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MANOHARAN Ganesh Babu

Main Referenced Co-authors
ABANKWA, Daniel  (11)
Uri, Asko (7)
Enkvist, Erki (6)
PAVIC, Karolina  (4)
GAIGNEAUX, Anthoula  (3)
Main Referenced Keywords
Humans (2); Signal Transduction (2); 3CLpro (1); Animals (1); Biochemistry, Genetics and Molecular Biology (all) (1);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (13)
Chemistry (4)
Biotechnology (2)
Immunology & infectious disease (1)
Oncology (1)

Publications (total 19)

The most downloaded
244 downloads
Siddiqui, F. A., Alam, C., Rosenqvist, P., Ora, M., Sabt, A., MANOHARAN, G. B., Bindu, L., OKUTACHI, S. O., CATILLON, M., Taylor, T., Abdelhafez, O. M., Lönnberg, H., Stephen, A. G., Papageorgiou, A. C., Virta, P., & ABANKWA, D. (2020). PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity. ACS Omega, 5 (1), 832-842. doi:10.1021/acsomega.9b03639 https://hdl.handle.net/10993/41426

The most cited

57 citations (OpenAlex)

Santio, N. M., Landor, S. K.-J., Vahtera, L., Yla-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., MANOHARAN, G. B., Uri, A., Lendahl, U., Sahlgren, C., & Koskinen, P. J. (2016). Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget, 7 (28), 43220-43238. doi:10.18632/oncotarget.9215 https://hdl.handle.net/10993/40425

STEFFEN, C.* , MANOHARAN, G. B.* , PAVIC, K., Yeste-Vázquez, A., Knuuttila, M., Arora, N., Zhou, Y., Härmä, H., GAIGNEAUX, A., Grossmann, T. N., & ABANKWA, D. (09 July 2024). Identification of an H-Ras nanocluster disrupting peptide. Communications Biology, 7 (1), 837. doi:10.1038/s42003-024-06523-9
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

MANOHARAN, G. B., STEFFEN, C., PAVIC, K., Yeste-Vázquez, A., Knuuttila, M., Arora, N., Zhou, Y., Härmä, H., GAIGNEAUX, A., Grossmann, T. N., & ABANKWA, D. (2023). Identification of an H-Ras nanocluster disrupting peptide. Cold Spring Harbor Laboratory. doi:10.1101/2023.09.07.556635

KAYA, P., SCHAFFNER-RECKINGER, E., MANOHARAN, G. B., Vukic, V., Kiriazis, A., LEDDA, M., Burgos, M., PAVIC, K., GAIGNEAUX, A., GLAAB, E., & ABANKWA, D. (2023). An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/58308. doi:10.1101/2023.08.23.554263

KAYA, P., SCHAFFNER-RECKINGER, E., MANOHARAN, G. B., Saley, B., & ABANKWA, D. (18 October 2022). Novel High Affinity Inhibitors Of The K-Ras Trafficking Chaperone PDE6D [Paper presentation]. The Fourth RAS Initiative Symposium, Frederick, United States.
Peer reviewed

MANOHARAN, G. B., PAVIC, K., Yeste Vazquez, A., Knuuttila, M., Grossmann, T. N., ABANKWA, D., & STEFFEN, C. (13 September 2022). Identification of a small peptide targeting the Raf/ Galectin interface to disrupt stabilised Ras signalling nanocluster [Paper presentation]. Small G proteins in cellular signalling and disease, Liverpool, United Kingdom.

