Profil

KREIS Stephanie

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

Main Referenced Co-authors
WURTH - MARGUE, Christiane  (24)
BEHRMANN, Iris  (18)
PHILIPPIDOU, Demetra  (17)
HAAN, Claude  (10)
KOZAR, Ines  (7)
Main Referenced Keywords
Melanoma (9); melanoma (7); Humans (5); cancer (4); cytokine (3);
Main Referenced Unit & Research Centers
ULHPC - University of Luxembourg: High Performance Computing (4)
University of Luxembourg (3)
Department of Life Sciences and Medicine (2)
Life Science Research Unit-University of Luxembourg (1)
Saarland University (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (46)
Microbiology (4)
Oncology (3)
Life sciences: Multidisciplinary, general & others (1)

Publications (total 54)

The most downloaded
412 downloads
Kozar, I., Margue, C., Rothengatter, S., Haan, C., & Kreis, S. (15 February 2019). Many ways to resistance: How melanoma cells evade targeted therapies. Biochimica et Biophysica Acta - Reviews on Cancer, 1871 (2), 313-322. doi:10.1016/j.bbcan.2019.02.002 https://hdl.handle.net/10993/38857

The most cited

190 citations (Scopus®)

Philippidou, D., Schmitt, M., Moser, D., Margue, C., Nazarov, P. V., Muller, A., Vallar, L., Nashan, D., Behrmann, I., & Kreis, S. (2010). Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma. Cancer Research, 70 (10), 4163-4173. doi:10.1158/0008-5472.CAN-09-4512 https://hdl.handle.net/10993/4989

GUREGHIAN, V., HERBST, H., KOZAR, I., MIHAJLOVIC, K., Malod-Dognin, N., Ceddia, G., ANGELI, C., WURTH-MARGUE, C., RANDIC, T., PHILIPPIDOU, D., TETSI NOMIGNI, M., HEMEDAN, A., TRANCHEVENT, L.-C., LONGWORTH, J., Bauer, M., BADKAS, A., GAIGNEAUX, A., Muller, A., OSTASZEWSKI, M., ... KREIS, S. (October 2023). A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma. Cancer Gene Therapy, 30 (10), 1330 - 1345. doi:10.1038/s41417-023-00640-z
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Rigg, E., Wang, J., Xue, Z., Lunavat, T. R., Liu, G., Hoang, T., Parajuli, H., Han, M., Bjerkvig, R., Nazarov, P. V., Nicot, N., KREIS, S., WURTH-MARGUE, C., TETSI NOMIGNI, M., Utikal, J., Miletic, H., Sundstrøm, T., Ystaas, L. A. R., Li, X., & Thorsen, F. (October 2023). Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes. Journal of Extracellular Vesicles, 12 (10), 12363. doi:10.1002/jev2.12363
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Bintener, T., Pires Pacheco, M. I., Philippidou, D., Margue, C., Kishk, A., Del Mistro, G., Di Leo, L., Moscardo Garcia, M., Halder, R., Sinkkonen, L., De Zio, D., Kreis, S., Kulms, D., & Sauter, T. (26 July 2023). Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma. Cell Death and Disease, 14 (468). doi:10.1038/s41419-023-05955-1
Peer reviewed

RANDIC, T., MAGNI, S., PHILIPPIDOU, D., Margue, C., GRZYB, K., PREIS, J. R., WROBLEWSKA, J. P., NAZAROV, P., MITTELBRONN, M., FRAUENKNECHT, K., SKUPIN, A., & KREIS, S. (25 July 2023). Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response. Cell Reports, 42 (7), 112696. doi:10.1016/j.celrep.2023.112696
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Wroblewska, J. P., Lach, M. S., Rucinski, M., Piotrowski, I., Galus, L., Suchorska, W. M., Kreis, S., & Marszałek, A. (2022). MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression. Frontiers in Cell and Developmental Biology. doi:10.3389/fcell.2022.1008901
Peer reviewed

