, R., Helbig, I., Hjalgrim, H., Hoffman-Zacharska, D., Jähn, J., Klein, K. M., Koeleman, B., Komarek, V., ... Sherr, E. (05 January 2017). De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies. American Journal of Human Genetics, 100 (1), 179. doi:10.1016/j.ajhg.2016.12.012
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Lal, D., Reinthaler, E., Dejanovic, May, P., Thiele, H., Lehesjoki, A.-E., Schwarz, G., Riesch, E., Ikram, A., van Duijn, C., Uitterlinden, A., Steinböck, H., Gruber-Sedlmayr, U., Neophytou, B., Zara, F., Hahn, A., Genetic Commission of the Italian League against Epilepsy, EuroEPINOMICS CoGIE Consortium, Balling, R., ... Neubauer, B. (2016). Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes. PLoS ONE. doi:10.1371/journal.pone.0150426
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Köhler, S., Vasilevsky, N. A., Engelstad, M., Foster, E., McMurry, J., Aymé, S., Baynam, G., Bello, S. M., Boerkoel, C. F., Boycott, K. M., Brudno, M., Buske, O. J., Chinnery, P. F., Cipriani, V., Connell, L. E., Dawkins, H. J. S., DeMare, L. E., Devereau, A. D., de Vries, B. B. A., ... Robinson, P. N. (2016). The Human Phenotype Ontology in 2017. Nucleic Acids Research. doi:10.1093/nar/gkw1039
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Yamamoto, H., Wittek, D., Gupta, R., Qin, B., Ueda, T., Krause, R., Yamamoto, K., Albrecht, R., Pech, M., & Nierhaus, K. H. (2016). 70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria. Proceedings of the National Academy of Sciences of the United States of America, 113 (9), 1180-9. doi:10.1073/pnas.1524554113
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Allen, G., Amoroso, N., Anghel, C., Balagurusamy, V., Bare, C., Beaton, D., Bellotti, R., Bennett, D., Boehme, K., Caberlotto, L., Campbell, F., Chang, Y.-C., Chen, B., Chen, C.-Y., Chien, T.-Y., Clark, T., Das, S., Davatzikos, C., Deng, J., ... Alzheimer's Disease Neuroimaging Initiative. (2016). Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 12 (6), 645-653. doi:10.1016/j.jalz.2016.02.006
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Syrbe, S., Hedrich, U. B. S., Riesch, E., Djémié, T., Müller, S., Møller, R. S., Maher, B., Hernandez-Hernandez, L., Synofzik, M., Caglayan, H. S., Arslan, M., Serratosa, J. M., Nothnagel, M., May, P., Krause, R., Löffler, H., Detert, K., Dorn, T., Vogt, H., ... Lemke, J. R. (09 March 2015). De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nature Genetics, 47 (4), 393-9. doi:10.1038/ng.3239
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Thomas, R. H., Zhang, L. M., Carvill, G. L., Archer, J. S., Heavin, S. B., Mandelstam, S. A., Craiu, D., Berkovic, S. F., Gill, D. S., Mefford, H. C., Scheffer, I. E., Paalotie, A., Lehesjoki, A.-E., Koeleman, B., Marini, C., Depienne, C., Pal, D., Hoffman-Zacharska, D., Leguern, E., ... Weber, Y. (03 March 2015). CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures. Neurology, 84 (9), 951-958. doi:10.1212/WNL.0000000000001305
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Larsen, J., Carvill, G. L., Gardella, E., Kluger, G., Schmiedel, G., Barisic, N., Depienne, C., Brilstra, E., Mang, Y., Nielsen, J. E. K., Kirkpatrick, M., Goudie, D., Goldman, R., Jähn, J. A., Jepsen, B., Gill, D., Döcker, M., Biskup, S., McMahon, J. M., ... EuroEPINOMICS RES Consortium CRP. (03 February 2015). The phenotypic spectrum of SCN8A encephalopathy. Neurology, 84 (5), 480-489. doi:10.1212/WNL.0000000000001211
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Lal, D., Steinbrucker, S., Schubert, J., Sander, T., Becker, F., Weber, Y., Lerche, H., Thiele, H., Krause, R., Lehesjoki, A.-E., Nurnberg, P., Palotie, A., Neubauer, B. A., Muhle, H., Stephani, U., Helbig, I., Becker, A. J., Schoch, S., Hansen, J., ... Lemke, J. R. (2015). Investigation of GRIN2A in common epilepsy phenotypes. Epilepsy Research, 115, 95-9. doi:10.1016/j.eplepsyres.2015.05.010
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Androsova, G., Krause, R., Winterer, G., & Schneider, R. (2015). Biomarkers of postoperative delirium and cognitive dysfunction. Frontiers in Aging Neuroscience, 7 (112). doi:10.3389/fnagi.2015.00112
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Galizia, E. C., Myers, C. T., Leu, C., de Kovel, C. G. F., Afrikanova, T., Cordero-Maldonado, M. L., Martins, T., Jacmin, M., Drury, S., Krishna Chinthapalli, V., Muhle, H., Pendziwiat, M., Sander, T., Ruppert, A.-K., Møller, R. S., Thiele, H., Krause, R., Schubert, J., Lehesjoki, A.-E., ... Sisodiya, S. M. (2015). CHD2 variants are a risk factor for photosensitivity in epilepsy. Brain: a Journal of Neurology. doi:10.1093/brain/awv052
Peer reviewed