MANOHARAN, G. B., Okutachi, S., & ABANKWA, D. (2022). Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells. PLoS ONE. doi:10.1371/journal.pone.0268635
Peer Reviewed verified by ORBi

GLAAB, E., MANOHARAN, G. B., & ABANKWA, D. (23 August 2021). A Pharmacophore Model for SARS-CoV-2 3CLpro Small Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors. Journal of Chemical Information and Modeling, 61 (8), 4082-4096. doi:10.1021/acs.jcim.1c00258
Peer Reviewed verified by ORBi

OKUTACHI, S. O., MANOHARAN, G. B., Kiriazis, A., LAURINI, C., CATILLON, M., McCormick, F., Yli-Kauhaluoma, J., & ABANKWA, D. (2021). A covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness. Frontiers in Cell and Developmental Biology. doi:10.3389/fcell.2021.665673
Peer Reviewed verified by ORBi

Siddiqui, F. A., Alam, C., Rosenqvist, P., Ora, M., Sabt, A., MANOHARAN, G. B., Bindu, L., OKUTACHI, S. O., CATILLON, M., Taylor, T., Abdelhafez, O. M., Lönnberg, H., Stephen, A. G., Papageorgiou, A. C., Virta, P., & ABANKWA, D. (2020). PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity. ACS Omega, 5 (1), 832-842. doi:10.1021/acsomega.9b03639
Peer Reviewed verified by ORBi

Siddiqui, F. A., Parkkola, H., MANOHARAN, G. B., & ABANKWA, D. (2019). Medium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay. SLAS Discovery. doi:10.1177/2472555219884033
Peer reviewed

MANOHARAN, G. B., Kopra, K., Eskonen, V., Harma, H., & ABANKWA, D. (February 2019). High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors. Analytical Biochemistry, 572, 25-32. doi:10.1016/j.ab.2019.02.015
Peer Reviewed verified by ORBi

Vahter, J., Viht, K., Uri, A., MANOHARAN, G. B., & Enkvist, E. (2018). Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2. Bioorganic & medicinal chemistry, 26 (18), 5062-5068. doi:10.1016/j.bmc.2018.09.003
Peer reviewed

Santio, N. M., Landor, S. K.-J., Vahtera, L., Yla-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., MANOHARAN, G. B., Uri, A., Lendahl, U., Sahlgren, C., & Koskinen, P. J. (2016). Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget, 7 (28), 43220-43238. doi:10.18632/oncotarget.9215
Peer Reviewed verified by ORBi

Ivan, T., Enkvist, E., Viira, B., MANOHARAN, G. B., Raidaru, G., Pflug, A., Alam, K. A., Zaccolo, M., Engh, R. A., & Uri, A. (2016). Bifunctional Ligands for Inhibition of Tight-Binding Protein–Protein Interactions. Bioconjugate Chemistry, 27 (8), 1900-1910. doi:10.1021/acs.bioconjchem.6b00293
Peer Reviewed verified by ORBi

MANOHARAN, G. B., Enkvist, E., & Uri, A. (2016). Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases. Biophysical Chemistry, 211, 39-48. doi:10.1016/j.bpc.2016.01.004
Peer Reviewed verified by ORBi

Ekambaram, R., MANOHARAN, G. B., Enkvist, E., Ligi, K., Knapp, S., & Uri, A. (2015). PIM kinase-responsive microsecond-lifetime photoluminescent probes based on selenium-containing heteroaromatic tricycle. RSC Advances. doi:10.1039/c5ra20777k
Peer Reviewed verified by ORBi

MANOHARAN, G. B., Enkvist, E., Kasari, M., Viht, K., Zenn, M., Prinz, A., Filhol, O., Herbergb, F. W., & Uri, A. (2015). FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases. Analytical Biochemistry. doi:10.1016/j.ab.2015.04.009
Peer Reviewed verified by ORBi

Ekambaram, R., Enkvist, E., MANOHARAN, G. B., Ugandi, M., Kasari, M., Viht, K., Knapp, S., Issinger, O.-G., & Uri, A. (2014). Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases. Chemical Communications. doi:10.1039/c3cc49198f
Peer Reviewed verified by ORBi

Vinayagam, V., Jayaraman, K., MANOHARAN, G. B., & Sankaranarayanan, M. (2012). Active site analysis of cis-epoxysuccinate hydrolase from Nocardia tartaricans using homology modeling and site-directed mutagenesis. Applied Microbiology and Biotechnology, 93 (6), 2377–2386.
Peer Reviewed verified by ORBi

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