Profil

ABANKWA Daniel

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

ORCID
0000-0003-2769-0745
Main Referenced Co-authors
MANOHARAN, Ganesh Babu  (7)
Siddiqui, Farid A. (4)
PAVIC, Karolina  (3)
CATILLON, Marie  (2)
CHIPPALKATTI, Rohan  (2)
Main Referenced Keywords
Ras (4); RAS (3); Humans (2); K-Ras (2); Nanocluster (2);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (21)
Human health sciences: Multidisciplinary, general & others (2)
Life sciences: Multidisciplinary, general & others (2)
Immunology & infectious disease (1)
Biotechnology (1)

Publications (total 24)

The most downloaded
752 downloads
Sahlgren, C., Meinander, A., Zhang, H., Cheng, F., Preis, M., Xu, C., Salminen, T., Toivola, D., Abankwa, D., Rosling, A., Karaman, D., Salo-Ahen, O., Österbacka, R., Eriksson, J., Willför, S., Petre, I., Peltonen, J., Leino, R., Johnson, M., ... Sandler, N. (2017). Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Advanced Healthcare Materials. doi:10.1002/adhm.201700258 https://hdl.handle.net/10993/34123

The most cited

35 citations (Scopus®)

Sahlgren, C., Meinander, A., Zhang, H., Cheng, F., Preis, M., Xu, C., Salminen, T., Toivola, D., Abankwa, D., Rosling, A., Karaman, D., Salo-Ahen, O., Österbacka, R., Eriksson, J., Willför, S., Petre, I., Peltonen, J., Leino, R., Johnson, M., ... Sandler, N. (2017). Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Advanced Healthcare Materials. doi:10.1002/adhm.201700258 https://hdl.handle.net/10993/34123

KAYA, P., SCHAFFNER-RECKINGER, E., MANOHARAN, G. B., Vukic, V., Kiriazis, A., LEDDA, M., Burgos, M., PAVIC, K., GAIGNEAUX, A., GLAAB, E., & ABANKWA, D. (2023). An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth. Cold Spring Harbor Laboratory. doi:10.1101/2023.08.23.554263

Manoharan, G. B., Guzmán, C., Najumudeen, A. K., & Abankwa, D. (2023). Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements. European Journal of Cell Biology. doi:10.1016/j.ejcb.2023.151314
Peer Reviewed verified by ORBi

Steffen, C., Kaya, P., Schaffner-Reckinger, E., & Abankwa, D. (2023). Eliminating oncogenic RAS: back to the future at the drawing board. Biochemical Society Transactions. doi:10.1042/BST20221343
Peer Reviewed verified by ORBi

Manoharan, G. B., Laurini, C., Bottone, S., Ben Fredj, N., & Abankwa, D. (2023). K-Ras Binds Calmodulin-Related Centrin1 with Potential Implications for K-Ras Driven Cancer Cell Stemness. Cancers. doi:10.3390/cancers15123087
Peer Reviewed verified by ORBi

Pavic, K., Gupta, N., Omella, J. D., Derua, R., Aakula, A., Huhtaniemi, R., Määttä, J. A., Höfflin, N., Okkeri, J., Wang, Z., Kauko, O., Varjus, R., Honkanen, H., Abankwa, D., Köhn, M., Hytönen, V. P., Xu, W., Nilsson, J., Page, R., ... Westermarck, J. (2023). Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature Communications, 14 (1), 1143. doi:10.1038/s41467-023-36693-9
Peer Reviewed verified by ORBi

Manoharan, G. B., Okutachi, S., & Abankwa, D. (2022). Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells. PLoS ONE. doi:10.1371/journal.pone.0268635
Peer Reviewed verified by ORBi

Pavic, K., Chippalkatti, R., & Abankwa, D. (2022). Drug targeting opportunities en route to Ras nanoclusters. Advances in Cancer Research, 153, 63-99. doi:10.1016/bs.acr.2021.07.005
Peer Reviewed verified by ORBi

Cipriani, C., Pires Pacheco, M. I., Kishk, A., Wachich, M., Abankwa, D., Schaffner-Reckinger, E., & Sauter, T. (2022). Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay. Pharmaceuticals (Basel, Switzerland), 15 (2). doi:10.3390/ph15020179
Peer reviewed

Glaab, E., Manoharan, G. B., & Abankwa, D. (23 August 2021). A Pharmacophore Model for SARS-CoV-2 3CLpro Small Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors. Journal of Chemical Information and Modeling, 61 (8), 4082-4096. doi:10.1021/acs.jcim.1c00258
Peer Reviewed verified by ORBi