Randic, T., Kozar, I., Margue, C., Utikal, J., & Kreis, S. (29 May 2021). NRAS mutant melanoma: Towards better therapies. Cancer Treatment Reviews, 99. doi:10.1016/j.ctrv.2021.102238
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Kozar, I., Philippidou, D., Margue, C., Gay, L., Renne, R., & Kreis, S. (2021). Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells. Cancers. doi:10.3390/cancers13051096
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Kirchmeyer, M., Servais, F., Ginolhac, A., Nazarov, P. V., Margue, C., Philippidou, D., Nicot, N., Behrmann, I., Haan, C., & Kreis, S. (2020). Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types. Journal of Molecular Biology. doi:10.1016/j.jmb.2020.09.011
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Walbrecq, G., Margue, C., Behrmann, I., & Kreis, S. (2020). Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells. International Journal of Molecular Sciences. doi:10.3390/ijms21145071
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Walbrecq, G., Lecha, O., Gaigneaux, A., Fougeras, M. R., Philippidou, D., Margue, C., Tetsi Nomigni, M., Bernardin, F., Dittmar, G., Behrmann, I., & Kreis, S. (2020). Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles. Cancers. doi:10.3390/cancers12030692
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Nazarov, P. V., Wienecke-Baldacchino, A. K., Zinovyev, A., Czerwińska, U., Muller, A., Nashan, D., Dittmar, G., Azuaje, F., & Kreis, S. (18 September 2019). Deconvolution of Transcriptomes and miRNomes by Independent Component Analysis Provides Insights Into Biological Processes and Clinical Outcomes of Melanoma Patients. BMC Medical Genomics, 12 (1) (132). doi:10.1186/s12920-019-0578-4
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Kozar, I., Margue, C., Rothengatter, S., Haan, C., & Kreis, S. (15 February 2019). Many ways to resistance: How melanoma cells evade targeted therapies. Biochimica et Biophysica Acta - Reviews on Cancer, 1871 (2), 313-322. doi:10.1016/j.bbcan.2019.02.002
Peer Reviewed verified by ORBi

Margue, C., Philippidou, D., Kozar, I., Cesi, G., Felten, P., Kulms, D., Letellier, E., Haan, C., & Kreis, S. (February 2019). Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells. Journal of Experimental and Clinical Cancer Research, 38 (1). doi:10.1186/s13046-019-1038-x
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Servais, F., Kirchmeyer, M., Hamdorf, M., Minoungou, W. N., Rose-John, S., Kreis, S., Haan, C., & Behrmann, I. (2019). Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3. Molecular Therapy: Nucleic Acids, 16, 419-433. doi:10.1016/j.omtn.2019.03.007
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Cesi, G., Philippidou, D., Kozar, I., Kim, Y. J., Bernardin, F., Van Niel, G., Wienecke-Baldacchino, A., Felten, P., Letellier, E., Dengler, S., Nashan, D., Haan, C., & Kreis, S. (2018). A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells. Molecular Cancer, (17:145). doi:10.1186/s12943-018-0886-x
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Bauer, A. S., Nazarov, P. V., Giese, N. A., Beghelli, S., Heller, A., Greenhalf, W., Costello, E., Muller, A., Bier, M., Strobel, O., Hackert, T., Vallar, L., Scarpa, A., Büchler, M. W., Neoptolemos, J. P., Kreis, S., & Hoheisel, J. D. (01 March 2018). Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. International Journal of Cancer, 142 (5), 1010–1021. doi:10.1002/ijc.31087
Peer reviewed

Rolvering, C., Zimmer, A. D., Ginolhac, A., Margue, C., Kirchmeyer, M., Servais, F., Hermanns, H. M., Hergovits, S., Nazarov, P. V., Nicot, N., Kreis, S., Haan, S., Behrmann, I., & Haan, C. (2018). The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies. Journal of Leukocyte Biology, 104, 969-985. doi:10.1002/JLB.MA1217-495R
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Kirchmeyer, M., Servais, F., Hamdorf, M., Nazarov, P. V., Ginolhac, A., Halder, R., Vallar, L., Glanemann, M., Rubie, C., Lammert, F., Kreis, S., & Behrmann, I. (2018). Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets. Journal of Leukocyte Biology. doi:10.1002/JLB.MA1217-499RR
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Mgrditchian, T., Arakelian, T., Paggetti, J., Noman, M., Viry, E., Moussay, E., Van Moer, K., Kreis, S., Guerin, C., Buart, S., Robert, C., Borg, C., Vielh, P., Chouaib, S., Berchem, G., & Janji, B. (31 October 2017). Targeting autophagy inhibits growth by enhancing NK cells infiltration in a CCL5-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 114 ((44)), 9271-E9279. doi:10.1073/pnas.1703921114
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Cesi, G., Walbrecq, G., Zimmer, A. D., Kreis, S., & Haan, C. (08 June 2017). ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells. Molecular Cancer, 8 (june). doi:10.1186/s12943-017-0667-y
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Kreis, S., Kozar, I., Cesi, G., Margue, C., & Philippidou, D. (2017). Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells. Biochimica et Biophysica Acta. doi:10.1016/j.bbagen.2017.04.005
Peer reviewed