Schubert, J., Siekierska, A., Langlois, M., May, P., Huneau, C., Becker, F., Muhle, H., Suls, A., Lemke, J. R., de Kovel, C. G. F., Thiele, H., Konrad, K., Kawalia, A., Toliat, M. R., Sander, T., Ruschendorf, F., Caliebe, A., Nagel, I., Kohl, B., ... Lerche, H. (02 November 2014). Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nature Genetics, 46 (12), 1327-32. doi:10.1038/ng.3130
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Appenzeller, S., Balling, R., Barisic, N., Baulac, S., Caglayan, H., Craiu, D., De Jonghe, P., Depienne, C., Dimova, P., Djemie, T., Gormly, P., Guerrini, R., Helbig, I., Hjalgrim, H., Hoffman-Zacharska, D., Jähn, Klein, K. M., Koeleman, B., Komarek, V., ... Epi4K Consortium. (25 September 2014). De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies. American Journal of Human Genetics, 4, 360-370. doi:10.1016/j.ajhg.2014.08.013
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Nava, C., Dalle, C., Rastetter, A., Striano, P., de Kovel, C. G. F., Nabbout, R., Cancès, C., Ville, D., Brilstra, E. H., Gobbi, G., Raffo, E., Bouteiller, D., Marie, Y., Trouillard, O., Robbiano, A., Keren, B., Agher, D., Roze, E., Lesage, S., ... Zara, F. (Other coll.). (2014). De novo mutations in HCN1 cause early infantile epileptic encephalopathy. Nature Genetics. doi:10.1038/ng.2952
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Chang, W.-C., Vakati, S., Krause, R., & Eulenstein, O. (2012). Exploring biological interaction networks with tailored weighted quasi-bicliques. BMC Bioinformatics, 13 Suppl 10, 16. doi:10.1186/1471-2105-13-S10-S16
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Wiedenhoeft, J., Krause, R., & Eulenstein, O. (2011). The plexus model for the inference of ancestral multidomain proteins. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 8 (4), 890-901. doi:10.1109/TCBB.2011.22
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Homilius, M., Wiedenhoeft, J., Thieme, S., Standfuss, C., Kel, I., & Krause, R. (2011). Cocos: Constructing multi-domain protein phylogenies. PLOS Currents, 3, 1240. doi:10.1371/currents.RRN1240
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Hafemeister, C., Krause, R., & Schliep, A. (2011). Selecting oligonucleotide probes for whole-genome tiling arrays with a cross-hybridization potential. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 8 (6), 1642-52. doi:10.1109/TCBB.2011.39
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Lister, A. L., Datta, R. S., Hofmann, O., Krause, R., Kuhn, M., Roth, B., & Schneider, R. (2010). Live Coverage of Intelligent Systems for Molecular Biology. PLoS Computational Biology, 6. doi:10.1371/journal.pcbi.1000640
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Lister, A. L., Datta, R. S., Hofmann, O., Krause, R., Kuhn, M., Roth, B., & Schneider, R. (2010). Live Coverage of Scientific Conferences Using Web Technologies. PLoS Computational Biology, 6 (1), 1-2. doi:10.1371/journal.pcbi.1000563
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Lee, J. S., Krause, R., Schreiber, J., Mollenkopf, H.-J., Kowall, J., Stein, R., Jeon, B.-Y., Kwak, J.-Y., Song, M.-K., Patron, J. P., Jorg, S., Roh, K., Cho, S.-N., & Kaufmann, S. H. E. (2008). Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain. Cell Host and Microbe, 3 (2), 97-103. doi:10.1016/j.chom.2008.01.002
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Rungsarityotin, W., Krause, R., Schodl, A., & Schliep, A. (2007). Identifying protein complexes directly from high-throughput TAP data with Markov random fields. BMC Bioinformatics, 8, 482. doi:10.1186/1471-2105-8-482
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Chu, W., Ghahramani, Z., Krause, R., & Wild, D. L. (2006). Identifying protein complexes in high-throughput protein interaction screens using an infinite latent feature model. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 231-42.
Peer reviewed

von Mering, C., Bork, P., Dandekar, T., & Krause, R. (2004). Shared components of protein complexes--versatile building blocks or biochemical artefacts? BioEssays, 26 (12), 1333-43. doi:10.1002/bies.20141
Peer reviewed

Krause, R., von Mering, C., & Bork, P. (2003). A comprehensive set of protein complexes in yeast: mining large scale protein-protein interaction screens. Bioinformatics, 19 (15), 1901-8. doi:10.1093/bioinformatics/btg344
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Gavin, A.-C., Bosche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A.-M., Cruciat, C.-M., Remor, M., Hofert, C., Schelder, M., Brajenovic, M., Ruffner, H., Merino, A., Klein, K., Hudak, M., Dickson, D., ... Superti-Furga, G. (2002). Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature, 415 (6868), 141-7. doi:10.1038/415141a
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