Siddiqui, F. A., Vukic, V., Salminen, T. A., & Abankwa, D. (2021). Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity. Biomolecules. doi:10.3390/biom11060836
Peer Reviewed verified by ORBi

Ahearn, I. M., Court, H. R., Siddiqui, F., Abankwa, D., & Philips, M. R. (2021). NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. Life Science Alliance. doi:10.26508/lsa.202000972
Peer Reviewed verified by ORBi

Chippalkatti, R., & Abankwa, D. (2021). Promotion of cancer cell stemness by Ras. Biochemical Society Transactions. doi:10.1042/BST20200964
Peer Reviewed verified by ORBi

Okutachi, S. O., Manoharan, G. B., Kiriazis, A., Laurini, C., Catillon, M., McCormick, F., Yli-Kauhaluoma, J., & Abankwa, D. (2021). A covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness. Frontiers in Cell and Developmental Biology. doi:10.3389/fcell.2021.665673
Peer Reviewed verified by ORBi

Parkkola, H., Siddiqui, F. A., Oetken-Lindholm, C., & Abankwa, D. (2021). FLIM-FRET Analysis of Ras Nanoclustering and Membrane-Anchorage. Methods in molecular biology (Clifton, N.J.), 2262, 233-250. doi:10.1007/978-1-0716-1190-6_13
Peer reviewed

Abankwa, D., & Gorfe, A. A. (November 2020). Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again. Biomolecules, 10 (11). doi:10.3390/biom10111522
Peer Reviewed verified by ORBi

Schommer, C., Sauter, T., Pang, J., & Abankwa, D. (2020). Proceedings of the AI4Health Lecture Series (2020). Paper presented at AI4Health Lectures Series (2020), Campus Belval, University of Luxembourg, Luxembourg.

Siddiqui, F. A., Alam, C., Rosenqvist, P., Ora, M., Sabt, A., Manoharan, G. B., Bindu, L., Okutachi, S. O., Catillon, M., Taylor, T., Abdelhafez, O. M., Lönnberg, H., Stephen, A. G., Papageorgiou, A. C., Virta, P., & Abankwa, D. (2020). PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity. ACS Omega, 5 (1), 832-842. doi:10.1021/acsomega.9b03639
Peer Reviewed verified by ORBi

Yurugi, H., Zhuang, Y., Siddiqui, F. A., Liang, H., Rosigkeit, S., Zeng, Y., Abou-Hamdan, H., Bockamp, E., Zhou, Y., Abankwa, D., Zhao, W., Désaubry, L., & Rajalingam, K. (2020). A subset of flavaglines inhibits KRAS nanoclustering and activation. Journal of Cell Science, 133 (12). doi:10.1242/jcs.244111
Peer Reviewed verified by ORBi

Siddiqui, F. A., Parkkola, H., Manoharan, G. B., & Abankwa, D. (2019). Medium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay. SLAS Discovery. doi:10.1177/2472555219884033
Peer reviewed

Manoharan, G. B., Kopra, K., Eskonen, V., Harma, H., & Abankwa, D. (February 2019). High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors. Analytical Biochemistry, 572, 25-32. doi:10.1016/j.ab.2019.02.015
Peer Reviewed verified by ORBi

Buehler, U., Schulenburg, K., Yurugi, H., Solman, M., Abankwa, D., Ulges, A., Tenzer, S., Bopp, T., Thiede, B., Zipp, F., & Rajalingam, K. (2018). Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity. The EMBO journal, 37 (16). doi:10.15252/embj.201899429
Peer reviewed

Sahlgren, C., Meinander, A., Zhang, H., Cheng, F., Preis, M., Xu, C., Salminen, T., Toivola, D., Abankwa, D., Rosling, A., Karaman, D., Salo-Ahen, O., Österbacka, R., Eriksson, J., Willför, S., Petre, I., Peltonen, J., Leino, R., Johnson, M., ... Sandler, N. (2017). Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Advanced Healthcare Materials. doi:10.1002/adhm.201700258
Peer Reviewed verified by ORBi

Posada, I., Lectez, B., Siddiqui, F., Oetken-Lindholm, C., Sharma, M., & Abankwa, D. (2017). Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1. Scientific Reports. doi:10.1038/s41598-017-09387-8
Peer Reviewed verified by ORBi

Posada, I., Lectez, B., Sharma, M., Oetken-Lindholm, C., Yetukuri, L., Zhou, Y., Aittokallio, T., & Abankwa, D. (04 July 2017). rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner. Oncotarget, Vol. 8 ((No. 27)), 44550-44566. doi:10.18632/oncotarget.17819
Peer reviewed

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