Profil

JARAZO Javier

University of Luxembourg

Main Referenced Co-authors
SCHWAMBORN, Jens Christian  (23)
ANTONY, Paul  (11)
BOLOGNIN, Silvia  (6)
GOMEZ GIRO, Gemma  (6)
KRÜGER, Rejko  (6)
Main Referenced Keywords
Deep Learning (2); iPSC (2); Mitophagy (2); Parkinson's disease (2); 3D cultures (1);
Main Referenced Unit & Research Centers
Griffith Institute for Drug Discovery (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Developmental and Cellular Biology (Schwamborn Group) (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Interventional Neuroscience (Hertel Group), Developmental and Cellular Biology (Schwamborn Group) (1)
Main Referenced Disciplines
Genetics & genetic processes (8)
Biochemistry, biophysics & molecular biology (6)
Life sciences: Multidisciplinary, general & others (6)
Biotechnology (3)
Neurology (2)

Publications (total 24)

The most downloaded
424 downloads
Kane, K., Lucumi Moreno, E., Hachi, S., Walter, M., Jarazo, J., Hankemeier, T., Vulto, P., Schwamborn, J. C., Thoma, M., & Fleming, R. M. (2017). Automated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease. bioRxiv. doi:10.1038/s41598-018-34828-3 https://hdl.handle.net/10993/33327

The most cited

268 citations (OpenCitations)

Monzel, A. S., Smits, L., Hemmer, K., Hachi, S., Lucumi Moreno, E., Van Wüllen, T. M., Jarazo, J., Walter, J., Werthschulte, I., Boussaad, I., Berger, E., Fleming, R. M., Bolognin, S., & Schwamborn, J. C. (2017). Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. doi:10.1016/j.stemcr.2017.03.010 https://hdl.handle.net/10993/30751

Garcia Santa Cruz, B., Sölter, J., Gomez Giro, G., Saraiva, C., Sabaté Soler, S., Modamio Chamarro, J., Barmpa, K., Schwamborn, J. C., Hertel, F., Jarazo, J., & Husch, A. (2022). Generalising from conventional pipelines using deep learning in high‑throughput screening workfows. Scientific Reports. doi:10.1038/s41598-022-15623-7
Peer Reviewed verified by ORBi

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446
Peer Reviewed verified by ORBi

Sabaté Soler, S., Nickels, S. L., Saraiva, C., Berger, E., Dubonyte, U., Barmpa, K., Lan, Y. J., Kouno, T., Jarazo, J., Robertson, G., Sharif, J., Koseki, H., Thome, C., Shin, J., Cowley, S., & Schwamborn, J. C. (2022). Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. doi:10.1002/glia.24167
Peer Reviewed verified by ORBi

Brown, S. J., Boussaad, I., Jarazo, J., Fitzgerald, J. C., Antony, P., Keatinge, M., Blechman, J., Schwamborn, J. C., Krüger, R., Placzek, M., & Bandmann, O. (2021). PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons. Scientific Reports. doi:10.1038/s41598-021-84278-7
Peer Reviewed verified by ORBi

Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L., Su, J., Arias-Fuenzalida, Walter, J., Gomez Giro, G., Monzel, A., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., ... Schwamborn, J. C. (2021). Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment. Movement Disorders. doi:10.1002/mds.28810
Peer Reviewed verified by ORBi

Hanss, Z., Larsen, S., Antony, P., Mencke, P., Massart, F., Jarazo, J., Schwamborn, J. C., Barbuti, P., Mellick, G., & Krüger, R. (2020). Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons. Movement Disorders. doi:10.1002/mds.28365
Peer Reviewed verified by ORBi

Kane, K., Jarazo, J., Lucumi Moreno, E., Fleming, R., & Schwamborn, J. C. (2020). Passive controlled flow for Parkinson’s disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip.
Peer reviewed

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Dietrich, C., Jarazo, J., Henck, J., Balachan, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (2020). Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/49376.

Gomez Giro, G., Arias-Fuenzalida, J., Jarazo, J., Zeuschner, D., Ali, M., Possemis, N., Bolognin, S., Halder, R., Jäger, C., Kuper, W., van Hasselt, P., Zaehres, H., del Sol Mesa, A., van der Putten, H., Schoeler, H., & Schwamborn, J. C. (2020). Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta Neuropathologica Communications. doi:10.1186/s40478-019-0871-7
Peer Reviewed verified by ORBi

Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease. Human Molecular Genetics. doi:10.1093/hmg/ddaa066
Peer Reviewed verified by ORBi

Garcia Santa Cruz, B., Jarazo, J., Saraiva, C., Gomez Giro, G., Modamio Chamarro, J., Sabaté Soler, S., Kyriaki, B., Antony, P., Schwamborn, J. C., Hertel, F., & Husch, A. (29 November 2019). From tech to bench: Deep Learning pipeline for image segmentation of high-throughput high-content microscopy data [Poster presentation]. Advances in Computational Biology, Barcelona, Spain.