Keller, A., Kreis, S., Leidinger, P., Maixner, F., Ludwig, N., Backes, C., Galata, V., Guerriero, G., Fehlmann, T., Franke, A., Meder, B., Zink, A., & Meese, E. (26 December 2016). miRNAs in ancient tissue specimens of the Tyrolean Iceman. Molecular Biology and Evolution, 34 (4), 793-801. doi:10.1093/molbev/msw291
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Heulot, M., Chevalier, N., Puyal, J., Margue, C., Michel, S., Kreis, S., Kulms, D., Barras, D., Nahimana, A., & Widmann, C. (27 September 2016). The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget, 7 (39). doi:10.18632/oncotarget.11841
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Cesi, G., Walbrecq, G., Margue, C., & Kreis, S. (10 June 2016). Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons". Cell Communication and Signaling, 14 (1), 13. doi:10.1186/s12964-016-0136-z
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Reinsbach, S., Wienecke, A., Ginolhac, A., Vallar, L., Krishna, Krishna, A., Nazarov, P., May, P., & Kreis, S. (2016). “Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients. European Journal of Cancer, 61 (Suppl.1), 32. doi:10.1016/S0959-8049(16)61101-2

Behrmann, I., Margue, C., & Kreis, S. (2015). Circulating microRNAs as candidate biomarkers for the surveillance of melanoma patients. EBioMedicine. doi:10.1016/j.ebiom.2015.07.015
Peer reviewed

Kaysen, A., Buschart, A., May, P., Laczny, C. C., Narayanasamy, S., Graf, N., Simon, A., Bittenbring, J., Kreis, S., Schneider, J., & Wilmes, P. (June 2015). Dynamic change of host gastrointestinal microbiome and immune status in relation to mucosal barrier effects during chemotherapy and immune ablative intervention in humans [Poster presentation]. The Human Microbiome, Heidelberg, Germany.

Kaysen, A., Heintz, A., Lebrun, L., Graf, N., Simon, A., Bittenbring, J., Kreis, S., Schneider, J., & Wilmes, P. (March 2015). Changes in the human gastrointestinal microbiome during cancer treatments [Poster presentation]. 5th International Human Microbiome Congress, Luxembourg-City, Luxembourg.

Servais, F., Kirchmeyer, M., Hamdorf, M., Haan, C., Casper, M., Lammert, F., Nazarov, P., Vallar, L., Kreis, S., & Behrmann, I. (2015). ID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases. Cytokine, 76 (1), 99. doi:10.1016/j.cyto.2015.08.198
Peer reviewed

Margue, C., Reinsbach, S., Philippidou, D., Beaume, N., Walters, C., Schneider, J., Nashan, D., Behrmann, I., & Kreis, S. (2015). Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer? Oncotarget, 6 (14), 12110-27. doi:10.18632/oncotarget.3661
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Kaysen, A., Heintz, A., Lebrun, L., Graf, N., Simon, A., Bittenbring, J., Kreis, S., Schneider, J., & Wilmes, P. (April 2014). Dynamic change of host gastrointestinal microbiome and immune status in relation to mucosal barrier effects during chemotherapy and immune ablative intervention in humans [Poster presentation]. Exploring Human Host-Microbiome Interactions in Health and Disease.

Margue, C., Philippidou, D., Reinsbach, S., Schmitt, M., Behrmann, I., & Kreis, S. (05 September 2013). New Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion. PLoS ONE, 8 (9). doi:10.1371/journal.pone.0073473
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Nazarov, P. V. A., Reinsbach, S., Muller, A. A., Nicot, N. A., Philippidou, D., Vallar, L. A., & Kreis, S. (2013). Interplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function. Nucleic Acids Research, 41 (5), 2817-2831. doi:10.1093/nar/gks1471
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Schmitt, M., Margue, C., Behrmann, I., & Kreis, S. (2012). MiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties. Current Molecular Medicine, 13 (4), 572-585. doi:10.2174/1566524011313040009
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Reinsbach, S., Nazarov, P. V., Philippidou, D., Schmitt, M., Wienecke, A., Muller, A., Vallar, L., Behrmann, I., & Kreis, S. (2012). Dynamic regulation of microRNA expression following interferonγ- induced gene transcription. RNA Biology, 9 (7), 987-989. doi:10.4161/rna.20494
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Schmitt, M. J., Philippidou, D., Reinsbach, S., Margue, C., Wienecke-Baldacchino, A., Nashan, D., Behrmann, I., & Kreis, S. (2012). Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells. Cell Communication and Signaling, 10. doi:10.1186/1478-811X-10-41
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Philippidou, D., Schmitt, M., Moser, D., Margue, C., Nazarov, P. V., Muller, A., Vallar, L., Nashan, D., Behrmann, I., & Kreis, S. (2010). Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma. Cancer Research, 70 (10), 4163-4173. doi:10.1158/0008-5472.CAN-09-4512
Peer Reviewed verified by ORBi

