[en] Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.
Pagano, Giulia ✱; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg ; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
MOUSSAY, Etienne ✱; University of Luxembourg ; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg
PAGGETTI, Jerome ✱; University of Luxembourg ; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg
✱ These authors have contributed equally to this work.
External co-authors :
no
Language :
English
Title :
Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia.
Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg Fonds National de la Recherche Scientifique (FNRS)-Télévie
Funding text :
This work was supported by grants from the Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg to EM and JP (C20/BM/14582635 and C20/BM/14592342) and from Fonds National de la Recherche Scientifique (FNRS)-Télévie to IFB and GP (7.4501.18, 7.4529.19, 7.6518.20, and 7.6603.21).
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