Garcia Santa Cruz, B., Jarazo, J., Schwamborn, J. C., Hertel, F., & Husch, A. (10 October 2019). Deep Learning Quality Control for High-Throughput High-Content Screening Microscopy Images [Poster presentation]. EMBO|EMBL Symposia - Seeing is Believing - Imaging the Molecular Processes of Life, Heidelberg, Germany.

Arias, J., Jarazo, J., Walter, J., Gomez Giro, G., Forster, J., Antony, P., Krüger, R., & Schwamborn, J. C. (2019). Automated high-throughput high-content autophagy and mitophagy analysis platform. Scientific Reports. doi:10.1038/s41598-019-45917-2
Peer Reviewed verified by ORBi

Jarazo, J., Qing, X., & Schwamborn, J. C. (2019). Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing. Frontiers in Genetics. doi:10.3389/fgene.2019.00190
Peer Reviewed verified by ORBi

Nickels, S., Walter, J., Bolognin, S., GERARD, D., Jäger, C., Qing, X., Tisserand, J., Jarazo, J., Hemmer, K., Harms, A., Halder, R., Lucarelli, P., Berger, E., Antony, P., Glaab, E., Hankemeier, T., Klein, C., Sauter, T., Sinkkonen, L., & Schwamborn, J. C. (2019). Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism and Related Disorders. doi:10.1016/j.parkreldis.2019.09.018
Peer Reviewed verified by ORBi

Walter, J., Bolognin, S., Antony, P., Nickels, S., Poovathhingal, S., Salamanca, L., Magni, S., Perfeito, R., Hoel, F., Qing, X., Jarazo, J., Arias-Fuenzalida, J., Ignac, T., Monzel, A. S., Gonzalez-Cano, L., Pereira de Almeida, L., Skupin, A., Tronstad, K., & Schwamborn, J. C. (2019). Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality. Stem Cell Reports. doi:10.1016/j.stemcr.2019.03.004
Peer Reviewed verified by ORBi

Kane, K., Lucumi Moreno, E., Hachi, S., Walter, M., Jarazo, J., Oliveira, M., Hankemeier, T., Vulto, P., Schwamborn, J. C., Thoma, M., & Fleming, R. (2019). Automated microfluidic cell culture of stem cell derived dopaminergic neurons. Scientific Reports. doi:10.1038/s41598-018-34828-3
Peer Reviewed verified by ORBi

Hanss, Z., Boussaad, I., Jarazo, J., Schwamborn, J. C., & Krüger, R. (2019). Quality Control Strategy for CRISPRCas9- based Gene Editing Complicated by a Pseudogene. Frontiers in Genetics. doi:10.3389/fgene.2019.01297
Peer Reviewed verified by ORBi

Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Lucumi Moreno, E., Nickels, S., Wasner, K., Ouzren, N., Walter, J., Grünewald, A., Glaab, E., Salamanca, L., Fleming, R. M. T., Antony, P., & Schwamborn, J. C. (2018). 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science. doi:10.1002/advs.201800927
Peer Reviewed verified by ORBi

Jarazo, J. (2018). THE PARKINSON’S DISEASE ASSOCIATED PINK1-PARKIN PATHWAY IN PATHOLOGY AND DEVELOPMENT [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/36140

Kane, K., Lucumi Moreno, E., Hachi, S., Walter, M., Jarazo, J., Hankemeier, T., Vulto, P., Schwamborn, J. C., Thoma, M., & Fleming, R. M. (2017). Automated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease. bioRxiv. doi:10.1038/s41598-018-34828-3

Arias, J., Jarazo, J., Qing, X., Walter, J., Gomez Giro, G., Nickels, S., Zaehres, H., Schoeler, H. R., & Schwamborn, J. C. (2017). FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling. Stem Cell Reports. doi:10.1016/j.stemcr.2017.08.026
Peer Reviewed verified by ORBi

Qing, X., Walter, J., Jarazo, J., Arias, J., Hillje, A.-L., & Schwamborn, J. C. (2017). CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons. Stem Cell Research. doi:10.1016/j.scr.2017.08.013
Peer reviewed

Monzel, A. S., Smits, L., Hemmer, K., Hachi, S., Lucumi Moreno, E., Van Wüllen, T. M., Jarazo, J., Walter, J., Werthschulte, I., Boussaad, I., Berger, E., Fleming, R. M., Bolognin, S., & Schwamborn, J. C. (2017). Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. doi:10.1016/j.stemcr.2017.03.010
Peer Reviewed verified by ORBi

Contact ORBilu