Margue, C., & Kreis, S. (2010). IL-24: Physiological and supraphysiological effects on normal and malignant cells. Current Medicinal Chemistry, 17 (29), 3318-3326. doi:10.2174/092986710793176311
Peer reviewed

Kreis, S., Philippidou, D., Margue, C., & Behrmann, I. (10 May 2008). IL-24: a classic cytokine and/or a potential cure for cancer? Journal of Cellular and Molecular Medicine, 12 (6A), 2505-2510. doi:10.1111/j.1582-4934.2008.00372.x
Peer reviewed

Kreis, S., Munz, G. A., Haan, S., Heinrich, P. C., & Behrmann, I. (2008). Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Molecular Cancer Research, 5 (12), 1331-41. doi:10.1158/1541-7786.MCR-07-0317
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Kreis, S., Philippidou, D., Margue, C., Rolvering, C., Haan, C., Dumoutier, L., Renauld, J.-C., & Behrmann, I. (2007). Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells. PLoS ONE, 2 (12), 1300. doi:10.1371/journal.pone.0001300
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Haan, C., Kreis, S., Margue, C., & Behrmann, I. (November 2006). Jaks and cytokine receptors - an intimate relationship. Biochemical Pharmacology, 72 (11), 1538-46. doi:10.1016/j.bcp.2006.04.013
Peer reviewed

Kreis, S., Schönfeld, H.-J. B., Melchior, C. A., Steiner, B. B. C., & Kieffer, N. A. (2005). The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions. Experimental Cell Research, 305 (1), 110-121. doi:10.1016/j.yexcr.2004.12.023
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Tremuth, L. A., Kreis, S., Melchior, C., Hoebeke, J., Rondé, P., Plançon, S., Takeda, K., & Kieffer, N. (2004). A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain. Journal of Biological Chemistry, 279 (21), 22258-22266. doi:10.1074/jbc.M400947200
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Melchior, C. A., Kreis, S., Janji, B. B., & Kieffer, N. A. (2002). Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1. Biochimica et Biophysica Acta-Gene Structure and Expression, 1575 (1-3), 117-122. doi:10.1016/S0167-4781(02)00247-6
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Hartter, H. K., Oyedele, O. I., Dietz, K., Kreis, S., Hoffman, J. P., & Muller, C. (2000). Placental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children. Pediatric Infectious Disease Journal, 19 (7), 635-641. doi:10.1097/00006454-200007000-00010
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Fack, F., Deroo, S., Kreis, S., & Muller, C. (2000). Heteroduplex mobility assay (HMA) pre-screening: An improved strategy for the rapid identification of inserts selected from phage-displayed peptide libraries. Molecular Diversity, 5 (1), 7-12. doi:10.1023/A:1011318710547
Peer reviewed

Vardas, E. A. B., & Kreis, S. (1999). Isolation of measles virus from a naturally-immune, asymptomatically re-infected individual. Journal of Clinical Virology, 13 (3), 173-179. doi:10.1016/S1386-6532(99)00026-8
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Vardas, E. A. D., Leary, P. M. B., Yeats, J. C., Badrodien, W. B., & Kreis, S. (1999). Case report and molecular analysis of subacute sclerosing panencephalitis in a South African child. Journal of Clinical Microbiology, 37 (3), 775-777. doi:10.1128/jcm.37.3.775-777.1999
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Truong, A. T., Kreis, S., Ammerlaan, W., Hartter, H. K., Adu, F., Omilabu, S. A., Oyefolu, A. O., Berbers, G. A. M., & Muller, C. (1999). Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates. Virus Research, 62 (1), 89-95. doi:10.1016/S0168-1702(99)00072-6
Peer reviewed

Kreis, S., & Schoub, B. D. (1998). Partial amplification of the measles virus nucleocapsid gene from stored sera and cerebrospinal fluids for molecular epidemiological studies. Journal of Medical Virology, 56 (2), 174-177. doi:10.1002/(SICI)1096-9071(199810)56:2<174::AID-JMV12>3.0.CO;2-G
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Kreis, S., & Whistler, T. (1997). Rapid identification of measles virus strains by the heteroduplex mobility assay. Virus Research, 47 (2), 47(2):197-203. doi:10.1016/S0168-1702(96)01413-X
Peer reviewed

Vardas, E., Andre, M., Kreis, S., Zachariades, N., & Schoub, B. (1997). Measles virus transmission from infected to immune individuals - Implications for measles control and elimination. South African Medical Journal, 87 (12), 1709.
Peer reviewed

Kreis, S., Vardas, E., & Whistler, T. (1997). Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype. Journal of General Virology, 78 (7), 1581-1587. doi:10.1099/0022-1317-78-7-1581
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