CELL LINE SEQUENCING, CELL LINE SUITABILITY EVALUATION, NETWORK ANALYSIS, TRANSLATIONAL RESEARCH, TEXT MINING; CELL LINE SUITABILITY EVALUATION; TRANSLATIONAL RESEARCH; TEXT MINING
Résumé :
[en] Cell lines are widely used in translational biomedical research to study the genetic basis of diseases. A major approach for experimental disease modeling are genetic perturbation experiments that aim to trigger selected cellular disease states. In this type of experiments it is crucial to ensure that the targeted disease- related genes and pathways are intact in the used cell line. In this work we are developing a framework which integrates genetic sequence information and disease- specific network analysis for evaluating disease-specific cell line suitability.
Centre de recherche :
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
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